Cited by 162Fatty Acid Research and HealthEdible Oils Quality and AnalysisProbiotics and Fermented Foods

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Effect of CLA supplementation on immune function in young healthy volunteers

Song, H-J, Grant, I, Rotondo, D, Mohede, I, Sattar, N, Heys, S D, Wahle, K W J·2005·European Journal of Clinical Nutrition

DOI 10.1038/sj.ejcn.1602102

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Abstract

Objectives This study investigated the effect of dietary CLA supplementation (3g/day; 50:50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human (male and female) volunteers.Design Double-blind, randomized, reference-controlled study. SUBJECT AND INTERVENTION: A total of 28 healthy male and female participants aged 25-50 y received either high oleic sunflower oil (reference) or 50% CLA 9-11 and 50% CLA 10-12 CLA isomers (50:50 CLA-triglyceride form). The treatments were given as supplements in soft-gel capsules providing a total 3 g (6 x 500 mg capsules) per day in treatment groups for 12 weeks. A 12-week washout period followed the intervention period.Results Levels of plasma IgA and IgM were increased (P < 0.05 and 0.01 respectively), while plasma IgE levels were decreased (P < 0.05). CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-alpha and IL-1beta (P < 0.05), but increased the levels of the anti-inflammatory cytokine, IL-10 (P < 0.05). Another aspect of immune function, delayed type hypersensitivity (DTH) response, was decreased during and after CLA supplementation (P < 0.05). However, plasma glucose, lipids, lymphocyte phenotypic results were not affected significantly by CLA.Conclusion This is the first study to show that CLA, a fatty acid naturally found in dairy and meat products, can beneficially affect immune function in healthy human volunteers.Sponsorship This study was supported by Loders-Croklaan, The Netherlands and SEERAD (Scottish Executive Environmental Rural and Agriculture Department).

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Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials
(1996) · The Lancet · doi:10.1016/s0140-6736(96)04292-4 · Cited by 1,564
Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention Study
Sattar, N., Gaw, A., Scherbakova, O., Ford, I., O’Reilly, D. S. J., Haffner, S. M., Isles, C., Macfarlane, P. W., Packard, C. J., Cobbe, S. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000080897.52664.94 · Cited by 1,506
Self-citation
Dietary Sources of Conjugated Dienoic Isomers of Linoleic Acid, a Newly Recognized Class of Anticarcinogens
Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L., & Pariza, M. W. (1992) · Journal of Food Composition and Analysis · doi:10.1016/0889-1575(92)90037-k · Cited by 1,197
Conjugated Linoleic Acid Is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase
Griinari, J. M., Nurmela, K., Corl, B. A., Lacy, S. H., Chouinard, P. Y., & Bauman, D. E. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2285 · Cited by 1,054
Lipoprotein-Associated Phospholipase A 2 as an Independent Predictor of Coronary Heart Disease
Packard, C. J., O’Reilly, D. S. J., CASLAKE, M. J., McMahon, A. D., Ford, I., Cooney, J., Macphee, C. H., Suckling, K. E., Krishna, M., Wilkinson, F. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431603 · Cited by 822
Advances in Conjugated Linoleic Acid Research
Sébédio, J., Christie, W. W., & Adlof, R. O. (2020) · AOCS Publishing eBooks · doi:10.4324/9780429270703 · Cited by 710
Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat.
Ip, C., Singh, M., Thompson, H. J., & Scimeca, J. A. (1994) · PubMed · Cited by 555
Conjugated linoleic acid supplementation in humans—metabolic effects
Smedman, A., & Vessby, B. O. (2001) · Lipids · doi:10.1007/s11745-001-0784-7 · Cited by 305
Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance
Risérus, U., Basu, S., Jovinge, S., Fredrikson, G. N., Ärnlöv, J., & Vessby, B. (2002) · Circulation · doi:10.1161/01.cir.0000033589.15413.48 · Cited by 292

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Authors: Song, H.-J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J.
Affiliations: University of Aberdeen (GB)
Robert Gordon University (GB)
University of Strathclyde (GB)
University of Glasgow (GB)
Corresponding author: Wahle, K W J
ORCID: Rotondo, D
Sattar, N
Wahle, K W J
Venue: European Journal of Clinical Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2005-01-12
Volume: 59
Issue: 4
Pages: 508-517
ISSN: 0954-3007 (ISSN-L)
1476-5640
DOI: 10.1038/sj.ejcn.1602102
OpenAlex: W2050217161
Cited by: 162
References: 35
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 11
FWCI: 9.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: European Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: conjugated linoleic acid, dietary supplementation, immune function, plasma immunoglobulins, IgA, IgM, IgE, cytokines, TNF-α, IL-1β, IL-10, delayed-type hypersensitivity, inflammatory cytokines, anti-inflammatory cytokines, plasma lipids, plasma glucose, lymphocyte phenotype, healthy young adults
MeSH terms: Adult, Blood Glucose, C-Reactive Protein, Double-Blind Method, Female, Humans, Hypersensitivity, Delayed, Immunity, Immunoglobulins, Lipids, Lymphocytes, Male, Reference Values, Sex Factors, Time Factors, Cytokines, Dietary Supplements, Linoleic Acids, Conjugated

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Effect of CLA supplementation on immune function in young healthy volunteers

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