Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
Abstract
In this study we revealed the participation of P2X(7) receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [(3)H]glutamate and [(3)H]GABA was decreased in the hippocampus of P2X(7) receptor-deficient mice. ATP (10 mM) elicited [(3)H]glutamate and [(3)H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium (30 microM) and the P2X(7)-selective antagonist Brilliant Blue G (1 microM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of P2X7R knockout mice.
“In accordance with these results, glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of the P2X7R KO mice [99].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [99]
Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919 · see citing works
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works
Altered Cytokine Production in Mice Lacking P2X7Receptors
Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works
Tissue distribution of the P2X7 receptor
Collo, G., Neidhart, S., Kawashima, E. H., Kosco‐Vilbois, M. H., North, R. A., & Buell, G. N. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00140-8 · Cited by 493 · see citing works
P2X <sub>7</sub> Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes
Duan, S., Anderson, C. M., Keung, E. C., Chen, Y., Chen, Y., & Swanson, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01320.2003 · Cited by 489 · see citing works
Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., & Posmantur, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209478200 · Cited by 488 · see citing works
Brilliant Blue G Selectively Blocks ATP-Gated Rat P2X7Receptors
Jiang, L., Mackenzie, A. B., North, R. A., & Surprenant, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.82 · Cited by 401 · see citing works
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394 · see citing works
The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death
Virgilio, F. D. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80045-x · Cited by 374 · see citing works
Deuchars, S. A., Atkinson, L., Brooke, R. E., Musa, H., Milligan, C. J., Batten, T. F. C., Buckley, N. J., Parson, S. H., & Deuchars, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07143.2001 · Cited by 287 · see citing works
Sperlágh, B., Köfalvi, A., Deuchars, J., Atkinson, L., J. Milligan, C., Buckley, N. J., & Vizi, E. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00920.x · Cited by 264 · see citing works
Reanalysis of P2X<sub>7</sub>Receptor Expression in Rodent Brain
Sim, J. A., Young, M. T., Sung, H.-Y., North, R. A., & Surprenant, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-04.2004 · Cited by 264 · see citing works
P2X7Receptor Expression after Ischemia in the Cerebral Cortex of Rats
Franke, H., Günther, A., Grosche, J., Schmidt, R., Roßner, S., Reinhardt, R., Faber‐Zuschratter, H., Schneider, D., & Illés, P. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.686 · Cited by 227 · see citing works
SAPK/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor
Humphreys, B. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002770200 · Cited by 199 · see citing works
P2X7 Receptors in Müller Glial Cells from the Human Retina
Pannicke, T., Fischer, W., Biedermann, B., Schädlich, H., Grosche, J., Faude, F., Wiedemann, P., Allgaier, C., Illés, P., Burnstock, G., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-05965.2000 · Cited by 185 · see citing works
Humphreys, B. D., Rice, J., Kertesy, S. B., & Dubyak, G. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61445-6 · Cited by 170 · see citing works
ATP Modulation of Excitatory Synapses onto Interneurons
Khakh, B. S., Gittermann, D., Cockayne, D. A., & Jones, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07426.2003 · Cited by 155 · see citing works
Armstrong, J. N., Brust, T., Lewis, R. G., & MacVicar, B. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05938.2002 · Cited by 136 · see citing works
Neuronal synthesis, storage and release of ATP
Sperlágh, B., & Vizi, S. E. (1996) · Seminars in Neuroscience · doi:10.1006/smns.1996.0023 · Cited by 122 · see citing works
P2X7 Receptors in Rat Brain: Presence in Synaptic Terminals and Granule Cells
Miras‐Portugal, M. T., Dı́az-Hernández, M., Giráldez, L., Hervás, C., Gómez‐Villafuertes, R., Pérez‐Sen, R., Gualix, J., & Pintor, J. J. (2003) · Neurochemical Research · doi:10.1023/a:1025690913206 · Cited by 98 · see citing works
