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Cited by 255Neuropeptides and Animal PhysiologyStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Social Defeat Stress-Induced Behavioral Responses are Mediated by the Endogenous Kappa Opioid System

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McLaughlin, Jay P, Li, Shuang, Valdez, Joseph, Chavkin, Theodore A, Chavkin, Charles·2006·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300872PMC PMC2096774
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Abstract

Previous studies have demonstrated that repeated forced-swim stress-induced behaviors (including analgesia, immobility, and increased drug reward) were mediated by the release of endogenous prodynorphin-derived opioid peptides and subsequent activation of the kappa opioid receptor (KOR). We tested the generality of these effects using a different type of stressful situation: repeated social defeat. C57Bl/6 mice subjected to social defeat stress (SDS) over 3 days showed a characteristic stress-induced immobility and defeated-postural response, as well as stress-induced analgesia (SIA). Daily pretreatment with the KOR antagonist nor-binaltorphimine (nor-BNI, 10 mg/kg, i.p.) blocked the SIA and significantly reduced the stress-induced immobility on the second and third days of SDS exposure. In contrast, prodynorphin gene-disrupted mice showed no significant increase in immobility, socially defeated postures, or SIA following repeated exposure to SDS. Since both stress and the kappa opioid system can modulate the response to drugs of abuse, we tested the effects of SDS on cocaine-conditioned place preference (CPP). SDS-exposed mice conditioned with cocaine (15 mg/kg, s.c.) showed significant potentiation of place-preference for the drug-paired chamber over the responses of unstressed mice. Nor-BNI pretreatment blocked stress-induced potentiation of cocaine-CPP. Consistent with this result, mice lacking the prodynorphin gene did not show stress-induced potentiation of cocaine-CPP, whereas wild-type littermates did. The findings suggest that chronic SDS may activate the kappa opioid system to produce analgesia, immobility, social defeat postures, and resulting in a potentiation of the acute rewarding properties of cocaine.

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Metadata

Authors
McLaughlin, J. P., Li, S., Valdez, J., Chavkin, T. A., & Chavkin, C.
Affiliations
  • Northeastern University (US)
  • University of Washington (US)
Corresponding author
Chavkin, Charles
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2005-08-17
Volume
31
Issue
6
Pages
1241-1248
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300872
PMC
PMC2096774
OpenAlex
W2023872238
Cited by
253
References
43
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 16 · 2019: 10 · 2018: 26 · 2017: 12 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 21
FWCI
3.27
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5p01da015916-05)
  • U.S. Public Health Service
  • National Institute on Drug Abuse (R01DA11672, P01DA15916, R01DA016898, P01-DA015916, R03DA016656, R01DA011672, R03 DA 16656)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
social defeat stress, kappa opioid receptor, nor-binaltorphimine, prodynorphin, stress-induced analgesia, immobility, cocaine conditioned place preference, endogenous opioids, chronic stress
MeSH terms
Analysis of Variance, Anesthetics, Local, Animals, Behavior, Animal, Cocaine, Conditioning, Operant, Enkephalins, Male, Mice, Inbred C57BL, Naltrexone, Narcotic Antagonists, Pain Measurement, Protein Precursors, Reaction Time, Social Behavior, Stress, Psychological, Receptors, Opioid, kappa, Mice, Knockout, Immobility Response, Tonic, Mice

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