Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients
Open accessAbstract
AIM: To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS: The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent quantitative polymerase chain reaction (FQ-PCR) was applied to detect F. nucleatum in CRC and normal tissues. The difference of F. nucleatum abundance between cancer and normal tissues and the relationship of F. nucleatum abundance with clinical variables were evaluated. Fluorescence in situ hybridization (FISH) analysis was performed on 22 CRC tissues with the highest F. nucleatum abundance by FQ-PCR testing to confirm FQ-PCR results. RESULTS: The median abundance of F. nucleatum in CRC tissues [0.242 (0.178-0.276)] was significantly higher than that in normal controls [0.050 (0.023-0.067)] (P < 0.001). F. nucleatum was over-represented in 88/101 (87.1%) CRC samples. The abundance of F. nucleatum determined by 2(-ΔCT) was significantly greater in tumor samples [0.242 (0.178, 0.276)] than in normal controls [0.050 (0.023, 0.067)] (P < 0.001). The frequency of patients with lymph node metastases was higher in the over-abundance group [52/88 (59.1%)] than in the under-abundance group [0/13 (0%)] (P < 0.005). No significant association of F. nucleatum with other clinico-pathological variables was observed (P > 0.05). FISH analysis also found more F. nucleatum in CRC than in normal tissues (median number 6, 25(th) 3, 75(th) 10 vs 2, 25(th) 1, 75(th) 5) (P < 0.01). CONCLUSION: F. nucleatum was enriched in CRC tissues and associated with CRC development and metastasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous studies of multiple cohorts worldwide have found similar associations between Fusobacterium nucleatum and colorectal cancer.
“Numerous studies, of multiple cohorts, of patients with CRC worldwide have found similar associations.23–27”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
The global health burden of infection‐associated cancers in the year 2002
Parkin, D. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21731 · Cited by 2,932 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works
<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works
<i>Fusobacterium nucleatum</i> in colorectal carcinoma tissue and patient prognosis
Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310101 · Cited by 1,080 · see citing works
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
Chen, W., Liu, F., Ling, Z., Tong, X., & Xiang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039743 · Cited by 1,029 · see citing works
Fusobacterium nucleatum: a commensal-turned pathogen
Han, Y. W. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.013 · Cited by 832 · see citing works
<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Ogino, S., Chan, A. T., Fuchs, C. S., & Giovannucci, E. L. (2010) · Gut · doi:10.1136/gut.2010.217182 · Cited by 521 · see citing works
Fusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works
Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2081-3 · Cited by 498 · see citing works
<i>Fusobacterium</i> in Colonic Flora and Molecular Features of Colorectal Carcinoma
Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1865 · Cited by 465 · see citing works
Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum / necrophorum
Swidsinski, A. V., Dörffel, Y., Loening-Baucke, V. A., Theissig, F., Rueckert, J.-C., Ismail, M., Rau, W. A., Gaschler, D., Weizenegger, M., Kühn, S., et al. (2009) · Gut · doi:10.1136/gut.2009.191320 · Cited by 441 · see citing works
Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
Colussi, D., Brandi, G., Bazzoli, F., & Ricciardiello, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816365 · Cited by 429 · see citing works
Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas
Shen, X. J., Rawls, J. F., Randall, T. A., Burcall, L., Mpande, C., Jenkins, N., Jovov, B., Abdo, Z., Sandler, R. S., & Keku, T. O. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12360 · Cited by 418 · see citing works
