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The gut flora as a forgotten organ
Open accessAbstract
The intestinal microflora is a positive health asset that crucially influences the normal structural and functional development of the mucosal immune system. Mucosal immune responses to resident intestinal microflora require precise control and an immunosensory capacity for distinguishing commensal from pathogenic bacteria. In genetically susceptible individuals, some components of the flora can become a liability and contribute to the pathogenesis of various intestinal disorders, including inflammatory bowel diseases. It follows that manipulation of the flora to enhance the beneficial components represents a promising therapeutic strategy. The flora has a collective metabolic activity equal to a virtual organ within an organ, and the mechanisms underlying the conditioning influence of the bacteria on mucosal homeostasis and immune responses are beginning to be unravelled. An improved understanding of this hidden organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and neoplastic disease processes.
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“In the absence of the resident microbiota, members of the TLR family have low or absent expression profiles in the gut, thus compromising appropriate neuroendocrine responses to pathogenic threats (O'Hara and Shanahan, 2006).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as O'Hara and Shanahan, 2006
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“Microbial abundance and community structure in the proximal intestine is affected by gastric acid, pancreaticobiliary secretions, and fast transit45.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [45]
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“Studies have since shown that gut bacteria play a vital role in regulating important aspects of brain development and function, along with other host physiology [5, 7].”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as [5]
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Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584
Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345
Cario, E., & Podolsky, D. K. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.7010-7017.2000 · Cited by 1,245
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R., Wheeler, M. T., Tsui, C., Hurley, P. J., Chien, M., Chai, S., Hitotsumatsu, O., et al. (2004) · Nature Immunology · doi:10.1038/ni1110 · Cited by 1,104
Research works printed but not linked: 1
- Rook GA, Brunet LR (2005) Microbes, immunoregulation and the gut. Gut 54: 317–320
Cited by
Sorted by citations
Items 401–500 of 1,012
Chen, Y., Chen, Z., Guo, R., Chen, N., Lu, H., Huang, S., Wang, J., & Li, L. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.04.005 · Cited by 135
Bioreactor technologies to support liver function in vitro
Ebrahimkhani, M. R., Neiman, J. A. S., Raredon, M. S. B., Hughes, D. J., & Griffith, L. G. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.011 · Cited by 141
Cañas, M.-A., Gíménez, R., Fábrega, M.-J., Toloza, L., Baldomà, L., & Badı́a, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160374 · Cited by 135
The evolution of animals and plants via symbiosis with microorganisms
Rosenberg, E., Sharon, G., Atad, I., & Zilber‐Rosenberg, I. (2010) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2010.00177.x · Cited by 139
Choy, Y. Y., Quifer‐Rada, P., Holstege, D. M., Frese, S. A., Calvert, C. C., Mills, D. A., Lamuela-Raventós, R. M., & Waterhouse, A. L. (2014) · Food & Function · doi:10.1039/c4fo00325j · Cited by 133
The normal intestinal microbiota
Marchesi, J. R., & Shanahan, F. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3282a56a99 · Cited by 136
Self-citationNonalcoholic fatty liver disease: a challenge from mechanisms to therapy.
Tarantino, G., Citro, V., & Capone, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010015 · Cited by 134
Aidy, S. E., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Holmes, E. C., Claus, S. P., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301955 · Cited by 141
Park, S., Ji, Y., Jung, H.-Y., Park, H., Kang, J., Choi, S.-H., Shin, H., Hyun, C.-K., Kim, K.-T., & Holzapfel, W. H. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7953-2 · Cited by 130
Lactic acid bacteria isolated from young calves – Characterization and potential as probiotics
Maldonado, N. C., de Ruiz, C. S., Otero, M. C., Sesma, F. J. M., & Nader-Macı́as, M. E. (2011) · Research in Veterinary Science · doi:10.1016/j.rvsc.2011.03.017 · Cited by 132
The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Dato, S., Rose, G., Crocco, P., Monti, D., Garagnani, P., Franceschi, C., & Passarino, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.011 · Cited by 135
