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First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients
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“In humans, altered ERK activation causes a variety of developmental disorders which have ASD-like symptoms, although the pathogenic mechanisms are not precisely understood.”
From Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice (2015) · cites this paper as [27]
In the citing paper
“It was reported that ASD is common in patients with 22q11.2 deletion syndrome27.”
From Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice (2015) · cites this paper as [27]
In the citing paper
“An NMDAR single-photon emission computed tomography (SPECT) study pointed to lower NMDAR activity in unmedicated patients with schizophrenia 19 , although this finding awaits confirmation with newer, more specific probes 20 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [19]
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Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?
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Rapin, I., & Tuchman, R. F. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282f49579 · Cited by 57
Olszewski, R. T., Wegorzewska, M. M., Monteiro, A. C., Krolikowski, K. A., Zhou, J., Kozikowski, A. P., Long, K. D., Mastropaolo, J. P., Deutsch, S. I., & Neale, J. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.016 · Cited by 56
Mutant models for genes associated with schizophrenia
Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370308 · Cited by 57
Metadata
- Authors
- Pilowsky, L. S., Bressan, R. A., Stone, J. M., Erlandsson, K., Mulligan, R. S., Krystal, J. H., & Ell, P. J.
- Affiliations
- King's College London (GB)
- University College London (GB)
- Yale University (US)
- Venue
- Molecular Psychiatry
- Published
- 2005-09-27
- Volume
- 11
- Issue
- 2
- Pages
- 118-119
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2066489132
- Cited by
- 278
- References
- 6
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 14 · 2016: 20 · 2015: 19 · 2014: 16 · 2013: 21 · 2012: 17
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Health (5k05aa014906-03)
- National Institute on Alcohol Abuse and Alcoholism (KO5 AA 014906-02)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- NMDA receptor, schizophrenia, medication-free patients, receptor availability, first-episode psychosis, ketamine, brain volume
- MeSH terms
- Analysis of Variance, Clozapine, Guanidines, Hippocampus, Humans, Functional Laterality, Reference Values, Schizophrenia, Tissue Distribution, Antipsychotic Agents, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Receptors, N-Methyl-D-Aspartate, Genetic Predisposition to Disease
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