Atkinson, L., Batten, T. F. C., Moores, T. S., Varoqui, H., Erickson, J. D., & Deuchars, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.065 · Cited by 80 · see citing works
Synaptic P2X 7 and Oxygen/Glucose Deprivation in Organotypic Hippocampal Cultures
Cavaliere, F., Amadio, S., Sancesario, G., Bernardi, G., & Volonté, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200404000-00004 · Cited by 74 · see citing works
Lundy, P. M., Hamilton, M. G., Mi, L., Gong, W., Vair, C., Sawyer, T. W., & Frew, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704624 · Cited by 51 · see citing works
An ATP-gated ion channel at the cell nucleus
Atkinson, L., Milligan, C. J., Buckley, N. J., & Deuchars, J. (2002) · Nature · doi:10.1038/420042a · Cited by 51 · see citing works
Species- and agonist-dependent differences in the deactivation-kinetics of P2X 7 receptors
Hibell, A. D., Thompson, K., Simon, J., Xing, M., Humphrey, P. P. A., & Michel, A. D. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100100412 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Physiology and Pathophysiology of Purinergic Neurotransmission
Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,579 · see citing works
P2X 7 Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca 2+ Signaling
Suadicani, S. O., Brosnan, C. F., & Scemes, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3902-05.2006 · Cited by 512 · see citing works
P2X7 receptors in the nervous system
Sperlágh, B., Vizi, E. S., Wirkner, K., & Illés, P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.007 · Cited by 374 · see citing works
Functional connexin “hemichannels”: A critical appraisal
Spray, D. C., Ye, Z., & Ransom, B. R. (2006) · Glia · doi:10.1002/glia.20429 · Cited by 319 · see citing works
P2X7 Receptors: Channels, Pores and More
Volonté, C., Apolloni, S., Skaper, S. D., & Burnstock, G. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712803581137 · Cited by 254 · see citing works
Nelson, D. W., Gregg, R. J., Kort, M. E., Perez‐Medrano, A., Voight, E. A., Wang, Y., Grayson, G. K., Namovic, M. T., Donnelly‐Roberts, D. L., Niforatos, W., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051202e · Cited by 235 · see citing works
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
Kaczmarek-Hájek, K., Lörinczi, É., Hausmann, R., & Nicke, A. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9314-7 · Cited by 223 · see citing works
Mechanisms of ATP‐ and glutamate‐mediated calcium signaling in white matter astrocytes
Hamilton, N. B., Vayro, S., Kirchhoff, F., Verkhratsky, A., Robbins, J., Górecki, D. C., & Butt, A. M. (2008) · Glia · doi:10.1002/glia.20649 · Cited by 215 · see citing works
Engel, T., Gómez‐Villafuertes, R., Tanaka, K., Mesuret, G., Sanz‐Rodriguez, A., García-Huerta, P., Miras‐Portugal, M. T., Henshall, D. C., & Dı́az-Hernández, M. (2011) · The FASEB Journal · doi:10.1096/fj.11-196089 · Cited by 196 · see citing works
P2 receptors and neuronal injury
Franke, H., Krügel, U., & Illés, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0071-8 · Cited by 184 · see citing works
Advances in the Potential Biomarkers of Epilepsy
Kobylarek, D., Iwanowski, P. S., Lewandowska, Z., Limphaibool, N., Szafranek, S., Labrzycka, A., & Kozubski, W. P. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00685 · Cited by 153 · see citing works
P2X7 receptors: Properties and relevance to CNS function
Duan, S., & Neary, J. T. (2006) · Glia · doi:10.1002/glia.20397 · Cited by 136 · see citing works
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
Csölle, C., Baranyi, M., Zsilla, G., Kittel, Á., Gölöncsér, F., Illes, P., Papp, E., Vizi, E. S., & Sperlágh, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066547 · Cited by 128 · see citing works
Self-citationMcQuillin, A., Bass, N. J., Choudhury, K., Puri, V., Kosmin, M., Lawrence, J., Curtis, D., & Gurling, H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.6 · Cited by 117 · see citing works
Csölle, C., Andó, R. D., Kittel, Á., Gölöncsér, F., Baranyi, M., Soproni, K., Zelena, D., Haller, J., Németh, T., Mócsai, A., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001933 · Cited by 108 · see citing works
“The activation of P2rx7s elicits Ca2+ influx (Miras-Portugal et al. 2003), followed by increased glutamate and subsequent c-aminobutyric acid (GABA) release (Alloisio et al. 2008; Papp et al. 2004; Patti et al. 2006; Sperlagh et al. 2002).”