Sonnenburg, J. L., Angenent, L. T., & Gordon, J. I. (2004) · Nature Immunology · doi:10.1038/ni1079 · Cited by 406 · see citing works
Co-occurrence of anaerobic bacteria in colorectal carcinomas
Warren, R. L., Freeman, D. J., Pleasance, S., Watson, P., Moore, R. A., Cochrane, K., Allen-Vercoe, E., & Holt, R. A. (2013) · Microbiome · doi:10.1186/2049-2618-1-16 · Cited by 348 · see citing works
Ito, M., Kanno, S., Nosho, K., Sukawa, Y., Mitsuhashi, K., Kurihara, H., Igarashi, H., Takahashi, T., Tachibana, M., Takahashi, H., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29488 · Cited by 288 · see citing works
Bishehsari, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i20.6055 · Cited by 266 · see citing works
Epigenetics and Colorectal Cancer Pathogenesis
Bardhan, K., & Liu, K. (2013) · Cancers · doi:10.3390/cancers5020676 · Cited by 256 · see citing works
Viljoen, K. S., Dakshinamurthy, A., Goldberg, P., & Blackburn, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119462 · Cited by 256 · see citing works
Ogino, S., Lochhead, P. J., Chan, A. T., Nishihara, R., Cho, E., Wolpin, B. M., Meyerhardt, J. A., Meissner, A., Schernhammer, E. S., Fuchs, C. S., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2012.214 · Cited by 213 · see citing works
Gaetti‐Jardim, E., Marcelino, S. L., Feitosa, A. C. R., Romito, G. A., & Ávila-Campos, M. J. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.013383-0 · Cited by 193 · see citing works
probeCheck – a central resource for evaluating oligonucleotide probe coverage and specificity
Loy, A., Arnold, R. R., Tischler, P., Rattei, T., Wagner, M., & Horn, M. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01706.x · Cited by 183 · see citing works
Role of intestinal epithelial cells in the innate immune defence of the pig intestine
Oswald, I. P. (2006) · Veterinary Research · doi:10.1051/vetres:2006006 · Cited by 165 · see citing works
Fusobacterium and Enterobacteriaceae: Important players for CRC?
Allen‐Vercoe, E., & Jobin, C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.014 · Cited by 132 · see citing works
The Role of the Gastrointestinal Microbiota in Colorectal Cancer
Rowland, I. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168191 · Cited by 129 · see citing works
Zoratto, F., Rossi, L., Verrico, M., Papa, A., Basso, E., Zullo, A., Tomao, L., Romiti, A., Russo, G. L., & Tomao, F. (2014) · Tumor Biology · doi:10.1007/s13277-014-1845-9 · Cited by 111 · see citing works
Bashir, A., Miskeen, A. Y., Bhat, A., Fazili, K. M., & Ganai, B. A. (2015) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000116 · Cited by 79 · see citing works
Strauss, J., White, A. P., Ambrose, C., McDonald, J. A. K., & Allen‐Vercoe, E. (2008) · Anaerobe · doi:10.1016/j.anaerobe.2008.12.003 · Cited by 72 · see citing works
Gentili, V., Gianesini, S., Balboni, P. G., Menegatti, E., Rotola, A., Zuolo, M., Caselli, E., Zamboni, P., & Luca, D. D. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1473-x · Cited by 40 · see citing works
Williams, S. T., & Beart, R. W. (1992) · Seminars in Surgical Oncology · doi:10.1002/ssu.2980080208 · Cited by 24 · see citing works
Fernández, L. M. B., Lasa, J. S., & Man, F. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000153 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Mármol, I., Sánchez‐de‐Diego, C., Pradilla-Dieste, A., Cerrada, E., & Yoldi, M. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,559 · see citing works
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
Brennan, C. A., & Garrett, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0129-6 · Cited by 1,205 · see citing works
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer
Wang, N., & Fang, J. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.08.010 · Cited by 395 · see citing works
Drewes, J. L., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., et al. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0040-3 · Cited by 335 · see citing works
