Chronic social defeat reduces myelination in the mouse medial prefrontal cortex

Lehmann, Michael L.; Weigel, Thaddeus K.; Elkahloun, Abdel G.; Herkenham, Miles

doi:10.1038/srep46548

Cited by 130Stress Responses and CortisolTreatment of Major DepressionNeurogenesis and neuroplasticity mechanisms

Chronic social defeat reduces myelination in the mouse medial prefrontal cortex

Open access

Lehmann, Michael L., Weigel, Thaddeus K., Elkahloun, Abdel G., Herkenham, Miles·2017·Scientific Reports

DOI 10.1038/srep46548PMC PMC5394533

Open this paper in CoChat — free account Open PDF

Abstract

The medial prefrontal cortex (mPFC) plays a key role in top-down control of the brain’s stress axis, and its structure and function are particularly vulnerable to stress effects, which can lead to depression in humans and depressive-like states in animals. We tested whether chronic social defeat produces structural alterations in the mPFC in mice. We first performed a microarray analysis of mPFC gene expression changes induced by defeat, and biological pathway analysis revealed a dominant pattern of down-regulation of myelin-associated genes. Indeed, 69% of the most significantly down-regulated genes were myelin-related. The down regulation was confirmed by in situ hybridization histochemistry for two strongly down-regulated genes, myelin oligodendrocyte glycoprotein ( Mog ) and ermin ( Ermn ), and by immunohistochemistry for myelin basic protein. To test for stress-induced changes in myelin integrity, aurophosphate (Black Gold) myelin staining was performed on mPFC sections. Quantitative stereologic analysis showed reduced myelinated fiber length and density. Behavioral analysis confirmed that the 14-day social defeat sessions resulted in induction of depressive-like states measured in social interaction and light/dark tests. The combined data suggest that chronic social defeat induces molecular changes that reduce myelination of the prefrontal cortex, which may be an underlying basis for stress-induced depressive states.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/srep46548

