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Cited by 206

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

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Arias‐Lopez, Carmen, Lazaro‐Trueba, Iciar, Kerr, Peter, Lord, Christopher J, Dexter, Tim, Iravani, Marjan, Ashworth, Alan, Silva, Augusto·2006·EMBO reports
DOI 10.1038/sj.embor.7400587
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Abstract

DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild‐type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild‐type p53 to a p53 response element in the promoter of Rad51 and the downregulation of Rad51 messenger RNA and protein by wild‐type p53, favoured by DNA damage. Moreover, wild‐type p53 inhibits Rad51 foci formation in response to double‐strand breaks, whereas p53 contact mutant R280K fails to repress Rad51 mRNA and protein expression and Rad51 foci formation. We propose that transcriptional repression of Rad51 by p53 participates in regulating homologous recombination, and impaired Rad51 repression by p53 mutants may contribute to malignant transformation.

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Citations

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Show all 5 references

Research works printed but not linked: 32

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Metadata

Authors
Arias‐Lopez, C., Lazaro‐Trueba, I., Kerr, P., Lord, C. J., Dexter, T., Iravani, M., Ashworth, A., & Silva, A.
Venue
EMBO reports
Publisher
Springer Science and Business Media LLC
Published
2006-02
Volume
7
Issue
2
Pages
219-224
ISSN
  • 1469-221X (ISSN-L)
  • 1469-3178
DOI
10.1038/sj.embor.7400587
OpenAlex
W2074699503
Cited by
206
References
5
FWCI
2.30
Type
journal article
Language
en
Open access
green
Licence

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CoChat. (2026). Citation check: p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene. https://app.cochat.ai/papers/10.1038/sj.embor.7400587
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Arias‐Lopez, C., Lazaro‐Trueba, I., Kerr, P., Lord, C. J., Dexter, T., Iravani, M., Ashworth, A., & Silva, A. (2006). p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene. EMBO reports. https://doi.org/10.1038/sj.embor.7400587

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