BackgroundResultGu, Y., Chen, Y., Zhang, X., Li, G.-W., Wang, C., & Huang, L.-Y. M. (2010) · Neuron Glia Biology · doi:10.1017/s1740925x10000116 · Cited by 106 · see citing works
Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release
Zimmermann, H. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9483-2 · Cited by 105 · see citing works
Regulation of Excitability by Extrasynaptic GABAA Receptors
Walker, M. C., & Semyanov, A. V. (2007) · Springer eBooks · doi:10.1007/400_2007_030 · Cited by 104 · see citing works
ATPergic signalling during seizures and epilepsy
Engel, T., Alves, M., Sheedy, C., & Henshall, D. C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.001 · Cited by 95 · see citing works
Selective P2X7 receptor antagonists for chronic inflammation and pain
Carroll, W. A., Donnelly‐Roberts, D. L., & Jarvis, M. F. (2008) · Purinergic Signalling · doi:10.1007/s11302-008-9110-6 · Cited by 94 · see citing works
Wirkner, K., Köfalvi, A., Fischer, W., Günther, A., Franke, H., Gröger‐Arndt, H., Nörenberg, W., Madarász, E., Vizi, E. S., Schneider, D., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03465.x · Cited by 89 · see citing works
Self-citationDoná, F., Ulrich, H., Persike, D. S., Conceição, I. M., Blini, J. P., Cavalheiro, É. A., & Fernandes, M. J. D. S. (2008) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.10.008 · Cited by 87 · see citing works
Acuña‐Castillo, C., Coddou, C., Bull, P., Brito-Echeverría, J., & Huidobro-Toro, J. P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04343.x · Cited by 84 · see citing works
Duplantier, A. J., Dombroski, M. A., Subramanyam, C., Beaulieu, A. M., Chang, S.-P., Gabel, C. A., Jordan, C. K., Kalgutkar, A. S. S., Kraus, K. G., Labasi, J. M., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.04.077 · Cited by 78 · see citing works
Sánchez‐Nogueiro, J., Marín‐García, P., & Miras‐Portugal, M. T. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.073 · Cited by 74 · see citing works
Yeung, D., Zabłocki, K., Lien, C., Jiang, T., Arkle, S., Brutkowski, W., Brown, J. F., Lochmüller, H., Simon, J., Barnard, E. A., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4022com · Cited by 69 · see citing works
P2X7 nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
Kong, Q., Wang, M., Liao, Z., Camden, J. M., Yu, S. O., Simonyi, Á., Sun, G. Y., Gonzalez, F. A., Erb, L., Seye, C. I., et al. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-7145-5 · Cited by 65 · see citing works
Functional Aspects of Redox Control During Neuroinflammation
Rosales‐Corral, S., Reiter, R. J., Tan, D., Ortiz, G. G., & López-Armas, G. D. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2629 · Cited by 64 · see citing works
Mesuret, G., Engel, T., Hessel, E. V. S., Sanz‐Rodriguez, A., Jimenez‐Pacheco, A., Miras‐Portugal, M. T., Dı́az-Hernández, M., & Henshall, D. C. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12272 · Cited by 61 · see citing works
Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS
Zhao, Y., Tang, Y., & Illés, P. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.641570 · Cited by 59 · see citing works
Metzger, M. W., Walser, S. M., Dedic, N., Aprile-Garcia, F., Jakubcakova, V., Adamczyk, M., Webb, K. J., Uhr, M., Refojo, D., Schmidt, M. V., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-16.2017 · Cited by 59 · see citing works
Franke, H., Klimke, K., Brinckmann, U., Grosche, J., Francke, M., Sperlágh, B., Reichenbach, A., Liebert, U. G., & Illés, P. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.04.022 · Cited by 58 · see citing works
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus
Sperlágh, B., Zsilla, G., Baranyi, M., Illés, P., & Vizi, E. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.035 · Cited by 58 · see citing works
P2 receptor-mediated modulation of neurotransmitter release—an update
Sperlágh, B., Heinrich, A., & Csölle, C. (2007) · Purinergic Signalling · doi:10.1007/s11302-007-9080-0 · Cited by 56 · see citing works
P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes
Lü, H., Burns, D., Garnier, P. E., Wei, G., Zhu, K., & Ying, W. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.095 · Cited by 57 · see citing works
León, D., Sánchez-Nogueiro, J., Marín-García, P., & Miras-Portugal, M. T. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.12.004 · Cited by 53 · see citing works
The role of P2X7 receptors in a rodent PCP-induced schizophrenia model
Koványi, B., Csölle, C., Calovi, S., Hanuska, A., Kató, E., Köles, L., Bhattacharya, A., Haller, J., & Sperlágh, B. (2016) · Scientific Reports · doi:10.1038/srep36680 · Cited by 52 · see citing works
P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression
Otrokocsi, L., Kittel, Á., & Sperlágh, B. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx046 · Cited by 52 · see citing works
Hracskó, Z., Baranyi, M., Csölle, C., Gölöncsér, F., Madarász, E., Kittel, Á., & Sperlágh, B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-28 · Cited by 50 · see citing works
Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice
Rodriguez-Alvarez, N., Jimenez-Mateos, E. M., Engel, T., Quinlan, S., Reschke, C. R., Conroy, R. M., Bhattacharya, A., Boylan, G. B., & Henshall, D. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.005 · Cited by 46 · see citing works
Andó, R. D., & Sperlágh, B. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.09.016 · Cited by 44 · see citing works
The P2X7 Receptor, a Multifaceted Receptor in Alzheimer’s Disease
Ronning, K. E., Déchelle-Marquet, P.-A., Che, Y., Guillonneau, X., Sennlaub, F., & Delarasse, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411747 · Cited by 43 · see citing works
Ahn, Y. H., Tang, Y., & Illés, P. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2258281 · Cited by 41 · see citing works
P2X7 receptors enhance glutamate release in hippocampal hilar neurons
Cho, J.-H., Choi, I.-S., & Jang, I.-S. (2010) · Neuroreport · doi:10.1097/wnr.0b013e32833d9142 · Cited by 37 · see citing works
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works
Point Mutation in the Mouse P2X 7 Receptor Affects Intercellular Calcium Waves in Astrocytes
Suadicani, S. O., Iglesias, R., Spray, D. C., & Scemes, E. (2009) · ASN NEURO · doi:10.1042/an20090001 · Cited by 37 · see citing works
Structure−Activity Relationship Studies onN′-Aryl Carbohydrazide P2X7Antagonists
Nelson, D. W., Sarris, K., Kalvin, D. M., Namovic, M. T., Grayson, G. K., Donnelly‐Roberts, D. L., Harris, R., Honoré, P., Jarvis, M. F., Faltynek, C. R., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701516f · Cited by 37 · see citing works
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
Alves, M., Gil, B., Villegas-Salmerón, J., Salari, V., Martins-Ferreira, R., Blázquez, M. A., Méndez, A. M., Gerbatin, R. R., Smith, J., de Diego-García, L., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.023 · Cited by 36 · see citing works
Csölle, C., & Sperlágh, B. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.011 · Cited by 36 · see citing works
Popova, M., Asatryan, L., Ostrovskaya, O. I., Wyatt, L. R., Li, K., Alkana, R. L., & Davies, D. L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06460.x · Cited by 35 · see citing works
Xiao, C., Zhou, C., Li, K., Davies, D. L., & Ye, J. H. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.139766 · Cited by 34 · see citing works
Amorim, R. P., Araújo, M. G. L., Valero, J., Lopes‐Cendes, Í., Pascoal, V., Malva, J. O., & Fernandes, M. J. D. S. (2017) · Purinergic Signalling · doi:10.1007/s11302-017-9573-4 · Cited by 33 · see citing works
Immunomodulatory Mechanism and Potential Therapies for Perinatal Hypoxic-Ischemic Brain Damage
Min, Y., Ling, E., & Li, F. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.580428 · Cited by 33 · see citing works
Anti-Prion Activity of Brilliant Blue G
Iwamaru, Y., Takenouchi, T., Murayama, Y., Okada, H., Imamura, M., Shimizu, Y., Hashimoto, M., Mohri, S., Yokoyama, T., & Kitani, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037896 · Cited by 32 · see citing works
Florjancic, A. S., Peddi, S., Perez‐Medrano, A., Li, B., Namovic, M. T., Grayson, G. K., Donnelly‐Roberts, D. L., Jarvis, M. F., & Carroll, W. A. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.01.095 · Cited by 32 · see citing works
P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus
Papp, L., Vizi, E. S., & Sperlágh, B. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.014 · Cited by 32 · see citing works
P2X7 receptor signaling during adult hippocampal neurogenesis
Gu, B. J., Weible, M. W., Leeson, H. C., Chan‐Ling, T., Lovelace, M. D., & Brownlie, J. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.257510 · Cited by 30 · see citing works
Variation in the purinergic P2RX7 receptor gene and schizophrenia
Hansen, T. F., Jakobsen, K. D., Fenger, M., Nielsen, J., Krane, K., Fink‐Jensen, A., Lublin, H., Ullum, H., Timm, S., Wang, A. G., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.05.026 · Cited by 31 · see citing works
Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons
Rubini, P., Pagel, G., Mehri, S., Marquardt, P., Riedel, T., & Illés, P. (2014) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-014-1005-1 · Cited by 29 · see citing works
regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes
Bennett, M. R., Farnell, L., & Gibson, W. G. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.07.024 · Cited by 28 · see citing works
Asatryan, L., Popova, M., Woodward, J. J., King, B. F., Alkana, R. L., & Davies, D. L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.044 · Cited by 27 · see citing works
Barros-Barbosa, A. R., Oliveira, Â., Lobo, M. G., Cordeiro, J. M., & Correia-de-Sá, P. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.005 · Cited by 24 · see citing works
Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?
