CoChat
Sign Up
Cited by 23Circadian rhythm and melatoninSleep and Wakefulness ResearchImpact of Light on Environment and Health

Transient anhedonia phenotype and altered circadian timing of behaviour during night-time dim light exposure in Per3−/− mice, but not wildtype mice

Open access
Martynhak, Bruno Jacson, Hogben, Alexandra L., Zanos, Panos, Georgiou, Polymnia, Andreatini, Roberto, Kitchen, Ian, Archer, Simon N., von Schantz, Malcolm +2 more·2017·Scientific Reports
DOI 10.1038/srep40399PMC PMC5223197
Open this paper in CoChat — free accountOpen PDF

Abstract

Industrialisation greatly increased human night-time exposure to artificial light, which in animal models is a known cause of depressive phenotypes. Whilst many of these phenotypes are ‘direct’ effects of light on affect, an ‘indirect’ pathway via altered sleep-wake timing has been suggested. We have previously shown that the Period3 gene, which forms part of the biological clock, is associated with altered sleep-wake patterns in response to light. Here, we show that both wild-type and Per3−/− mice showed elevated levels of circulating corticosterone and increased hippocampal Bdnf expression after 3 weeks of exposure to dim light at night, but only mice deficient for the PERIOD3 protein (Per3−/−) exhibited a transient anhedonia-like phenotype, observed as reduced sucrose preference, in weeks 2–3 of dim light at night, whereas WT mice did not. Per3−/− mice also exhibited a significantly smaller delay in behavioural timing than WT mice during weeks 1, 2 and 4 of dim light at night exposure. When treated with imipramine, neither Per3−/− nor WT mice exhibited an anhedonia-like phenotype, and neither genotypes exhibited a delay in behavioural timing in responses to dLAN. While the association between both Per3−/− phenotypes remains unclear, both are alleviated by imipramine treatment during dim night-time light.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/srep40399

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Studies have reported no association between light at night and mood in C57Bl/6 mice, suggesting a potential strain-specific effect of light at night.

    “However, studies have also reported no association between LAN and mood in C57Bl/6 mice suggesting a potential strain specific effect of LAN96,97.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [96]

    The Results (Sucrose preference; page unavailable) report no reduction in sucrose preference in wild-type mice during four weeks of dim light at night. The Discussion identifies the model as C57bl/6 and contrasts it with a different strain in which depressive-like behaviour had been reported. This supports a possible strain difference, but the study measured only sucrose preference during this exposure period, not an absence of any association between light at night and mood generally. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 71 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Martynhak, B. J., Hogben, A. L., Zanos, P., Georgiou, P., Andreatini, R., Kitchen, I., Archer, S. N., von Schantz, M., Bailey, A., & van der Veen, D. R.
Affiliations
  • University of Surrey (GB)
  • Universidade Federal do Paraná (BR)
  • St George's, University of London (GB)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-01-10
Volume
7
Issue
1
Pages
40399-40399
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep40399
PMC
PMC5223197
OpenAlex
W2570210165
Cited by
23
References
71
Citations by year
2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Northumbria Research Link (Northumbria University) (acceptedVersion)
  • St George's Online Research Archive (St George's University of London) (acceptedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords
circadian rhythm, dim light at night, artificial light exposure, anhedonia, sucrose preference, corticosterone, brain-derived neurotrophic factor, hippocampus, sleep timing, imipramine, depression, biological clock
MeSH terms
Animals, Circadian Rhythm, Gene Expression Regulation, Hippocampus, Humans, Imipramine, Motor Activity, Sleep, Sleep Wake Disorders, Photoperiod, Mice, Knockout, Brain-Derived Neurotrophic Factor, Mice, Period Circadian Proteins, Circadian Clocks, Anhedonia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review