The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Effect of CLA supplementation on immune function in young healthy volunteers
Abstract
Objectives This study investigated the effect of dietary CLA supplementation (3g/day; 50:50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human (male and female) volunteers.Design Double-blind, randomized, reference-controlled study. SUBJECT AND INTERVENTION: A total of 28 healthy male and female participants aged 25-50 y received either high oleic sunflower oil (reference) or 50% CLA 9-11 and 50% CLA 10-12 CLA isomers (50:50 CLA-triglyceride form). The treatments were given as supplements in soft-gel capsules providing a total 3 g (6 x 500 mg capsules) per day in treatment groups for 12 weeks. A 12-week washout period followed the intervention period.Results Levels of plasma IgA and IgM were increased (P < 0.05 and 0.01 respectively), while plasma IgE levels were decreased (P < 0.05). CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-alpha and IL-1beta (P < 0.05), but increased the levels of the anti-inflammatory cytokine, IL-10 (P < 0.05). Another aspect of immune function, delayed type hypersensitivity (DTH) response, was decreased during and after CLA supplementation (P < 0.05). However, plasma glucose, lipids, lymphocyte phenotypic results were not affected significantly by CLA.Conclusion This is the first study to show that CLA, a fatty acid naturally found in dairy and meat products, can beneficially affect immune function in healthy human volunteers.Sponsorship This study was supported by Loders-Croklaan, The Netherlands and SEERAD (Scottish Executive Environmental Rural and Agriculture Department).
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“Most recently, NHANES data for 5867 adolescents aged 12 -19 years showed no relationship between serum 25(OH)D 3 and CRP concentrations (748) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [748]
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“However, two studies that investigated cellular markers of inflammation both reported an anti-inflammatory effect of vitamin D (747,748) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [748]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663
Implication of Conjugated Linoleic Acid (CLA) in Human Health
Dilzer, A., & Park, Y. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.501409 · Cited by 377
Fatty Acids as Modulators of the Immune Response
Fritsche, K. L. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092610 · Cited by 316
Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1203 · Cited by 312
Metadata
- Authors
- Song, H.-J., Grant, I., Rotondo, D., Mohede, I., Sattar, N., Heys, S. D., & Wahle, K. W. J.
- Affiliations
- University of Aberdeen (GB)
- Robert Gordon University (GB)
- University of Strathclyde (GB)
- University of Glasgow (GB)
- Corresponding author
- Wahle, K W J
- Venue
- European Journal of Clinical Nutrition
- Published
- 2005-01-12
- Volume
- 59
- Issue
- 4
- Pages
- 508-517
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2050217161
- Cited by
- 162
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 11
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- conjugated linoleic acid, dietary supplementation, immune function, plasma immunoglobulins, IgA, IgM, IgE, cytokines, TNF-α, IL-1β, IL-10, delayed-type hypersensitivity, inflammatory cytokines, anti-inflammatory cytokines, plasma lipids, plasma glucose, lymphocyte phenotype, healthy young adults
- MeSH terms
- Adult, Blood Glucose, C-Reactive Protein, Double-Blind Method, Female, Humans, Hypersensitivity, Delayed, Immunity, Immunoglobulins, Lipids, Lymphocytes, Male, Reference Values, Sex Factors, Time Factors, Cytokines, Dietary Supplements, Linoleic Acids, Conjugated
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