Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

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Impact of Microplastics on Human Health: Risks, Diseases, and Affected Body Systems

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Scientific Evidence about the Risks of Micro and Nanoplastics (MNPLs) to Human Health and Their Exposure Routes through the Environment

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Analysing micro- and nanoplastics with cutting-edge infrared spectroscopy techniques: a critical review

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Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study

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Post-mortem evidence of microplastic bioaccumulation in human organs: insights from advanced imaging and spectroscopic analysis

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Lumbriculus variegatus (oligochaeta) exposed to polyethylene microplastics: biochemical, physiological and reproductive responses

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Harnessing PET to track micro- and nanoplastics in vivo

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Micro and nanoplastics ravaging our agroecosystem: A review of occurrence, fate, ecological impacts, detection, remediation, and prospects

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Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence

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Assessing the level of airborne polystyrene microplastics using thermogravimetry-mass spectrometry: Results for an agricultural area

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Presence of microplastics in commercial canned tuna

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Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats

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Microplastics in Internal Tissues of Companion Animals from Urban Environments

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Cellular Uptake, Transport, and Organelle Response After Exposure to Microplastics and Nanoplastics: Current Knowledge and Perspectives for Environmental and Health Risks

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Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis

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Effect of micro- and nanoplastic particles on human macrophages

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Micro- and Nanoplastic-Mediated Pathophysiological Changes in Rodents, Rabbits, and Chickens: A Review

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Questioning the suitability of available microplastics models for risk assessment – A critical review

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Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats

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Micro- and nanoplastic contamination in livestock production: Entry pathways, potential effects and analytical challenges

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Microplastic reorganization in urban river before and after rainfall

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Microplastics and Human Health: Our Great Future to Think About Now

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Evidence of small microplastics (<100 μm) ingestion by Pacific oysters (Crassostrea gigas): A novel method of extraction, purification, and analysis using Micro-FTIR

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Results of a 30-day safety assessment in young mice orally exposed to polystyrene nanoparticles

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Ecotoxicological effects of micro- and nanoplastics on terrestrial food web from plants to human beings

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Microplastic occurrence after conventional and nanofiltration processes at drinking water treatment plants: Preliminary results

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Microplastic Accumulation and Degradation in Environment via Biotechnological Approaches

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Reality Check: Experimental Studies on Microplastics Lack Realism

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Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

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Spectral imaging for characterization and detection of plastic substances in branded teabags

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Microbeads in personal care products: An overlooked environmental concern

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Impact of polyethylene terephthalate microfiber length on cellular responses in the Mediterranean mussel Mytilus galloprovincialis

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Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78/IRE1α/JNK axis induced apoptosis and endoplasmic reticulum stress

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Genotoxicity of Microplastics on Living Organisms: Effects on Chromosomes, DNA and Gene Expression

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Environmental prevalence, fate, impacts, and mitigation of microplastics—a critical review on present understanding and future research scope

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Polystyrene micro- and nanoplastics affect locomotion and daily activity of Drosophila melanogaster

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Ecological and human health risks of atmospheric microplastics (MPs): a review

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Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.

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Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

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The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway

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Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk

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Polystyrene Microplastics Affect the Reproductive Performance of Male Mice and Lipid Homeostasis in Their Offspring

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Incineration-Generated Polyethylene Micro-Nanoplastics Increase Triglyceride Lipolysis and Absorption in an In Vitro Small Intestinal Epithelium Model

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A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction

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Degradation and optimization of microplastic in aqueous solutions with graphene oxide-based nanomaterials

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Review of microplastics in the indoor environment: Distribution, human exposure and potential health impacts

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Characteristics, Toxic Effects, and Analytical Methods of Microplastics in the Atmosphere

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Residential houses — a major point source of microplastic pollution: insights on the various sources, their transport, transformation, and toxicity behaviour

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Mapping Microplastics in Humans: Analysis of Polymer Types, and Shapes in Food and Drinking Water—A Systematic Review

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Microplastic polymer properties as deterministic factors driving terrestrial plastisphere microbiome assembly and succession in the field

