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How dopamine dysregulation leads to psychotic symptoms? Abnormal mesolimbic and mesostriatal prediction error signalling in psychosis
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“Furthermore, the extent of the observed conduction delays were found to be dependent on the frequency of stimulation, with high frequency stimulation resulting in larger and more variable conduction delays than low frequency stimulation.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [77]
In the citing paper
“Rasminsky and Sears 77 experimentally dysmyelinated the ventral roots of the spinal cord in rats and found that the conduction velocities of impulses traveling along these fibers were both slower and abnormally variable compared with impulses traveling along healthy fibers.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [77]
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van Os, J., Rutten, B. P., & Poulton, R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn117 · Cited by 713
Palaniyappan, L., & Liddle, P. F. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100176 · Cited by 548
Neural correlates of value, risk, and risk aversion contributing to decision making under risk
Christopoulos, G. I., Tobler, P. N., Bossaerts, P., Dolan, R. J., & Schultz, W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-09.2009 · Cited by 451
“Ventral striatum ROI was hand drawn in MRIcro (Rorden and Brett, 2000) according to the anatomical description by Martinez et al. (2003), as used previously (Murray et al., 2008), adjusted to the anatomical specificities of our sample.”
Voon, V., Mole, T. B., Banca, P., Porter, L., Morris, L., Mitchell, S., Lapa, T. R., Karr, J., Harrison, N. A., Potenza, M. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102419 · Cited by 462
A Review of Reward Processing and Motivational Impairment in Schizophrenia
Strauss, G. P., Waltz, J. A., & Gold, J. M. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt197 · Cited by 474
Dopaminergic dysfunction in schizophrenia: Salience attribution revisited
Heinz, A., & Schlagenhauf, F. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq031 · Cited by 412
Luman, M., Tripp, G., & Scheres, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.021 · Cited by 335
“Additionally, researchers have shown that BOLD responses in the VTA reflect positive reward prediction errors (D’Ardenne et al., 2008; Murray et al., 2008).”
BackgroundOchsner, K. N. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.024 · Cited by 336
Dopaminergic basis of salience dysregulation in psychosis
Winton-Brown, T. T., Fusar-Poli, P., Ungless, M. A., & Howes, O. D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.003 · Cited by 231
A Transdiagnostic Review of Negative Symptom Phenomenology and Etiology
Strauss, G. P., & Cohen, A. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx066 · Cited by 238
Neural and Behavioral Correlates of Aberrant Salience in Individuals at Risk for Psychosis
Roiser, J. P., Howes, O. D., Chaddock, C. A., Joyce, E. M., & McGuire, P. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs147 · Cited by 205
Alterations of the Brain Reward System in Antipsychotic Naïve Schizophrenia Patients
Nielsen, M. Ø., Rostrup, E., Wulff, S., Bak, N. K., Lublin, H., Kapur, S., & Glenthoj, B. Y. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.007 · Cited by 224
Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions
Schlagenhauf, F., Sterzer, P., Schmack, K., Ballmaier, M., Rapp, M., Wrase, J., Juckel, G., Gallinat, J., & Heinz, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.016 · Cited by 195
Deficits in predictive coding underlie hallucinations in schizophrenia
Horga, G., Schatz, K. C., Abi-Dargham, A., & Peterson, B. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0200-14.2014 · Cited by 176
“Recent findings in schizophrenia studies support abnormalities in PE signals for reward (Murray et al., 2008; Gradin et al., 2011) that relate to delusion propensity (Corlett et al., 2007), but mechanistic evidence on how disruptions in predictive coding may produce psychotic symptoms is lacking.”
