Cited by 1,471Microplastics and Plastic PollutionEnvironmental Toxicology and EcotoxicologyPharmaceutical and Antibiotic Environmental Impacts

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

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Abstract

Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.

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  1. Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M. & Thompson, R. C. Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.). Environ Sci Technol 42, 5026–5031 (2008). · DOI · Paper page

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Metadata

Authors
Deng, Y., Zhang, Y., Lemos, B., & Ren, H.
Affiliations
  • State Key Laboratory of Pollution Control and Resource Reuse (CN)
  • Harvard University (US)
Corresponding author
Zhang, Yan
Venue
Scientific Reports
Published
2017-04-24
Volume
7
Issue
1
Pages
46687-46687
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2608368045
Cited by
1,471
References
50
Citations by year
2026: 160 · 2025: 243 · 2024: 267 · 2023: 220 · 2022: 244 · 2021: 160 · 2020: 101 · 2019: 50 · 2018: 22 · 2017: 3
FWCI
21.70
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21407076, 21304045, 21507058)
Topics
  • Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords
microplastics, polystyrene microplastics, tissue accumulation, particle size effects, liver, kidney, intestine, energy metabolism, lipid metabolism, oxidative stress, neurotoxicity biomarkers, metabolomics, biomarkers, mouse model, health risks
MeSH terms
Animals, Environmental Exposure, Kidney, Liver, Male, Mice, Inbred ICR, Particle Size, Polystyrenes, Risk Factors, Tissue Distribution, Water Pollutants, Chemical, Biomarkers, Gastrointestinal Tract, Metabolomics

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