Cited by 107Adenosine and Purinergic SignalingNeuroscience and Neuropharmacology ResearchPain Mechanisms and Treatments

Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

Papp, Lilla, Vizi, E. Sylvester, Sperlágh, Beáta·2004·Neuroreport

Abstract

In this study we revealed the participation of P2X(7) receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [(3)H]glutamate and [(3)H]GABA was decreased in the hippocampus of P2X(7) receptor-deficient mice. ATP (10 mM) elicited [(3)H]glutamate and [(3)H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium (30 microM) and the P2X(7)-selective antagonist Brilliant Blue G (1 microM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R.

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Crossref · 10.1097/00001756-200410250-00017

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26 of 26 references verified0 citation errors · 0 not checkable

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  • Glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of P2X7R knockout mice.

    “In accordance with these results, glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of the P2X7R KO mice [99].”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [99]

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Authors
Papp, L., Vizi, E. S., & Sperlágh, B.
Affiliations
HUN-REN Institute of Experimental Medicine (HU)
Venue
Neuroreport
Published
2004-10
Volume
15
Issue
15
Pages
2387-2391
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2000362394
Cited by
102
References
26
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
P2X7 receptor, GABA release, glutamate release, hippocampus, Brilliant Blue G, P2 receptor antagonists, electrical stimulation
MeSH terms
Adenosine Triphosphate, Analysis of Variance, Animals, Benzenesulfonates, Electric Stimulation, gamma-Aminobutyric Acid, Hippocampus, Platelet Aggregation Inhibitors, Pyridoxal Phosphate, RNA, Messenger, Tritium, Receptors, Purinergic P2, Mice, Knockout, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, Purinergic P2X7, In Vitro Techniques

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