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chronic social defeat for up to two weeks is associated with reduction of myelination particularly in the mPFC, hippocampus and nucleus accumbens.
“Chronic social defeat for up to two weeks is associated with reduction of myelination particularly in the mPFC, hippocampus and nucleus accumbens [48,49]”
From Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies (2025) · cites this paper as [49]
The Abstract reports reduced myelinated fiber length and density in the mouse mPFC after 14 days of social defeat. It does not report reduced myelination in the hippocampus or nucleus accumbens, so those regions are not supported by this source. (LLM, conf=0.90)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Stress and the Individual
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472 · see citing works
White matter in learning, cognition, and psychiatric disorders
Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Subcortical brain alterations in major depressive disorder: Findings from the ENIGMA Major Depressive Disorder working group
for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172 · see citing works
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
A critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922 · see citing works
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858 · see citing works
A new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794 · see citing works
Impaired adult myelination in the prefrontal cortex of socially isolated mice
Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685 · see citing works
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659 · see citing works
A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge
Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., Kim, S.-Y., Adhikari, A., Tye, K. M., Frank, L. M., & Deisseroth, K. (2012) · Nature · doi:10.1038/nature11617 · Cited by 645 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Forward frontal fields: phylogeny and fundamental function
Wise, S. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.008 · Cited by 478 · see citing works
Anterior Cingulate, Gyrus Rectus, and Orbitofrontal Abnormalities in Elderly Depressed Patients: An MRI-Based Parcellation of the Prefrontal Cortex
Ballmaier, M., Toga, A. W., Blanton, R. E., Sowell, E. R., Lavretsky, H., Peterson, J. R., Pham, D. L., & Kumar, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.99 · Cited by 384 · see citing works
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works
Abnormal Structural Networks Characterize Major Depressive Disorder: A Connectome Analysis
Korgaonkar, M. S., Fornito, A., Williams, L. M., & Grieve, S. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.018 · Cited by 367 · see citing works
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr, M., Valentine, G. W., Li, X., Gourley, S. L., Taylor, J. R., & Duman, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.006 · Cited by 341 · see citing works
Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats
Hamani, C., Diwan, M., Macedo, C. E., Brandão, M. L., Shumake, J., Gonzalez-Lima, F., Raymond, R., Lozano, A. M., Fletcher, P. J., & Nobrega, J. N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.025 · Cited by 324 · see citing works
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
Schloesser, R. J., Lehmann, M., Martinowich, K., Manji, H. K., & Herkenham, M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.34 · Cited by 319 · see citing works
Self-citation
Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
Klempan, T. A., Sequeira, A., Canetti, L., Lalovic, A., Ernst, C., ffrench-Mullen, J., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002110 · Cited by 294 · see citing works
Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis
Lee, S., Park, J., Lee, W., Kim, H., Park, H., Mori, K., & Suk, K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5273-08.2009 · Cited by 280 · see citing works
Environmental Enrichment Confers Stress Resiliency to Social Defeat through an Infralimbic Cortex-Dependent Neuroanatomical Pathway
Lehmann, M. L., & Herkenham, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0577-11.2011 · Cited by 234 · see citing works
Self-citation
Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression Implications for pathophysiology of DST nonsuppression
Holsboer, F., von Bardeleben, U., Wiedemann, K., Müller, O. A., & Stalla, G. K. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90237-x · Cited by 221 · see citing works
Subcortical Brain Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group
Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E. A., Tiemeier, H. W., Albert Hofman, D., Niessen, W. J., et al. (2015) · QUT ePrints (Queensland University of Technology) · Cited by 207 · see citing works
White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies
Tham, M. W., Woon, P. S., Sum, M. Y., Lee, T.-S. W., & Sim, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.013 · Cited by 206 · see citing works
Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2
Birey, F., Kloc, M. L., Chavali, M., Hussein, I., Wilson, M., Christoffel, D. J., Chen, T., Frohman, M. A., Robinson, J. K., Russo, S. J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.046 · Cited by 204 · see citing works
Stereological length estimation using spherical probes
Mouton, P. R., Gokhale, A. M., Ward, N. L., & West, M. J. (2002) · Journal of Microscopy · doi:10.1046/j.1365-2818.2002.01006.x · Cited by 203 · see citing works
Neurons express hemoglobin α‐ and β‐chains in rat and human brains
Richter, F., Meurers, B. H., Zhu, C., Medvedeva, V. P., & Chesselet, M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22062 · Cited by 202 · see citing works
Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain
Alonso, G. (2000) · Glia · doi:10.1002/1098-1136(200009)31:3 · Cited by 191 · see citing works
Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
Mucha, M. W., Skrzypiec, A. E., Schiavon, E., Attwood, B. K., Kucerova, E., & Pawlak, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107936108 · Cited by 189 · see citing works
A putative functional role for oligodendrocytes in mood regulation
Edgar, N. M., & Sibille, E. L. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.34 · Cited by 186 · see citing works
Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression
Regenold, W. T., Phatak, P., Marano, C. M., Gearhart, L., Viens, C. H., & Hisley, K. C. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.12.019 · Cited by 178 · see citing works
A review of white matter microstructure alterations of pathways of the reward circuit in depression
Bracht, T., Linden, D. E. J., & Keedwell, P. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.041 · Cited by 172 · see citing works
Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis
Lehmann, M. L., Brachman, R. A., Martinowich, K., Schloesser, R. J., & Herkenham, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3878-12.2013 · Cited by 168 · see citing works
Self-citation
