Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance
Abstract
BACKGROUND: Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we reported that the t10c12 CLA-isomer caused insulin resistance in abdominally obese men via unknown mechanisms. The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory biomarkers and to investigate the relationship between these factors and induced insulin resistance. METHODS AND RESULTS: In a double-blind placebo-controlled trial, 60 men with metabolic syndrome were randomized to one of 3 groups receiving t10c12 CLA, a CLA mixture, or placebo for 12 weeks. Insulin sensitivity (euglycemic clamp), serum lipids, in vivo lipid peroxidation (determined as urinary 8-iso-PGF(2alpha) [F2-isoprostanes]), 15-ketodihydro PGF(2alpha), plasma vitamin E, plasma C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 were assessed before and after treatment. Supplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia. The increases in 8-iso-PGF(2alpha), but not in C-reactive protein, were significantly and independently related to aggravated insulin resistance. Oxidative stress was related to increased vitamin E levels, suggesting a compensatory mechanism. CONCLUSIONS: t10c12 CLA supplementation increases oxidative stress and inflammatory biomarkers in obese men. The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance. These unfavorable effects of t10c12 CLA might be of clinical importance with regard to cardiovascular disease, in consideration of the widespread use of dietary supplements containing this fatty acid.
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Cites
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898 · see citing works
Morrow, J. D., Frei, B. B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,340 · see citing works
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,241 · see citing works
Davı̀, G., Ciabattoni, G., Consoli, A., Mezzetti, A., Falco, A., Santarone, S., Pennese, E., Vitacolonna, E., Bucciarelli, T., Costantini, F., et al. (1999) · Circulation · doi:10.1161/01.cir.99.2.224 · Cited by 742 · see citing works
Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
Gudmundsen, O., Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., & Wadstein, J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.2943 · Cited by 595 · see citing works
Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 593 · see citing works
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.
Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kanety, H., & Bashan, N. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1562 · Cited by 483 · see citing works
Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease
Patrono, C., & FitzGerald, G. A. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.11.2309 · Cited by 453 · see citing works
Risérus, U., Arner, P., Brismar, K., & Vessby, B. O. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1516 · Cited by 435 · see citing works
Smoking induces insulin resistance—a potential link with the insulin resistance syndrome
ATTVALL, S., FOWELIN, J., LAGER, I., VON SCHENCK, H., & SMITH, U. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00680.x · Cited by 363 · see citing works
Endothelial Dysfunction: Cause of the Insulin Resistance Syndrome
Pinkney, J. H., Stehouwer, C. D. A., Coppack, S. W., & Yudkin, J. S. (1997) · Diabetes · doi:10.2337/diab.46.2.s9 · Cited by 350 · see citing works
Conjugated linoleic acid supplementation in humans—metabolic effects
Smedman, A., & Vessby, B. O. (2001) · Lipids · doi:10.1007/s11745-001-0784-7 · Cited by 305 · see citing works
Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge
MacDonald, H. B. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718082 · Cited by 284 · see citing works
Risérus, U., Berglund, L., & Vessby, B. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801659 · Cited by 284 · see citing works
Conjugated linoleic acid: implications for human health
Whigham, L. D., Cook, M. E., & Atkinson, R. L. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0735 · Cited by 283 · see citing works
Basu, S. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90042-4 · Cited by 254 · see citing works
Seigler, L., & Wu, W. T. (1981) · Clinical Chemistry · doi:10.1093/clinchem/27.6.838 · Cited by 217 · see citing works
Nilsson, J. Å., Jovinge, S. V., Niemann, A., Reneland, R., & Lithell, H. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.8.1199 · Cited by 200 · see citing works