Immunological co-ordination between gut and lungs in SARS-CoV-2 infection
Ahlawat, S., Asha, A., & Sharma, K. K. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198103 · Cited by 137
Rendueles, O., Ferrières, L., Frétaud, M., Bégaud, É., Herbomel, P., Levraud, J., & Ghigo, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002815 · Cited by 134
Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases
Tu, P., Chi, L., Bodnar, W. M., Zhang, Z., Gao, B., Bian, X., Stewart, J. R., Fry, R. C., & Lü, K. (2020) · Toxics · doi:10.3390/toxics8010019 · Cited by 136
The potter’s wheel: the host’s role in sculpting its microbiota
Bevins, C. L., & Salzman, N. H. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0830-3 · Cited by 134
Guo, S., Gillingham, T. Z., Guo, Y., Meng, D., Zhu, W., Walker, W. A., & Ganguli, K. A. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001310 · Cited by 129
Donato, V., Ayala, F. R., Cogliati, S., Bauman, C., Costa, J. G., Leñini, C., & Grau, R. R. (2017) · Nature Communications · doi:10.1038/ncomms14332 · Cited by 135
Cionci, N. B., Baffoni, L., Gaggìa, F., & Gioia, D. D. (2018) · Nutrients · doi:10.3390/nu10111723 · Cited by 138
Mechanisms of Action of Probiotics in Intestinal Diseases
O’Hara, A. M., & Shanahan, F. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.26 · Cited by 127
Self-citationThe Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors
Minalyan, A., Gabrielyan, L., Scott, D. R., Jacobs, J. P., & Pisegna, J. R. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0577-6 · Cited by 134
Effects and mechanisms of tea for the prevention and management of cancers: An updated review
Xu, X., Zhao, C., Cao, S., Tang, G., Gan, R., & Li, H. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1588223 · Cited by 128
Probiotics as a biological detoxification tool of food chemical contamination: A review
Średnicka, P., Juszczuk‐Kubiak, E., Wójcicki, M., Akimowicz, M., & Roszko, M. Ł. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112306 · Cited by 139
Belmonte, L., Beutheu Youmba, S., Bertiaux-Vandaële, N., Antonietti, M., Lecleire, S., Zalar, A., Gourcerol, G., Leroi, A.-M., Déchelotte, P., Coëffier, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042777 · Cited by 126
Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates
Ling, Z., Liu, X., Luo, Y., Yuan, L., Nelson, K. E., Wang, Y., Xiang, C., & Li, L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-390 · Cited by 127
Microbiota and dietary interactions – an update to the hygiene hypothesis?
Frei, R., Lauener, R. P., Crameri, R., & O’Mahony, L. (2012) · Allergy · doi:10.1111/j.1398-9995.2011.02783.x · Cited by 132
From lifetime to evolution: timescales of human gut microbiota adaptation
Quercia, S., Candela, M., Giuliani, C., Turroni, S., Luiselli, D., Rampelli, S., Brigidi, P., Franceschi, C., Bacalini, M. G., Garagnani, P., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00587 · Cited by 131
Alexopoulou, A. A., Papadopoulos, N., Eliopoulos, D. G., Alexaki, A., Tsiriga, A., Toutouza, M. G., & Pectasides, D. G. (2013) · Liver International · doi:10.1111/liv.12152 · Cited by 127
Eslamparast, T., Zamani, F., Hekmatdoost, A., Sharafkhah, M., Eghtesad, S., Malekzadeh, R., & Poustchi, H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000919 · Cited by 130
Taylor, B., Woodfall, G., Sheedy, K., O’Riley, M., Rainbow, K., Bramwell, E., & Kellow, N. J. (2017) · Nutrients · doi:10.3390/nu9050461 · Cited by 128
Phage Therapy: Concept to Cure
Keen, E. C. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00238 · Cited by 135
Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
Noh, K., Kang, Y., Nepal, M. R., Jeong, K., Oh, D., Kang, M. Y., Lee, S., Kang, W., Jeong, H. G., & Jeong, T. C. (2016) · Molecules · doi:10.3390/molecules21030337 · Cited by 126
Capo, F., Wilson, A., & Cara, F. D. (2019) · Microorganisms · doi:10.3390/microorganisms7090336 · Cited by 136
Breast and gut microbiome in health and cancer
Zhang, J., Xia, Y., & Sun, J. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.08.002 · Cited by 130
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Guerre, P. (2020) · Toxins · doi:10.3390/toxins12120769 · Cited by 139
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Zhao, H., Lu, Z., & Lu, Y. (2022) · Food & Function · doi:10.1039/d1fo03206b · Cited by 128
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Ma, N., Chen, X., Johnston, L. J., & Ma, X. (2022) · iMeta · doi:10.1002/imt2.54 · Cited by 124
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Paulos, C. M., Kaiser, A., Wrzesinski, C., Hinrichs, C. S., Cassard, L., Boni, A., Muranski, P. J., Sanchez-Perez, L. A., Palmer, D. C., Yu, Z., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1378 · Cited by 124
Saha, P., Yeoh, B. S., Singh, R., Chandrasekar, B., Vemula, P. K., Haribabu, B., Vijay‐Kumar, M., & Jala, V. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156811 · Cited by 121
