Recent advances in CNS P2X7 physiology and pharmacology: Focus on neuropsychiatric disorders

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

Calcia, M., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4218-9 · Cited by 710 · see citing works

Integrating neuroimmune systems in the neurobiology of depression

Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 395 · see citing works

P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390 · see citing works

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works

Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Keystone, E. C., Wang, M. M., Layton, M., Hollis, S., & McInnes, I. B. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-143578 · Cited by 318 · see citing works

Structural basis for subtype-specific inhibition of the P2X7 receptor

Karasawa, A., & Kawate, T. (2016) · eLife · doi:10.7554/elife.22153 · Cited by 308 · see citing works

Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis

Leighton, S. P., Nerurkar, L., Krishnadas, R., Johnman, C., Graham, G. J., & Cavanagh, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.205 · Cited by 291 · see citing works

The role of the innate immune system in psychiatric disorders

Jones, K. A., & Thomsen, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.002 · Cited by 274 · see citing works

Brain microglia in psychiatric disorders

Mondelli, V., Vernon, A. C., Turkheimer, F., Dazzan, P., & Pariante, C. M. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30101-3 · Cited by 262 · see citing works

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl166 · Cited by 261 · see citing works

Efficacy and Safety of CE-224,535, an Antagonist of P2X 7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

Stock, T. C., Bloom, B. J., Wei, N., Ishaq, S., Park, W., WANG, X., Gupta, P. K., & MEBUS, C. A. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.110874 · Cited by 246 · see citing works

Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7Antagonists

Nelson, D. W., Gregg, R. J., Kort, M. E., Perez‐Medrano, A., Voight, E. A., Wang, Y., Grayson, G. K., Namovic, M. T., Donnelly‐Roberts, D. L., Niforatos, W., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051202e · Cited by 235 · see citing works

Microglial activation and progressive brain changes in schizophrenia

Laskaris, L., Biase, M. A. D., Everall, I., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V., & Pantelis, C. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13364 · Cited by 227 · see citing works

Gene expression in major depressive disorder

Jansen, R., Penninx, B. W. J. H., Madar, V, Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A., van der Wee, N., Smit, J. H., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.57 · Cited by 224 · see citing works

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224 · see citing works

The microglial ATP‐gated ion channel P2X7 as a CNS drug target

Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder

Leday, G. G. R., Vértes, P. E., Richardson, S. T., Greene, J. R., Regan, T. W., Khan, S. A., Henderson, R., Freeman, T. C., Pariante, C. M., Harrison, N. A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.021 · Cited by 219 · see citing works

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

Barden, N., Harvey, M., Gagné, B., Shink, É., Tremblay, M., Raymond, C., Labbé, M., Villeneuve, A., Rochette, D., Bordeleau, L., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30303 · Cited by 201 · see citing works

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ ‐47965567

Bhattacharya, A., Wang, Q., Ao, H., Shoblock, J. R., Lord, B., Aluisio, L. E., Fraser, I. C., Nepomuceno, D. H., Neff, R. A., Welty, N., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12314 · Cited by 200 · see citing works

Microglia: Proliferation and activation driven by the P2X7 receptor

Monif, M., Burnstock, G., & Williams, D. A. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.021 · Cited by 196 · see citing works

The role of microglial P2X7: modulation of cell death and cytokine release

He, Y., Taylor, N., Fourgeaud, L., & Bhattacharya, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0904-8 · Cited by 194 · see citing works

Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder

Söderlund, J., Olsson, S. K., Samuelsson, M., Walther–Jallow, L., Johansson, C., Erhardt, S., Landén, M., & Engberg, G. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100080 · Cited by 182 · see citing works

Neuronal P2X7 Receptors Revisited: Do They Really Exist?

Illes, P., Khan, T. M., & Rubini, P. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3103-16.2017 · Cited by 179 · see citing works

Two haplotypes of the P2X 7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion

Stokes, L., Fuller, S. J., Sluyter, R., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-150862 · Cited by 174 · see citing works

The P2X7 Receptor-Interleukin-1 Liaison

Giuliani, A. L., Sarti, A. C., Falzoni, S., & Di Virgilio, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00123 · Cited by 166 · see citing works

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works

Role of neuro-immunological factors in the pathophysiology of mood disorders

Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

Wilkinson, S. M., Gunosewoyo, H., Barron, M. L., Boucher, A. A., McDonnell, M., Turner, P., Morrison, D. E., Bennett, M. R., McGregor, I. S., Rendina, L. M., et al. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500054n · Cited by 143 · see citing works

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Tan, S., Wang, Y., Chen, K., Long, Z., & Zou, J. (2017) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00131 · Cited by 142 · see citing works

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

Eser, A., Colombel, J., Rutgeerts, P. J., Vermeire, S., Vogelsang, H., Braddock, M., Persson, T., & Reinisch, W. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000514 · Cited by 138 · see citing works

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

Territo, P. R., Meyer, J. A., Peters, J. S., Riley, A. K., McCarthy, B. P., Gao, M., Wang, M., Green, M. A., Zheng, Q., & Hutchins, G. D. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.181354 · Cited by 138 · see citing works

Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression.

