An intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Open accessAbstract
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released in the brain, where they have fundamentally important roles in social behaviours. In humans, disruptions of these peptide systems have been linked to several neurobehavioural disorders, including Prader-Willi syndrome, affective disorders and obsessive-compulsive disorder, and polymorphisms of V1a vasopressin receptor have been linked to autism. Here we report that the rat olfactory bulb contains a large population of interneurons which express vasopressin, that blocking the actions of vasopressin in the olfactory bulb impairs the social recognition abilities of rats and that vasopressin agonists and antagonists can modulate the processing of information by olfactory bulb neurons. The findings indicate that social information is processed in part by a vasopressin system intrinsic to the olfactory system.
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Antagonism of V1aRs in several different CNS sites impairs social recognition.
“Antagonism of V1aRs in several different CNS sites impairs social recognition [73; 74]”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [73]
A similar process may also occur via vasopressin release from inhibitory olfactory bulb interneurons, in conjunction with cholinergic mechanisms.
“A similar process may also occur via AVP release, from inhibitory OB interneurons, in conjunction with cholinergic mechanisms (76,77).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [76]
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- Authors
- Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., Meddle, S. L., Engelmann, M., & Ludwig, M.
- Affiliations
- University of Edinburgh (GB)
- Jichi Medical University (JP)
- Center for Excellence in Molecular Cell Science (CN)
- Max Planck Society (DE)
- Roslin Institute (GB)
- Corresponding author
- Ludwig, Mike
- ORCID
- Venue
- Nature
- Published
- 2010-02-24
- Volume
- 464
- Issue
- 7287
- Pages
- 413-417
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2842245
- OpenAlex
- W2008597980
- Cited by
- 213
- References
- 39
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 18 · 2020: 13 · 2019: 8 · 2018: 19 · 2017: 11 · 2016: 12 · 2015: 24 · 2014: 20 · 2013: 14 · 2012: 13
- FWCI
- 23.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, public-domain)
- RePEc: Research Papers in Economics (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutscher Akademischer Austauschdienst
- Deutsche Forschungsgemeinschaft
- Ministry of Education, Culture, Sports, Science and Technology
- Biotechnology and Biological Sciences Research Council (BB/F019009/1)
- Japan Society for the Promotion of Science
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- vasopressin, olfactory bulb, social recognition, interneurons, social behavior, oxytocin, peptide hormones, vasopressin receptor, olfactory processing
- MeSH terms
- Animals, Interneurons, Olfactory Bulb, Social Behavior, Vasopressins, Rats, Sprague-Dawley, Rats, Wistar, Receptors, Vasopressin, Recognition, Psychology, Rats, Antidiuretic Hormone Receptor Antagonists
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