Cited by 534Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky, Isadora F, Hu, Shuang-Bao, Szegda, Kathleen L, Westphal, Heiner, Young, Larry J·2004·Neuropsychopharmacology

DOI 10.1038/sj.npp.1300360

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Abstract

Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.

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Authors: Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J.
Affiliations: Emory University (US)
National Institutes of Health (US)
Corresponding author: Bielsky, Isadora F
ORCID: Young, Larry J
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2003-11-26
Volume: 29
Issue: 3
Pages: 483-493
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300360
OpenAlex: W2084931825
Cited by: 531
References: 52
Citations by year: 2026: 16 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 26 · 2021: 24 · 2020: 15 · 2019: 20 · 2018: 19 · 2017: 26 · 2016: 21 · 2015: 21 · 2014: 35 · 2013: 30 · 2012: 25
FWCI: 32.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (9876754)
National Institutes of Health (NIH-R01, IBN-9876754, RR‐00165)
National Institute of Mental Health (K02MH064692, R01 MH56897, K02 MH64692, R01MH056897)
National Center for Research Resources (RR-00 165, P51RR000165)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin, vasopressin V1a receptor, knockout mice, social recognition, anxiety-like behavior, oxytocin, social behavior, emotionality, autism spectrum disorder, anxiety disorders, stereotypy, olfactory learning and memory
MeSH terms: Animals, Anxiety, Female, Genotype, Male, Mice, Inbred C57BL, Social Behavior, Receptors, Vasopressin, Mice, Knockout, Maze Learning, Recognition, Psychology, Mice

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

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