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67911 · Cited by 148 · see citing works
PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress
Lehmann, M. L., Mustafa, T., Eiden, A. M., Herkenham, M. A., & Eiden, L. E. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.006 · Cited by 132 · see citing works
Self-citation
Ermin, A Myelinating Oligodendrocyte-Specific Protein That Regulates Cell Morphology
Brockschnieder, D., Sabanay, H., Riethmacher, D., & Peles, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-05.2006 · Cited by 128 · see citing works
Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
Kim, S., & Webster, M. J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.99 · Cited by 127 · see citing works
A Pi Form of Glutathione‐S‐Transferase Is a Myelin‐and Oligodendrocyte‐Associated Enzyme in Mouse Brain
Tansey, F. A., & Cammer, W. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02104.x · Cited by 120 · see citing works
A New Model of Cuprizone-Mediated Demyelination/Remyelination
Sachs, H. H., Bercury, K., Popescu, D., Narayanan, S., & Macklin, W. B. (2014) · ASN Neuro · doi:10.1177/1759091414551955 · Cited by 115 · see citing works
Plasma Corticosterone Activates SGK1 and Induces Morphological Changes in Oligodendrocytes in Corpus Callosum
Miyata, S., Koyama, Y., Takemoto, K., Yoshikawa, K., Ishikawa, T., Taniguchi, M., Inoue, K., Aoki, M., Hori, O., Katayama, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019859 · Cited by 114 · see citing works
Cortical Control of Affective Networks
Kumar, S., Black, S. J., Hultman, R., Szabo, S. T., DeMaio, K. D., Du, J., Katz, B. M., Feng, G., Covington, H. E., & Dzirasa, K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0092-12.2013 · Cited by 110 · see citing works
Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression
Miyata, S., Taniguchi, M., Koyama, Y., Shimizu, S., Tanaka, T., Yasuno, F., Yamamoto, A., Iida, H., Kudo, T., Katayama, T., et al. (2016) · Scientific Reports · doi:10.1038/srep23084 · Cited by 102 · see citing works
Lipocalin 2 is a Choroid Plexus Acute-Phase Protein
Marques, F., Rodrigues, A. J., Sousa, J. C., Coppola, G., Geschwind, D. H., Sousa, N., Correia‐Neves, M., & Palha, J. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600557 · Cited by 95 · see citing works
Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression
Orsetti, M., Brisco, F. D., Canonico, P. L., Genazzani, A. A., & Ghi, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06155.x · Cited by 87 · see citing works
Social stress increases expression of hemoglobin genes in mouse prefrontal cortex
Stankiewicz, A. M., Gościk, J., Swiergiel, A. H., Majewska, A., Wieczorek, M., Juszczak, G. R., & Lisowski, P. (2014) · BMC Neuroscience · doi:10.1186/s12868-014-0130-6 · Cited by 86 · see citing works
Stress-induced changes in primate prefrontal profiles of gene expression
Karssen, A. M., Her, S., Li, J. Z., Patel, P. D., Meng, F., Bunney, W. E., Jones, E. G., Watson, S. J., Akil, H., Myers, R., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002095 · Cited by 82 · see citing works
A Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders
Gorman, J. M., & Docherty, J. P. (2010) · Journal of Neuropsychiatry · doi:10.1176/jnp.2010.22.3.256 · Cited by 79 · see citing works
White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study
Zuo, N., Fang, J., Lv, X., Zhou, Y., Yang, H., Li, T., Tong, H., Wang, X., Wang, W.-D., & Jiang, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037561 · Cited by 74 · see citing works
Translation-State Analysis of Gene Expression in Mouse Brain after Focal Ischemia
MacManus, J. P., Graber, T. E., Luebbert, C., Preston, E., Rasquinha, I., Smith, B., & Webster, J. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000123141.67811.91 · Cited by 61 · see citing works
Urine Scent Marking (USM): A Novel Test for Depressive-Like Behavior and a Predictor of Stress Resiliency in Mice
Lehmann, M. L., Geddes, C. E., Lee, J. L., & Herkenham, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069822 · Cited by 56 · see citing works
Self-citation
Altered white matter integrity in individuals with cognitive vulnerability to depression: a tract-based spatial statistics study
Xiao, J., He, Y., McWhinnie, C. M., & Yao, S. (2015) · Scientific Reports · doi:10.1038/srep09738 · Cited by 53 · see citing works
A novel, rapid, quantitative cell-counting method reveals oligodendroglial reduction in the frontopolar cortex in major depressive disorder
Hayashi, Y., Nihonmatsu-Kikuchi, N., Yu, X., Ishimoto, K., Hisanaga, S.-I., & Tatebayashi, Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.84 · Cited by 52 · see citing works
Reduced evoked fos expression in activity-related brain regions in animal models of behavioral depression
Stone, E. A., Lehmann, M. L., Lin, Y., & Quartermain, D. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.04.010 · Cited by 42 · see citing works
Self-citation
The recovery trajectory of adolescent social defeat stress-induced behavioral, 1H-MRS metabolites and myelin changes in Balb/c mice
Zhang, H., Yan, G., Xu, H., Fang, Z., Zhang, J., Zhang, J., Wu, R., Kong, J., & Huang, Q. (2016) · Scientific Reports · doi:10.1038/srep27906 · Cited by 42 · see citing works
Brain Alpha- and Beta-Globin Expression after Intracerebral Hemorrhage
He, Y., Hua, Y., Lee, J.-Y., Liu, W., Keep, R. F., Wang, M. M., & Xi, G. (2010) · Translational Stroke Research · doi:10.1007/s12975-009-0004-x · Cited by 41 · see citing works
Chronic stress regulates NG2+ cell maturation and myelination in the prefrontal cortex through induction of death receptor 6
Yang, Y., Zhang, Y., Luo, F., & Li, B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.01.003 · Cited by 38 · see citing works
Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
Barreto, R. A., Walker, F. R., Dunkley, P. R., Day, T. A., & Smith, D. W. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-125 · Cited by 37 · see citing works
Identification of oligodendrocytes in experimental disease models
Ness, J. K., Valentino, M., McIver, S. R., & Goldberg, M. P. (2005) · Glia · doi:10.1002/glia.20206 · Cited by 31 · see citing works
A Hypothesized Role for Dendritic Remodeling in the Etiology of Mood and Anxiety Disorders
Gorman, J. M., & Docherty, J. P. (2010) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.22.3.256 · Cited by 22 · see citing works
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Sarlus, H., Wang, X., Cedazo-Mı́nguez, Á., Schultzberg, M., & Oprica, M. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-99 · Cited by 21 · see citing works
Development of myelination and cholinergic innervation in the central auditory system of a prosimian primate (Otolemur garnetti)
Miller, D. J., Lackey, E. P., Hackett, T. A., & Kaas, J. H. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23379 · Cited by 15 · see citing works
Oligodendrocytes as glucocorticoids target cells: functional analysis of the glycerol phosphate dehydrogenase gene
Cheng, J. D., & de Vellis, J. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000201)59:3

