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Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Open accessAbstract
Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.
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“In vivo studies examining the impacts of microplastics in mammals have also shown effects at high exposure concentrations, including changes in energy and lipid metabolism and oxidative stress (polystyrene particles 5μm in diameter at a concentration of 1.46×106 particles/0.5mL and 20μm in diameter at a concentration of 2.27×104 particles/0.5mL)30”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
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“Although some in vitro and in vivo studies examining impacts of microplastics on mammals show effects, such as intestinal barrier disfunction and alteration of biomarkers,30,31”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
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“However, it is unclear if toxicological effects from either of these mechanisms are occurring in humans, and at what thresholds effects occur.”
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Metadata
- Authors
- Deng, Y., Zhang, Y., Lemos, B., & Ren, H.
- Affiliations
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Harvard University (US)
- Corresponding author
- Zhang, Yan
- Venue
- Scientific Reports
- Published
- 2017-04-24
- Volume
- 7
- Issue
- 1
- Pages
- 46687-46687
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5402289
- OpenAlex
- W2608368045
- Cited by
- 1,471
- References
- 50
- Citations by year
- 2026: 160 · 2025: 243 · 2024: 267 · 2023: 220 · 2022: 244 · 2021: 160 · 2020: 101 · 2019: 50 · 2018: 22 · 2017: 3
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21407076, 21304045, 21507058)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- microplastics, polystyrene microplastics, tissue accumulation, particle size effects, liver, kidney, intestine, energy metabolism, lipid metabolism, oxidative stress, neurotoxicity biomarkers, metabolomics, biomarkers, mouse model, health risks
- MeSH terms
- Animals, Environmental Exposure, Kidney, Liver, Male, Mice, Inbred ICR, Particle Size, Polystyrenes, Risk Factors, Tissue Distribution, Water Pollutants, Chemical, Biomarkers, Gastrointestinal Tract, Metabolomics
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