Microbiota, Inflammation and Colorectal Cancer
Lucas, C., Barnich, N., & Nguyen, H. T. T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061310 · Cited by 318 · see citing works
The oral microbiota and its role in carcinogenesis
Stasiewicz, M., & Karpiński, T. M. M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.002 · Cited by 288 · see citing works
Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location
Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284 · see citing works
Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation
Engevik, M. A., Danhof, H. A., Ruan, W. H., Engevik, A. C., Chang‐Graham, A. L., Engevik, K. A., Shi, Z., Zhao, Y., Ardis, C. K., Krystofiak, E., et al. (2021) · mBio · doi:10.1128/mbio.02706-20 · Cited by 275 · see citing works
Hsieh, Y.-Y., Tung, S.-Y., Pan, H.-Y., Yen, C.-W., Xu, H.-W., Lin, Y.-J., Deng, Y.-F., Hsu, W.-T., Wu, C.-S., & Li, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18596-0 · Cited by 269 · see citing works
Abed, J., Maalouf, N., Manson, A. L., Earl, A. M., Parhi, L., Emgård, J., Klutstein, M., Tayeb, S., Almogy, G., Atlan, K., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00400 · Cited by 269 · see citing works
<i>Fusobacterium nucleatum</i>and colorectal cancer: A review
Shang, F.-M., & Liu, H.-L. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i3.71 · Cited by 258 · see citing works
Ogino, S., Nowak, J. A., Hamada, T., Milner, D. A., & Nishihara, R. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012818 · Cited by 256 · see citing works
Hamada, T., Zhang, X., Mima, K., Bullman, S., Sukawa, Y., Nowak, J. A., Kosumi, K., Masugi, Y., Twombly, T. S., Cao, Y., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0174 · Cited by 232 · see citing works
Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS /KRT7
Chen, S., Su, T., Zhang, Y., Lee, A. A., He, J., Ge, Q., Wang, L., Si, J., Zhuo, W., & Wang, L. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1695494 · Cited by 232 · see citing works
Self-citationPin, G., Tian, Z., Kong, X., Yang, L., Shan, X., Dong, B., Ding, X., Jing, X., Jiang, C., Jiang, N., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01677-w · Cited by 209 · see citing works
Song, W., Tiruthani, K., Wang, Y., Shen, L., Hu, M., Dorosheva, O., Qiu, K., Kinghorn, K., Liu, R., & Huang, L. (2018) · Advanced Materials · doi:10.1002/adma.201805007 · Cited by 194 · see citing works
Fusobacterium nucleatum and colorectal cancer: A mechanistic overview
Goradel, N. H., Heidarzadeh, S., Jahangiri, S., Farhood, B., Mortezaee, K., Khanlarkhani, N., & Negahdari, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27250 · Cited by 176 · see citing works
The gut microbiome and colorectal cancer: a review of bacterial pathogenesis
Dahmus, J., Kotler, D. L., Kastenberg, D. M., & Kistler, C. A. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.04.07 · Cited by 177 · see citing works
LaCourse, K. D., Zepeda‐Rivera, M. A., Kempchinsky, A. G., Baryiames, A. A., Minot, S. S., Johnston, C. D., & Bullman, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111625 · Cited by 174 · see citing works
Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Ogino, S., Nowak, J. A., Hamada, T., Phipps, A. I., Peters, U., Milner, D. A., Giovannucci, E. L., Nishihara, R., Giannakis, M., Garrett, W. S., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315537 · Cited by 169 · see citing works
Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population
Yamaoka, Y., Suehiro, Y., Hashimoto, S., Hoshida, T., Fujimoto, M., Watanabe, M., Imanaga, D., Sakai, K., Matsumoto, T., Nishioka, M., et al. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1382-6 · Cited by 158 · see citing works
Gut Microbiota, Fusobacteria, and Colorectal Cancer
Kelly, D., Yang, L., & Pei, Z. (2018) · Diseases · doi:10.3390/diseases6040109 · Cited by 147 · see citing works
Role of gut microbiota in the pathogenesis of colorectal cancer; a review article.
