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Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems
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“Importantly, we found that second-generation (generation 2+) DNAm biomarkers, such as PCGrimAge12, SystemsAge11 and DunedinPACE10, showed the strongest and most consistent responsiveness.”
From Responsiveness of epigenetic aging biomarkers to longevity interventions in humans (2026) · cites this paper as [11]
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“Epigenetic age deviations consistently predict morbidity, mortality and other aging-related outcomes7–11.”
From Responsiveness of epigenetic aging biomarkers to longevity interventions in humans (2026) · cites this paper as [11]
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A guideline of selecting and reporting intraclass correlation coefficients for reliability research
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Validation of biomarkers of aging
Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02784-9 · Cited by 361
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Walker, K. A., Ficek, B. N., & Westbrook, R. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00333 · Cited by 259
Underlying features of epigenetic aging clocks in vivo and in vitro.
Liu, Z., Leung, D., Thrush, K., Zhao, W., Ratliff, S., Tanaka, T., Schmitz, L. L., Smith, J. A., Ferrucci, L., & Levine, M. E. (2020) · Aging Cell · doi:10.1111/acel.13229 · Cited by 227
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Cited by
Sorted by citations
Whitman, E. T., Elliott, M. L., Knodt, A. R., Abraham, W. C., Anderson, T. J., Cutfield, N. J., Hogan, S., Ireland, D., Melzer, T. R., Ramrakha, S., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00897-z · Cited by 37
Responsiveness of epigenetic aging biomarkers to longevity interventions in humans
Sehgal, R., Borrus, D., Armstrong, J. F., Gonzalez, J., Kasamoto, J., Markov, Y., Priyanka, A., Smith, R., Carreras-Gallo, N., Lasky-Su, J., et al. (2026) · Nature Medicine · doi:10.1038/s41591-026-04562-9 · Cited by 31
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Metadata
- Authors
- Sehgal, R., Markov, Y., Qin, C., Meer, M., Hadley, C., Shadyab, A. H., Casanova, R., Manson, J. E., Bhatti, P., Moore, A. Z., Crimmins, E. M., Hagg, S., Assimes, T. L., Whitsel, E. A., Higgins-Chen, A. T., & Levine, M.
- ORCID
- Venue
- Nature Aging
- Published
- 2025-09-15
- Volume
- 5
- Issue
- 9
- Pages
- 1880-1896
- ISSN
- 2662-8465
- PMC
- PMC13222069
- Cited by
- 79
- References
- 12
- Language
- en
- Licence
- Funders
- Gruber Foundation (-)
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