Cited by 187RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

Fox-1 family of RNA-binding proteins

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Kuroyanagi, Hidehito·2009·Cellular and Molecular Life Sciences

Abstract

The Fox-1 family of RNA-binding proteins are evolutionarily conserved regulators of tissue-specific alternative splicing in metazoans. The Fox-1 family specifically recognizes the (U)GCAUG stretch in regulated exons or in flanking introns, and either promotes or represses target exons. Recent unbiased bioinformatics analyses of alternatively spliced exons and comparison of various vertebrate genomes identified the (U)GCAUG stretch as a highly conserved and widely distributed element enriched in intronic regions surrounding exons with altered inclusion in muscle, heart, and brain, consistent with specific expression of Fox-1 and Fox-2 in these tissues. Global identification of Fox-2 target RNAs in living cells revealed that many of the Fox-2 target genes themselves encode splicing regulators. Further systematic elucidation of target genes of the Fox-1 family and other splicing regulators in various tissues will lead to a comprehensive understanding of splicing regulatory networks.

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  • RBFOX binding upstream of, or within, an alternative exon typically inhibits exon inclusion, whereas downstream binding usually promotes splicing.

    “RBFOX binding upstream of, or within, an alternative exon typically inhibits exon inclusion, whereas downstream binding usually promotes splicing48.”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [48]

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Authors
Kuroyanagi, H.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Kuroyanagi, Hidehito
Venue
Cellular and Molecular Life Sciences
Published
2009-08-18
Volume
66
Issue
24
Pages
3895-3907
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2057774013
Cited by
187
References
78
Citations by year
2026: 5 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 23 · 2015: 10 · 2014: 10 · 2013: 17 · 2012: 11
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Tokyo Medical and Dental University
  • Japan Society for the Promotion of Science
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
RNA-binding proteins, alternative splicing, intronic splicing enhancer, muscle, heart, brain, splicing regulators, splicing regulatory network, vertebrate genomes
MeSH terms
RNA Splicing Factors, Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Humans, Molecular Sequence Data, RNA-Binding Proteins, Spliceosomes, Sequence Homology, Amino Acid, Alternative Splicing

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