BackgroundThe schizophrenia syndrome, circa 2024: What we know and how that informs its nature
Tandon, R., Nasrallah, H. A., Akbarian, S., Carpenter, W. T., DeLisi, L. E., Gäebel, W., Green, M. F., Gur, R. E., Heckers, S., Kane, J. M., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.11.015 · Cited by 205
Reinforcement and Reversal Learning in First-Episode Psychosis
Murray, G. K., Cheng, F., Clark, L., Barnett, J. H., Blackwell, A. D., Fletcher, P. C., Robbins, T. W., Bullmore, E. T., & Jones, P. B. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn078 · Cited by 155
Self-citationImprovement of Brain Reward Abnormalities by Antipsychotic Monotherapy in Schizophrenia
Nielsen, M. Ø., Rostrup, E., Wulff, S., Bak, N. K., Broberg, B. V., Lublin, H., Kapur, S., & Glenthoj, B. Y. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.847 · Cited by 151
Corlett, P. R. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.012.2009 · Cited by 146
Self-citationSchizophrenia, myelination, and delayed corollary discharges: a hypothesis
Whitford, T. J., Ford, J. M., Mathalon, D. H., Kubicki, M., & Shenton, M. E. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq105 · Cited by 140
Sonuga-Barke, E. J. S., & Fairchild, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.004 · Cited by 124
Heinz, A., Murray, G. K., Schlagenhauf, F., Sterzer, P., Grace, A. A., & Waltz, J. A. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby154 · Cited by 123
Self-citationTrust versus paranoia: abnormal response to social reward in psychotic illness
Gromann, P. M., Heslenfeld, D. J., Fett, A.-K. J., Joyce, D. W., Shergill, S. S., & A, L. K. M. (2013) · Brain · doi:10.1093/brain/awt076 · Cited by 103
“Combined with the finding of impaired reward prediction errors in psychosis (Murray et al., 2008), this offers an alternative interpretation of the trust game paradigm, suggesting that trust game interactions may be influenced by reward processing and risk sensitivity.”
ResultGraff‐Guerrero, A., Mizrahi, R., Agid, O., Marcon, H., Barsoum, P., Rusjan, P., Wilson, A. A., Zipursky, R. B., & Kapur, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.199 · Cited by 107
“Thus alterations in these receptors could contribute to the hyperactivity of this midbrain dopamine system which is believed to play an important role in the genesis of schizophrenic symptoms (Murray et al, 2008).”
BackgroundSchlagenhauf, F., Rapp, M. A., Huys, Q. J. M., Beck, A., Wüstenberg, T., Deserno, L., Buchholz, H., Kalbitzer, J., Buchert, R., Bauer, M., et al. (2012) · Human Brain Mapping · doi:10.1002/hbm.22000 · Cited by 105
“…and O’Doherty, 2007; Cohen, 2007; Cohen and Ranganath, 2005; D’Ardenne et al., 2008; Gershman et al., 2009; Kahnt et al., 2009; Krugel et al., 2009; Murray et al., 2008; O’Doherty et al., 2004; O’Doherty et al., 2003; Palminteri et al., 2009; Pessiglione et al., 2006; Rodriguez et al., 2006;…”
Esslinger, C., Englisch, S., Inta, D., Rausch, F., Schirmbeck, F. N., Mier, D. U., Kirsch, P., Meyer‐Lindenberg, A., & Zink, M. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.025 · Cited by 110
Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI
Lohani, S., Poplawsky, A. J., Kim, S.-G., & Moghaddam, B. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.102 · Cited by 89
Vinckier, F., Gaillard, R., Palminteri, S., Rigoux, L., Salvador, A., Fornito, A., Adapa, R., Krebs, M. O., Pessiglione, M., & Fletcher, P. C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.73 · Cited by 87
Self-citationde Leeuw, M., Kahn, R. S., & Vink, M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu153 · Cited by 91
Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients
Katthagen, T., Kaminski, J. A., Heinz, A., Buchert, R., & Schlagenhauf, F. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa055 · Cited by 79
The relevance of reward pathways for schizophrenia
Ziauddeen, H., & Murray, G. K. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328336661b · Cited by 85
Self-citationNegative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic, A., Repovs, G., Corlett, P. R., & Barch, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.010 · Cited by 75
Self-citationFletcher, P. C., Napolitano, A., Skeggs, A. L., Miller, S. R., Delafont, B., Cambridge, V. C., de Wit, S., Nathan, P. J., Brooke, A. C., O’Rahilly, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3323-10.2010 · Cited by 75
“The midbrain region was defined within a sphere with radius 12 mm centered at x, y, z 0, 15, 9 mm, as in previous work from our group (Murray et al., 2008).”