Jahani‐Sherafat, S., Alebouyeh, M., Moghim, S., Amoli, H. A., & Ghasemian-Safaei, H. (2018) · Europe PMC (PubMed Central) · Cited by 143 · see citing works
The Role of the Gut Microbiota in Colorectal Cancer Causation
Hinai, E. A., Walton, G., & Commane, D. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215295 · Cited by 141 · see citing works
Gethings-Behncke, C., Coleman, H. G., Jordão, H. W. T., Longley, D. B., Crawford, N., Murray, L., & Kunzmann, A. T. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1295 · Cited by 137 · see citing works
The role of microbiota in the development of colorectal cancer
Dai, Z., Zhang, J., Wu, Q., Chen, J., Liu, J., Wang, L., Chen, C., Xu, J., Zhang, H., Shi, C., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32017 · Cited by 133 · see citing works
Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism
Ou, S., Wang, H., Tao, Y., Luo, K., Ye, J., Ran, S., Guan, Z., Wang, Y., Hu, H., & Huang, R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1020583 · Cited by 135 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
Wang, S., Liu, Y., Li, J., Zhao, L., Yan, W., Lin, B., Guo, X., & Wei, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710165 · Cited by 126 · see citing works
Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer
Temraz, S. N., Nassar, F. J., Nasr, R., Charafeddine, M., Mukherji, D., & Shamseddine, A. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174155 · Cited by 119 · see citing works
Hamada, T., Keum, N., Nishihara, R., & Ogino, S. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1272-3 · Cited by 114 · see citing works
Proença, M. A., Biselli, J. M., Succi, M., Severino, F. E., Berardinelli, G. N., Caetano, A., Reis, R. M., Hughes, D. J., & Silva, A. E. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i47.5351 · Cited by 109 · see citing works
Yan, X., Liu, L., Li, H., Qin, H., & Sun, Z. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s145949 · Cited by 110 · see citing works
Kendong, S. M. A., Ali, R. A. R., Nawawi, K. N. M., Ahmad, H. F., & Mokhtar, N. M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.744606 · Cited by 108 · see citing works
Hamada, T., Nowak, J. A., Milner, D. A., Song, M., & Ogino, S. (2019) · The Journal of Pathology · doi:10.1002/path.5236 · Cited by 100 · see citing works
In Silico Analysis of Putrefaction Pathways in Bacteria and Its Implication in Colorectal Cancer
Kaur, H., Das, C., & Mande, S. S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02166 · Cited by 99 · see citing works
Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps
Liang, S., Mao, Y. K., Liao, M., Xu, Y., Chen, Y.-C., Huang, X., Wei, C., Wu, C., Wang, Q., Pan, X., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37399 · Cited by 96 · see citing works
Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence
Vacante, M., Ciuni, R., Basile, F., & Biondi, A. (2020) · Biomedicines · doi:10.3390/biomedicines8110489 · Cited by 96 · see citing works
Ranjbar, M., Salehi, R., Javanmard, S. H., Rafiee, L., Faraji, H., jafarpor, S., Ferns, G. A., Ghayour‐Mobarhan, M., Manian, M., & Nedaeinia, R. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01886-z · Cited by 95 · see citing works
The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis
Zhang, L., Leng, X.-X., Qi, J., Wang, N., Han, J., Tao, Z., Zhuang, Z.-Y., Ren, Y., Xie, Y., Jiang, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01784-w · Cited by 94 · see citing works
Yamamoto, H., & Imai, K. (2019) · Seminars in Oncology · doi:10.1053/j.seminoncol.2019.08.003 · Cited by 74 · see citing works
Koi, M., Okita, Y., & Carethers, J. M. (2018) · Journal of the Anus Rectum and Colon · doi:10.23922/jarc.2017-055 · Cited by 76 · see citing works
Fusobacterium’s link to colorectal neoplasia sequenced: A systematic review and future insights
Hussan, H., Clinton, S. K., Roberts, K., & Bailey, M. T. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i48.8626 · Cited by 73 · see citing works
Fujiwara, N., Kitamura, N., Yoshida, K., Yamamoto, T., Ozaki, K., & Kudo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176207 · Cited by 72 · see citing works
Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
Zhang, S., Cai, S., & Ma, Y. (2018) · Journal of Cancer · doi:10.7150/jca.24048 · Cited by 73 · see citing works
Benedetti, F., Curreli, S., & Zella, D. (2020) · Microorganisms · doi:10.3390/microorganisms8091351 · Cited by 75 · see citing works
Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma
Shi, C., Li, Z., Zheng, J., 孔为民, Fan, T., Jian, D., Cheng, X., Zhao, H., Ma, J., Tang, H., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02352-6 · Cited by 73 · see citing works
Kasper, S. H., Morell-Perez, C., Wyche, T. P., Sana, T. R., Lieberman, L. A., & Hett, E. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-62139-z · Cited by 69 · see citing works
Role of gut microbiota in epigenetic regulation of colorectal Cancer