Flagged first, then by citations

Research works printed but not linked: 1

Paxinos G. & Franklin K. B. J. The mouse brain in stereotaxic coordinates. Compact 2nd edn, (Elsevier Academic Press, 2004).

Sorted by citations

Oligodendrocyte lineage cells and depression
Zhou, B., Zhu, Z., Ransom, B. R., & Tong, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00930-0 · Cited by 239 · see citing works
Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms
Teissier, A., Magueresse, C. L., Olusakin, J., da Costa, B. L. S. A., Stasi, A. M. D., Bacci, A., Kawasawa, Y. I., Vaidya, V. A., & Gaspar, P. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0493-2 · Cited by 154 · see citing works
Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior
Ferreira, A. C. E., Neves, P., & Gozzelino, R. (2019) · Pharmaceuticals · doi:10.3390/ph12030126 · Cited by 148 · see citing works
The Behavioral Sequelae of Social Defeat Require Microglia and Are Driven by Oxidative Stress in Mice
Lehmann, M. L., Weigel, T. K., Poffenberger, C. N., & Herkenham, M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0184-19.2019 · Cited by 138 · see citing works
Self-citation
Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice
Bonnefil, V., Dietz, K., Amatruda, M., Wentling, M., Aubry, A. V., Dupree, J. L., Temple, G., Park, H.-J., Burghardt, N. S., Casaccia, P., et al. (2019) · eLife · doi:10.7554/elife.40855 · Cited by 123 · see citing works
Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice
Jafari, Z., Kolb, B. E., & Mohajerani, M. H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.06.011 · Cited by 113 · see citing works
Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
Lehmann, M. L., Weigel, T. K., Cooper, H. A., Elkahloun, A. G., Kigar, S. L., & Herkenham, M. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-28737-8 · Cited by 96 · see citing works
Self-citation
Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress
Liu, J., Dietz, K., Hodes, G. E., Russo, S. J., & Casaccia, P. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22533 · Cited by 75 · see citing works
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 70 · see citing works
Adolescent maturation of the prefrontal cortex: Role of stress and sex in shaping adult risk for compromise
Shaw, G. A., Dupree, J. L., & Neigh, G. N. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12626 · Cited by 74 · see citing works
Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
Kokkosis, A. G., Madeira, M. M., Mullahy, M., & Tsirka, S. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01512-y · Cited by 70 · see citing works
The Effects of Chronic Stress on Brain Myelination in Humans and in Various Rodent Models
Antontseva, E. V., Bondar, N. P., Reshetnikov, V. V., & Merkulova, T. I. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.013 · Cited by 64 · see citing works
Disrupted Folate Metabolism with Anesthesia Leads to Myelination Deficits Mediated by Epigenetic Regulation of ERMN
Zhang, L., Xue, Z., Liu, Q., Liu, Y., Xi, S., Cheng, Y., Li, J., Yan, J., Shen, Y., Xiao, C., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.04.048 · Cited by 64 · see citing works
Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression
Khan, A. R., Geiger, L., Wiborg, O., & Czéh, B. (2020) · Cells · doi:10.3390/cells9041026 · Cited by 62 · see citing works
Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress
Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., Saarnio, S., Balcells, I., Ameslon, P., Greco, D., et al. (2018) · eNeuro · doi:10.1523/eneuro.0166-18.2018 · Cited by 63 · see citing works
Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
Luo, Y., Xiao, Q., Wang, J., Jiang, L. H., Hu, M., Jiang, Y., Tang, J., Liang, X., Qi, Y., Dou, X., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0662-8 · Cited by 57 · see citing works
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 56 · see citing works
Adult neurogenesis and its role in brain injury and psychiatric diseases
Hayashi, Y., Jinnou, H., Sawamoto, K., & Hitoshi, S. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14557 · Cited by 55 · see citing works
Analysis of cerebrovascular dysfunction caused by chronic social defeat in mice
Lehmann, M. L., Poffenberger, C. N., Elkahloun, A. G., & Herkenham, M. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.030 · Cited by 49 · see citing works
Self-citation
Circuit-Based Biomarkers for Mood and Anxiety Disorders
Xia, F., & Kheirbek, M. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.004 · Cited by 54 · see citing works
The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression
Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Xia, S.-H., Zinsmaier, A. K., Tan, C., Li, W., Browne, C. J., Walker, D. M., Salery, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9494 · Cited by 53 · see citing works
Chronic Unpredictable Stress Reduces Immunostaining for Connexins 43 and 30 and Myelin Basic Protein in the Rat Prelimbic and Orbitofrontal Cortices
Miguel-Hidalgo, J. J., Moulana, M., Deloach, P. H., & Rajkowska, G. (2018) · Chronic Stress · doi:10.1177/2470547018814186 · Cited by 49 · see citing works
Function and Mechanism of Myelin Regulation in Alcohol Abuse and Alcoholism
Rice, J., & Gu, C. (2019) · BioEssays · doi:10.1002/bies.201800255 · Cited by 49 · see citing works
Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine
Huang, C., Wu, Z., Wang, D., Qu, Y., Zhang, J., Jiang, R., Xu, X., Xu, X., Wang, Y., Liu, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02288-5 · Cited by 48 · see citing works
Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders
Birey, F., Kokkosis, A. G., & Aguirre, A. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.016 · Cited by 46 · see citing works
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation
Lynall, M.-E., Kigar, S. L., Lehmann, M. L., DePuyt, A. E., Tuong, Z. K., Listwak, S. J., ELKAHLOUN, A. G., Bullmore, E. T., Herkenham, M. A., & Clatworthy, M. R. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.002 · Cited by 43 · see citing works
Self-citation
Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities
Huang, Z., Zhang, Y., Zou, P., Zong, X., & Zhang, Q. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00861-w · Cited by 46 · see citing works
Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice
Jin, C., Kang, H., Ryu, J. R., Kim, S., Zhang, Y., Lee, Y., Kim, Y., & Han, K. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00250 · Cited by 41 · see citing works
Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress
Reshetnikov, V. V., Kisaretova, P. E., Ershov, N., Merkulova, T. I., & Bondar, N. P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110068 · Cited by 40 · see citing works
Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans
Long, K. L. P., Chao, L. L., Kazama, Y., An, A., Hu, K. Y., Peretz, L., Muller, D. C. Y., Roan, V. D., Misra, R., Toth, C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01745-5 · Cited by 41 · see citing works
Juvenile exposure to acute traumatic stress leads to long-lasting alterations in grey matter myelination in adult female but not male rats
Breton, J., Barraza, M. K., Hu, K. Y., Frias, S. J., Long, K. L. P., & Kaufer, D. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100319 · Cited by 33 · see citing works
CCR2 monocytes repair cerebrovascular damage caused by chronic social defeat stress
Lehmann, M. L., Samuels, J. D., Kigar, S. L., Poffenberger, C. N., Lotstein, M. L., & Herkenham, M. A. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.011 · Cited by 30 · see citing works
Self-citation
Effects of chronic social stress on oligodendrocyte proliferation-maturation and myelin status in prefrontal cortex and amygdala in adult mice
Poggi, G., Albiez, J., & Pryce, C. R. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100451 · Cited by 31 · see citing works
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles
Sadino, J. M., Bradeen, X., Kelly, C. J., Brusman, L. E., Walker, D. M., & Donaldson, Z. R. (2023) · eLife · doi:10.7554/elife.80517 · Cited by 28 · see citing works
Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice
Takahashi, K., Kurokawa, K., Hong, L., Miyagawa, K., Mochida-Saito, A., Iwasa, M., Iwasa, H., Nakagawasai, O., Tadano, T., Takeda, H., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.01.047 · Cited by 29 · see citing works
Abnormal oligodendrocyte function in schizophrenia explains the long latent interval in some patients
Fessel, J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01879-0 · Cited by 28 · see citing works
The role of adolescent sleep quality in the development of anxiety disorders: A neurobiologically-informed model
Jamieson, D., Shan, Z., Lagopoulos, J., & Hermens, D. F. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101450 · Cited by 28 · see citing works
Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior
Takahashi, K., Kurokawa, K., Hong, L., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105112 · Cited by 28 · see citing works
Social cognitive neuroscience in the digital age
Doheny, M. M., & Lighthall, N. R. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1168788 · Cited by 27 · see citing works
Social Defeat Stress in Adolescent Mice Induces Depressive-like Behaviors with Reduced Oligodendrogenesis
Shimizu, T., Ishida, A., Hagiwara, M., Ueda, Y., Hattori, A., Tajiri, N., & Hida, H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.002 · Cited by 26 · see citing works
Dysmyelination by Oligodendrocyte‐Specific Ablation of Ninj2 Contributes to Depressive‐Like Behaviors
Sun, Y., Chen, X., Ou, Z., Wang, Y., Chen, W., Zhao, T., Liu, C., & Chen, Y. (2021) · Advanced Science · doi:10.1002/advs.202103065 · Cited by 24 · see citing works
Serotonin Signals Overcome Loser Mentality in Drosophila
Hu, S. W., Yang, Y. T., Sun, Y., Zhan, Y., & Zhu, Y. (2020) · iScience · doi:10.1016/j.isci.2020.101651 · Cited by 23 · see citing works
Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia
Li, M., Xiao, L., & Chen, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.823708 · Cited by 23 · see citing works
Immunology of oligodendrocyte precursor cells in vivo and in vitro
Antel, J. P., Lin, Y. H., Cui, Q., Pernin, F., Kennedy, T. E., Ludwin, S. K., & Healy, L. M. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.006 · Cited by 22 · see citing works
Paternal bisphenol a diet changes prefrontal cortex proteome and provokes behavioral dysfunction in male offspring
Luo, G., Wei, R., Wang, S., & Wang, J. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.06.050 · Cited by 21 · see citing works
Fear Deficits in HypomyelinatedTpppKnock-Out Mice
Nguyen, H., Meservey, L. M., Ishiko, N., Zhou, M., Huang, T., & Fu, M. (2020) · eNeuro · doi:10.1523/eneuro.0170-20.2020 · Cited by 20 · see citing works
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
Caldwell, M., Ayo‐Jibunoh, V., Mendoza, J. C., Brimblecombe, K. R., Reynolds, L. M., Jiang, X. Y. Z., Alarcon, C., Fiore, E., Tomaio, J. N., Phillips, G. R., et al. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02695-y · Cited by 18 · see citing works
Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult
Ziaei, A., Garcia‐Miralles, M., Radulescu, C. I., Sidik, H., Silvin, A., Bae, H., Bonnard, C., Yusof, N. A. B. M., Bardile, C. F., Tan, L. J., et al. (2022) · Brain Pathology · doi:10.1111/bpa.13064 · Cited by 17 · see citing works
The GABA(B1) receptor within the infralimbic cortex is implicated in stress resilience and vulnerability in mice
Zou, H.-W., Li, Z.-L., Jing, X.-Y., Wang, Y., Liu, Y.-J., & Li, L. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113240 · Cited by 16 · see citing works
White Matter Changes Following Chronic Restraint Stress and Neuromodulation: A Diffusion Magnetic Resonance Imaging Study in Young Male Rats
Seewoo, B., Feindel, K., Won, Y., Joos, A., Figliomeni, A., Hennessy, L. A., & Rodger, J. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.08.006 · Cited by 13 · see citing works
Effects of 17β-trenbolone exposure on sex hormone synthesis and social behaviours in adolescent mice
Zhang, S., Zhang, S., Zhu, D., Jiao, Z., Zhao, X. J., Sun, M., Che, Y., & Feng, X. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125679 · Cited by 17 · see citing works
Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A Longitudinal in vivo Diffusion Tensor Imaging Study
Nagy, S. A., Vranesics, A., Varga, Z., Csabai, D., Bruszt, N., Bali, Z. K., Perlaki, G., Hernádi, I., Berente, Z., Miseta, A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00474 · Cited by 15 · see citing works
Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments
Stankiewicz, A. M., Jaszczyk, A., Gościk, J., & Juszczak, G. R. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110558 · Cited by 15 · see citing works
Nutritional interventions for promoting stress resilience: Recent progress using psychosocial stress models of rodents
Toyoda, A. (2020) · Animal Science Journal · doi:10.1111/asj.13478 · Cited by 16 · see citing works
Down-regulation of ERMN expression in relapsing remitting multiple sclerosis
Esfahani, B. S., Gharesouran, J., Ghafouri‐Fard, S., Talebian, S., Arsang‐Jang, S., Omrani, M. D., Taheri, M. N., & Rezazadeh, M. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00429-w · Cited by 14 · see citing works
A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex
Frankowska, M., Surówka, P., Gawlińska, K., Borczyk, M., Korostyński, M., Filip, M., & Smaga, I. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1303718 · Cited by 13 · see citing works
Transcriptomic signature of early life stress in male rat prefrontal cortex
Green, N. F. O., Maniam, J., Riese, J., Morris, M. J., & Voineagu, I. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100316 · Cited by 13 · see citing works
Experience-related reductions of myelin and axon diameter in adulthood
Lazari, A., Koudelka, S., & Sampaio‐Baptista, C. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00070.2018 · Cited by 13 · see citing works
The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
Xu, Y., Fang, Z., Wu, C., Xu, H., Kong, J., Huang, Q., & Zhang, H. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s247497 · Cited by 12 · see citing works
Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus
Kurokawa, K., Takahashi, K., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105213 · Cited by 12 · see citing works
Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway
Fu, A., Qiao, F., Feng, H., & Luo, Q. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114464 · Cited by 13 · see citing works
General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain
Hang, W., 浙江大学医学院附属第一医院麻醉科, 浙. 杭. 3., Yang, Y.-C., Hu, Y.-H., Fang, F.-Q., Wang, L., Qian, X.-H., McQuillan, P. M., Xiong, H., Leng, J., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.413 · Cited by 11 · see citing works
Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse
Louie, A. Y., Kim, J. S., Drnevich, J. M., Dibaeinia, P., Koito, H., Sinha, S., McKim, D. B., Soto‐Díaz, K., Nowak, R. A., Das, A., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02862-2 · Cited by 11 · see citing works
Pathophysiology in cortico-amygdala circuits and excessive aversion processing: the role of oligodendrocytes and myelination
Poggi, G., Klaus, F., & Pryce, C. R. (2024) · Brain Communications · doi:10.1093/braincomms/fcae140 · Cited by 10 · see citing works
Understanding the Links among Maternal Diet, Myelination, and Depression: Preclinical and Clinical Overview
Smaga, I. (2022) · Cells · doi:10.3390/cells11030540 · Cited by 11 · see citing works
A Rapamycin-Inducible Glial-Neurovascular Network Promotes Adaptation after Chronic Social Defeat
Vennin, C., Hewel, C., Todorov, H., Wendelmuth, M., Radyushkin, K., Heimbach, A., Horenko, I., Ayash, S., Müller, M. B., Schweiger, S., et al. (2022) · Cells · doi:10.3390/cells11213405 · Cited by 10 · see citing works
Node of Ranvier remodeling in chronic psychosocial stress and anxiety
Koskinen, M.-K., Laine, M. A., Abdollahzadeh, A., Gigliotta, A., Mazzini, G., Journée, S. H., Alenius, V., Trontti, K., Tohka, J., Hyytiä, P., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01568-6 · Cited by 10 · see citing works
Low myelin-related values in the fornix and thalamus of 7 Tesla MRI of major depressive disorder patients
Shim, J.-M., Cho, S., Kang, C., & Kang, S. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1214738 · Cited by 8 · see citing works
Rapamycin Exerts an Antidepressant Effect and Enhances Myelination in the Prefrontal Cortex of Chronic Restraint Stress Mice
Zhang, J., Li, W., Qi, Y., Liu, L., Hou, S., & Ju, J. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.10.025 · Cited by 10 · see citing works
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential
Deng, Q., Parker, E., Wu, C., Zhu, L., Liu, T. C., Duan, R., & Yang, L. (2024) · Aging and Disease · doi:10.14336/ad.2024.0239 · Cited by 10 · see citing works
Alteration in NMDAR subunits in different brain regions of chronic unpredictable mild stress (CUMS) rat model
Chen, J., Luo, Y., Liang, X., Kong, X., Xiao, Q., Tang, J., Qi, Y., Tang, Y. C., & Xiu, Y. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0255 · Cited by 9 · see citing works
Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making
Alizamini, M. M., Chen, X., Nie, L., Dai, Z., Liu, Y., Haghparast, A., Wu, N., Zhang, J., Shen, F., Sui, N., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110523 · Cited by 9 · see citing works
Acute stress reveals different impacts in male and female Zdhhc7-deficient mice
Kerkenberg, N., Hohoff, C., Zhang, M., Lang, I., Schettler, C., Ponimaskin, E. G., Wachsmuth, L., Faber, C., Baune, B. T., & Zhang, W. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02275-y · Cited by 9 · see citing works
Functional genomic insights into the environmental determinants of mammalian fitness
Snyder‐Mackler, N., & Lea, A. J. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.08.001 · Cited by 11 · see citing works
A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data
Xiong, J., Hagenauer, M. H., Rhoads, C. A., Flandreau, E. I., Rempel-Clower, N., Hernandez, E., Nguyen, D. M., Saffron, A., Duan, T. Q., Watson, S. J., et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71197 · Cited by 8 · see citing works
