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Gut microbiome pattern reflects healthy ageing and predicts survival in humans
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“Recent studies have also mapped age-related shifts in gut microbiota, revealing functional changes that modulate cellular senescence through intertwined metabolic and immune pathways107,108.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [108]
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“individual gut microbiomes become increasingly more unique to each individual with age”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [280]
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“In older age, healthy participants show continued drift towards a unique microbial composition, whereas this drift is reduced or absent in individuals in worse health.”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [280]
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“this uniqueness is associated with well-known microbial metabolites involved in immune regulation, inflammation, and aging”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [280]
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“The identified microbiome pattern of healthy aging is characterized by a depletion of core taxa, such as Bacteroides, present across most humans.”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [280]
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“in individuals approaching extreme age, retention of high Bacteroides levels and a low gut microbiome uniqueness measure are significantly associated with decreased survival.”
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Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
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Undulating changes in human plasma proteome profiles across the lifespan
Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0673-2 · Cited by 981
American Gut: an Open Platform for Citizen-Science Microbiome Research
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Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14177-z · Cited by 791
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
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Sexual-dimorphism in human immune system aging
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Metadata
- Authors
- Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., Yurkovich, J. T., Kado, D. M., Cauley, J. A., Zmuda, J., Lane, N. E., Magis, A. T., Lovejoy, J. C., Hood, L., Gibbons, S. M., Orwoll, E. S., & Price, N. D.
- ORCID
- Venue
- Nature Metabolism
- Published
- 2021-02-18
- Volume
- 3
- Issue
- 2
- Pages
- 274-286
- ISSN
- 2522-5812
- PMC
- PMC8169080
- Cited by
- 675
- References
- 16
- Language
- en
- Update notices
- correction (2021-03-18)
- Licence
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (2U19AG023122-11A1, 5U19AG023122-13, AG042124)
- Washington Research Foundation, Institute for Systems Biology
- M.J. Murdock Charitable Trust
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