Zhao, Y., Wang, C., & Goel, A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188490 · Cited by 68 · see citing works
Advani, S., Advani, P. G., DeSantis, S. M., Brown, D. W., VonVille, H. M., Lam, M. S., Loree, J. M., Sarshekeh, A. M., Bressler, J., López, D. S., et al. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.07.008 · Cited by 66 · see citing works
Fusobacterium nucleatum: ecology, pathogenesis and clinical implications
Jiang, S., Chen, Y., & Fang, J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01237-z · Cited by 70 · see citing works
Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Repass, J. F., Reproducibility Project: Cancer Biology, Iorns, E. J., Denis, A., Williams, S. R., Perfito, N., & Errington, T. M. (2018) · eLife · doi:10.7554/elife.25801 · Cited by 63 · see citing works
Shariati, A., Razavi, S., Ghaznavi‐Rad, E., Jahanbin, B., Akbari, A., Norzaee, S., & Darban‐Sarokhalil, D. (2021) · Infectious Agents and Cancer · doi:10.1186/s13027-021-00381-4 · Cited by 60 · see citing works
Queen, J., Domingue, J. C., White, J. R., Stevens, C. M., Udayasuryan, B., Nguyen, T. T. D., Wu, S., Ding, H., Fan, H., McMann, M., et al. (2022) · mBio · doi:10.1128/mbio.02991-21 · Cited by 59 · see citing works
Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
Lee, S. A., Liu, F., Riordan, S. M., Lee, C. S., & Zhang, L. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00566 · Cited by 59 · see citing works
Shao, W., Fujiwara, N., Mouri, Y., Kisoda, S., Yoshida, K., Yoshida, K., Yumoto, H., Ozaki, K., Ishimaru, N., & Kudo, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-94384-1 · Cited by 57 · see citing works
Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
Ganesan, K., Guo, S., Fayyaz, S., Zhang, G., & Xu, B. (2019) · Cancers · doi:10.3390/cancers11101592 · Cited by 58 · see citing works
Role of the intestinal microbiome in colorectal cancer surgery outcomes
Lauka, L., Reitano, E., Carra, M. C., Gaiani, F., Gavriilidis, P., Brunetti, F., de’Angelis, G. L., Sobhani, I., & de’Angelis, N. (2019) · World Journal of Surgical Oncology · doi:10.1186/s12957-019-1754-x · Cited by 58 · see citing works
Fusobacterium nucleatum is enriched in invasive biofilms in colorectal cancer
Queen, J., Cing, Z., Minsky, H. B., Nandi, A., Southward, T., Ferri, J., McMann, M., Iyadorai, T., Vadivelu, J., Roslani, A. C., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00717-7 · Cited by 55 · see citing works
Fusobacterium nucleatum and Colorectal Cancer
Li, R., Shen, J., & Xu, Y. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s357922 · Cited by 53 · see citing works
Viruses and Bacteria Associated with Cancer: An Overview
Zella, D., & Gallo, R. C. (2021) · Viruses · doi:10.3390/v13061039 · Cited by 50 · see citing works
Wu, N., Feng, Y., Lyu, N., Wang, D., Yu, W., & Hu, Y. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i18.1981 · Cited by 49 · see citing works
Ou, S., Chen, H., Wang, H., Ye, J., Liu, H., Tao, Y., Ran, S., Mu, X., Liu, F., Zhu, S., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04527-3 · Cited by 46 · see citing works
Liu, H., Yu, Y., Dong, A., Elsabahy, M., Yang, Y., & Gao, H. (2023) · Exploration · doi:10.1002/exp.20230092 · Cited by 46 · see citing works
Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer
Liu, Y., Baba, Y., Ishimoto, T., Iwatsuki, M., Hiyoshi, Y., Miyamoto, Y., Yoshida, N., Wu, R., & Baba, H. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1512-9 · Cited by 47 · see citing works
Wheatley, R. C., Kilgour, E., Jacobs, T., Lamarca, Á., Hubner, R. A., Valle, J. W., & McNamara, M. G. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01583-8 · Cited by 45 · see citing works
The Four Horsemen in Colon Cancer
Hernández-Luna, M. A., López-Briones, S., & Lurı́a-Pérez, R. (2019) · Journal of Oncology · doi:10.1155/2019/5636272 · Cited by 44 · see citing works
Role of Mycoplasma Chaperone DnaK in Cellular Transformation
Benedetti, F., Cocchi, F., Latinovic, O., Curreli, S., Krishnan, S., Munawwar, A., Gallo, R. C., & Zella, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041311 · Cited by 42 · see citing works
Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer
Okuda, S., Shimada, Y., Tajima, Y., Yuza, K., Hirose, Y., Ichikawa, H., Nagahashi, M., Sakata, J., Ling, Y., Miura, N., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.05.049 · Cited by 42 · see citing works
Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship
Rezaee, M. A., Nouri, R., Hasani, A., Shirazi, K. M., Alivand, M. R., Sepehri, B., Sotoodeh, S., & Hemmati, F. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210910094827 · Cited by 45 · see citing works
Prognostic impact of the Fusobacterium nucleatum status in colorectal cancers
Chen, Y., Lu, Y., Ke, Y., & Li, Y. (2019) · Medicine · doi:10.1097/md.0000000000017221 · Cited by 40 · see citing works
Self-citationGut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?