Chronic social defeat stress caused region-specific oligodendrogenesis impairment in adolescent mice
Chen, H., Kang, Z., Liu, X., Zhao, Y., Fang, Z., Zhang, J., & Zhang, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1074631 · Cited by 8 · see citing works
Dominant and Subordinate Relationship Formed by Repeated Social Encounters Alters Gut Microbiota in Greater Long-Tailed Hamsters
Zhao, J., Li, G., Lü, W., Huang, S., & Zhang, Z. (2019) · Microbial Ecology · doi:10.1007/s00248-019-01462-z · Cited by 8 · see citing works
Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies
Milewski, T. M., Lee, W., Young, R. L., Hofmann, H. A., & Curley, J. P. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011548 · Cited by 7 · see citing works
Interaction between Oligodendrocytes and Interneurons in Brain Development and Related Neuropsychiatric Disorders
Liu, Y., Yuan, J., Dong, Y., Jiang, S., Zhang, M., & Zhao, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073620 · Cited by 7 · see citing works
White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder
Uldall, S. W., Lundell, H., Baaré, W. F. C., Siebner, H. R., Rostrup, E., & Carlsson, J. M. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102929 · Cited by 7 · see citing works
Single‐Cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance
Sun, Q., Xu, W., Liu, Y., Zhan, S., Shao, X., Wu, Z., Weng, P., Cheng, K., & Zhang, X. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202101170 · Cited by 7 · see citing works
Oligodendroglia are primed for antigen presentation in response to chronic stress induced microglial-derived inflammation
Madeira, M. M., Hage, Z., Kokkosis, A. G., Nnah, K., Guzman, R., Schappell, L. E., Koliatsis, D., Resutov, E., Nadkarni, N. A., Rahme, G. J., et al. (2024) · Glia · doi:10.1002/glia.24661 · Cited by 4 · see citing works
Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice
Zhu, P., Tang, J., Liang, X., Luo, Y., Wang, J., Li, Y., Xiao, K., Li, J., Deng, Y., Jiang, L. H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.936045 · Cited by 6 · see citing works
Effect of Xiaoyaosan on brain volume and microstructure diffusion changes to exert antidepressant-like effects in mice with chronic social defeat stress
Li, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1414295 · Cited by 6 · see citing works
Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study
Pascual-Antón, R., Blasco‐Serra, A., Muñoz‐Moreno, E., Pilar-Cuéllar, F., Garro-Martínez, E., Florensa-Zanuy, E., López-Gil, X., Campa, V. M., Sòria, G., & Adell, A. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02354-0 · Cited by 6 · see citing works
Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types
Fessel, J. (2023) · Discover Mental Health · doi:10.1007/s44192-022-00029-8 · Cited by 6 · see citing works
Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders
Miguel-Hidalgo, J. J. (2023) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20230001 · Cited by 6 · see citing works
Molecular laterality encodes stress susceptibility in the medial prefrontal cortex
Chae, S., Hong, J., Kang, K., Shin, A., Kim, D., Lee, S., Kim, M., Jung, I., & Kim, D. (2021) · Molecular Brain · doi:10.1186/s13041-021-00802-w · Cited by 7 · see citing works
Clemastine enhances myelin formation in the striatum and medial prefrontal cortex and improves sociability in a neonatal rat hypoxic-ischemic model
Feng, Y., Ma, X., Zong, X., Jordan, J. D., Wu, C. Y., Tešić, V., Lee, R. H., & Zhang, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117916 · Cited by 5 · see citing works
Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress
Şahin, Z., Ozkurkculer, A., Kalkan, Ö. F., Özkaya, A., Koç, A., Koca, R. Ö., Solak, H., Görmüş, Z. I. S., & Kutlu, S. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02160-5 · Cited by 5 · see citing works
Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring
Jastrzębska, J., Frankowska, M., Wesołowska, J., Filip, M., & Smaga, I. (2024) · Current Neuropharmacology · doi:10.2174/1570159x23666241014164940 · Cited by 4 · see citing works
Myelin damage in major depressive disorder: Insights from neuroimaging, molecular mechanisms, and therapeutic perspectives
Wang, Y., Xiong, Z., Chen, M. L., & Zhu, Z. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106607 · Cited by 4 · see citing works
Genetic background modulates the effect of glucocorticoids on proliferation, differentiation and myelin formation of oligodendrocyte lineage cells
Gigliotta, A., Mingardi, J., Cummings, S. E., Alikhani, V., Trontti, K., Barbon, A., Kothary, R., & Hovatta, I. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16285 · Cited by 3 · see citing works
Understanding stress‐induced transmission of peripherally derived factors into the brain and responses in non‐neuronal cells
Kudo, M., Yamamoto, S., Hiraga, S., & Masuda, T. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16262 · Cited by 2 · see citing works
Prenatal fentanyl exposure affects social dominance and myelination patterns in the adult mouse brain
Uchegbu, C., Nguyen, T., Sood, I., Blankenship, K., He, H., Stanwood, G. D., Vied, C., & Graham, D. L. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110583 · Cited by 2 · see citing works
Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression
Komatsu, H., Takeuchi, H., Ono, C., Yu, Z., Kikuchi, Y., Kakuto, Y., Funakoshi, S., Ono, T., Kawashima, R., Taki, Y., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.631475 · Cited by 2 · see citing works
Genetic Tools in Rodents to Study Cannabinoid Functions
Monory, K., de Azúa, I. R., & Lutz, B. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_550 · Cited by 1 · see citing works
Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization
Milewski, T. M., Lee, W., Rada, K. R., & Curley, J. P. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70295 · Cited by 2 · see citing works
Stress alters hypothalamic gene expression in adolescent male Golden hamsters
Moran, K. M., Milewski, T. M., Curley, J. P., & Delville, Y. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70067 · Cited by 1 · see citing works

