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P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease

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P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases

Zelentsova, A. S., Deykin, A. V., Soldatov, V. O., Ulezko, A. A., Borisova, A. Y., Belyaeva, V. S., Skorkina, M. Y., & Angelova, P. R. (2022) · eNeuro · doi:10.1523/eneuro.0092-22.2022 · Cited by 39 · see citing works

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

Cervetto, C., Vergani, L., Passalacqua, M., Ragazzoni, M., Venturini, A., Cecconi, F., Berretta, N., Mercuri, N. B., D’Amelio, M., Maura, G., et al. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8377-3 · Cited by 38 · see citing works

Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression

Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works

Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes

Cervetto, C., Frattaroli, D., Venturini, A., Passalacqua, M., Nobile, M., Alloisio, S., Tacchetti, C., Maura, G., Agnati, L. F., & Marcoli, M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.011 · Cited by 33 · see citing works

Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis

Grygorowicz, T., Strużyńska, L., Sułkowski, G., Chalimoniuk, M., & Sulejczak, D. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.08.021 · Cited by 33 · see citing works

Anti-Prion Activity of Brilliant Blue G

Iwamaru, Y., Takenouchi, T., Murayama, Y., Okada, H., Imamura, M., Shimizu, Y., Hashimoto, M., Mohri, S., Yokoyama, T., & Kitani, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037896 · Cited by 32 · see citing works

Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP

Cervetto, C., Maura, G., & Marcoli, M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.154955 · Cited by 32 · see citing works

Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis

Kongsui, R., Beynon, S. B., Johnson, S. J., Mayhew, J., Kuter, P., Nilsson, M., & Walker, F. R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.017 · Cited by 29 · see citing works

The P2X7 receptor as a route for non‐exocytotic glutamate release: dependence on the carboxyl tail

Cervetto, C., Alloisio, S., Frattaroli, D., Mazzotta, M. C., Milanese, M., Gavazzo, P., Passalacqua, M., Nobile, M., Maura, G., & Marcoli, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12143 · Cited by 29 · see citing works

Calmidazolium selectively inhibits exocytotic glutamate release evoked by P2X7 receptor activation

Cervetto, C., Mazzotta, M. C., Frattaroli, D., Alloisio, S., Nobile, M., Maura, G., & Marcoli, M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.034 · Cited by 29 · see citing works

regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes

Bennett, M. R., Farnell, L., & Gibson, W. G. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.07.024 · Cited by 28 · see citing works

Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity

Zhang, P., Xu, Q., Xue, L., Zheng, H., Yan, J., Xiao, Y., & Xu, G. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12663 · Cited by 28 · see citing works

Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists

Karoutzou, O., Kwak, S., Lee, S., Martínez‐Falguera, D., Sureda, F. X., Vázquez, S., Kim, Y., & Barniol‐Xicota, M. (2018) · Molecules · doi:10.3390/molecules23010230 · Cited by 27 · see citing works

Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex

Barros-Barbosa, A. R., Oliveira, Â., Lobo, M. G., Cordeiro, J. M., & Correia-de-Sá, P. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.005 · Cited by 24 · see citing works

P2X7 receptors in the central nervous system

Miras‐Portugal, M. T., Ortega, F., Gómez‐Villafuertes, R., Gualix, J., Pérez‐Sen, R., & Delicado, E. G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114472 · Cited by 24 · see citing works

P2X7 receptor activation downmodulates Na+-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes

Barros-Barbosa, A. R., Lobo, M. G., Ferreirinha, F., Correia-de-Sá, P., & Cordeiro, J. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.026 · Cited by 23 · see citing works

Heterodimer of A2A and oxytocin receptors regulating glutamate release in adult striatal astrocytes

Amato, S., Averna, M., Guidolin, D., Pedrazzi, M., Pelassa, S., Capraro, M., Passalacqua, M., Bozzo, M., Gatta, E., Anderlini, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042326 · Cited by 23 · see citing works

Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22

Leal, B., Barros‐Barbosa, A., Ferreirinha, F., Chaves, J., Rangel, R., Santos, A., Carvalho, C., Martins-Ferreira, R., Samões, R., Freitas, J., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.910662 · Cited by 23 · see citing works

Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors

Minns, M., & Trinkaus‐Randall, V. (2016) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2016.0009 · Cited by 23 · see citing works

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

Currò, D., Navarra, P., Samengo, I., & Martire, M. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01153-y · Cited by 18 · see citing works

Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders

Sáez-Orellana, F., Godoy, P. A., Silva-Grecchi, T., Barra, K., & Fuentealba, J. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.06.009 · Cited by 20 · see citing works

Urotensin II receptor and acetylcholine release from mouse cervical spinal cord nerve terminals

Bruzzone, F., Cervetto, C., Mazzotta, M. C., Bianchini, P., Ronzitti, E., Leprince, J., Diaspro, A., Maura, G., Vallarino, M. C., Vaudry, H., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.070 · Cited by 19 · see citing works

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

Battilocchio, C., Guetzoyan, L. J., Cervetto, C., Mannelli, L. D. C., Frattaroli, D., Baxendale, I. R., Maura, G., Rossi, A., Sautebin, L., Biava, M., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400079h · Cited by 18 · see citing works

