Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 2,176

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

The Bcl-2 apoptotic switch in cancer development and therapy

Open access
Adams, J M, Cory, S·2007·Oncogene

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1210220

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 127

  1. Adams JM . (2003). Ways of dying: multiple pathways to apoptosis. Genes Dev 17: 2481–2495. · DOI · Paper page
  2. Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI et al. (2003). Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 22: 6653–6664. · DOI
  3. Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace Jr AJ . (2000). An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60: 6101–6110.
  4. Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B et al. (2005). Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J 24: 2096–2103. · DOI · Paper page
  5. Bellot G, Cartron PF, Er E, Oliver L, Juin P, Armstrong LC et al. (2006). TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ [Epub ahead of print]. · DOI
  6. Bouillet P, Cory S, Zhang L-C, Strasser A, Adams JM . (2001). Degenerative disorders caused by Bcl-2 deficiency are prevented by loss of its BH3-only antagonist Bim. Dev Cell 1: 645–653. · DOI · Paper page
  7. Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, Köntgen F et al. (1999). Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735–1738. · DOI · Paper page
  8. Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P et al. (2004). The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell 16: 807–818. · DOI · Paper page
  9. Certo M, Moore Vdel G, Nishino M, Wei G, Korsmeyer S, Armstrong SA et al. (2006). Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9: 351–365. · DOI · Paper page
  10. Chauhan D, Velankar M, Brahmandam M, Hideshima T, Podar K, Richardson P et al. (2006). A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene [Epub ahead of print]. · DOI
  11. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. (2005). Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393–403. · DOI · Paper page
  12. Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ . (2003). VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science 301: 513–517. · DOI · Paper page
  13. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T et al. (2001). BCL-2, BCL-xL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705–711. · DOI · Paper page
  14. Chou CH, Lee RS, Yang-Yen HF . (2006). An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. Mol Biol Cell 17: 3952–3963. · DOI
  15. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M et al. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102: 13944–13949. · DOI · Paper page
  16. Cory S, Huang DCS, Adams JM . (2003). The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590–8607. · DOI · Paper page
  17. Cuconati A, Mukherjee C, Perez D, White E . (2003). DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17: 2922–2932. · DOI · Paper page
  18. Degenhardt K, Chen G, Lindsten T, White E . (2002). BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell 2: 193–203. · DOI
  19. Deng X, Gao F, Flagg T, May Jr WS . (2004). Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci USA 101: 153–158. · DOI
  20. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I et al. (2002). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 111: 51–62. · DOI
  21. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I et al. (2003). Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 115: 503. · doi:10.1016/s0092-8674(03)00892-4
  22. Dijkers PF, Medema RH, Lammers JJ, Koenderman L, Coffer PJ . (2000). Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201–1204. · DOI · Paper page
  23. Dzhagalov I, St John A, He YW . (2006). The anti-apoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood [Epub ahead of print]. · DOI · Paper page
  24. Egle A, Harris AW, Bath ML, O'Reilly L, Cory S . (2004a). VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 103: 2276–2283. · DOI
  25. Egle A, Harris AW, Bouillet P, Cory S . (2004b). Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 101: 6164–6169. · DOI · Paper page
  26. Eischen CM, Rehg JE, Korsmeyer SJ, Cleveland JL . (2002). Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res 62: 2184–2191.
  27. Eischen CM, Woo D, Roussel MF, Cleveland JL . (2001). Apoptosis triggered by myc-induced suppression of Bcl-XL or Bcl-2 Is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063–5070. · DOI
  28. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L et al. (2005). BH3-only proteins Puma and Bim are rate-limiting for {gamma}-radiation and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 106: 4131–4138. · DOI · Paper page
  29. Fernandez Y, Verhaegen M, Miller TP, Rush JL, Steiner P, Opipari Jr AW et al. (2005). Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res 65: 6294–6304. · DOI
  30. Fesik SW . (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876–885. · DOI · Paper page
  31. Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H et al. (2006). Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem 281: 31440–31447. · DOI
