The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Two-dimensional Layered MoS2 Biosensors Enable Highly Sensitive Detection of Biomolecules
Open accessAbstract
We present a MoS 2 biosensor to electrically detect prostate specific antigen (PSA) in a highly sensitive and label-free manner. Unlike previous MoS 2-FET-based biosensors, the device configuration of our biosensors does not require a dielectric layer such as HfO 2 due to the hydrophobicity of MoS 2. Such an oxide-free operation improves sensitivity and simplifies sensor design. For a quantitative and selective detection of PSA antigen, anti-PSA antibody was immobilized on the sensor surface. Then, introduction of PSA antigen, into the anti-PSA immobilized sensor surface resulted in a lable-free immunoassary format. Measured off-state current of the device showed a significant decrease as the applied PSA concentration was increased. The minimum detectable concentration of PSA is 1 pg/mL, which is several orders of magnitude below the clinical cut-off level of ~4 ng/mL. In addition, we also provide a systematic theoretical analysis of the sensor platform – including the charge state of protein at the specific pH level and self-consistent channel transport. Taken together, the experimental demonstration and the theoretical framework provide a comprehensive description of the performance potential of dielectric-free MoS 2-based biosensor technology.
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Metadata
- Authors
- Lee, J., Dak, P., Lee, Y., Park, H., Choi, W., Alam, M. A., & Kim, S.
- Venue
- Scientific Reports
- Published
- 2014-12-17
- Volume
- 4
- Issue
- 1
- Pages
- 7352-7352
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1997038703
- Cited by
- 318
- References
- 29
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- gold
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