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Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice

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Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei

Zeng, Y., Deng, B., Kang, Z., Araujo, P., Mjøs, S. A., Liu, R., Lin, J., Yang, T., & Qu, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114871 · Cited by 65

Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium

DeLoid, G. M., Yang, Z., Bazina, L., Kharaghani, D., Sadrieh, F., & Demokritou, P. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134706 · Cited by 64

Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet–Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis

Zhai, Z., Yang, Y., Chen, S., & Wu, Z. (2024) · Environmental Health Perspectives · doi:10.1289/ehp13913 · Cited by 69

Microplastic Particles Detected in Fetal Cord Blood, Placenta, and Meconium: A Pilot Study of Nine Mother–Infant Pairs in South China

Zhu, M., Li, X., Lin, W., Zeng, D., Yang, P., Ni, W., Chen, Z., Lin, B., Lai, L., Ouyang, Z., et al. (2024) · Toxics · doi:10.3390/toxics12120850 · Cited by 66

Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway

Pan, L., Yu, D., Zhang, Y., Zhu, C., Yin, Q., Hu, Y., Zhang, X., Yue, R., & Xiong, X. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146753 · Cited by 58

Ecological risk assessment of marine microplastics using the analytic hierarchy process: A case study in the Yangtze River Estuary and adjacent marine areas

Zhang, F., Peng, G., Xu, P., Zhu, L., Li, C., Wei, N., & Li, D. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127960 · Cited by 58

Multi-omics reveals that Bifidobacterium breve M-16V may alleviate the immune dysregulation caused by nanopolystyrene

Li, N., Wang, J., Liu, P., Li, J., & Xu, C. (2022) · Environment International · doi:10.1016/j.envint.2022.107191 · Cited by 61

Occurrence, transport, and toxicity of microplastics in tropical food chains: perspectives view and way forward

Kataria, N., Yadav, S., Garg, V. K., Rene, E. R., Jiang, J., Rose, P. K., Kumar, M., & Khoo, K. S. (2024) · Environmental Geochemistry and Health · doi:10.1007/s10653-024-01862-2 · Cited by 60

Immunotoxicity of microplastics: Carrying pathogens and destroying the immune system

Zhi, L., Li, Z., Su, Z. W., & Wang, J. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117817 · Cited by 61

Isolation and characterization of microplastics from the human respiratory system: Sputum, broncho-alveolar lavage fluid, and pleural fluid simultaneously

Momeni, M. K., Taghipour, H., Ghayebzadeh, M., Mohammadi, M., & Keikhaee, R. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125389 · Cited by 59

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Chen, W., Zhu, R., Ye, X., Sun, Y., Tang, Q., Liu, Y., Yan, F., Yu, T., Zheng, X., & Tu, P. (2021) · Food & Function · doi:10.1039/d1fo02983e · Cited by 58

Biological Effects of Polystyrene Micro- and Nano- Plastics on Human Intestinal Organoid-Derived Epithelial Tissue Models Without and with M Cells

Chen, Y., Williams, A. M., Gordon, E., Rudolph, S., Longo, B. N., Li, G., & Kaplan, D. L. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102680 · Cited by 63

The internal dose makes the poison: higher internalization of polystyrene particles induce increased perturbation of macrophages

Collin‐Faure, V., Vitipon, M., Torres, A., Tanyeres, O., Dalzon, B., & Rabilloud, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1092743 · Cited by 60

Current research and perspective of microplastics (MPs) in soils (dusts), rivers (lakes), and marine environments in China

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Detecting the release of plastic particles in packaged drinking water under simulated light irradiation using surface-enhanced Raman spectroscopy

Lin, P., Wu, I.-H., Tsai, C.-Y., Kirankumar, R., & Hsieh, S. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339516 · Cited by 56

Exposure to Polystyrene nanoparticles induces liver damage in rat via induction of oxidative stress and hepatocyte apoptosis

Yasin, N. A. E., El‐Naggar, M. E., Ahmed, Z. S. O., Galal, M. K., Rashad, M. M., Youssef, A. M., & Elleithy, E. M. M. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103911 · Cited by 57