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake
Baron, A., Steinberg, H. O., Brechtel, G., & Johnson, A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.2.e248 · Cited by 198 · see citing works
Gniwotta, C., Morrow, J. D., Roberts, L. J., & Kühn, H. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3236 · Cited by 196 · see citing works
Sampson, M., Gopaul, N. K., Davies, I. R., Hughes, D. A., & CARRIER, M. J. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.537 · Cited by 170 · see citing works
Conjugated linoleic acid induces lipid peroxidation in humans
Basu, S., Smedman, A., & Vessby, B. O. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01193-5 · Cited by 156 · see citing works
Basu, S. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90070-9 · Cited by 141 · see citing works
Gopaul, N. K., Manraj, M., Hébé, A., YAN, S., Johnston, A. E., CARRIER, M. J., & Änggård, E. (2001) · Diabetologia · doi:10.1007/s001250051679 · Cited by 132 · see citing works
Higdon, J. V., Liu, J., Du, S.-H., Morrow, J. D., Ames, B. N., & Wander, R. C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.714 · Cited by 124 · see citing works
Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity
BASU, S., Risérus, U., Turpeinen, A. M., & Vessby, B. (2000) · Clinical Science · doi:10.1042/cs0990511 · Cited by 112 · see citing works
Leung, Y. H., & Liu, R. H. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991163d · Cited by 96 · see citing works
Carantoni, M., Abbasi, F., Warmerdam, F. A. R. M., Klebanov, M., Wang, P., Chen, Y. I., Azhar, S., & Reaven, G. M. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.5.762 · Cited by 65 · see citing works
Closing in on the cause of insulin resistance and type 2 diabetes
Brady, M., & Saltiel, A. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8216 · Cited by 19 · see citing works
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Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Dietary fats and prevention of type 2 diabetes
Risérus, U., Willett, W. C., & Hu, F. B. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.002 · Cited by 753 · see citing works
Health effects of trans-fatty acids: experimental and observational evidence
Mozaffarian, D., Aro, A., & Willett, W. C. (2009) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602973 · Cited by 662 · see citing works
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663 · see citing works
Armitage, J. A., Khan, I. Y., Taylor, P. D., Nathanielsz, P. W., & Poston, L. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.072009 · Cited by 531 · see citing works
Nutrition, physical activity, and cardiovascular disease: An update
IGNARRO, L., Balestrieri, M. L., & Claudio Napoli, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.030 · Cited by 443 · see citing works
ISSN exercise & sport nutrition review: research & recommendations
Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428 · see citing works
Kratz, M., Baars, T., & Guyenet, S. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0418-1 · Cited by 422 · see citing works
Implication of Conjugated Linoleic Acid (CLA) in Human Health
Dilzer, A., & Park, Y. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.501409 · Cited by 377 · see citing works
Position of the American Dietetic Association and Dietitians of Canada: Dietary Fatty Acids
Kris‐Etherton, P. M., Innis, S. M., Assocition, A. D., & Canada, D. O. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.07.024 · Cited by 373 · see citing works
den Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371 · see citing works
Perspective on the safety and effectiveness of conjugated linoleic acid
Pariza, M. W. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1132s · Cited by 351 · see citing works
Steffen, L. M., Kroenke, C. H., Yu, X., Pereira, M. A., Slattery, M. L., Horn, L. V., Gross, M. D., & Jacobs, D. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1169 · Cited by 334 · see citing works
German, J. B., & Dillard, C. J. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957098 · Cited by 316 · see citing works
Conjugated linoleic acid and obesity control: efficacy and mechanisms
Wang, Y. W., & Jones, P. J. H. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802641 · Cited by 312 · see citing works
Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1203 · Cited by 312 · see citing works
Mechanisms of Action of trans Fatty Acids