Chronic Social Stress Impairs Prefrontal Cortical Myelination in Juvenile MicePreprint
Sun, X., Yu, Q.-H.-H., Luo, F., & Li, B. (2020) · Research Square · doi:10.21203/rs.3.rs-54172/v1
Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice
Bonnefil, V., Dietz, K., Amatruda, M., Wentling, M., Aubry, A. V., Dupree, J. L., Temple, G., Park, H.-J., Burghardt, N. S., Casaccia, P., et al. (2019) · eLife · doi:10.7554/elife.40855 · Cited by 123 · see citing works
Analysis of ultrastructural alterations in the mouse medial prefrontal cortex toward the understanding of pathophysiology of social stress-induced depressive-like behaviors
Nagai, H., & Furuyashiki, T. (2020) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.93.0_1-yia-03
Chronic social stress causes long-term structural alterations of neuronal projections to the medial prefrontal cortex in mice
Okuda, Y., Shinohara, R., Sonobe, H., Maruyama, Y., Yamaguchi, M., Ito, K. N., Sato, A., Osakada, F., & Furuyashiki, T. (2023) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.97.0_2-b-ss09-3
Social defeat stress increased interfaces between microglia and neurons in the medial prefrontal cortex of mice
Nagai, M., Nagai, H., & Furuyashiki, T. (2020) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.93.0_2-p-171

Authors: Lehmann, M. L., Weigel, T. K., Elkahloun, A. G., & Herkenham, M.
Affiliations: National Institutes of Health (US)
Corresponding author: Lehmann, Michael L.
ORCID: Lehmann, Michael L.
Weigel, Thaddeus K.
Elkahloun, Abdel G.
Herkenham, Miles
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-04-18
Volume: 7
Issue: 1
Pages: 46548-46548
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/srep46548
PMC: PMC5394533
OpenAlex: W2607371682
Cited by: 127
References: 69
Citations by year: 2026: 5 · 2025: 7 · 2024: 17 · 2023: 12 · 2022: 20 · 2021: 25 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 3
FWCI: 6.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (ZIAMH001090, Z01MH001090)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: chronic social defeat, medial prefrontal cortex, myelination, myelin gene expression, myelin oligodendrocyte glycoprotein, myelin basic protein, stress-induced depression, depression-like behavior, myelinated fiber density, neuroplasticity
MeSH terms: Animals, Male, Myelin Sheath, Stress, Psychological, Prefrontal Cortex, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic social defeat reduces myelination in the mouse medial prefrontal cortex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks