The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Bcl-2 apoptotic switch in cancer development and therapy
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
The Bcl2 family: regulators of the cellular life-or-death switch
Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032
Self-citationDirect Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108 · cited 2×
“Multiple targets of this transcription factor have been implicated, and it has even been proposed that p53 has a direct apoptogenic role at the mitochondrion by engaging either Bcl-xL and Bcl-2 (Mihara et al., 2003) or Bax (Chipuk et al., 2004).”
BackgroundLetai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., & Korsmeyer, S. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00127-7 · Cited by 1,677
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Verdine, G. L., & Korsmeyer, S. J. (2004) · Science · doi:10.1126/science.1099191 · Cited by 1,349
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327
Self-citationMcDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., & Newmeyer, D. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.003 · Cited by 1,185
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1499 · Cited by 874
Research works printed but not linked: 127
- Adams JM . (2003). Ways of dying: multiple pathways to apoptosis. Genes Dev 17: 2481–2495. · DOI · Paper page
- Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI et al. (2003). Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 22: 6653–6664. · DOI
- Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace Jr AJ . (2000). An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60: 6101–6110.
- Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B et al. (2005). Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J 24: 2096–2103. · DOI · Paper page
- Bellot G, Cartron PF, Er E, Oliver L, Juin P, Armstrong LC et al. (2006). TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ [Epub ahead of print]. · DOI
- Bouillet P, Cory S, Zhang L-C, Strasser A, Adams JM . (2001). Degenerative disorders caused by Bcl-2 deficiency are prevented by loss of its BH3-only antagonist Bim. Dev Cell 1: 645–653. · DOI · Paper page
- Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, Köntgen F et al. (1999). Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735–1738. · DOI · Paper page
- Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P et al. (2004). The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell 16: 807–818. · DOI · Paper page
- Certo M, Moore Vdel G, Nishino M, Wei G, Korsmeyer S, Armstrong SA et al. (2006). Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9: 351–365. · DOI · Paper page
- Chauhan D, Velankar M, Brahmandam M, Hideshima T, Podar K, Richardson P et al. (2006). A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene [Epub ahead of print]. · DOI
- Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. (2005). Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393–403. · DOI · Paper page
- Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ . (2003). VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 301: 513–517. · DOI · Paper page
- Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T et al. (2001). BCL-2, BCL-xL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705–711. · DOI · Paper page
- Chou CH, Lee RS, Yang-Yen HF . (2006). An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. Mol Biol Cell 17: 3952–3963. · DOI
- Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M et al. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102: 13944–13949. · DOI · Paper page
- Cory S, Huang DCS, Adams JM . (2003). The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590–8607. · DOI · Paper page
- Cuconati A, Mukherjee C, Perez D, White E . (2003). DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17: 2922–2932. · DOI · Paper page
- Degenhardt K, Chen G, Lindsten T, White E . (2002). BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell 2: 193–203. · DOI
- Deng X, Gao F, Flagg T, May Jr WS . (2004). Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci USA 101: 153–158. · DOI
- Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I et al. (2002). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111: 51–62. · DOI
- Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I et al. (2003). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 115: 503. · doi:10.1016/s0092-8674(03)00892-4
- Dijkers PF, Medema RH, Lammers JJ, Koenderman L, Coffer PJ . (2000). Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201–1204. · DOI · Paper page
- Dzhagalov I, St John A, He YW . (2006). The anti-apoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood [Epub ahead of print]. · DOI · Paper page
- Egle A, Harris AW, Bath ML, O'Reilly L, Cory S . (2004a). VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 103: 2276–2283. · DOI
- Egle A, Harris AW, Bouillet P, Cory S . (2004b). Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 101: 6164–6169. · DOI · Paper page
- Eischen CM, Rehg JE, Korsmeyer SJ, Cleveland JL . (2002). Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res 62: 2184–2191.