Oteng, A., & Kersten, S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz125 · Cited by 309 · see citing works
Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans
Gaullier, J., Halse, J., Høye, K., Kristiansen, K., Fagertun, H., Vik, H., & Gudmundsen, O. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1118 · Cited by 292 · see citing works
Modulation of human immune and inflammatory responses by dietary fatty acids
Kelley, D. S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00576-7 · Cited by 282 · see citing works
Conjugated linoleic acids as functional food: an insight into their health benefits
Benjamin, S., & Spener, F. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-36 · Cited by 274 · see citing works
F 2 -Isoprostanes in Human Health and Diseases: From Molecular Mechanisms to Clinical Implications
Basu, S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1956 · Cited by 268 · see citing works
Moloney, F., Yeow, T.-P., Mullen, A., Nolan, J. J., & Roche, H. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.887 · Cited by 247 · see citing works
Conjugated Linoleic Acid: Potential Health Benefits as a Functional Food Ingredient
Kim, J. H., Kim, Y., Kim, Y. J., & Park, Y. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033028 · Cited by 244 · see citing works
Risérus, U., Vessby, B. O., Ärnlöv, J., & Basu, S. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.279 · Cited by 243 · see citing works
Mechanisms of body fat modulation by conjugated linoleic acid (CLA)
Park, Y., & Pariza, M. W. (2006) · Food Research International · doi:10.1016/j.foodres.2006.11.002 · Cited by 242 · see citing works
Larsson, S. C., Bergkvist, L., & Wolk, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.894 · Cited by 231 · see citing works
Dietary Factors That Promote or Retard Inflammation
Basu, A., Devaraj, S., & Jialal, I. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000214295.86079.d1 · Cited by 222 · see citing works
Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes
Brown, J. M., Sandberg, M. B., Jensen, S. S., Morrison, R. F., STORKSON, J. M., Lea-Currie, R., Pariza, M. W., Mandrup, S., & McIntosh, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300001-jlr200 · Cited by 222 · see citing works
Andersson, A., Tengblad, S., Karlström, B., Kamal-Eldin, A., Landberg, R., Basu, S., Åman, P., & Vessby, B. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1401 · Cited by 221 · see citing works
ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation
Basu, S. (2003) · Free Radical Research · doi:10.1080/10715760310001646895 · Cited by 211 · see citing works
Efficacy and safety of dietary supplements containing CLA for the treatment of obesity
Larsen, T. M., Toubro, S., & Astrup, A. V. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300011-jlr200 · Cited by 205 · see citing works
cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats
Corl, B. A., Barbano, D. M., Bauman, D. E., & Ip, C. C. Y. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2893 · Cited by 195 · see citing works
Gaullier, J., Halse, J., Høivik, H. O., Høye, K., Syvertsen, C., Nurminiemi, M., Hassfeld, C., Einerhand, A. W. C., O’Shea, M., & Gudmundsen, O. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507381324 · Cited by 182 · see citing works
Trans fatty acids and cardiovascular health: research completed?
Brouwer, I. A., Wanders, A. J., & Katan, M. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.43 · Cited by 180 · see citing works
Melanson, E. L., Astrup, A. V., & Donahoo, W. T. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000229004 · Cited by 175 · see citing works
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation
Brown, J. M., Sandberg, M. B., Chung, S., Fabiyi, O., Morrison, R. F., Mandrup, S., & McIntosh, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401766200 · Cited by 173 · see citing works
Effect of CLA supplementation on immune function in young healthy volunteers
Song, H.-J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602102 · Cited by 162 · see citing works
Moloney, F., Toomey, S., Noone, E., Nugent, A. P., Allan, B. B., Loscher, C. E., & Roche, H. M. (2007) · Diabetes · doi:10.2337/db06-0384 · Cited by 157 · see citing works
Anti‐obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid
Li, J., Huang, C. J., & Xie, D. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700399 · Cited by 157 · see citing works
Conjugated linoleic acid (CLA): Good or bad trans fat?