Koo, J. W., & Duman, R. S. (2009) · PubMed · Cited by 128 · see citing works

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

Csölle, C., Baranyi, M., Zsilla, G., Kittel, Á., Gölöncsér, F., Illes, P., Papp, E., Vizi, E. S., & Sperlágh, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066547 · Cited by 128 · see citing works

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

Karasawa, A., Michalski, K., Mikhelzon, P., & Kawate, T. (2017) · eLife · doi:10.7554/elife.31186 · Cited by 127 · see citing works

Symptoms of Postpartum Depression Associated with Elevated Levels of Interleukin-1 Beta During the First Month Postpartum

Corwin, E. J., Johnston, N., & Pugh, L. (2008) · Biological Research For Nursing · doi:10.1177/1099800408323220 · Cited by 111 · see citing works

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

Ali, Z., Laurijssens, B. E., Ostenfeld, T., McHugh, S. M., Stylianou, A., Scott‐Stevens, P., Hosking, L. K., Dewit, O., Richardson, J. C., & Chen, C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04320.x · Cited by 111 · see citing works

P2X7 Receptor as a Therapeutic Target

Marchi, E. D., Orioli, E., Ben, D. D., & Adinolfi, E. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.11.004 · Cited by 111 · see citing works

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

Boucher, A. A., Arnold, J. C., Hunt, G. E., Spiro, A., Spencer, J., Brown, C., McGregor, I. S., Bennett, M. R., & Kassiou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.049 · Cited by 108 · see citing works

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice

Csölle, C., Andó, R. D., Kittel, Á., Gölöncsér, F., Baranyi, M., Soproni, K., Zelena, D., Haller, J., Németh, T., Mócsai, A., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001933 · Cited by 108 · cited 4× · see citing works

Association between depression and the Gln460Arg polymorphism of P2RX7 gene: A dimensional approach

Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari‐Szekely, M., & Nemoda, Z. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30799 · Cited by 100 · see citing works

Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

Ory, D., Celen, S., Gijsbers, R., den Haute, C. V., Postnov, A. A., Koole, M. J. B., Vandeputte, C., Andrés, J.-I., Alcázar, J., Angelis, M. D., et al. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.169995 · Cited by 93 · see citing works

P2X7 receptor antagonists: a patent review (2010–2015)

Park, J.-H., & Kim, Y. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1246538 · Cited by 92 · see citing works

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts

Soronen, P., Mantere, O., Melartin, T. K., Suominen, K. H., Vuorilehto, M. S., Rytsälä, H. J., Arvilommi, P., Holma, I. A. K., Holma, M., Jylhä, P. J., et al. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31179 · Cited by 91 · see citing works

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A‐740003 as a novel tracer of neuroinflammation

Janssen, B., Vugts, D. J., Funke, U., et al. (2014) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3206 · Cited by 83 · see citing works

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Chrovian, C. C., Soyode-Johnson, A., Peterson, A. A., Gelin, C. F., Deng, X., Dvorak, C. A., Carruthers, N. I., Lord, B., Fraser, I. C., Aluisio, L. E., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01279 · Cited by 82 · see citing works

Localization of the gate and selectivity filter of the full-length P2X7 receptor

Pippel, A., Stolz, M., Woltersdorf, R., Kless, A., Schmalzing, G., & Markwárdt, F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610414114 · Cited by 81 · see citing works

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Duplantier, A. J., Dombroski, M. A., Subramanyam, C., Beaulieu, A. M., Chang, S.-P., Gabel, C. A., Jordan, C. K., Kalgutkar, A. S. S., Kraus, K. G., Labasi, J. M., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.04.077 · Cited by 78 · see citing works

Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression

Bhattacharya, A., & Drevets, W. C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_43 · Cited by 76 · see citing works

Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Abdi, M. H., Beswick, P., Billinton, A., Chambers, L. J., Charlton, A., Collins, S. D., Collis, K. L., Dean, D. K., Fonfría, E., Gleave, R. J., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.07.033 · Cited by 74 · see citing works

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Letavic, M. A., Savall, B. M., Allison, B. D., Aluisio, L. E., Andrés, J. I., Angelis, M. D., Ao, H., Beauchamp, D. A., Bonaventure, P., Bryant, S., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00408 · Cited by 74 · see citing works

Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432

Lord, B., Aluisio, L. E., Shoblock, J. R., Neff, R. A., Varlinskaya, E. I., Ceusters, M., Lovenberg, T. W., Carruthers, N. I., Bonaventure, P., Letavic, M. A., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.218487 · Cited by 73 · see citing works

