THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction
Open accessAbstract
Recent evidence has implicated the endocannabinoid (eCB) system in nicotine addiction. The eCB system also has an important role in reward mechanisms, and nicotine addiction has been associated with aberrant reward processing. Motivated by this evidence, we tested the hypothesis that eCB modulation of reward processing is altered in subjects with a nicotine addiction (NAD). For this purpose, we compared reward-related activity in NAD with healthy controls (HC) in a pharmacological magnetic resonance imaging (MRI) study using Δ(9)-tetrahydrocannabinol (THC) administration to challenge the eCB system. Eleven HC and 10 NAD participated in a 3-T functional MRI (fMRI) study with a double-blind, cross-over, placebo-controlled design, using a Monetary Incentive Delay (MID) paradigm with three reward levels. Reward activity in the nucleus accumbens (NAcc) and caudate putamen during anticipation and feedback of reward was compared after THC and placebo. fMRI results indicated a significant reduction of reward anticipation activity in the NAcc in NAD after THC administration, which was not present in HC. This is indicated by a significant group by drug by reward interaction. Our data show that THC significantly reduces the NAcc response to monetary reward anticipation in NAD. These results suggest that nicotine addiction is associated with altered eCB modulation of reward processing in the NAcc. This study adds important human data to existing evidence implicating the eCB system in nicotine addiction.
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Several fMRI studies using the monetary incentive delay task find ventral striatal activation changes without reaction-time changes, which suggests reaction time may be an insensitive reward-processing marker.
“It should be noted that in various studies utilizing fMRI and the monetary incentive delay task, changes in ventral striatal activation are often found in the absence of changes in reaction time (Jansma et al., 2013; Saji et al., 2013; Smoski et al., 2011), suggesting that reaction time may lack sensitivity as a marker for reward processing.”
From The effects of early life stress on reward processing (2018) · cites this paper as Jansma et al., 2013
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- Authors
- Jansma, J. M., van Hell, H. H., Vanderschuren, L. J. M. J., Bossong, M. G., Jager, G., Kahn, R. S., & Ramsey, N. F.
- Affiliations
- University Medical Center Utrecht (NL)
- Utrecht University (NL)
- King's College London (GB)
- Corresponding author
- Ramsey, N F
- Venue
- Translational Psychiatry
- Published
- 2013-02-26
- Volume
- 3
- Issue
- 2
- Pages
- e234-e234
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3590996
- OpenAlex
- W2121876426
- Cited by
- 58
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 17 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 2
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Research Online (University of Wollongong) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- Socio-Environmental Systems Modeling (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Top Institute Pharma (T5-107)
- National Center for Advancing Translational Sciences (L30 TR001787)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, endocannabinoid system, tetrahydrocannabinol, nucleus accumbens, reward anticipation, reward processing, caudate-putamen
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Nucleus Accumbens, Reaction Time, Reward, Dronabinol, Tobacco Use Disorder, Cross-Over Studies, Young Adult
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