Cai, R., Kalappa, B. I., Brozoski, T. J., Ling, L. L., & Caspary, D. M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00556.2013 · Cited by 24 · see citing works
Milius, D., Gröger‐Arndt, H., Stanchev, D., Lange‐Dohna, C., Roßner, S., Sperlágh, B., Wirkner, K., & Illés, P. (2007) · Toxicology · doi:10.1016/j.tox.2007.05.028 · Cited by 22 · see citing works
Baranowska‐Bosiacka, I., Listos, J., Gutowska, I., Machoy‐Mokrzyńska, A., Kolasa, A., Tarnowski, M., Puchałowicz, K., Prokopowicz, A., Talarek, S., Listos, P., et al. (2015) · Toxicology · doi:10.1016/j.tox.2015.10.003 · Cited by 20 · see citing works
The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression
Wang, K., Huang, S., Fu, D., Yang, X., Ma, L., Zhang, T., Zhao, W., Deng, D., Ding, Y., Zhang, Y., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14536 · Cited by 19 · see citing works
The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder
Gonçalves, M. C. B., Andrejew, R., & Gubert, C. (2022) · CNS Drugs · doi:10.1007/s40263-022-00934-0 · Cited by 19 · see citing works
Wei, Y., Guo, W., Sun, F., Fu, W., Zheng, D.-H., Chen, X., Li, S., Zang, Z., Zhang, C., Liu, S., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv003 · Cited by 19 · see citing works
Huang, H., Zheng, S., Chen, M., Xie, L., Li, Z., Guo, M. A., Wang, J., Lu, M., & Zhu, X. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101993 · Cited by 18 · see citing works
Mamad, O., Heiland, M., Lindner, A. U., Hill, T. D. M., Ronroy, R. M., Rentrup, K. F., Sanz‐Rodriguez, A., Langa, E., Heller, J. P., Moreno, Ó., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1308478 · Cited by 17 · see citing works
Ion Channel Blockers for the Treatment of Neuropathic Pain
Colombo, E. V., Francisconi, S., Faravelli, L., Izzo, E., & Pevarello, P. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.10.19 · Cited by 18 · see citing works
Morytko, M. J., Betschmann, P., Woller, K. R., Ericsson, A. M., Chen, H., Donnelly‐Roberts, D. L., Namovic, M. T., Jarvis, M. F., Carroll, W. A., & Rafferty, P. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.01.094 · Cited by 16 · see citing works
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease
Juvenal, G. D. A., Higa, G. S. V., Marques, L. B., Zampieri, T. T., Viana, F. J. C., Britto, L. R. G., Tang, Y. C., Illés, P., Virgilio, F. D., Ulrich, H., et al. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10034-x · Cited by 16 · see citing works
Effects of Acute Perinatal Asphyxia in the Rat Hippocampus
Frizzo, J. K., Cardoso, M. P., de Assis, A. M., Perry, M. L. S., Volonté, C., & Frizzo, M. E. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9492-1 · Cited by 14 · see citing works
Cellular basis of learning and memory in the carotid body
Gold, O. M. S., Bardsley, E. N., Ponnampalam, A. P., Pauža, A. G., & Paton, J. F. R. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.902319 · Cited by 15 · see citing works
Huang, L., Mut-Arbona, P., Varga, B., Török, B., Brunner, J., Arszovszki, A., Iring, A., Kisfali, M., Vizi, E. S., & Sperlágh, B. (2023) · iScience · doi:10.1016/j.isci.2023.107560 · Cited by 10 · see citing works
Jackson, T., Seifi, M., Górecki, D. C., & Swinny, J. D. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01110-6 · Cited by 10 · see citing works
Ren, X.-Y., Rubini, P., Engel, T., Tang, Y., & Illés, P. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107989 · Cited by 9 · see citing works
ATP-Mediated Signaling in the Nervous System
Sperlágh, B. (2008) · Springer eBooks · doi:10.1007/978-0-387-30382-6_10 · Cited by 9 · see citing works
Glial Purinergic Signaling‐Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders
Huang, L., Tang, Y., & Sperlágh, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1075440 · Cited by 9 · see citing works
