Cholinergic transmission from the basal forebrain modulates social memory in male mice
Abstract
Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter-the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of soc…
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Cholinergic signaling in the amygdala is necessary for social recognition, social memory formation, social stress responsivity, and fear learning.
“Cholinergic signaling in the amygdala is necessary for social recognition [56], social memory formation [57,58], social stress responsivity [59] and fear learning [60].”
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Self-citationBRD9 activates transcription in neurons and BRD9 inhibitor blocks epilepsy behavior in mice
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- Authors
- Kljakic, O., Al‐Onaizi, M., Janíčková, H., Chen, K. S., Guzman, M. S., Prado, M. A. M., & Prado, V. F.
- Affiliations
- Western University (CA)
- Robarts Research Institute, Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada
- Corresponding author
- Prado, Marco A. M.
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2021-08-13
- Volume
- 54
- Issue
- 6
- Pages
- 6075-6092
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W3186921374
- Cited by
- 22
- References
- 91
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canada First Research Excellence Fund (Accelerator Award)
- Natural Sciences and Engineering Research Council of Canada (402524‐2013 RGPIN)
- Canadian Institutes of Health Research (PJT 159781, PJT 162431)
- Kuwait University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- cholinergic neurotransmission, social memory, social preferences, basal forebrain, vesicular acetylcholine transporter, acetylcholine release, hippocampus, prefrontal cortex, striatum, amygdala, social behavior, neuropsychiatric disorders
- MeSH terms
- Acetylcholine, Animals, Hippocampus, Male, Cholinergic Agents, Vesicular Acetylcholine Transport Proteins, Mice, Basal Forebrain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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