Maternal exposure to polystyrene microplastics impairs social behavior in mouse offspring with a potential neurotoxicity

So, Y. H., Shin, H. S., Lee, S., Moon, H. J., Jang, H. J., Lee, E., & Jung, E. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.10.013 · Cited by 57

The size-dependence and reversibility of polystyrene nanoplastics-induced lipid accumulation in mice: Possible roles of lysosomes

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Autophagic event and metabolomic disorders unveil cellular toxicity of environmental microplastics on marine polychaete Hediste diversicolor

Missawi, O., Venditti, M., Cappello, T., Zitouni, N., Marco, G. D., Boughattas, I., Bousserrhıne, N., Belbekhouche, S., Minucci, S., Maisano, M. S., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119106 · Cited by 56

Nanoplastics as an Invisible Threat to Humans and the Environment

Joksimović, N., Selaković, D., Jovicic, N. U., Janković, N., Pradeepkumar, P., Eftekhari, A., & Rosic, G. L. (2022) · Journal of Nanomaterials · doi:10.1155/2022/6707819 · Cited by 61

When toxicity of plastic particles comes from their fluorescent dye: a preliminary study involving neotropical Physalaemus cuvieri tadpoles and polyethylene microplastics

Malafaia, G., da Luz, T. M., Ahmed, M. A. I., Karthi, S., & Araújo, A. P. D. C. (2022) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2022.100054 · Cited by 58

Long-term exposure to microplastics induces intestinal function dysbiosis in rare minnow (Gobiocypris rarus)

Hou, M., Xu, C., Zou, X., Xia, Z., Su, L., Qiu, N., Cai, L., Yu, F., Wang, Q., Zhao, X., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114157 · Cited by 55

Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)

Martín-Folgar, R., Torres-Ruíz, M., de Alba, M., Cañas, A., González, M. D. C., & Morales, M. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137077 · Cited by 58

Accumulation and ecotoxicological effects induced by combined exposure of different sized polyethylene microplastics and oxytetracycline in zebrafish

Yu, Z., Yan, C., Qiu, D., Zhang, X., Wen, C., & Dong, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120977 · Cited by 58

Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems

Huang, J., Sun, X., Wang, Y., Su, J., Li, G., Wang, X., Yang, Y., Zhang, Y., Li, B., Zhang, G., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115447 · Cited by 58

PS-MPs promotes the progression of inflammation and fibrosis in diabetic nephropathy through NLRP3/Caspase-1 and TGF-β1/Smad2/3 signaling pathways

Feng, L., Chen, C., Xiong, X., Wang, X., Li, X., Kuang, Q., Wei, X., Gao, L., Niu, X., Li, Q., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116102 · Cited by 61

From insects to mammals! Tissue accumulation and transgenerational transfer of micro/nano-plastics through the food chain

Wang, Y., Nan, X., Sun, H., Shi, Y., Miao, J., Li, Y., Han, X., Zhang, N., Wang, H., Ren, N., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136424 · Cited by 57

Bioremediation of hemotoxic and oxidative stress induced by polyethylene microplastic in Clarias gariepinus using lycopene, citric acid, and chlorella

Sayed, A. E. H., Hamed, M., Badrey, A. E. A., & Soliman, H. A. M. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109189 · Cited by 54

Spatiotemporal distribution of microplastics in surface water, biofilms, and sediments in the world's largest drinking water diversion project

Huang, S., Peng, C., Wang, Z., Xiong, X., Bi, Y., Liu, Y., & Li, D. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148001 · Cited by 53

Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells

Li, S., Ma, Y., Ye, S., Su, Y., Hu, D., & Xiao, F. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113071 · Cited by 53

Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis

Windheim, J., Colombo, L., Battajni, N. C., Russo, L., Cagnotto, A., Diomede, L., Bigini, P., Vismara, E., Fiumara, F., Gabbrielli, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810329 · Cited by 56

The possible impacts of nano and microplastics on human health: lessons from experimental models across multiple organs