Self-citationDopamine and Huntington’s disease
Schwab, L. C., Garas, S. N., Drouin‐Ouellet, J., Mason, S., Stott, S., & Barker, R. A. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1025383 · Cited by 79
Are psychiatric diagnoses of psychosis scientific and useful?: The case of schizophrenia
Van Os, J. (2010) · Journal of Mental Health · doi:10.3109/09638237.2010.492417 · Cited by 65
Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia
Gaebler, A. J., Mathiak, K., Koten, J. W., König, A. A., Koush, Y., Weyer, D., Depner, C., Matentzoglu, S., Edgar, J. C., Willmes, K., et al. (2015) · Brain · doi:10.1093/brain/awv049 · Cited by 68
Exploring the Neural Correlates of Delusions of Reference
Menon, M., Schmitz, T. W., Anderson, A. K., Graff, A., Korostil, M., Mamo, D. C., Gerretsen, P., Addington, J., Remington, G. J., & Kapur, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.037 · Cited by 64
Park, I. H., Lee, B. C., Kim, J., Kim, J. I., & Koo, M.-S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2524-16.2017 · Cited by 61
“…a 15 mm radius centered at MNI coordinates of x 0, y 15, z 9), and the NAc, including the adjacent head of the caudate nucleus (NAc/CNH) (a sphere with a 10 mm radius at Talairach coordinates of x 12, y 10, z 2), was defined based on prior studies (Knutson and Wimmer, 2007; Murray et al., 2008).”
BackgroundMethodIncentive motivation in first-episode psychosis: A behavioural study
Murray, G. K., Clark, L., Corlett, P. R., Blackwell, A. D., Cools, R., Jones, P. B., Robbins, T. W., & Poustka, L. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-34 · Cited by 61
Self-citationNeural Circuitry of Salience and Reward Processing in Psychosis
Kesby, J. P., Murray, G. K., & Knolle, F. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.003 · Cited by 55
Self-citationDeserno, L., Beck, A., Huys, Q. J. M., Lorenz, R. C., Buchert, R., Buchholz, H., Plotkin, M., Kumakara, Y., Cumming, P. D., Heinze, H., et al. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12802 · Cited by 57
“…et al., 2006; Rodriguez et al., 2006; Tobler et al., 2006; Bray & O’Doherty, 2007; Cohen, 2007; Schonberg et al., 2007; D’Ardenne et al., 2008; Murray et al., 2008; Gershman et al., 2009; Kahnt et al., 2009; Krugel et al., 2009; Palminteri et al., 2009; Valentin & O’Doherty, 2009), which…”
GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons
Benamer, N., Marti, F., Luján, R., Hepp, R., Aubier, T. G., Дупин, А. М., Frébourg, G., Pons, S., Maskos, U., Fauré, P., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.137 · Cited by 56
Rausch, F., Mier, D., Eifler, S., Esslinger, C., Schilling, C., Schirmbeck, F., Englisch, S., Meyer-Lindenberg, A., Kirsch, P., & Zink, M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.020 · Cited by 55
“The supposed disruption in prediction error signaling has been attributed to hypo-activity in VS, because dopamine signaling is thought to encode the precision or uncertainty of prediction errors (Juckel et al., 2006b; Murray et al., 2008).”
Boehme, R., Deserno, L., Gleich, T., Katthagen, T., Pankow, A., Behr, J., Buchert, R., Roiser, J. P., Heinz, A., & Schlagenhauf, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-15.2015 · Cited by 56
“In schizophrenia, attenuated striatal RPE signals were observed (Murray et al., 2008; Gradin et al., 2011; Deserno et al., 2013; Schlagenhauf et al., 2014).”