- Eischen CM, Woo D, Roussel MF, Cleveland JL . (2001). Apoptosis triggered by myc-induced suppression of Bcl-XL or Bcl-2 Is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063–5070. · DOI
- Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L et al. (2005). BH3-only proteins Puma and Bim are rate-limiting for {gamma}-radiation and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 106: 4131–4138. · DOI · Paper page
- Fernandez Y, Verhaegen M, Miller TP, Rush JL, Steiner P, Opipari Jr AW et al. (2005). Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res 65: 6294–6304. · DOI
- Fesik SW . (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876–885. · DOI · Paper page
- Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H et al. (2006). Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem 281: 31440–31447. · DOI
- Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N et al. (2004). Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279: 21085–21095. · DOI · Paper page
- Green DR . (2005). Apoptotic pathways: ten minutes to dead. Cell 121: 671–674. · DOI · Paper page
- Hamasaki A, Sendo F, Nakayama K, Ishida N, Negishi I, Nakayama K-I et al. (1998). Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J Exp Med 188: 1985–1992. · DOI
- Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57–70. · DOI · Paper page
- Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C et al. (2005). Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 436: 807–811. · DOI · Paper page
- Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW . (2004). Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci USA 101: 9333–9338. · DOI
- Hildeman DA, Zhu Y, Mitchell TC, Bouillet P, Strasser A, Kappler J et al. (2002). Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim. Immunity 16: 759–767. · DOI · Paper page
- Hinds MG, Day CL . (2005). Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol 15: 690–699. · DOI
- Hsu YT, Youle RJ . (1997). Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem 272: 13829–13834. · DOI · Paper page
- Hsu Y-T, Youle RJ . (1998). Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem 273: 10777–10783. · DOI · Paper page
- Huang DC, Hahne M, Schroeter M, Frei K, Fontana A, Villunger A et al. (1999). Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL . Proc Natl Acad Sci USA 96: 14871–14876. · DOI · Paper page
- Huang DCS, Strasser A . (2000). BH3-only proteins – essential initiators of apoptotic cell death. Cell 103: 839–842. · DOI · Paper page
- Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M . (2000). Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci USA 97: 10872–10877. · DOI
- Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J et al. (2003). Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321–328. · DOI · Paper page
- Johnstone RW, Ruefli AA, Lowe SW . (2002). Apoptosis: a link between cancer genetics and chemotherapy. Cell 108: 153–164. · DOI
- Kim BJ, Ryu SW, Song BJ . (2006b). JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation, mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281: 21256–21265. · DOI · Paper page
- Kim PK, Annis MG, Dlugosz PJ, Leber B, Andrews DW . (2004). During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Mol Cell 14: 523–529. · DOI
- Knudson CM, Johnson GM, Lin Y, Korsmeyer SJ . (2001). Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 61: 659–665.
- Kondo S, Shinomura Y, Miyazaki Y, Kiyohara T, Tsutsui S, Kitamura S et al. (2000). Mutations of the bak gene in human gastric and colorectal cancers. Cancer Res 60: 4328–4330.
- Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S et al. (2006). Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10: 375–388. · DOI · Paper page
- Kuribara R, Honda H, Matsui H, Shinjyo T, Inukai T, Sugita K et al. (2004). Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitor. Mol Cell Biol 24: 6172–6183. · DOI
- Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC et al. (2006). Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 103: 14907–14912. · DOI · Paper page
- Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R et al. (2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331–342. · DOI · Paper page
- Lakhani SA, Masud A, Kuida K, Porter Jr GA, Booth CJ, Mehal WZ et al. (2006). Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311: 847–851. · DOI · Paper page
- Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ . (2003). Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 278: 18811–18816. · DOI · Paper page
- Liu X, Dai S, Zhu Y, Marrack P, Kappler JW . (2003). The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity 19: 341–352. · DOI · Paper page
- Lucken-Ardjomande S, Martinou JC . (2005). Newcomers in the process of mitochondrial permeabilization. J Cell Sci 118: 473–483. · DOI
- McDonnell TJ, Korsmeyer SJ . (1991). Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 349: 254–256. · DOI · Paper page
- Meijerink JPP, Mensink EJBM, Wang K, Sedlak TW, Slöetjes AW, de Witte T et al. (1998). Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91: 2991–2997. · DOI · Paper page
- Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, Siebert R, Climent J, Fresquet V et al. (2006). Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood [Epub ahead of print]. · DOI
- Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P et al. (2003). p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577–590. · DOI · Paper page
- Ming L, Wang P, Bank A, Yu J, Zhang L . (2006). PUMA dissociates Bax and Bcl-XL to induce apoptosis in colon cancer cells. J Biol Chem 281: 16034–16042. · DOI
- Miyashita T, Reed JC . (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293–299. · DOI · Paper page
- Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K . (2006). The X-ray structure of a Bak homodimer reveals an inhibitory zinc binding site. Mol Cell 24: 677–688. · DOI
- Motoyama N, Kimura T, Takahashi T, Watanabe T, Nakano T . (1999). bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. J Exp Med 189: 1691–1698. · DOI
- Motoyama N, Wang FP, Roth KA, Sawa H, Nakayama K, Nakayama K et al. (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice. Science 267: 1506–1510. · DOI · Paper page
- Nakayama K, Nakayama K-I, Negishi I, Kuida K, Sawa H, Loh DY . (1994). Targeted disruption of bcl-2αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 91: 3700–3704. · DOI · Paper page
- Nakayama K-I, Nakayama K, Izumi N, Kulda K, Shinkai Y, Louie MC et al. (1993). Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261: 1584–1588. · DOI · Paper page
- Newmeyer DD, Ferguson-Miller S . (2003). Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112: 481–490. · DOI · Paper page
- Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F et al. (2003). Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17: 1475–1486. · DOI · Paper page
- Nikrad M, Johnson T, Puthalalath H, Coultas L, Adams J, Kraft AS . (2005). The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther 4: 443–449. · DOI
- Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM . (1999). Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA 96: 14943–14948. · DOI · Paper page
- Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ . (2006). A membrane-targeted BID BH3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem 281: 36999–37008. · DOI
- Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. (2005). An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435: 677–681. · DOI · Paper page
- Opferman J, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K et al. (2005). Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307: 1101–1104. · DOI · Paper page
- Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ . (2003). Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426: 671–676. · DOI · Paper page
- Parone PA, James DI, Da Cruz S, Mattenberger Y, Donze O, Barja F et al. (2006). Inhibiting the mitochondrial fission machinery does not prevent bax/bak-dependent apoptosis. Mol Cell Biol 26: 7397–7408. · DOI
- Patel JH, McMahon SB . (2006). BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC induced apoptosis. J Biol Chem [Epub ahead of print]. · DOI
- Pellegrini M, Belz G, Bouillet P, Strasser A . (2003). Shut down of an acute T cell immune response to viral infection is mediated by the pro-apoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci USA 100: 14175–14180. · DOI
- Print CG, Loveland KL, Gibson L, Meehan T, Stylianou A, Wreford N et al. (1998). Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci USA 95: 12424–12431. · DOI · Paper page
- Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B et al. (2003). JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38: 899–914. · DOI · Paper page
- Puthalakath H, Strasser A . (2002). Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9: 505–512. · DOI · Paper page
- Puthalakath H, Huang DCS, O'Reilly LA, King SM, Strasser A . (1999). The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3: 287–296. · DOI · Paper page
- Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V et al. (2005). Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res 65: 6282–6293. · DOI · Paper page
- Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC et al. (1997). Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967–969. · DOI · Paper page
- Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK et al. (2005). Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol 25: 4591–4601. · DOI
- Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J et al. (2003). Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5: 733–740. · DOI · Paper page
- Ross AJ, Waymire KG, Moss JE, Parlow AF, Skinner MK, Russell LD et al. (1998). Testicular degeneration in Bclw-deficient mice. Nat Genet 18: 251–256. · DOI · Paper page
- Sadowsky JD, Fairlie WD, Hadley EB, Lee H-S, Umezawa N, Nikolovska-Coleska Z et al. (2006). Characterization of (a/b+a)-peptide antagonists of BH3 domain/Bcl-XLrecognition: toward general strategies for developing foldamer-based inhibitors of protein–protein interactions. J Am Chem Soc in press. · DOI
- Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y et al. (2005). Chimeric (alpha/beta+alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc 127: 11966–11968. · DOI
- Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M et al. (1997). Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275: 983–986. · DOI · Paper page
- Schmidt T, Korner K, Karsunky H, Korsmeyer S, Muller R, Moroy T . (1999). The activity of the murine bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53. Cell Death Differ 6: 873–882. · DOI
- Schmitt CA, Rosenthal CT, Lowe SW . (2000). Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 6: 1029–1035. · DOI · Paper page
- Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ . (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879–888. · DOI · Paper page
- Shibata MA, Liu ML, Knudson MC, Shibata E, Yoshidome K, Bandey T et al. (1999). Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. EMBO J 18: 2692–2701. · DOI
- Shoemaker AR, Oleksijew A, Bauch J, Belli BA, Borre T, Bruncko M et al. (2006). A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res 66: 8731–8739. · DOI
- Strasser A, Harris AW, Bath ML, Cory S . (1990). Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348: 331–333. · DOI · Paper page
- Strasser A, Harris AW, Cory S . (1991a). Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889–899. · DOI · Paper page
- Strasser A, Harris AW, Cory S . (1993). Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene 8: 1–9.
- Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S . (1995). Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14: 6136–6147. · DOI · Paper page
- Strasser A, O'Connor L, Dixit VM . (2000). Apoptosis signaling. Ann Rev Biochem 69: 217–245. · DOI · Paper page
- Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S et al. (1991b). Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 88: 8661–8665. · DOI · Paper page
- Strasser A . (2005). The role of BH3-only proteins in the immune system. Nat Rev Immunol 5: 189–200. · DOI · Paper page
- Suzuki M, Youle RJ, Tjandra N . (2000). Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103: 645–654. · DOI · Paper page
- Tagawa H, Karnan S, Suzuki R, Matsuo K, Zhang X, Ota A et al. (2005). Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 24: 1348–1358. · DOI · Paper page
- Tan TT, Degenhardt K, Nelson DA, Beaudoin B, Nieves-Neira W, Bouillet P et al. (2005). Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell 7: 227–238. · DOI · Paper page
- van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE et al. (2006). The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10: 389–399. · DOI · Paper page
- Vaux DL, Cory S, Adams JM . (1988). Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440–442. · DOI · Paper page
- Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ . (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229–240. · DOI · Paper page
- Vousden KH, Lu X . (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594–604. · DOI · Paper page
- Wagner KU, Claudio E, Rucker III EB, Riedlinger G, Broussard C, Schwartzberg PL et al. (2000). Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127: 4949–4958. · DOI
- Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J et al. (2006). A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 24: 199–210. · DOI · Paper page
- Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727–730. · DOI · Paper page
- Willis SN, Adams JM . (2005). Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617–625. · DOI · Paper page
- Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. (2005). Pro-apoptotic Bak is sequestered by Mc1-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19: 1294–1305. · DOI · Paper page
- Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. (2007). Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science in press. · DOI · Paper page
- Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ . (1997). Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281–1292. · DOI · Paper page
- Yin CY, Knudson CM, Korsmeyer SJ, Van Dyke T . (1997). Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637–640. · DOI · Paper page
- Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ . (1996). Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xL . Cell 87: 619–628. · DOI · Paper page
- Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ . (2000). Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290: 1761–1765. · DOI · Paper page
- Zhang Y, Adachi M, Kawamura R, Imai K . (2005). Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis. Cell Death Differ 13: 129–140. · DOI
- Zhao Y, Tan J, Zhuang L, Jiang X, Liu ET, Yu Q . (2005). Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci USA 102: 16090–16095. · DOI
- Zhong Q, Gao W, Du F, Wang X . (2005). Mule/ARF-BP1, a BH3-Only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121: 1085–1095. · DOI · Paper page
- Zhu Y, Liu X, Hildeman D, Peyerl FW, White J, Kushnir E et al. (2006). Bax does not have to adopt its final form to drive T cell death. J Exp Med 203: 1147–1152. · DOI
- Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X et al. (2004). Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci USA 101: 7681–7686. · DOI
- Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB . (2001). BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15: 1481–1486. · DOI · Paper page
Cited by
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219
Self-citationABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058
Self-consumption: the interplay of autophagy and apoptosis
Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172
Mitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270
Croce, C. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072367 · Cited by 1,055
Targeting IAP proteins for therapeutic intervention in cancer
Fulda, S., & Vucic, D. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3627 · Cited by 837