Fontes, B. L. M., Souza, L. C. D. S. E., de Oliveira, A. P. S. D. S., da Fonseca, R. N., Neto, M. P. C., & Pinheiro, C. R. (2024) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2024.2330962 · Cited by 61

Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice

Wen, Y., Deng, S., Wang, B., Zhang, F., Luo, T., Kuang, H., Kuang, X., Yuan, Y., Huang, J., & Zhang, D. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116439 · Cited by 53

Complex Bilateral Interactions Determine the Fate of Polystyrene Micro- and Nanoplastics and Soil Protists: Implications from a Soil Amoeba

Zhang, S., He, Z., Wu, C., Wang, Z., Mai, Y., Hu, R., Zhang, X., Huang, W., Tian, Y., Xia, D., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c06178 · Cited by 53

Bioaccumulation of functionalized polystyrene nanoplastics in sea cucumber Apostichopus japonicus (Selenka, 1867) and their toxic effects on oxidative stress, energy metabolism and mitochondrial pathway

Gu, Y., Xu, D., Liu, J., Chen, Y., Wang, J., Song, Y., Sun, B., & Xia, B. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121015 · Cited by 54

Prevalence and implications of microplastics in potable water system: An update

Menon, V., Sharma, S., Gupta, S., Ghosal, A., Nadda, A. K., Jose, R., Sharma, P., Kumar, S., Singh, P., & Raizada, P. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.137848 · Cited by 54

Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis

Liu, W., Zhang, B., Yao, Q., Feng, X., Shen, T., Guo, P., Wang, P., Bai, Y., Li, B., Wang, P., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1103289 · Cited by 59

Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages

Meng, X., Ge, L., Zhang, J., Xue, J., Gonzalez-Gil, G., Vrouwenvelder, J. S., & Li, Z. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164687 · Cited by 53

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang, C., Yeh, H., Shiu, R.-F., Chin, W., & Yen, T. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i9.1011 · Cited by 62

Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers

Mishra, S. K., Sanyal, T., Kundu, P., Kumar, R., Ghosh, D., Chakrabarti, G., Sikdar, N., Bhattacharya, S., Paul, S., & Das, A. K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02409-4 · Cited by 61

Oxidative Properties of Polystyrene Nanoparticles with Different Diameters in Human Peripheral Blood Mononuclear Cells (In Vitro Study)

Malinowska, K., Bukowska, B., Krokosz, A., & Sicińska, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094406 · Cited by 56

Measurement of Low Concentration of Micro-Plastics by Detection of Bioaffinity-Induced Particle Retention Using Surface Plasmon Resonance Biosensors

Huang, C.-J., Gudivada, V. N., Chen, Y., Chen, J., & Dong, G. (2021) · Biosensors · doi:10.3390/bios11070219 · Cited by 55

Commentary: Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

Tang, B. L. (2017) · Frontiers in Environmental Science · doi:10.3389/fenvs.2017.00063 · Cited by 23

Tissue Accumulation of Microplastics and Toxic Effects: Widespread Health Risks of Microplastics Exposure

Deng, Y., Yan, Z., Zhu, Q., & Zhang, Y. (2020) · The handbook of environmental chemistry · doi:10.1007/698_2020_454 · Cited by 24

In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal ExposurePreprint

Garcia, M. A., Romero, A. S., Merkley, S. D., Meyer-Hagen, J. L., Forbes, C., Hayek, E. E., Sciezka, D. P., Templeton, R., González-Estrella, J., Jin, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.02.542598 · Cited by 22

Distribution and Tissue Damage After a Single Microplastic Exposure in Mice

Chen, X., Wang, C., Shen, Y., & Zhou, Q. (2025) · Egyptian Academic Journal of Biological Sciences. D, Histology and Histochemistry · doi:10.21608/eajbsd.2025.419963 · Cited by 1

Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites

Zhang, Z., Chan, H., Chan, H., Peng, J., Zhu, P., Li, J., Jiang, X., Zhang, Z., Wang, Y., Tan, Z., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132503 · Cited by 207