BackgroundOrganic psychosis: The pathobiology and treatment of delusions
Joyce, E. M. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12973 · Cited by 52
Sense of agency, associative learning, and schizotypy
Moore, J. W., Dickinson, A., & Fletcher, P. C. (2011) · Consciousness and Cognition · doi:10.1016/j.concog.2011.01.002 · Cited by 51
“…that recent models of the symptoms of schizophrenia emphasise the role of disturbed prediction error generated by surprising events (Corlett, Honey, & Fletcher, 2007; Corlett et al., 2007; Fletcher & Frith, 2009; Gray, Feldon, Rawlins, Hemsley, & Smith, 1991; Kapur, 2003; Murray et al., 2008).”
Self-citationDistinct Medial Temporal Lobe Network States as Neural Contexts for Motivated Memory Formation
Murty, V. P., & Adcock, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-50406-3_15 · Cited by 55
“Functional magnetic resonance imaging (fMRI) and electrophysiological studies have reliably documented VTA activation during reward motivated behaviors (D’Ardenne et al. 2008; Murray et al. 2008; Zaghloul et al. 2009; Carter et al. 2009; Krebs et al. 2011).”
BackgroundMurray, G. K., Corlett, P. R., & Fletcher, P. C. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq005 · Cited by 46
Self-citationDeficits in context-dependent adaptive coding of reward in schizophrenia
Kirschner, M., Hager, O. M., Bischof, M., Hartmann-Riemer, M. N., Kluge, A., Seifritz, E., Tobler, P. N., & Kaiser, S. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.20 · Cited by 43
Dysfunction of a Cortical Midline Network During Emotional Appraisals in Schizophrenia
Holt, D. J., Lakshmanan, B. M., Freudenreich, O., GOFF, D. C., Rauch, S. L., & Kuperberg, G. R. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp067 · Cited by 45
Using Computational Patients to Evaluate Illness Mechanisms in Schizophrenia
Hoffman, R. E., Grasemann, U., Gueorguieva, R. V., Quinlan, D. M., Lane, D., & Miikkulainen, R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.036 · Cited by 43
Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders
Stefano, G. B., Samuel, J., & Kream, R. M. (2017) · Medical Science Monitor · doi:10.12659/msm.899478 · Cited by 42
Reward-driven decision-making impairments in schizophrenia
Saperia, S., Da Silva, S., Siddiqui, I., Agid, O., Daskalakis, Z. J., Ravindran, A., Voineskos, A. N., Zakzanis, K. K., Remington, G., & Foussias, G. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.11.004 · Cited by 41
Schizophrenia aetiology: Do gene-environment interactions hold the key?
The European Network of Schizophrenia Networks for the Study of Gene-Environment Interactions(EU-GEI) (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.003 · Cited by 53
Altered Neural Processing of the Need to Stop in Young Adults at Risk for Stimulant Dependence
Harlé, K. M., Shenoy, P., Stewart, J. L., Tapert, S. F., Yu, A. J., & Paulus, M. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2297-13.2014 · Cited by 39
Reward anticipation in schizophrenia: A coordinate-based meta-analysis
Leroy, A., Amad, A., D’Hondt, F., Pins, D., Jaafari, N., Thomas, P., & Jardri, R. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.041 · Cited by 38
“On the one hand, reward anticipation seems to be involved in the genesis of positive symptoms, i.e., hallucinations and delusions (Kapur, 2003; Murray et al., 2008), while suppressed reward processing could contribute to the reinforcement of negative symptoms, such as anhedonia (Barch and…”
BackgroundGriffiths, O., Langdon, R. A., Pelley, M. E. L., & Coltheart, M. (2014) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2014.897601 · Cited by 38
“…behavioural and imaging studies that have used associative learning paradigms (Corlett et al., 2007; Gradin et al., 2011; Jensen et al., 2008; Murray et al., 2008) to identify the neural underpinnings of the aberrant prediction error signalling that may play a key role in the formation and…”
BackgroundResultInfluentialSchizophrenia: A Computational Reinforcement Learning Perspective
Frank, M. J. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn123 · Cited by 38
Elementary sensory deficits in schizophrenia indexed by impaired visual mismatch negativity
Farkas, K., Stefanics, G., Marosi, C., & Csukly, G. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.05.011 · Cited by 35
“That is, delusions have been proposed to be secondary phenomena arising from a failure to explain away sensory prediction errors (Kapur, 2003) which in turn might lead to a compensatory increase in the precision of higher-level beliefs (Murray et al., 2008; Corlett et al., 2011; Adams et al., 2013).”
BackgroundMild Reinforcement Learning Deficits in Patients With First-Episode Psychosis
Chang, W. C., Waltz, J. A., Gold, J. M., Chan, T. C. W., & Chen, E. Y. H. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw060 · Cited by 37
Binge drinking differentially affects cortical and subcortical microstructure
Morris, L. S., Dowell, N. G., Cercignani, M., Harrison, N. A., & Voon, V. (2018) · Addiction Biology · doi:10.1111/adb.12493 · Cited by 34
“The ventral striatal anatomical ROI, as used previously in other studies (Murray et al. 2008), was hand drawn using MRIcro based on the definition of the ventral striatum by Martinez et al. (2003).”
MethodWhite, D. M., Kraguljac, N. V., Reid, M. A., & Lahti, A. C. (2015) · Schizophrenia · doi:10.1038/npjschz.2014.1 · Cited by 34
Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing
Papanastasiou, E., Mouchlianitis, E. D., Joyce, D. W., McGuire, P. K., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.1973 · Cited by 32
Gromann, P. M., Shergill, S. S., de Haan, L., Meewis, D. G. J., Fett, A.-K. J., Korver‐Nieberg, N., & A, L. K. M. (2014) · Psychological Medicine · doi:10.1017/s0033291714000737 · Cited by 32
Hanssen, E., van Buuren, M., van Atteveldt, N., Lemmers-Jansen, I. L. J., & Fett, A.-K. J. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674211010327 · Cited by 33
“…al., 2014), within the mPFC and TPJ during mentalizing (Green et al., 2015; Lee et al., 2004; Pinkham et al., 2008), and within the caudate during both non-social (Juckel et al., 2006b; Murray et al., 2008) and, more importantly, social reward processing (Fett et al., 2019; Gromann et al., 2013).”
BackgroundHernaus, D., Gold, J. M., Waltz, J. A., & Frank, M. J. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.03.014 · Cited by 28
Modeling subjective relevance in schizophrenia and its relation to aberrant salience
Katthagen, T., Mathys, C., Deserno, L., Walter, H., Kathmann, N., Heinz, A., & Schlagenhauf, F. (2018) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1006319 · Cited by 29
Models of neuromodulation for computational psychiatry
Iglesias, S., Tomiello, S., Schneebeli, M., & Stephan, K. E. (2016) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1420 · Cited by 28
Functional connectivity and grey matter volume of the striatum in schizophrenia
Koch, K., Rus, O. G., Reeß, T. J., Schachtzabel, C., Wagner, G., Schultz, C. C., Sorg, C., & Schlösser, R. G. M. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.138099 · Cited by 29
The emerging biology of delusions
Murray, G. (2010) · Psychological Medicine · doi:10.1017/s0033291710000413 · Cited by 29
Self-citationNegative symptoms, striatal dopamine and model-free reward decision-making in schizophrenia
Brandl, F., Knolle, F., Avram, M., Leucht, C., Yakushev, I., Priller, J., Leucht, S., Ziegler, S., Wunderlich, K., & Sorg, C. (2023) · Brain · doi:10.1093/brain/awac268 · Cited by 24
Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals
Hernaus, D., Xu, Z., Brown, E. C., Ruiz, R., Frank, M. J., Gold, J. M., & Waltz, J. A. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-018-0643-z · Cited by 21
“In some, but not all, individuals with psychotic symptoms, RL deficits can be linked to aberrant VS RPE signals at the neural level (Maia & Frank, 2017; Murray et al., 2008) and, potentially, to increased presynaptic dopamine function at the neurochemical level (Boehme et al., 2015).”
BackgroundResultDelusional Predictions and Explanations
Parrott, M. (2019) · The British Journal for the Philosophy of Science · doi:10.1093/bjps/axz003 · Cited by 22
Are persistent delusions in schizophrenia associated with aberrant salience?
Abboud, R., Roiser, J. P., Khalifeh, H., Ali, S., Harrison, I., Killaspy, H. T., & Joyce, E. M. (2016) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2016.04.002 · Cited by 23
“Consistent with this model, numerous studies have demonstrated reinforcement learning deficits in schizophrenia (Gold et al., 2008;Murray et al., 2008b;Waltz et al., 2007;Waltz and Gold, 2007), although the patients included in these studies were mostly receiving medication; important because…”
ResultFrontostriatal pathways gate processing of behaviorally relevant reward dimensions
Weber, S. C., Kahnt, T., Quednow, B. B., & Tobler, P. N. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005722 · Cited by 18
Edwards, C., Cella, M., Tarrier, N., & Wykes, T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.08.013 · Cited by 28
“Abnormal prediction error signalling in the striatum in people with schizophrenia has been seen in fMRI studies, with both reduced and increased activation in response to unexpected rewards reported (Gradin et al., 2011; Morris et al., 2012; Murray et al., 2008).”
Cortical salience network activation precedes the development of delusion severity
Raij, T. T., Mäntylä, T. J. S., Mantere, O., Kieseppä, T., & Suvisaari, J. (2016) · Psychological Medicine · doi:10.1017/s0033291716001057 · Cited by 20
“CSN is linked with the mesostriatal dopaminergic system (Murray et al. 2008; Palaniyappan & Liddle, 2012; Raij et al. 2015) and, thus, the mesostriatal hyperdopaminergic state observed in psychosis (Howes et al. 2012) may be linked to CSN functioning.”
BackgroundSchiwy, L. C., Forlim, C. G., Fischer, D. J., Kühn, S., Becker, M., & Gallinat, J. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.06.008 · Cited by 20
Atypical processing of uncertainty in individuals at risk for psychosisPreprint
Cole, D. M., Diaconescu, A. O., Pfeiffer, U. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/796300 · Cited by 17
Computational Models of Hallucinations
Jardri, R., & Denève, S. (2013) · The Neuroscience of Hallucinations · doi:10.1007/978-1-4614-4121-2_16 · Cited by 16
Decreased Cross-Domain Mutual Information in Schizophrenia From Dynamic Connectivity States
Salman, M. S., Vergara, V. M., Damaraju, E., & Calhoun, V. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00873 · Cited by 15
“For instance, positive symptoms, characterized by abnormal salience processing and hallucinations, have shown links to abnormal functional activation in midbrain, speech and auditory cortices in SZs (Murray et al., 2008; Sommer et al., 2008).”
BackgroundFunctional Brain Imaging in Schizophrenia
Meyer‐Lindenberg, A., & Bullmore, E. T. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch17 · Cited by 16
Self-citation20 Years of Aberrant Salience in Psychosis: What Have We Learned?
Corlett, P. R., & Fraser, K. M. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240556 · Cited by 22
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“Patients with psychotic disorder show aberrant activation of these brain areas, which are often associated with mentalizing and reward processing (Juckel et al., 2006; Murray et al., 2008; Schilbach et al., 2016; Bartholomeusz et al., 2018).”
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Delusional Beliefs in the Clinical Context
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“For example, endorsements of the gendered dichotomy of emotionality, whereby women are permitted to freely express their emotions and men are urged to adopt stoicism and emotional restraint [14], are pervasive in male research samples across ages [15], culture [16], and occupational demographics.”
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Metadata
- Authors
- Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C.
- Affiliations
- University of Cambridge (GB)
- Pitié-Salpêtrière Hospital (FR)
- Venue
- Molecular Psychiatry
- Published
- 2008-02-19
- Volume
- 13
- Issue
- 3
- Pages
- 239-239
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2032074381
- Cited by
- 119
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 13 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 3 · 2012: 7
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine dysregulation, psychosis, mesolimbic system, mesostriatal pathway, reward prediction error, dopamine signaling
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