The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Estrogen accelerates the resolution of inflammation in macrophagic cells
Open accessAbstract
Although 17β-estradiol (E 2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a previously unreported ERα-mediated effect of E 2 on the inflammatory machinery. The study showed that the activation of the intracellular estrogen receptor shortens the LPS-induced pro-inflammatory phase and, by influencing the intrinsic and extrinsic programs, triggers the resolution of inflammation in RAW 264.7 cells. Through the regulation of the SOCS3 and STAT3 signaling pathways, E 2 facilitates the progression of the inflammatory process toward the IL10-dependent “acquired deactivation” phenotype, which is responsible for tissue remodeling and the restoration of homeostatic conditions. The present study may provide an explanation for increased susceptibility to chronic inflammatory diseases in women after menopause and it suggests novel anti-inflammatory treatments for such disorders.
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Cites
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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SOCS proteins, cytokine signalling and immune regulation
Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2093 · Cited by 1,580
International Union of Pharmacology. LXIV. Estrogen Receptors
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Cited by
Sex-specific features of microglia from adult mice
Villa, A., Gelosa, P., Castiglioni, L., Cimino, M., Rizzi, N., Pepe, G., Lolli, F., Marcello, E., Sironi, L., Vegeto, E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.048 · Cited by 651
Self-citationEstrogens, Neuroinflammation, and Neurodegeneration
Villa, A., Vegeto, E., Poletti, A., & Maggi, A. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1007 · Cited by 423
Self-citationColombo, G., Cubero, R. J. A., Kanari, L., Venturino, A., Schulz, R., Scolamiero, M., Agerberg, J., Mathys, H., Tsai, L.-H., Chachólski, W., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01167-6 · Cited by 100
Pepe, G., Braga, D., Renzi, T. A., Villa, A., Bolego, C., D’Avila, F., Barlassina, C., Maggi, A., Locati, M., & Vegeto, E. (2017) · Scientific Reports · doi:10.1038/srep44270 · Cited by 80
Self-citationA framework for developing sex-specific engineered heart models
Lock, R., Al Asafen, H., Fleischer, S., Tamargo, M., Zhao, Y., Radisic, M., & Vunjak-Novakovic, G. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00381-1 · Cited by 50
Metadata
- Authors
- Villa, A., Rizzi, N., Vegeto, E., Ciana, P., & Maggi, A.
- Venue
- Scientific Reports
- Published
- 2015-10-19
- Volume
- 5
- Issue
- 1
- Pages
- 15224-15224
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1759257429
- Cited by
- 272
- References
- 10
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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