Interleukin-1β Serum Levels is Increased in Antidepressant-Free Elderly Depressed Patients

Diniz, B. S., Teixeira, A. L., Talib, L. L., Gattaz, W. F., & Forlenza, O. V. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181c2947f · Cited by 69 · see citing works

P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders

Chrovian, C. C., Rech, J. C., Bhattacharya, A., & Letavic, M. A. (2014) · Progress in medicinal chemistry · doi:10.1016/b978-0-444-63380-4.00002-0 · Cited by 67 · see citing works

Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine

Gubert, C., Fries, G. R., Pfaffenseller, B., Ferrari, P., Coutinho‐Silva, R., Morrone, F. B., Kapczinski, F. P., & Battastini, A. M. O. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9031-z · Cited by 64 · see citing works

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

Fantoni, E., Ben, D. D., Falzoni, S., Virgilio, F. D., Lovestone, S., & Gee, A. D. (2017) · EJNMMI Research · doi:10.1186/s13550-017-0275-2 · Cited by 62 · see citing works

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis

Czamara, D., Müller-Myhsok, B., & Lucae, S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.003 · Cited by 60 · see citing works

Understanding the role of P2X7 in affective disorders—are glial cells the major players?

Stokes, L., Spencer, S. J., & Jenkins, T. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00258 · Cited by 58 · see citing works

A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334

Lord, B., Ameriks, M. K., Wang, Q., Fourgeaud, L., Vliegen, M., Verluyten, W. L. M., Haspeslagh, P., Carruthers, N. I., Lovenberg, T. W., Bonaventure, P., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.09.026 · Cited by 55 · see citing works

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms

Halmai, Z., Dome, P., Vereczkei, A., Abdul-Rahman, O., Szekely, A., Gonda, X., Faludi, G., Sasvari-Szekely, M., & Nemoda, Z. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.033 · Cited by 55 · see citing works

The role of P2X7 receptors in a rodent PCP-induced schizophrenia model

Koványi, B., Csölle, C., Calovi, S., Hanuska, A., Kató, E., Köles, L., Bhattacharya, A., Haller, J., & Sperlágh, B. (2016) · Scientific Reports · doi:10.1038/srep36680 · Cited by 52 · see citing works

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

Letavic, M. A., Lord, B., Bischoff, F., Hawryluk, N. A., Pieters, S., Rech, J. C., Sales, Z. S., Velter, A. I., Ao, H., Bonaventure, P., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400040v · Cited by 51 · see citing works

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

Otrokocsi, L., Kittel, Á., & Sperlágh, B. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx046 · Cited by 51 · see citing works

Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder

Backlund, L., Nikamo, P., Hukic, D. S., Ek, I. R., Träskman‐Bendz, L., Landén, M., Edman, G., Schalling, M., Frisén, L., & Ösby, U. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00952.x · Cited by 50 · see citing works

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

Savall, B. M., Wu, D., Angelis, M. D., Carruthers, N. I., Ao, H., Wang, Q., Lord, B., Bhattacharya, A., & Letavic, M. A. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00089 · Cited by 50 · see citing works

Lack of Association of P2RX7 Gene rs2230912 Polymorphism with Mood Disorders: A Meta-Analysis

Feng, W.-P., Zhang, B., Li, W., & Liu, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088575 · Cited by 48 · see citing works

P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1

Backlund, L., Lavebratt, C., Frisén, L., Nikamo, P., Sudic, D. H., Träskman‐Bendz, L., Landén, M., Edman, G., Vawter, M. P., Ösby, U., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043057 · Cited by 41 · see citing works

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

Chen, X., Pierce, B. S., Naing, W., Grapperhaus, M. L., & Phillion, D. P. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.03.094 · Cited by 39 · see citing works

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

Swanson, D. M., Savall, B. M., Coe, K. J., Schoetens, F., Koudriakova, T. B., Skaptason, J., Wall, J. L., Rech, J. C., Deng, X., Angelis, M. D., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00989 · Cited by 38 · see citing works

Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

Beswick, P., Billinton, A., Chambers, L. J., Dean, D. K., Fonfría, E., Gleave, R. J., Medhurst, S. J., Michel, A. D., Moses, A. P., Patel, S., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.107 · Cited by 27 · see citing works

Inflammatory illness: Why the next wave of antidepressants may target the immune system

Wetsman, N. (2017) · Nature Medicine · doi:10.1038/nm0917-1009 · Cited by 10 · see citing works

The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

P2X7 Receptor Signaling in Stress and Depression

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works

Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders

Bhattacharya, A., & Jones, D. N. C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.015 · Cited by 105 · see citing works

P2X7 Receptor: A Potential Therapeutic Target for Depression?

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