The potential of the P2X7 receptor as a therapeutic target in a sub-chronic PCP-induced rodent model of schizophrenia

Huang, H., Zheng, S., Chen, M., Xie, L., Li, Z., Guo, M. A., Wang, J., Lu, M., & Zhu, X. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101993 · Cited by 18 · see citing works

Glial ATP and Large Pore Channels Modulate Synaptic Strength in Response to Chronic Inactivity

Rafael, A., Cairus, A., Tizzoni, M., Abudara, V., & Vitureira, N. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01919-0 · Cited by 17 · see citing works

Evidence for two conductive pathways in P2X7 receptor: differences in modulation and selectivity

Alloisio, S., Garbo, A. D., Barbieri, R., Bozzo, L., Ferroni, S., & Nobile, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06649.x · Cited by 17 · see citing works

Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex

Averna, M., Pellegrini, M., Cervetto, C., Pedrazzi, M., Bavestrello, M., TULLIO, R. D., Salamino, F., Pontremoli, S., & Melloni, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139750 · Cited by 16 · see citing works

Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease

Juvenal, G. D. A., Higa, G. S. V., Marques, L. B., Zampieri, T. T., Viana, F. J. C., Britto, L. R. G., Tang, Y. C., Illés, P., Virgilio, F. D., Ulrich, H., et al. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10034-x · Cited by 16 · see citing works

Purinergic modulation of glutamate transmission: An expanding role in stress-linked neuropathology

Mayhew, J., Graham, B. A., Biber, K. P. H., Nilsson, M., & Walker, F. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.023 · Cited by 13 · see citing works

P2X7 Receptors in Neurohypophysial Terminals: Evidence for their Role in Arginine‐Vasopressin Secretion

Cuadra, A. E., Custer, E. E., Bosworth, E., & Lémos, J. R. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24453 · Cited by 10 · see citing works

P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission

Vitureira, N., Rafael, A., & Abudara, V. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09965-8 · Cited by 7 · see citing works

P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice

Domingos, L. B., da Silva-Júnior, A. F., Diniz, C. R. A. F., Rosa, J., Terzian, A. L. B., & Resstel, L. B. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110177 · Cited by 6 · see citing works

Intracellular Signaling Pathways Integrating the Pore Associated with P2X7R Receptor with Other Large Pores

Ferreira, L. G. B., Reis, R. A. D. M., Alves, L. A., & Fari, R. X. (2012) · InTech eBooks · doi:10.5772/38842 · Cited by 6 · see citing works

Purinergic Signalling in the Central Nervous System

Burnstock, G., & Verkhratsky, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28863-0_8 · Cited by 6 · see citing works

Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 receptors, and therapeutic potential

Xiong, W., Su, Y., Verkhratsky, A., & Yi, C. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110705 · Cited by 3 · see citing works

Astrocyte origin of activity‐dependent release of ATP and glutamate in hippocampal slices: real‐time measurement utilizing microelectrode biosensors

Sershen, H. W. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02072.x · Cited by 3 · see citing works

The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions

Kachappilly, N., Pizzo, P., & Basso, E. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110876 · Cited by 2 · see citing works

Adenosine Metabolism

Hubbard, J. A., & Binder, D. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802401-0.00010-7 · Cited by 1 · see citing works

Efeito neuroprotetor do antagonismo do receptor P2X7 no Parkinsonismo experimental induzido por 6-OHDA

do Carmo, M. R. S. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Purinergic Signaling in Depression

Ribeiro, D. E., Kaster, M. P., Ulrich, H., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_7

P2X7 Receptor as a Therapeutic Target for Neuropathic Pain: From Mechanisms to Translational Strategies

Chen, D., Zhang, S., Guo, Y., Zhao, X., Mao, P., Hai, X., Yang, Z., & 赵光海 (2026) · Current Pain and Headache Reports · doi:10.1007/s11916-026-01511-6

BindingDB Entry 50043200: TBA

BindingDB (2014) · UC San Diego · doi:10.7270/q2jq12dd

Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals

Alloisio, S., Cervetto, C., Passalacqua, M., Barbieri, R., Maura, G., Nobile, M., & Marcoli, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.041 · Cited by 56 · see citing works

Neuronal P2X₇Receptors Are Targeted to Presynaptic Terminals in the Central and Peripheral Nervous Systems

Deuchars, S. A., Atkinson, L., Brooke, R. E., Musa, H., Milligan, C. J., Batten, T. F. C., Buckley, N. J., Parson, S. H., & Deuchars, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07143.2001 · Cited by 287 · see citing works

Involvement of P2X₇ receptors in the regulation of neurotransmitter release in the rat hippocampus

Sperlágh, B., Köfalvi, A., Deuchars, J., Atkinson, L., J. Milligan, C., Buckley, N. J., & Vizi, E. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00920.x · Cited by 264 · see citing works

P2X7 receptors exert a permissive role on the activation of release-enhancing presynaptic α7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals

Patti, L., Raiteri, L., Grilli, M., Parodi, M., Raiteri, M., & Marchi, M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.016 · Cited by 46 · see citing works

Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex

Barros-Barbosa, A. R., Oliveira, Â., Lobo, M. G., Cordeiro, J. M., & Correia-de-Sá, P. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.005 · Cited by 24 · see citing works