Pathophysiological Aspects of Temporal Lobe Epilepsy and the Role of P2X Receptors
Fernandes, M. J. D. S., Naffah‐Mazzacoratti, M. D. G., & Cavalheiro, É. A. (2010) · The Open Neuroscience Journal · doi:10.2174/1874082001004010035 · Cited by 7 · see citing works
Domingos, L. B., da Silva-Júnior, A. F., Diniz, C. R. A. F., Rosa, J., Terzian, A. L. B., & Resstel, L. B. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110177 · Cited by 6 · see citing works
Purinergic Signalling in the Central Nervous System
Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_8 · Cited by 6 · see citing works
Zhang, L., Verwer, R. W. H., van Heerikhuize, J. J., Balesar, R. A., Corrêa‐da‐Silva, F., Slabe, Z., Lucassen, P. J., & Swaab, D. F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.22.516142 · Cited by 4 · see citing works
Faria, R. X., Ferreira, L. G. B., & Alves, L. A. (2012) · InTech eBooks · doi:10.5772/29146 · Cited by 2 · see citing works
Ethanol Interference on Adenosine System
Vasconcelos, S., Escudeiro, S. D. S., Luza, A., Soares, P. M., Vieira, A., Silva, L., Cilene, K., Macdo, D., Cla, F., & Fonteles, M. M. F. (2012) · InTech eBooks · doi:10.5772/33791 · Cited by 3 · see citing works
The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions
Kachappilly, N., Pizzo, P., & Basso, E. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110876 · Cited by 2 · see citing works
Kuan, Y., Li, F., Cheng, S., Chang, W.-P., & Shyu, B. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.05.014 · Cited by 2 · see citing works
Leeson, H. C., Chan‐Ling, T., Lovelace, M. D., Jeremy, B., Weible, M. W., & Gu, B. J. (2019) · Journal of Visualized Experiments · doi:10.3791/59313 · Cited by 2 · see citing works
Targeting the purinergic P2X7 receptor in epilepsy: Cell types matter
Engel, T., Salari, V., Sun, M.-J., & Mitra, M. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110973 · Cited by 1 · see citing works
Leeson, H. C., Chan‐Ling, T., Lovelace, M. D., Jeremy, B., Weible, M. W., & Gu, B. J. (2019) · Journal of Visualized Experiments · doi:10.3791/59313-v · Cited by 1 · see citing works
Hubbard, J. A., & Binder, D. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802401-0.00010-7 · Cited by 1 · see citing works
Investigating the association between P2X7 receptors, microglia and the actions of morphine
Medhurst, S. J. (2011) · Edinburgh Research Archive (University of Edinburgh)
P2X7 Receptor Regulation of Hippocampal Neural Progenitor Cells
Leeson, H. C. (2017) · Griffith Research Online · doi:10.25904/1912/2024
Ralevic, V. (2008) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60387-3
de Souza, D. G., Nonose, Y., Souza, D. O., & Almeida, R. F. (2021) · Journal of Visualized Experiments · doi:10.3791/62292
乳癌抑制遺伝子BRCA1の機能解析 : CDK2-BRCA1-NPM pathway(第105回日本外科学会定期学術集会)
太田, 智., 呉, 文., 速水, 亮., 佐藤, 工., & 福田, 護. (2005) · 日本外科学会雑誌
Friday, S. C. (2008) · Deep Blue (University of Michigan)
- Authors
- Papp, L., Vizi, E. S., & Sperlágh, B.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Venue
- Neuroreport
- Published
- 2004-10
- Volume
- 15
- Issue
- 15
- Pages
- 2387-2391
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2000362394
- Cited by
- 102
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- P2X7 receptor, GABA release, glutamate release, hippocampus, Brilliant Blue G, P2 receptor antagonists, electrical stimulation
- MeSH terms
- Adenosine Triphosphate, Analysis of Variance, Animals, Benzenesulfonates, Electric Stimulation, gamma-Aminobutyric Acid, Hippocampus, Platelet Aggregation Inhibitors, Pyridoxal Phosphate, RNA, Messenger, Tritium, Receptors, Purinergic P2, Mice, Knockout, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, Purinergic P2X7, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review