Cited by 22Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeuroendocrine regulation and behavior

Cholinergic transmission from the basal forebrain modulates social memory in male mice

Kljakic, Ornela, Al‐Onaizi, Mohammed, Janíčková, Helena, Chen, Kevin S., Guzman, Monica S., Prado, Marco A. M., Prado, Vania F.·2021·European Journal of Neuroscience

Abstract

Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter-the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of soc…

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Crossref · 10.1111/ejn.15400

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Authors
Kljakic, O., Al‐Onaizi, M., Janíčková, H., Chen, K. S., Guzman, M. S., Prado, M. A. M., & Prado, V. F.
Affiliations
  • Western University (CA)
  • Robarts Research Institute, Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada
Corresponding author
Prado, Marco A. M.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2021-08-13
Volume
54
Issue
6
Pages
6075-6092
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W3186921374
Cited by
22
References
91
Citations by year
2026: 2 · 2025: 9 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canada First Research Excellence Fund (Accelerator Award)
  • Natural Sciences and Engineering Research Council of Canada (402524‐2013 RGPIN)
  • Canadian Institutes of Health Research (PJT 159781, PJT 162431)
  • Kuwait University
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
cholinergic neurotransmission, social memory, social preferences, basal forebrain, vesicular acetylcholine transporter, acetylcholine release, hippocampus, prefrontal cortex, striatum, amygdala, social behavior, neuropsychiatric disorders
MeSH terms
Acetylcholine, Animals, Hippocampus, Male, Cholinergic Agents, Vesicular Acetylcholine Transport Proteins, Mice, Basal Forebrain

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