Tarashi, S., Siadat, S. D., Badi, S. A., Zali, M. R., Biassoni, R., Ponzoni, M., & Moshiri, A. (2019) · Microorganisms · doi:10.3390/microorganisms7110561 · Cited by 39 · see citing works
Oral microbiota and gastrointestinal cancer
Zhang, Y., Niu, Q., Fan, W., Huang, F. P., & He, H. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194153 · Cited by 38 · see citing works
Clinical Features and Outcomes of Fusobacterium Species Infections in a Ten-Year Follow-up
Carretero, R. G., Lomba, M. L., Carrasco-Fernandez, B., & Durán-Valle, M. T. (2017) · The Journal of Critical Care Medicine · doi:10.1515/jccm-2017-0029 · Cited by 36 · see citing works
Mjelle, R., Sjursen, W., Thommesen, L., Sætrom, P., & Hofsli, E. (2019) · BMC Cancer · doi:10.1186/s12885-019-5330-0 · Cited by 36 · see citing works
Fusobacterium nucleatum, the communication with colorectal cancer
Luo, K., Zhang, Y., Xv, C., Ji, J., Lou, G., Guo, X., Chen, M., Zhang, Y., Wei, H., Guo, M., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108988 · Cited by 37 · see citing works
Wu, W., Ouyang, Y., Zheng, P., Xu, X., He, C., Xie, C., Hong, J., Lü, N., Zhu, Y., & Li, N. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1027448 · Cited by 37 · see citing works
Gut Microbiome in Health and Disease
Lavelle, A., & Hill, C. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.02.003 · Cited by 34 · see citing works
The gastrointestinal microbiota in colorectal cancer cell migration and invasion
Henstra, C., van Praagh, J., Olinga, P., & Nagelkerke, A. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10130-x · Cited by 32 · see citing works
Altered Gut Microbiota in Patients With Peutz-Jeghers Syndrome
Wan, S., Huang, G., Wang, J.-X., Tian, L., Zuo, X., Li, Y., & Yu, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.881508 · Cited by 31 · see citing works
Global compositional and functional states of the human gut microbiome in health and diseasePreprint
Lee, S., Portlock, T., Chatelier, E. L., García-Guevara, F., Clasen, F., Oñate, F. P., Pons, N., Begum, N., Harzandi, A., Proffitt, C., et al. (2024) · Genome Research · doi:10.1101/gr.278637.123 · Cited by 35 · see citing works
The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis
Datorre, J. G., de Carvalho, A. C., Guimarães, D. P., & Reis, R. M. (2020) · Pathobiology · doi:10.1159/000512175 · Cited by 32 · see citing works
Diagnostic Performance of Intestinal Fusobacterium nucleatum in Colorectal Cancer
Peng, B., Cao, C.-Y., Li, W., Zhou, Y., Zhang, Y., Nie, Y., Cao, Y., & Li, Y. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.232814 · Cited by 30 · see citing works
Self-citationColov, E. P., Degett, T. H., Raskov, H., & Gögenür, I. (2020) · Apmis · doi:10.1111/apm.13032 · Cited by 28 · see citing works
Diagnostic accuracy of Fusobacterium nucleatum IgA and IgG ELISA test in colorectal cancer
Kurt, M., & Yumuk, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-81171-1 · Cited by 27 · see citing works
Elahi, Z., Shariati, A., Bostanghadiri, N., Dadgar-Zankbar, L., Razavi, S., Norzaee, S., Arasi, S. V., & Darban‐Sarokhalil, D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22602 · Cited by 27 · see citing works
Bostanghadiri, N., Razavi, S., Shariati, A., Talebi, M., Mirkalantari, S., Razavi, À. E., & Darban‐Sarokhalil, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1302719 · Cited by 27 · see citing works