  32. Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N et al. (2004). Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279: 21085–21095. · DOI · Paper page
  33. Green DR . (2005). Apoptotic pathways: ten minutes to dead. Cell 121: 671–674. · DOI · Paper page
  34. Hamasaki A, Sendo F, Nakayama K, Ishida N, Negishi I, Nakayama K-I et al. (1998). Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J Exp Med 188: 1985–1992. · DOI
  35. Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57–70. · DOI · Paper page
  36. Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C et al. (2005). Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 436: 807–811. · DOI · Paper page
  37. Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW . (2004). Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci USA 101: 9333–9338. · DOI
  38. Hildeman DA, Zhu Y, Mitchell TC, Bouillet P, Strasser A, Kappler J et al. (2002). Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member, Bim. Immunity 16: 759–767. · DOI · Paper page
  39. Hinds MG, Day CL . (2005). Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol 15: 690–699. · DOI
  40. Hsu YT, Youle RJ . (1997). Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem 272: 13829–13834. · DOI · Paper page
  41. Hsu Y-T, Youle RJ . (1998). Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem 273: 10777–10783. · DOI · Paper page
  42. Huang DC, Hahne M, Schroeter M, Frei K, Fontana A, Villunger A et al. (1999). Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL . Proc Natl Acad Sci USA 96: 14871–14876. · DOI · Paper page
  43. Huang DCS, Strasser A . (2000). BH3-only proteins – essential initiators of apoptotic cell death. Cell 103: 839–842. · DOI · Paper page
  44. Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M . (2000). Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci USA 97: 10872–10877. · DOI
  45. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J et al. (2003). Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321–328. · DOI · Paper page
  46. Johnstone RW, Ruefli AA, Lowe SW . (2002). Apoptosis: a link between cancer genetics and chemotherapy. Cell 108: 153–164. · DOI
  47. Kim BJ, Ryu SW, Song BJ . (2006b). JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation, mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281: 21256–21265. · DOI · Paper page
  48. Kim PK, Annis MG, Dlugosz PJ, Leber B, Andrews DW . (2004). During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Mol Cell 14: 523–529. · DOI
  49. Knudson CM, Johnson GM, Lin Y, Korsmeyer SJ . (2001). Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 61: 659–665.
  50. Kondo S, Shinomura Y, Miyazaki Y, Kiyohara T, Tsutsui S, Kitamura S et al. (2000). Mutations of the bak gene in human gastric and colorectal cancers. Cancer Res 60: 4328–4330.
  51. Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S et al. (2006). Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10: 375–388. · DOI · Paper page
  52. Kuribara R, Honda H, Matsui H, Shinjyo T, Inukai T, Sugita K et al. (2004). Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitor. Mol Cell Biol 24: 6172–6183. · DOI
  53. Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DC et al. (2006). Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 103: 14907–14912. · DOI · Paper page
  54. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R et al. (2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331–342. · DOI · Paper page
  55. Lakhani SA, Masud A, Kuida K, Porter Jr GA, Booth CJ, Mehal WZ et al. (2006). Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311: 847–851. · DOI · Paper page
  56. Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ . (2003). Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 278: 18811–18816. · DOI · Paper page
  57. Liu X, Dai S, Zhu Y, Marrack P, Kappler JW . (2003). The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity 19: 341–352. · DOI · Paper page
  58. Lucken-Ardjomande S, Martinou JC . (2005). Newcomers in the process of mitochondrial permeabilization. J Cell Sci 118: 473–483. · DOI
  59. McDonnell TJ, Korsmeyer SJ . (1991). Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 349: 254–256. · DOI · Paper page
  60. Meijerink JPP, Mensink EJBM, Wang K, Sedlak TW, Slöetjes AW, de Witte T et al. (1998). Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91: 2991–2997. · DOI · Paper page
  61. Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, Siebert R, Climent J, Fresquet V et al. (2006). Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood [Epub ahead of print]. · DOI
  62. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P et al. (2003). p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577–590. · DOI · Paper page
  63. Ming L, Wang P, Bank A, Yu J, Zhang L . (2006). PUMA dissociates Bax and Bcl-XL to induce apoptosis in colon cancer cells. J Biol Chem 281: 16034–16042. · DOI
  64. Miyashita T, Reed JC . (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293–299. · DOI · Paper page
  65. Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K . (2006). The X-ray structure of a Bak homodimer reveals an inhibitory zinc binding site. Mol Cell 24: 677–688. · DOI
  66. Motoyama N, Kimura T, Takahashi T, Watanabe T, Nakano T . (1999). bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. J Exp Med 189: 1691–1698. · DOI
  67. Motoyama N, Wang FP, Roth KA, Sawa H, Nakayama K, Nakayama K et al. (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice. Science 267: 1506–1510. · DOI · Paper page
  68. Nakayama K, Nakayama K-I, Negishi I, Kuida K, Sawa H, Loh DY . (1994). Targeted disruption of bcl-2αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 91: 3700–3704. · DOI · Paper page
  69. Nakayama K-I, Nakayama K, Izumi N, Kulda K, Shinkai Y, Louie MC et al. (1993). Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261: 1584–1588. · DOI · Paper page
  70. Newmeyer DD, Ferguson-Miller S . (2003). Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112: 481–490. · DOI · Paper page
  71. Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F et al. (2003). Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17: 1475–1486. · DOI · Paper page
  72. Nikrad M, Johnson T, Puthalalath H, Coultas L, Adams J, Kraft AS . (2005). The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther 4: 443–449. · DOI
  73. Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM . (1999). Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA 96: 14943–14948. · DOI · Paper page
  74. Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ . (2006). A membrane-targeted BID BH3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem 281: 36999–37008. · DOI
  75. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. (2005). An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435: 677–681. · DOI · Paper page
  76. Opferman J, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K et al. (2005). Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307: 1101–1104. · DOI · Paper page
  77. Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ . (2003). Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426: 671–676. · DOI · Paper page
  78. Parone PA, James DI, Da Cruz S, Mattenberger Y, Donze O, Barja F et al. (2006). Inhibiting the mitochondrial fission machinery does not prevent bax/bak-dependent apoptosis. Mol Cell Biol 26: 7397–7408. · DOI
  79. Patel JH, McMahon SB . (2006). BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC induced apoptosis. J Biol Chem [Epub ahead of print]. · DOI
  80. Pellegrini M, Belz G, Bouillet P, Strasser A . (2003). Shut down of an acute T cell immune response to viral infection is mediated by the pro-apoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci USA 100: 14175–14180. · DOI
  81. Print CG, Loveland KL, Gibson L, Meehan T, Stylianou A, Wreford N et al. (1998). Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci USA 95: 12424–12431. · DOI · Paper page
  82. Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B et al. (2003). JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38: 899–914. · DOI · Paper page
  83. Puthalakath H, Strasser A . (2002). Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9: 505–512. · DOI · Paper page
  84. Puthalakath H, Huang DCS, O'Reilly LA, King SM, Strasser A . (1999). The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3: 287–296. · DOI · Paper page
  85. Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V et al. (2005). Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res 65: 6282–6293. · DOI · Paper page
  86. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC et al. (1997). Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967–969. · DOI · Paper page
  87. Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK et al. (2005). Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol 25: 4591–4601. · DOI
  88. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J et al. (2003). Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5: 733–740. · DOI · Paper page
  89. Ross AJ, Waymire KG, Moss JE, Parlow AF, Skinner MK, Russell LD et al. (1998). Testicular degeneration in Bclw-deficient mice. Nat Genet 18: 251–256. · DOI · Paper page
  90. Sadowsky JD, Fairlie WD, Hadley EB, Lee H-S, Umezawa N, Nikolovska-Coleska Z et al. (2006). Characterization of (a/b+a)-peptide antagonists of BH3 domain/Bcl-XLrecognition: toward general strategies for developing foldamer-based inhibitors of protein–protein interactions. J Am Chem Soc in press. · DOI
  91. Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y et al. (2005). Chimeric (alpha/beta+alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc 127: 11966–11968. · DOI
  92. Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M et al. (1997). Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275: 983–986. · DOI · Paper page
  93. Schmidt T, Korner K, Karsunky H, Korsmeyer S, Muller R, Moroy T . (1999). The activity of the murine bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53. Cell Death Differ 6: 873–882. · DOI
  94. Schmitt CA, Rosenthal CT, Lowe SW . (2000). Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 6: 1029–1035. · DOI · Paper page
  95. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ . (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879–888. · DOI · Paper page
  96. Shibata MA, Liu ML, Knudson MC, Shibata E, Yoshidome K, Bandey T et al. (1999). Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. EMBO J 18: 2692–2701. · DOI
  97. Shoemaker AR, Oleksijew A, Bauch J, Belli BA, Borre T, Bruncko M et al. (2006). A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res 66: 8731–8739. · DOI
  98. Strasser A, Harris AW, Bath ML, Cory S . (1990). Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348: 331–333. · DOI · Paper page
  99. Strasser A, Harris AW, Cory S . (1991a). Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889–899. · DOI · Paper page
  100. Strasser A, Harris AW, Cory S . (1993). Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene 8: 1–9.
  101. Strasser A, Harris AW, Huang DCS, Krammer PH, Cory S . (1995). Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14: 6136–6147. · DOI · Paper page
  102. Strasser A, O'Connor L, Dixit VM . (2000). Apoptosis signaling. Ann Rev Biochem 69: 217–245. · DOI · Paper page
  103. Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S et al. (1991b). Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 88: 8661–8665. · DOI · Paper page
  104. Strasser A . (2005). The role of BH3-only proteins in the immune system. Nat Rev Immunol 5: 189–200. · DOI · Paper page
  105. Suzuki M, Youle RJ, Tjandra N . (2000). Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103: 645–654. · DOI · Paper page
  106. Tagawa H, Karnan S, Suzuki R, Matsuo K, Zhang X, Ota A et al. (2005). Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 24: 1348–1358. · DOI · Paper page
  107. Tan TT, Degenhardt K, Nelson DA, Beaudoin B, Nieves-Neira W, Bouillet P et al. (2005). Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell 7: 227–238. · DOI · Paper page
  108. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE et al. (2006). The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10: 389–399. · DOI · Paper page
  109. Vaux DL, Cory S, Adams JM . (1988). Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440–442. · DOI · Paper page
  110. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ . (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229–240. · DOI · Paper page
  111. Vousden KH, Lu X . (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594–604. · DOI · Paper page
  112. Wagner KU, Claudio E, Rucker III EB, Riedlinger G, Broussard C, Schwartzberg PL et al. (2000). Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 127: 4949–4958. · DOI
  113. Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J et al. (2006). A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 24: 199–210. · DOI · Paper page
  114. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727–730. · DOI · Paper page
  115. Willis SN, Adams JM . (2005). Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617–625. · DOI · Paper page
  116. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. (2005). Pro-apoptotic Bak is sequestered by Mc1-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19: 1294–1305. · DOI · Paper page
  117. Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. (2007). Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science in press. · DOI · Paper page
  118. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ . (1997). Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281–1292. · DOI · Paper page
  119. Yin CY, Knudson CM, Korsmeyer SJ, Van Dyke T . (1997). Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637–640. · DOI · Paper page
  120. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ . (1996). Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xL . Cell 87: 619–628. · DOI · Paper page
  121. Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ . (2000). Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290: 1761–1765. · DOI · Paper page
  122. Zhang Y, Adachi M, Kawamura R, Imai K . (2005). Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis. Cell Death Differ 13: 129–140. · DOI
  123. Zhao Y, Tan J, Zhuang L, Jiang X, Liu ET, Yu Q . (2005). Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci USA 102: 16090–16095. · DOI
  124. Zhong Q, Gao W, Du F, Wang X . (2005). Mule/ARF-BP1, a BH3-Only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121: 1085–1095. · DOI · Paper page
  125. Zhu Y, Liu X, Hildeman D, Peyerl FW, White J, Kushnir E et al. (2006). Bax does not have to adopt its final form to drive T cell death. J Exp Med 203: 1147–1152. · DOI
  126. Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X et al. (2004). Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci USA 101: 7681–7686. · DOI
  127. Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB . (2001). BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15: 1481–1486. · DOI · Paper page

Cited by

See all 2,176

Metadata

Authors
Adams, J. M., & Cory, S.
Venue
Oncogene
Published
2007-02-26
Volume
26
Issue
9
Pages
1324-1337
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2150048195
Cited by
2,176
References
17
FWCI
49.93
Type
journal article
Language
en
Open access
green
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.