Beneficial Bile Acid Metabolism from Lactobacillus plantarum of Food Origin
Open accessAbstract
Bile acid (BA) signatures are altered in many disease states. BA metabolism is an important microbial function to assist gut colonization and persistence, as well as microbial survival during gastro intestinal (GI) transit and it is an important criteria for potential probiotic bacteria. Microbes that express bile salt hydrolase (BSH), gateway BA modifying enzymes, are considered to have an advantage in the gut. This property is reported as selectively limited to gut-associated microbes. Food-associated microbes have the potential to confer health benefits to the human consumer. Here, we report that food associated Lactobacillus plantarum strains are capable of BA metabolism, they can withstand BA associated stress and propagate, a recognised important characteristic for GIT survival. Furthermore, we report that these food associated Lactobacillus plantarum strains have the selective ability to alter BA signatures in favour of receptor activation that would be beneficial to humans. Indeed, all of the strains examined showed a clear preference to alter human glycol-conjugated BAs, although clear strain-dependent modifications were also evident. This study demonstrates that BA metabolism by food-borne non-pathogenic bacteria is beneficial to both microbe and man and it identifies an evolutionary-conserved characteristic, previously considered unique to gut residents, among food-associated non-pathogenic isolates.
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Another lowering-cholesterol mechanism by LAB is through bile salt hydrolase activity, which decreases resorption of bile acids by bile acid deconjugation and increases elimination of deconjugated bile acids in enterohepatic circulation, leading to new bile acids synthesis from cholesterol in the liver.
“Another lowering-cholesterol mechanism by LAB is through bile salt hydrolase activity (BSH), which decreases the resorption of bile acids by bile acid deconjugation and increases the elimination of the deconjugated bile acids in the enterohepatic circulation, leading to new bile acids synthesis from cholesterol in the liver [142].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [142]
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Experimental — accuracy not yet measuredSpecific probiotics, in particular Lactobacillus species sensu lato, have shown bile salt hydrolase activity.
“Specific probiotics, in particular Lactobacillus species (sensu lato), have shown BSH activity.16”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [16]
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“16 This activity could influence lipid metabolism and cholesterol levels in the host through the activation of specific signalling pathways.”
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- Authors
- Prete, R., Long, S. L., Gallardo, A. L., Gahan, C. G., Corsetti, A., & Joyce, S. A.
- Affiliations
- University of Teramo (IT)
- University College Cork (IE)
- Corresponding author
- Joyce, Susan A.
- Venue
- Scientific Reports
- Published
- 2020-01-24
- Volume
- 10
- Issue
- 1
- Pages
- 1165-1165
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6981223
- OpenAlex
- W3001000734
- Cited by
- 165
- References
- 72
- Citations by year
- 2026: 12 · 2025: 36 · 2024: 39 · 2023: 22 · 2022: 24 · 2021: 24 · 2020: 7 · 2019: 1
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- HAL (submittedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Funders
- Science Foundation Ireland (SFI/12/RC/, 16/ERA-HDHL/3358, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- bile acid metabolism, Lactobacillus plantarum, bile salt hydrolase, probiotic bacteria, bile acid conjugates, intestinal colonization
- MeSH terms
- Animals, Bile Acids and Salts, Brassica, Bread, Cheese, Dose-Response Relationship, Drug, Fermentation, Food Microbiology, Humans, Saliva, Swine, Probiotics, Olea, Lactiplantibacillus plantarum, Lactobacillus plantarum
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