Cited by 125Muscle Physiology and DisordersNutrition and Health in AgingAdipokines, Inflammation, and Metabolic Diseases

A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats

Open access
Collins, Kelsey H., Paul, Heather A., Hart, David A., Reimer, Raylene A., Smith, Ian C., Rios, Jaqueline L., Seerattan, Ruth A., Herzog, Walter·2016·Scientific Reports

Abstract

The chronic low-level inflammation associated with obesity is known to deleteriously affect muscle composition. However, the manner in which obesity leads to muscle loss has not been explored in detail or in an integrated manner following a short-term metabolic challenge. In this paper, we evaluated the relationships between compromised muscle integrity, diet, systemic inflammatory mediators, adipose tissue, and gut microbiota in male Sprague-Dawley rats. We show that intramuscular fat, fibrosis, and the number of pro-inflammatory cells increased by 3-days and was sustained across 28-days of high-fat high-sugar feeding compared to control-diet animals. To understand systemic contributors to muscle damage, dynamic changes in gut microbiota and serum inflammatory markers were evaluated. Data from this study links metabolic challenge to persistent compromise in muscle integrity after just 3-days, a finding associated with altered gut microbiota and systemic inflammatory changes. These data contribute to our understanding of early consequences of metabolic challenge on multiple host systems, which are important to understand as obesity treatment options are developed. Therefore, intervention within this early period of metabolic challenge may be critical to mitigate these sustained alterations in muscle integrity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/srep37278

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Tardif N. et al. Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation. Aging Cell 13, 1001– 1011 (2014). 25139155 PMC4326920

Cited by

Sorted by citations

Authors
Collins, K. H., Paul, H. A., Hart, D. A., Reimer, R. A., Smith, I. C., Rios, J. L., Seerattan, R. A., & Herzog, W.
Affiliations
  • University of Calgary (CA)
  • University of British Columbia (CA)
Corresponding author
Herzog, Walter
Venue
Scientific Reports
Published
2016-11-17
Volume
6
Issue
1
Pages
37278-37278
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2549601621
Cited by
125
References
37
Citations by year
2026: 8 · 2025: 12 · 2024: 16 · 2023: 9 · 2022: 12 · 2021: 14 · 2020: 17 · 2019: 13 · 2018: 14 · 2017: 10
FWCI
6.41
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (13157-13-2)
  • Killam Trusts
  • Ministério da Educação
  • Alberta Innovates
  • Canadian Institutes of Health Research (36475_1, MOP115076)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
high-fat high-sugar diet, obesity, muscle integrity, muscle damage, intramuscular fat, muscle fibrosis, systemic inflammation, gut microbiota, adipose tissue, metabolic challenge, short-term dietary intervention
MeSH terms
Gastrointestinal Microbiome, Animals, Dietary Carbohydrates, Dietary Fats, Male, Rats, Sprague-Dawley, Muscle, Skeletal, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review