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0668-z · Cited by 688
Tumour cell survival signalling by the ERK1/2 pathway
Balmanno, K., & Cook, S. J. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.148 · Cited by 484
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451
Jares, P., Colomer, D., & Campo, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2230 · Cited by 466
Caenepeel, S., Brown, S. P., Belmontes, B., Moody, G., Keegan, K. S., Chui, D., Whittington, D. A., Huang, X., Poppe, L., Cheng, A. C., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0387 · Cited by 432
Peirs, S., Matthijssens, F., Goossens, S., Van de Walle, I., Ruggero, K., de Bock, C. E., Degryse, S., Canté-Barrett, K., Briot, D., Clappier, E., et al. (2014) · Blood · doi:10.1182/blood-2014-05-574566 · Cited by 264
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Pang, S. H. M., D’Rozario, J., Mendonca, S., Bhuvan, T., Payne, N. L., Zheng, D., Hisana, A., Wallis, G., Barugahare, A., Powell, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26834-3 · Cited by 245
Cell fate decision mediated by p53 pulses
Zhang, X.-P., Liu, F., Cheng, Z., & Wang, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813088106 · Cited by 253
Basit, F., Cristofanon, S., & Fulda, S. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.45 · Cited by 211
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein
Arbel, N., Ben-Hail, D., & Shoshan-Barmatz, V. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.345918 · Cited by 179
Arbel, N., & Shoshan-Barmatz, V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.082990 · Cited by 168
Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
Bruncko, M., Wang, L., Sheppard, G. S., Phillips, D. C., Tahir, S. K., Xue, J., Erickson, S., Fidanze, S., Fry, E., Hasvold, L., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501258m · Cited by 164
Drug Resistance in Colorectal Cancer: From Mechanism to Clinic
Wang, Q., Shen, X., Chen, G., & Du, J. (2022) · Cancers · doi:10.3390/cancers14122928 · Cited by 160
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
Lv, D., Pal, P., Liu, X., Jia, Y., Thummuri, D., Zhang, P., Hu, W., Pei, J., Zhang, Q., Zhou, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27210-x · Cited by 158
Li, H., Wang, P., Sun, Q., Ding, W.-X., Yin, X.-M., Sobol, R. W., Stolz, D. B., Yu, J., & Zhang, L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4475 · Cited by 150
Lindner, A. U., Concannon, C. G., Boukes, G. J., Cannon, M. D., Llambi, F., Ryan, D., Boland, K., Kehoe, J., McNamara, D. A., Murray, F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2269 · Cited by 105
Zhang, Q., Hu, C., Huang, J., Liu, W., Lai, W., Leng, F., Tang, Q., Liu, Y., Wang, Q., Zhou, M., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0318-z · Cited by 96
Zhang, X., Thummuri, D., He, Y., Liu, X., Zhang, P., Zhou, D., & Zheng, G. (2019) · Chemical Communications · doi:10.1039/c9cc07217a · Cited by 86
Liu, J., Li, S., Wang, Q., Feng, Y., Xing, H., Yang, X., Guo, Y., Guo, Y., Sun, H., Liu, X., et al. (2024) · Blood · doi:10.1182/blood.2023019706 · Cited by 76
The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential
Bieghs, L., Johnsen, H. E., Maes, K., Menu, E., Van Valckenborgh, E., Overgaard, M. T., Nyegaard, M., Conover, C. A., Vanderkerken, K., & De Bruyne, E. (2016) · Oncotarget · doi:10.18632/oncotarget.8982 · Cited by 61
Zimmerman, M. A., Huang, Q., Li, F., Liu, X., & Li, C.-Y. (2013) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2013.05.003 · Cited by 59
Gai, X., Tu, K., Li, C., Lu, Z., Roberts, L. R., & Zheng, X. (2015) · Cell Death & Disease · doi:10.1038/cddis.2015.76 · Cited by 54
RetractedBH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death
Wade, M., Rodewald, L. W., Espinosa, J. M., & Wahl, G. M. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6072 · Cited by 48
Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells
Li, J., Xu, M., Yang, Z., Li, A., & Dong, J. (2010) · Cancer Investigation · doi:10.1080/07357900903286966 · Cited by 26
Natarajan, U., Venkatesan, T., Dhandayuthapani, S., Dondapatti, P., & Rathinavelu, A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109742 · Cited by 11
Metadata
- Authors
- Adams, J. M., & Cory, S.
- Venue
- Oncogene
- Published
- 2007-02-26
- Volume
- 26
- Issue
- 9
- Pages
- 1324-1337
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2150048195
- Cited by
- 2,176
- References
- 17
- FWCI
- 49.93
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.