Park, Y. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.12.002 · Cited by 151 · see citing works
The Diversity of Health Effects of Individual trans Fatty Acid Isomers
Gebauer, S. K., Psota, T., & Kris‐Etherton, P. M. (2007) · Lipids · doi:10.1007/s11745-007-3095-8 · Cited by 151 · see citing works
Tarnopolsky, M. A., Zimmer, A., Paikin, J. S., Safdar, A., Aboud, A., Pearce, E., Roy, B. D., & Doherty, T. J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000991 · Cited by 147 · see citing works
Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions
Kritchevsky, D., Tepper, S. A., Wright, S., Czarnecki, S. K., Wilson, T. A., & Nicolosi, R. J. (2004) · Lipids · doi:10.1007/s11745-004-1273-8 · Cited by 147 · see citing works
Coffee Consumption and Insulin Sensitivity
Ärnlöv, J. (2004) · JAMA · doi:10.1001/jama.291.10.1199-b · Cited by 146 · see citing works
Prevention and Treatment of the Metabolic Syndrome
Daskalopoulou, S. S., Mikhailidis, D. P., & Elisaf, M. (2004) · Angiology · doi:10.1177/00033197040550i601 · Cited by 147 · see citing works
Effects of Two Conjugated Linoleic Acid Isomers on Body Fat Mass in Overweight Humans
Malpuech‐Brugère, C., de Venne, W. P. H. G. V., Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Sæbø, A., Lassel, T. S., Chardigny, J., Sébédio, J. L., et al. (2004) · Obesity Research · doi:10.1038/oby.2004.68 · Cited by 144 · see citing works
Ris�rus, U., Vessby, B., Arner, P., & Zethelius, B. (2004) · Diabetologia · doi:10.1007/s00125-004-1421-8 · Cited by 139 · see citing works
Salas‐Salvadó, J., Márquez‐Sandoval, F., & Bulló, M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600723953 · Cited by 132 · see citing works
Basu, S. (2006) · Medicinal Research Reviews · doi:10.1002/med.20098 · Cited by 130 · see citing works
Castañeda‐Gutiérrez, E., Overton, T. R., Butler, W. R., & Bauman, D. E. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)72775-2 · Cited by 126 · see citing works
Conjugated linoleic acid: health implications and effects on body composition
Rainer, L., & Heiss, C. J. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.03.016 · Cited by 125 · see citing works
Metabolically active functional food ingredients for weight control
Kovacs, E. M. R., & Mela, D. J. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00203.x · Cited by 124 · see citing works
Conjugated Linoleic Acid Supplementation for Twelve Weeks Increases Lean Body Mass in Obese Humans
Steck, S. E., Chalecki, A. M., Miller, P. C., Conway, J., Austin, G. L., Hardin, J. W., Albright, C. D., & Thuillier, P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1188 · Cited by 118 · see citing works
Nerpin, E., Risérus, U., Ingelsson, E., Sundström, J., Jobs, M., Larsson, A. O., Basu, S., & Ärnlöv, J. (2008) · Diabetes Care · doi:10.2337/dc08-0369 · Cited by 118 · see citing works
Tholstrup, T., Raff, M., Basu, S., Nonboe, P., Sejrsen, K., & Straarup, E. M. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.237 · Cited by 117 · see citing works
Prevention of Mammary Cancer with Conjugated Linoleic Acid: Role of the Stroma and the Epithelium
Ip, M. M., Masso‐Welch, P. A., & Ip, C. C. Y. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1025739506536 · Cited by 115 · see citing works
Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Grimble, R. F., Williams, C. M., Calder, P. C., & Yaqoob, P. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1626 · Cited by 111 · see citing works
Human health effects of conjugated linoleic acid from milk and supplements
McCaffrey, T. A., Keaveney, E. M., Wallace, J. M. W., Binns, N. M., & Livingstone, M. B. E. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000114 · Cited by 110 · see citing works
Factors Regulating Isoprostane Formation In Vivo
Basu, S., & Helmersson, J. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.221 · Cited by 110 · see citing works
Desroches, S., Chouinard, P. Y., Galibois, I., Corneau, L., Delisle, J., Lamarche, B., Couture, P., & Bergeron, N. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.309 · Cited by 108 · see citing works
Mollica, M. P., Trinchese, G., Cimmino, F., Penna, E., Cavaliere, G., Tudisco, R., Musco, N., Manca, C., Catapano, A., Monda, M., et al. (2021) · Nutrients · doi:10.3390/nu13041111 · Cited by 107 · see citing works
Obesity Modulates the Association among APOE Genotype, Insulin, and Glucose in Men
Elosúa, R., Demissie, S., Cupples, L. A., Meigs, J. B., Wilson, P. W. F., Schaefer, E. J., Corella, D., & Ordovás, J. M. (2003) · Obesity Research · doi:10.1038/oby.2003.201 · Cited by 107 · see citing works
