The immunogenetics of neurological disease
Open accessAbstract
Summary: Genes encoding antigen‐presenting molecules within the human major histocompatibility complex ( MHC ) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin‐like receptor ( KIR ) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. The findings of immunogenetic association studies are consistent with a polygenic model of inheritance in the heterogeneous and multifactorial nature of complex traits in various neurological diseases. Future investigation is highly recommended to evaluate both coding and non‐coding variation in immunogenetic loci using high‐throughput high‐resolution next‐generation sequencing technologies in diverse ethnic groups to fully appreciate their role in neurological diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The associated diseases include a large number of traits queried from an HLA-specific Phewas, including neurological diseases and diseases with risk factors for Alzheimer's disease, pointing to potential shared and/or interacting mechanisms and co-morbidities.
“the associated diseases include a large number of traits queried from an HLA-specific Phewas111, including neurological diseases (for example, Parkinson’s disease112,113) and diseases with risk factors for Alzheimer’s disease (for example, hyperthyroidism114), pointing to potential shared and/or interacting mechanisms and co-morbidities”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380 · see citing works
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I., & Weinshenker, B. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17551-x · Cited by 3,239 · see citing works
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works
Schizophrenia risk from complex variation of complement component 4
Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works
Genome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
Ruiter, A. M., Meilof, J. F., Somanje-Bolweg, R. R. J., van Gorsel, E., & Kalkers, N. F. (2017) · Case Reports in Neurology · doi:10.1159/000455942 · Cited by 1,762 · see citing works
Common variants conferring risk of schizophrenia
†Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., et al. (2009) · Nature · doi:10.1038/nature08186 · Cited by 1,677 · see citing works
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235 · see citing works
Gene map of the extended human MHC
Horton, R., Wilming, L. G., Rand, V., Lovering, R. C., Bruford, E. A., Khodiyar, V., Lush, M. J., Povey, S., Talbot, C. C., Wright, M. W., et al. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1489 · Cited by 1,201 · see citing works
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C., Gao, X., Astemborski, J. A., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M. W., et al. (2004) · Science · doi:10.1126/science.1097670 · Cited by 1,178 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
Hiby, S. E., Walker, J. J., O’Shaughnessy, K. M., Redman, C. W. G., Carrington, M. N., Trowsdale, J., & Moffett, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041214 · Cited by 1,122 · see citing works
Complete sequence and gene map of a human major histocompatibility complex
The MHC sequencing consortium (1999) · Nature · doi:10.1038/44853 · Cited by 1,069 · see citing works
Nalls, M., Plagnol, V., Hernandez, D., Sharma, M., Sheerin, U., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62345-8 · Cited by 986 · see citing works
KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
Vilches, C., & Parham, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.134942 · Cited by 984 · see citing works
Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Fauriat, C., Long, E. O., Ljunggren, H., & Bryceson, Y. T. (2009) · Blood · doi:10.1182/blood-2009-08-238469 · Cited by 894 · see citing works
Functional requirement for class I MHC in CNS development and plasticity
Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000) · Science · doi:10.1126/science.290.5499.2155 · Cited by 828 · see citing works
The HLA genomic loci map: expression, interaction, diversity and disease
Shiina, T., Hosomichi, K., Inoko, H., & Kulski, J. K. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2008.5 · Cited by 788 · see citing works
Hamza, T. H., Zabetian, C. P., Tenesa, A., Laederach, A., Montimurro, J. S., Yearout, D., Kay, D. M., Doheny, K. F., Paschall, J. E., Pugh, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.642 · Cited by 779 · see citing works
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
Martin, M. P., Qi, Y., Gao, X., Yamada, E., Martin, J. N., Pereyra, F., Colombo, S. F., Brown, E. E., Shupert, W. L., Phair, J. J., et al. (2007) · Nature Genetics · doi:10.1038/ng2035 · Cited by 750 · see citing works
González-Galarza, F. F., Christmas, S. E., Middleton, D., & Jones, A. R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1128 · Cited by 720 · see citing works
Cytokine networks in neuroinflammation
Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 681 · see citing works
Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0203-5 · Cited by 619 · see citing works
Inflammation in neurodegenerative diseases—An update
Amor, S., Peferoen, L. A. N., Vogel, D. Y. S., Breur, M., van der Valk, P., Baker, D., & van Noort, J. M. (2014) · Immunology · doi:10.1111/imm.12233 · Cited by 550 · see citing works
Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548 · see citing works
Do, C. B., Tung, J. Y., Dorfman, E., Kiefer, A. K., Drabant, E. M., Francke, U., Mountain, J. L., Goldman, S. M., Tanner, C. M., Langston, J. W., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002141 · Cited by 515 · see citing works
Kamatani, Y., Wattanapokayakit, S., Ochi, H., Kawaguchi, T., Takahashi, A., Hosono, N., Kubo, M., Tsunoda, T., Kamatani, N., Kumada, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.348 · Cited by 514 · see citing works
HLA class II‐associated genetic susceptibility in multiple sclerosis: A critical evaluation
Olerup, O., & Hillert, J. A. (1991) · Tissue Antigens · doi:10.1111/j.1399-0039.1991.tb02029.x · Cited by 483 · see citing works
Parham, P., & Moffett, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3370 · Cited by 481 · see citing works
Promise and pitfalls of the Immunochip
Cortes, A., & Brown, M. A. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3204 · Cited by 479 · see citing works
HISTOCOMPATIBILITY DETERMINANTS IN MULTIPLE SCLEROSIS, WITH SPECIAL REFERENCE TO CLINICAL COURSE
Jersild, C., Hansen, G., Svejgaard, A., Fog, T., Thomsen, M., & Dupont, B. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90970-7 · Cited by 467 · see citing works
Induction of MHC Class I Genes in Neurons
Neumann, H., Cavalié, A., Jenne, D. E., & Wekerle, H. (1995) · Science · doi:10.1126/science.7624779 · Cited by 449 · see citing works
Hsu, K. C., Chida, S., Geraghty, D. E., & Dupont, B. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.19004.x · