Intervention-induced enhancement in intrinsic brain activity in healthy older adults
Open accessAbstract
This study examined the effects of a multimodal intervention on spontaneous brain activity in healthy older adults. Seventeen older adults received a six-week intervention that consisted of cognitive training, Tai Chi exercise, and group counseling, while 17 older adults in a control group attended health knowledge lectures. The intervention group demonstrated enhanced memory and social support compared to the control group. The amplitude of low frequency fluctuations (ALFF) in the middle frontal gyrus, superior frontal gyrus, and anterior cerebellum lobe was enhanced for the intervention group, while the control group showed reduced ALFF in these three regions. Moreover, changes in trail-making performance and well-being could be predicted by the intervention-induced changes in ALFF. Additionally, individual differences in the baseline ALFF were correlated with intervention-related changes in behavioral performance. These findings suggest that a multimodal intervention is effective in improving cognitive functions and well-being and can induce functional changes in the aging brain. The study extended previous training studies by suggesting resting-state ALFF as a marker of intervention-induced plasticity in older adults.
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Neuroimaging studies have demonstrated that short-term interventions of 1-3 months can elicit significant changes in brain structure and function, including alterations in grey matter volume, functional connectivity, and activation patterns in regions associated with cognitive functions.
“Neuroimaging studies have demonstrated that even short-term interventions of 1–3 months can elicit significant changes in brain structure and function, including alterations in grey matter volume, functional connectivity and activation patterns in regions associated with cognitive functions.4245”
From Effectiveness of exercise for improving cognition, memory and executive function: a systematic umbrella review and meta-meta-analysis (2025) · cites this paper as [42]
The Abstract and Discussion report that a six-week intervention in healthy older adults changed spontaneous brain activity, and the paper describes functional-connectivity changes found with the same intervention in a preceding study. It does not report intervention-induced changes in grey matter volume; its own imaging result concerns brain function rather than structure. No page numbers are available in our copy. (LLM, conf=0.85)
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“Enhanced ALFF in the middle frontal gyrus, superior frontal gyrus, and anterior cerebellum lobe was also observed in healthy older adults following multimodal cognitive traning, with these changes associated with improvements in cognitive performance (Yin et al., 2014).”
BackgroundInfluentialMaruyama, T., Takeuchi, H., Taki, Y., Motoki, K., Jeong, H., Kotozaki, Y., Nakagawa, S., Nouchi, R., Iizuka, K., Yokoyama, R., et al. (2018) · Neural Plasticity · doi:10.1155/2018/6574178 · Cited by 17 · see citing works
“Moreover, it was suggested that resting-state ALFF is a marker of intervention-induced plasticity [16].”
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“For older adults, six weeks of an integrated intervention enhanced the ALFF of the superior frontal gyrus and medial frontal gyrus, and individual differences based on the ALFF were related to postintervention behavioral changes [71].”
BackgroundCognitive training modified age-related brain changes in older adults with subjective memory decline
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“, 2013) and training-related performance improvements (Yin et al., 2014).”
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“In recent years, a number of studies have emerged that have provided further understanding of how individuals can maintain their cognitive abilities and delay or resist the process of decline in older age (Voss et al., 2010; Yin et al., 2015).”
Helping older adults overcome the challenges of technology
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A Multimodal Intervention to Improve Cognition in Community-dwelling Older Adults
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“45 Zheng et al. 44 reported increases and decreases occurring simultaneously in the same network (DMN) depending upon the specific brain ROI examined.”
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“On this basis, the authors interpreted the blunted ALFF increase in WKY rats as reduced functional plasticity of NAc activity, in line with human intervention studies in which longitudinal changes in ALFF have been used as an indirect marker of experience-dependent brain plasticity 60,61 .”
Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies
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“These structural changes are believed to underlie the observed cognitive improvements and highlight the potential of cognitive training to induce neuroplasticity even in aging brains (L. Nguyen et al. 2019; Park & Bischof 2013; Yin et al. 2014) (Table 3).”
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“…the purpose of this intervention was to promote inter-individual (i.e., social support from significant others, friends, and teachers) and intra-individual protective factors (i.e., self-esteem, emotion management, positive coping, and optimism about future) (Tam et al., 2020; Yin et al., 2014).”
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“Similarly, elderly individuals receiving cognitive and Tai Chi training demonstrated increased cerebellar ALFF accompanied by improvements in memory performance (80).”
- Authors
- Yin, S., Zhu, X., Li, R., Niu, Y., Wang, B., Zheng, Z., Huang, X., Huo, L., & Li, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Juan
- Venue
- Scientific Reports
- Published
- 2014-12-04
- Volume
- 4
- Issue
- 1
- Pages
- 7309-7309
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4255189
- OpenAlex
- W1991434113
- Cited by
- 57
- References
- 58
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Funders
- National Natural Science Foundation of China (31070916,, 31470998, Y1CX251005, Y2CX131003, 31200847, KSCX2-EW-J-8, 31271108, 111000C038)
- Chinese Academy of Sciences (31271108, 31070916, KSCX2-EWJ-8, Y1CX251005, 111000C038, 31200847, Y1CX251005, 111000C038, Y2CX131003, 31470998)
- Institute of Psychology, Chinese Academy of Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- multimodal intervention, older adults, amplitude of low-frequency fluctuation, resting-state brain activity, cognitive training, Tai Chi, group counseling, memory, social support, well-being, individual differences, neuroplasticity, brain aging, middle frontal gyrus, superior frontal gyrus, anterior cerebellum
- MeSH terms
- Aged, Aging, Brain Mapping, Cerebellum, Cognition, Double-Blind Method, Female, Frontal Lobe, Humans, Individuality, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Social Support
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