Pros and cons of CLA consumption: an insight from clinical evidences
Benjamin, S., Prakasan, P., Sreedharan, S., Wright, A. G., & Spener, F. (2015) · Nutrition & Metabolism · doi:10.1186/1743-7075-12-4 · Cited by 106 · see citing works
The effects of conjugated linoleic acid on human health-related outcomes
Tricon, S., Burdge, G. C., Williams, C. M., Calder, P. C., & Yaqoob, P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005418 · Cited by 104 · see citing works
Arbonés-Mainar, J. M., Navarro, M. Á., Guzmán, M., Arnal, C., Surra, J. C., Acı́n, S., Carnicer, R., Osada, J., & Roche, H. M. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.01.015 · Cited by 102 · see citing works
Ärnlöv, J., Zethelius, B., Risérus, U., Basu, S., Berne, C., Vessby, B., Alfthan, G., & Helmersson, J. (2008) · Diabetologia · doi:10.1007/s00125-008-1189-3 · Cited by 99 · see citing works
Raff, M., Tholstrup, T., Basu, S., Nonboe, P., Sørensen, M. T., & Straarup, E. M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.509 · Cited by 98 · see citing works
Conjugated Linoleic Acid Impairs Endothelial Function
Taylor, J. S. W., Williams, S., Rhys, R., James, P., & Frenneaux, M. P. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000199679.40501.ac · Cited by 97 · see citing works
Nutraceutical resources for diabetes prevention – an update
McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.036 · Cited by 93 · see citing works
Sabir, A. A., Unver, A., & Kara, Z. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5571 · Cited by 92 · see citing works
Tholstrup, T., Raff, M., Straarup, E. M., Lund, P., Basu, S., & Bruun, J. M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1445 · Cited by 91 · see citing works
Henriksen, E. J., Teachey, M. K., Taylor, Z. C., Jacob, S., Ptock, A., Krämer, K., & Hasselwander, O. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00013.2003 · Cited by 89 · see citing works
Metabolic effects of conjugated linoleic acid in humans: the Swedish experience
Risérus, U., Smedman, A., Basu, S., & Vessby, B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1146s · Cited by 87 · see citing works
Kennedy, A. J., Overman, A., LaPoint, K., Hopkins, R. G., West, T., Chuang, C., Martinez, K., Bell, D., & McIntosh, M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800258-jlr200 · Cited by 86 · see citing works
Kelley, D. S., & Erickson, K. L. (2003) · Lipids · doi:10.1007/s11745-003-1072-2 · Cited by 83 · see citing works
Valeille, K., Férézou, J., Amsler, G., Quignard‐Boulangé, A., Parquet, M., Gripois, D., Dorovska‐Taran, V., & Martin, J. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00130.2005 · Cited by 82 · see citing works
A Prospective Study ofTrans-Fatty Acid Levels in Blood and Risk of Prostate Cancer
Chavarro, J. E., Stampfer, M. J., Campos, H., Kurth, T., Willett, W. C., & Ma, J. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0673 · Cited by 80 · see citing works
Omega 6 fatty acids for the primary prevention of cardiovascular disease
Al-Khudairy, L., Hartley, L., Clar, C., Flowers, N., Hooper, L., & Rees, K. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011094.pub2 · Cited by 79 · see citing works
Penedo, L. A., Nunes, J. C., da Gama, M. A. S., Leite, P. E. C., Quírico‐Santos, T., & Torres, A. G. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.006 · Cited by 79 · see citing works
Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models
Taylor, C. G., & Zahradka, P. C. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1164s · Cited by 79 · see citing works
de Roos, B., Rucklidge, G. J., Reid, M., Ross, K., Duncan, G., Navarro, M. Á., Arbonés-Mainar, J. M., Guzmán-García, M. A., Osada, J., Browne, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-3953fje · Cited by 76 · see citing works
Warren, J. M., Simon, V. A., Bartolini, G., Erickson, K. L., Mackey, B. E., & Kelley, D. S. (2003) · Lipids · doi:10.1007/s11745-003-1090-0 · Cited by 75 · see citing works
Yuan, G., Chen, X., & Li, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505050c · Cited by 76 · see citing works
High ω-3 Fatty Acid Content in Alpine Cheese
Hauswirth, C. B., Scheeder, M. R. L., & Beer, J. H. (2003) · Circulation · doi:10.1161/01.cir.0000105989.74749.dd · Cited by 74 · see citing works
Conjugated linoleic acid increased C-reactive protein in human subjects