Nie, S., Wang, A., & Yuan, Y. (2020) · Journal of Cancer · doi:10.7150/jca.50918 · Cited by 27 · see citing works
Effect of gut microbiota in the colorectal cancer and potential target therapy
Li, J., Zhu, Y., Yang, L., & Wang, Z. (2022) · Discover Oncology · doi:10.1007/s12672-022-00517-x · Cited by 29 · see citing works
Mohammadi, M., Mirzaei, H., & Motallebi, M. (2021) · Anaerobe · doi:10.1016/j.anaerobe.2021.102501 · Cited by 26 · see citing works
Gut Microbiome in Patients With Early-Stage and Late-Stage Melanoma
Witt, R. G., Cass, S. H., Tran, T., Damania, A. V., Nelson, E. E., Sirmans, E., Burton, E. M., Chelvanambi, M., Johnson, S. B., Tawbi, H. A., et al. (2023) · JAMA Dermatology · doi:10.1001/jamadermatol.2023.2955 · Cited by 26 · see citing works
Таширева, Л. А., Михайлович, П. В., Манских, В. Н., Denisov, E. V., Savelieva, O. E., Кайгородова, Е. В., & Zavyalova, M. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917050029 · Cited by 26 · see citing works
Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer
Chen, W., Zhang, X., Zhang, Y.-P., Yue, C.-B., Wang, Y.-L., Pan, H., Zhang, Y., Liu, H., & Zhang, Y. (2022) · Current Medical Science · doi:10.1007/s11596-022-2597-1 · Cited by 25 · see citing works
Implication of gut microbes and its metabolites in colorectal cancer
Kumar, A., Ali, A., Kapardar, R. K., Dar, G. M., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04422-2 · Cited by 26 · see citing works
Microbiome in drug resistance to colon cancer
Pandey, K. R., & Umar, S. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100472 · Cited by 24 · see citing works
Kossenas, K., & Constantinou, C. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00377-x · Cited by 23 · see citing works
Rye, M. S., Garrett, K. L., Holt, R. A., Platell, C. F. E., & McCoy, M. J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262416 · Cited by 23 · see citing works
Fusobacterium nucleatum : Unraveling its potential role in gastric carcinogenesis
Petkevičius, V., Lehr, K., Kupčinskas, J., & Link, A. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i35.3972 · Cited by 22 · see citing works
- Authors
- Li, Y.-Y., Ge, Q.-X., Cao, J., Zhou, Y.-J., Du, Y.-L., Shen, B., Wan, Y.-J. Y., & Nie, Y.-Q.
- Affiliations
- Guangzhou First People's Hospital (CN)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 11
- Pages
- 3227
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4789998
- OpenAlex
- W2330539438
- Cited by
- 175
- References
- 38
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 11 · 2023: 13 · 2022: 20 · 2021: 26 · 2020: 25 · 2019: 23 · 2018: 22 · 2017: 10 · 2016: 2
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Guangzhou First People's Hospital
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- Fusobacterium nucleatum, colorectal cancer, gut microbiota, tumor invasion, lymph node metastasis, Chinese patients
- MeSH terms
- Adult, Aged, Aged, 80 and over, China, DNA, Bacterial, Female, Fusobacterium Infections, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Colorectal Neoplasms, Fusobacterium nucleatum, In Situ Hybridization, Fluorescence, Ribotyping, Asian People, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review