Direct-Fed Microbials and Their Impact on the Intestinal Microflora and Immune System of Chickens
Lee, K.-W., Lillehoj, H. S., & Siragusa, G. R. (2010) · The Journal of Poultry Science · doi:10.2141/jpsa.009096 · Cited by 127
Wang, Y., Liu, J., Li, Q., Wang, Y., & Wang, C. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1647-6 · Cited by 123
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications
Baba, Y., Iwatsuki, M., Yoshida, N., Watanabe, M., & Baba, H. (2017) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12014 · Cited by 123
Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
Boeckmans, J., Natale, A., Rombaut, M., Buyl, K., Rogiers, V., Kock, J. D., Vanhaecke, T., & Rodrigues, R. M. (2019) · Cells · doi:10.3390/cells9010037 · Cited by 126
Johnson, M. E., Stringer, A., & Bobrovskaya, L. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.02.013 · Cited by 122
Infection, inflammation, and chronic diseases: consequences of a modern lifestyle
Ehlers, S., & Kaufmann, S. H. E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.02.003 · Cited by 124
Human Microbiome and its Association With Health and Diseases
Thani, A. A. A., Marei, H. E. S., Hamdi, W. S., Nasrallah, G. K., Zowalaty, M. E. E., Khodor, S. A., Al‐Asmakh, M., Aziz, H. A., & Cenciarelli, C. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25284 · Cited by 130
Grandeur Alliances: Symbiont Metabolic Integration and Obligate Arthropod Hematophagy
Rio, R. V. M., Attardo, G. M., & Weiss, B. L. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.05.002 · Cited by 122
Alemany-Cosme, E., González, E. S., Moret, I., Mateos, B., Iborra, M., Nos, P., Sandoval, J., & Beltrán, B. (2021) · Antioxidants · doi:10.3390/antiox10010064 · Cited by 132
Gut microbiome health and dysbiosis: A clinical primer
Bidell, M. R., Hobbs, A. L. V., & Lodise, T. P. (2022) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2731 · Cited by 146
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Cox, L. M., Cho, I., Young, S. A., Anderson, W. H. K., Waters, B. J., Hung, S., Gao, Z., Mahana, D., Bihan, M., Alekseyenko, A. V., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-219477 · Cited by 123
The role of infection in the aetiology of inflammatory bowel disease
Hansen, R., Thomson, J., El-Omar, E. M., & Hold, G. L. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-009-0191-y · Cited by 127
Neilson, A. P., & Ferruzzi, M. G. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133725 · Cited by 121
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Kovatcheva‐Datchary, P., & Arora, T. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.017 · Cited by 122
Dysbiosis: from fiction to function
Tiffany, C. R., & Bäumler, A. J. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00230.2019 · Cited by 127
Bashraheel, S. S., Dömling, A. S. S., & Goda, S. K. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110009 · Cited by 128
Giuffrè, M., Campigotto, M., Campisciano, G., Comar, M., & Crocè, L. S. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2019 · Cited by 122
Regulation of surface architecture by symbiotic bacteria mediates host colonization
Liu, C. H., Lee, S. M., VanLare, J. M., Kasper, D. L., & Mazmanian, S. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709266105 · Cited by 121
Influence of H7N9 virus infection and associated treatment on human gut microbiota
Qin, N., Zheng, B., Yao, J., Guo, L., Zuo, J., Wu, L., Zhou, J., Liu, L., Guo, J., Ni, S., et al. (2015) · Scientific Reports · doi:10.1038/srep14771 · Cited by 126
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628741 · Cited by 133
Pyrosequencing-based analysis of fecal microbial communities in three purebred pig lines
Pajarillo, E. A. B., Chae, J. P., Balolong, M. P., Kim, H. B., Seo, K.-S., & Kang, D. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-4270-2 · Cited by 119
Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes
Arora, T., & Tremaroli, V. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.761834 · Cited by 126
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Linares, D. M., Ross, R. P., & Stanton, C. (2015) · Bioengineered · doi:10.1080/21655979.2015.1126015 · Cited by 123
Peng, M., & Biswas, D. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1203286 · Cited by 122
Takagi, R., Sasaki, K., Sasaki, D., Fukuda, I., Tanaka, K., Yoshida, K., Kondo, A., & Osawa, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160533 · Cited by 120
Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility
Riganelli, L., Iebba, V., Piccioni, M. G., Illuminati, I., Bonfiglio, G., Neroni, B., Calvo, L., Gagliardi, A., Levrero, M., Merlino, L., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00350 · Cited by 126
The microbiota and its metabolites in colonic mucosal health and cancer risk
Vipperla, K., & O'Keefe, S. J. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612452012 · Cited by 116
Motherway, M. O., O’Driscoll, J., Fitzgerald, G. F., & van Sinderen, D. (2008) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00071.x · Cited by 117
Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer
Candela, M., Guidotti, M., Fabbri, A., Brigidi, P., Franceschi, C., & Fiorentini, C. (2010) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2010.501760 · Cited by 117
An iterative workflow for mining the human intestinal metaproteome
Rooijers, K., Kolmeder, C. A., Juste, C., Dore, J. M., de Been, M., Boeren, S. A., Galan, P., Beauvallet, C., de Vos, W. M., & Schaap, P. J. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-6 · Cited by 118
Rajpoot, M., Sharma, A. K., Sharma, A. K., & Gupta, G. K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.02.003 · Cited by 119
Role of secretory IgA in the mucosal sensing of commensal bacteria
Mathias, A., Pais, B., Favre, L., Benyacoub, J., & Corthésy, B. (2014) · Gut Microbes · doi:10.4161/19490976.2014.983763 · Cited by 115
Development of oral food-grade delivery systems: Current knowledge and future challenges
Benshitrit, R. C., Levi, C. S., Levi-Tal, S., Shimoni, E., & Lesmes, U. (2011) · Food & Function · doi:10.1039/c1fo10068h · Cited by 115
Mu, C., Yang, Y., Su, Y., Zoetendal, E. G., & Zhu, W. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00797 · Cited by 122
Gut bacteria–host metabolic interplay during conventionalisation of the mouse germfree colon
Aidy, S. E., Derrien, M., Merrifield, C. A., Levenez, F., Dore, J. M., Boekschoten, M. V., Dekker, J. P., Holmes, E. C., Zoetendal, E. G., van Baarlen, P., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.142 · Cited by 116
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Ji, B., & Nielsen, J. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00219 · Cited by 116
Katouli, M. (2010) · PubMed Central · Cited by 112
Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China
Liu, J., Yang, H., Yin, Z., Jiang, X., Zhong, H., Qiu, D., Zhu, F., & Li, R. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2853-z · Cited by 115
Hygiene and other early childhood influences on the subsequent function of the immune system
Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109
Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis
Su, C., Su, L., Li, Y., Long, S. R., Chang, J. H., Zhang, W., Walker, W. A., Xavier, R. J., Cherayil, B. J., & Shi, H. N. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.20 · Cited by 111
Mihajlovski, A., Alric, M., & Brugère, J. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.06.007 · Cited by 112
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Sharma, V., Singh, T. G., Garg, N., Dhiman, S., Gupta, S., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11050678 · Cited by 111
Dysbiosis—A consequence of Paneth cell dysfunction
Salzman, N. H., & Bevins, C. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.006 · Cited by 117
Multimodal Role of Amino Acids in Microbial Control and Drug Development
Idrees, M. M., Mohammad, A. R., Karodia, N., & Rahman, A. (2020) · Antibiotics · doi:10.3390/antibiotics9060330 · Cited by 120
New Insights into the Immune System Using Dirty Mice
Hamilton, S. E., Badovinac, V. P., Beura, L. K., Pierson, M. J., Jameson, S. C., Masopust, D., & Griffith, T. S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000171 · Cited by 111
Ahlawat, S., Kumar, P., Mohan, H., Goyal, S., & Sharma, K. K. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1876631 · Cited by 113
Intestinal microbiota and its functions
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Metadata
- Authors
- O'Hara, A. M., & Shanahan, F.
- Affiliations
- National University of Ireland (IE)
- Corresponding author
- Shanahan, Fergus
- ORCID
- Shanahan, Fergus
- Venue
- The EMBO Reports
- Published
- 2006-07-01
- Volume
- 7
- Issue
- 7
- Pages
- 688-693
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1500832
- OpenAlex
- W2117727476
- Cited by
- 2,791
- References
- 54
- Citations by year
- 2026: 67 · 2025: 127 · 2024: 186 · 2023: 174 · 2022: 230 · 2021: 217 · 2020: 243 · 2019: 198 · 2018: 179 · 2017: 184 · 2016: 168 · 2015: 147 · 2014: 123 · 2013: 134 · 2012: 121
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland
- Alimentary Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- gut microbiota, mucosal immunity, inflammatory bowel disease, mucosal homeostasis, bacterial metabolic activity, microbiome manipulation, intestinal disorders, pathogenesis
- MeSH terms
- Animals, Bacteria, Digestive System, Digestive System Diseases, Germ-Free Life, Homeostasis, Humans, Intestinal Mucosa, Models, Biological, Immunity, Mucosal
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