Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

Conserved role of intragenic DNA methylation in regulating alternative promoters

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Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

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Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

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Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

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Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

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Long-term depression in the CNS

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Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer

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Contribution of SHANK3 Mutations to Autism Spectrum Disorder

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Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

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Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

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Advances in the Treatment of Fragile X Syndrome

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Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

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The Shank family of scaffold proteins

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Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

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Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

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A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

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Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons <i>In Vivo</i>

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Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

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Molecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of <i>SHANK3/PROSAP2</i> in the major neurological symptoms

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The postsynaptic density proteins Homer and Shank form a polymeric network structure

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Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

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ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease

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Long-term depression: multiple forms and implications for brain function

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Novel de novo SHANK3 mutation in autistic patients

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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

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Disruption of the ProSAP2 Gene in a t(12;22)(q24.1;q13.3) Is Associated with the 22q13.3 Deletion Syndrome

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A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Kinney, G. G., O’Brien, J. A., Lemaire, W., Burno, M., Bickel, D. J., Clements, M. K., Chen, T., Wisnoski, D. D., Lindsley, C. W., Tiller, P. R., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079244 · Cited by 298 · see citing works

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis

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Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons

Roussignol, G., Ango, F., Romorini, S., Tu, J. C., Sala, C., Worley, P. F., Bockaert, J., & Fagni, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4354-04.2005 · Cited by 293 · see citing works

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292 · see citing works

Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a

Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288 · see citing works

Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

Gallagher, S. M., Daly, C. A., Bear, M. F., & Huber, K. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5407-03.2004 · Cited by 254 · see citing works

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

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A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signals

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Identification of a recurrent breakpoint within the <i>SHANK3</i> gene in the 22q13.3 deletion syndrome

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Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP Family

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Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

Uslaner, J. M., Parmentier‐Batteur, S., Flick, R. B., Surles, N. O., Lam, J. S. H., McNaughton, C. H., Jacobson, M. A., & Hutson, P. H. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.022 · Cited by 193 · see citing works

Synaptic Strength as a Function of Post- versus Presynaptic Expression of the Neural Cell Adhesion Molecule NCAM

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Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression

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Key Role of the Postsynaptic Density Scaffold Proteins Shank and Homer in the Functional Architecture of Ca 2+ Homeostasis at Dendritic Spines in Hippocampal Neurons

Sala, C., Roussignol, G., Meldolesi, J., & Fagni, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4822-04.2005 · Cited by 160 · see citing works

Regulation by Metabotropic Glutamate Receptor 5 of LTP in the Dentate Gyrus of Freely Moving Rats: Relevance for Learning and Memory Formation

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Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis

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Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression

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A self-adapting approach for the detection of bursts and network bursts in neuronal cultures

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The Metabotropic Glutamate Receptor, mGluR5, is a Key Determinant of Good and Bad Spatial Learning Performance and Hippocampal Synaptic Plasticity

Manahan-Vaughan, D., & Braunewell, K.-H. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi047 · Cited by 138 · see citing works

Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs largePreprint

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Linkage of the Actin Cytoskeleton to the Postsynaptic Density via Direct Interactions of Abp1 with the ProSAP/Shank Family

Qualmann, B., Boeckers, T. M., Jeromin, M., Gundelfinger, E. D., & Kessels, M. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5479-03.2004 · Cited by 134 · see citing works

Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

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ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53

Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., & Böckers, T. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01204.x · Cited by 121 · see citing works

C‐terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3

Boeckers, T. M., Liedtke, T., Spilker, C., Dresbach, T., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02910.x · Cited by 113 · see citing works

Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

Seeburg, D. P., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1853-08.2008 · Cited by 106 · see citing works

Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease

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A Functional Role of Postsynaptic Density-95-Guanylate Kinase-Associated Protein Complex in Regulating Shank Assembly and Stability to Synapses

Romorini, S., Piccoli, G., Jiang, M., Grossano, P., Tonna, N., Passafaro, M., Zhang, M., & Sala, C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3314-04.2004 · Cited by 96 · see citing works

Postsynaptic Shank Antagonizes Dendrite Branching Induced by the Leucine-Rich Repeat Protein Densin-180

Quitsch, A., Berhörster, K., Liew, C. W., Richter, D., & Kreienkamp, H.-J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2699-04.2005 · Cited by 95 · see citing works

Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors

Moriyoshi, K., Iijima, K., Fujii, H., Ito, H., Cho, Y., & Nakanishi, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403042101 · Cited by 93 · see citing works

Interstitial 22q13 deletions: genes other than SHANK3 have major effects on cognitive and language development

Wilson, H. L., Crolla, J. A., Walker, D., Artifoni, L., Dallapiccola, B., Takano, T., Vasudevan, P., Huang, S., Maloney, V., Yobb, T., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.107 · Cited by 85 · see citing works

Low-frequency stimulation enhances burst activity in cortical cultures during development

Bologna, L. L., Nieus, T. R., Tedesco, M., Chiappalone, M., Benfenati, F., & Sergio Martinoia, A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.018 · Cited by 79 · see citing works

DNA methylation regulates tissue‐specific expression of Shank3

Beri, S., Tonna, N., Menozzi, G., Bonaglia, M. C., Sala, C., & Giorda, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04539.x · Cited by 74 · see citing works

Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines

Shiraishi‐Yamaguchi, Y., Sato, Y., Sakai, R., Mizutani, A., Knöpfel, T., Mori, N., Mikoshiba, K., & Furuichi, T. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-25 · Cited by 70 · see citing works

Metabotropic glutamate receptor subtype 5 antagonism in learning and memory

Simonyi, Á., Schachtman, T. R., & Christoffersen, G. R. J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.12.039 · Cited by 66 · see citing works

Chromosome 22q13.3 deletion syndrome with a de novo interstitial 22q13.3 cryptic deletion disrupting SHANK3

Delahaye‐Duriez, A., Toutain, A., Aboura, A., Dupont, C., Tabet, A., Benzacken, B., Élion, J., Verloès, A., Pipiras, E., & Drunat, S. (2009) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2009.05.004 · Cited by 58 · see citing works

Synaptic Cross-talk between N-Methyl-d-aspartate Receptors and LAPSER1-β-Catenin at Excitatory Synapses

Schmeißer, M. J., Grabrucker, A. M., Bockmann, J., & Boeckers, T. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020628 · Cited by 53 · see citing works

Experience-dependent modification of mechanisms of long-term depression

Jo, J., Ball, S. M., Seok, H., Oh, S. B., Massey, P. V., Molnár, E., Bashir, Z. I., & Cho, K. (2006) · Nature Neuroscience · doi:10.1038/nn1637 · Cited by 49 · see citing works

Proteomic Analysis of Activity-Dependent Synaptic Plasticity in Hippocampal Neurons

Piccoli, G., Verpelli, C., Tonna, N., Romorini, S., Alessio, M., Nairn, A. C., Bachi, A., & Sala, C. (2007) · Journal of Proteome Research · doi:10.1021/pr0701308 · Cited by 46 · see citing works

Replica-moulded polydimethylsiloxane culture vessel lids attenuate osmotic drift in long-term cell cultures

Blau, A. W., Neumann, T., Ziegler, C., & Benfenati, F. (2009) · Journal of Biosciences · doi:10.1007/s12038-009-0009-3 · Cited by 39 · see citing works

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

Wilson, C., Doms, R. W., & Lee, V. M. ‐. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10776 · Cited by 37 · see citing works

Regulation of dendritic spine morphology by SPIN90, a novel Shank binding partner

Kim, S., Choi, K. Y., Cho, I. H., Rhy, J. H., Kim, S. H., Park, C., Kim, E., & Song, W. K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06039.x · Cited by 21 · see citing works

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works

Modeling Autism by SHANK Gene Mutations in Mice

Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works

Dendritic Spines: The Locus of Structural and Functional Plasticity

Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465 · see citing works

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent <i>Shank3</i> Null Mutant Mice

Yang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6107-11.2012 · Cited by 369 · see citing works

Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

Kouser, M., Speed, H. E., Dewey, C. M., Reimers, J. M., Widman, A. J., Gupta, N., Liu, S., Jaramillo, T. C., Bangash, M. A., Xiao, B., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3017-13.2013 · Cited by 283 · see citing works

Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders

Boccuto, L., Lauri, M., Sarasua, S. M., Skinner, C. D., Buccella, D., Dwivedi, A., Orteschi, D., Collins, J. S., Zollino, M., Visconti, P., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.175 · Cited by 240 · see citing works

Environmental Factors in Autism

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Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

Grabrucker, A. M., Schmeisser, M. J., Schoen, M., & Boeckers, T. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.003 · Cited by 233 · see citing works

Translational animal models of autism and neurodevelopmental disorders

Crawley, J. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/jcrawley · Cited by 227 · see citing works

An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

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Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

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SHANK3 controls maturation of social reward circuits in the VTA

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CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors

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Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4‐9 Deletion Mouse Model of Autism

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CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

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Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders

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Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function

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Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1

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Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

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A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons

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Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles

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SNAP-25 regulates spine formation through postsynaptic binding to p140Cap

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Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin‐expressing inhibitory interneurons

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Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

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Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

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Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

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Dendritic spine actin cytoskeleton in autism spectrum disorder

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An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function

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Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

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Direct current stimulation induces mGluR5‐dependent neocortical plasticity

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The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

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Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

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Fear Extinction Induces mGluR5-Mediated Synaptic and Intrinsic Plasticity in Infralimbic Neurons

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Shank–cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses

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Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses

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Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development

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Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction

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SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region

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The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders

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Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice

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Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

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Absence of strong strain effects in behavioral analyses ofShank3-deficient mice

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Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability

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Selective basal ganglia vulnerability to energy deprivation: Experimental and clinical evidences

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Bipolar affective disorder and early dementia onset in a male patient with SHANK3 deletion

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Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection

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Synapse-to-Nucleus Signaling in Neurodegenerative and Neuropsychiatric Disorders

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Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism

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Modulation of behavior by scaffolding proteins of the post-synaptic density

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Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator

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Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

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Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

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Cerebellar Dysfunction, Cerebro-cerebellar Connectivity and Autism Spectrum Disorders

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SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

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Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin–Lowry syndrome

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Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time

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Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors

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Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses

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