Fibroblast growth factor 21 and browning of white adipose tissue

Brown Adipose Tissue: Function and Physiological Significance

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Unexpected evidence for active brown adipose tissue in adult humans

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

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Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

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Transcriptional Control of Brown Fat Determination by PRDM16

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Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

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Adipose tissue in control of metabolism

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Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

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Brown adipose tissue as a secretory organ

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Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues

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Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

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BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

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A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

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Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

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Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

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A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects

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Sympathetic and sensory innervation of brown adipose tissue

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Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

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FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

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Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

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Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

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Brown adipose tissue in the parametrial fat pad of the mouse

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Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

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FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

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Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel‐dependent mechanisms

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Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

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Brown adipose tissue and heat production in the newborn infant

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Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

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Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

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Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

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Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

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Interplay between FGF21 and insulin action in the liver regulates metabolism

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Control of lipolysis by natriuretic peptides and cyclic GMP

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Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

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Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

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Adipose tissue: an endocrine organ playing a role in metabolic regulation

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Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.

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Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

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Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.

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Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

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Exercise increases serum fibroblast growth factor 21 (FGF21) levels

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Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

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Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

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Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice

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Fibroblast growth factor 21 and its novel association with oxidative stress

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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

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β3‐Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat

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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

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Fibroblast growth factor-21, energy balance and obesity

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Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-α

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Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

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FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

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White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways

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Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

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Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism

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Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk

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Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa

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