Smedman, A., Basu, S., Jovinge, S. V., Fredrikson, G. N., & Vessby, B. O. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041419 · Cited by 73 · see citing works
Ip, M. M., McGee, S. O., Masso‐Welch, P. A., Ip, C., Meng, X., Ou, L., & Shoemaker, S. F. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm018 · Cited by 69 · see citing works
Turpeinen, A. M., Ylönen, N., von Willebrand, E., Basu, S., & Aro, A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507886326 · Cited by 68 · see citing works
Putera, H. D., Doewes, R. I., Shalaby, M. N., Ramírez‐Coronel, A. A., Clayton, Z. S., Abdelbasset, W. K., Murtazaev, S. S., Jalil, A. T., Rahimi, P., Nattagh‐Eshtivani, E., et al. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00758-9 · Cited by 67 · see citing works
Review:Trans-forming beef to provide healthier fatty acid profiles
Dugan, M. E. R., Aldai, N., Aalhus, J. L., Rolland, D. C., & Kramer, J. K. G. (2011) · Canadian Journal of Animal Science · doi:10.4141/cjas2011-044 · Cited by 67 · see citing works
Isoprostanes, Prostaglandins and Tocopherols in Pre-eclampsia, Normal Pregnancy and Non-pregnancy
Ishihara, O., Hayashi, M., Osawa, H., Kobayashi, K., Takeda, S., Vessby, B. O., & Basu, S. (2004) · Free Radical Research · doi:10.1080/10715760412331273421 · Cited by 66 · see citing works
Syvertsen, C., Halse, J., Høivik, H. O., Gaullier, J.-M., Nurminiemi, M., Kristiansen, K., Einerhand, A. W. C., O’Shea, M., & Gudmundsen, O. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803482 · Cited by 66 · see citing works
Weng, L.-C. C., Steffen, L. M., Szklo, M., Nettleton, J. A., Chambless, L. E., & Folsom, A. R. (2013) · Nutrients · doi:10.3390/nu5051719 · Cited by 63 · see citing works
Martins, S. V., Lopes, P. A., Alfaia, C. M., Ribeiro, V. S., Guerreiro, T. V., Fontes, C. M. G. A., Castro, M., Soveral, G., & Prates, J. A. M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507781448 · Cited by 64 · see citing works
Joseph, S. V., Jacques, H., Plourde, M., Mitchell, P. L., McLeod, R. S., & Jones, P. J. H. (2011) · Journal of Nutrition · doi:10.3945/jn.110.135087 · Cited by 63 · see citing works
Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health
Zulet, M. A., Marti, A., Parra, M. D., & Martínez, J. A. (2005) · Journal of Physiology and Biochemistry · doi:10.1007/bf03168454 · Cited by 62 · see citing works
Uncommon Fatty Acids and Cardiometabolic Health
Li, K., Sinclair, A. J., Zhao, F., & Li, D. (2018) · Nutrients · doi:10.3390/nu10101559 · Cited by 62 · see citing works
Trans fatty acids and insulin resistance
Risérus, U. (2006) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2006.04.008 · Cited by 62 · see citing works
Dietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humans
Kuhnt, K., Wagner, A., Kraft, J., Basu, S., & Jahreis, G. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.981 · Cited by 61 · see citing works
Eighteen‑carbon trans fatty acids and inflammation in the context of atherosclerosis
Valenzuela, C. A., Baker, E. J., Miles, E. A., & Calder, P. C. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.101009 · Cited by 63 · see citing works
Smedman, A., Vessby, B. O., & Basu, S. (2004) · Clinical Science · doi:10.1042/cs20030105 · Cited by 60 · see citing works
- Authors
- Risérus, U., Basu, S., Jovinge, S., Fredrikson, G. N., Ärnlöv, J., & Vessby, B.
- Affiliations
- From the Department of Public Health and Caring Sciences/Geriatrics, Uppsala University (U.R., S.B., J.Ä., B.V.), Uppsala, Sweden, and the Department of Cardiology/Medicine, University Hospital MAS, Lund University (S.J., G.N.F.), Lund, Sweden.
- Uppsala University (SE)
- ORCID
- Jovinge, Stefan
- Venue
- Circulation
- Published
- 2002-10-08
- Volume
- 106
- Issue
- 15
- Pages
- 1925-1929
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2164592152
- Cited by
- 292
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 20 · 2012: 9
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- conjugated linoleic acid, CLA isomers, oxidative stress, lipid peroxidation, C-reactive protein, inflammation, insulin resistance, metabolic syndrome, obesity, weight loss supplements, vitamin E, 8-isoprostane
- MeSH terms
- Adult, Aged, Blood Glucose, C-Reactive Protein, Double-Blind Method, Humans, Inflammation, Insulin Resistance, Isomerism, Kinetics, Linoleic Acids, Lipoproteins, VLDL, Male, Middle Aged, Triglycerides, Lipid Peroxidation, Biomarkers, Cytokines, Oxidative Stress, Anti-Obesity Agents, Metabolic Syndrome, F2-Isoprostanes
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