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Cited by 317

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition

Open access
Kim, Han-Shin, Lee, Sang-Hoon, Byun, Youngjoo, Park, Hee-Deung·2015·Scientific Reports
DOI 10.1038/srep08656
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Abstract

Pseudomonas aeruginosa is a well-known pathogenic bacterium that forms biofilms and produces virulence factors via quorum sensing (QS). Interfering with normal QS interactions between signal molecules and their cognate receptors is a developing strategy for attenuating its virulence. Here we tested the hypothesis that 6-gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. In silico studies demonstrated molecular binding occurs between 6-gingerol and the QS receptor LasR through hydrogen bonding and hydrophobic interactions. Experimentally 6-gingerol reduced biofilm formation, several virulence factors (e.g., exoprotease, rhamnolipid and pyocyanin) and mice mortality. Further transcriptome analyses demonstrated that 6-gingerol successfully repressed QS-induced genes, specifically those related to the production of virulence factors. These results strongly support our hypothesis and offer insight into the molecular mechanism that caused QS gene repression.

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Metadata

Authors
Kim, H.-S., Lee, S.-H., Byun, Y., & Park, H.-D.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2015-03-02
Volume
5
Issue
1
Pages
8656-8656
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep08656
OpenAlex
W2009317737
Cited by
317
References
50
FWCI
9.91
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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