Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1β in rats
Abstract
Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1beta can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone. The present experiment provides independent confirmation that intracerebroventricular administration of 10 ng IL-1beta in the rat can have a selective effect on the retrieval of trial unique information about the location of food on an eight-arm radial maze. The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration. Further evidence comes from the blockade of the associated impairment in working memory by coadministration of the glucocorticoid receptor antagonist RU486. Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Furthermore, rats given the ethyl-EPA diet for 8 weeks were unaffected by the disruptive effects of IL-1beta on working memory. IL-1beta-induced suppression of mitogen-stimulated release of the anti-inflammatory cytokine IL-10 was also blocked by treatment with ethyl-EPA. Collectively, these data demonstrate that IL-1beta can impair memory function by elevating the concentration of corticosterone and that prior consumption of 1% ethyl-EPA can block both the neuroendocrine and cognitive effects of IL-1beta. These findings in turn may indicate beneficial effects of ethyl-EPA in the treatment of cognitive and affective disorders in which inflammation and stress play a critical role.
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Preclinical evidence suggests that a diet enriched in n-3 polyunsaturated fatty acid (ethyl-eicosapentaenoic acid) may attenuate IL-1-induced memory impairment and block IL-1-induced increases in serum corticosterone concentration.
“Preclinical evidence suggests that a diet enriched in n-3 PUFA (i.e. ethyl-eicosapentaenoic acid) may attenuate IL-1-induced memory impairment and block IL-1-induced increases in serum corticosterone concentration [134].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [134]
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- Authors
- Song, C., Phillips, A. G., Leonard, B. E., & Horrobin, D. F.
- Affiliations
- University of British Columbia (CA)
- Maastricht University (NL)
- Corresponding author
- Song, C
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2003-12-16
- Volume
- 9
- Issue
- 6
- Pages
- 630-638
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2050920409
- Cited by
- 91
- References
- 54
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- eicosapentaenoic acid, IL-1β, corticosterone, memory impairment, working memory, spatial memory, prostaglandin E2, omega-3 fatty acids, IL-10, glucocorticoid receptor, neuroinflammation, stress
- MeSH terms
- Administration, Oral, Animals, Corticosterone, Interleukin-1, Male, Memory, Memory Disorders, Space Perception, Eicosapentaenoic Acid, Dinoprostone, Interleukin-10, Rats, Long-Evans, Rats
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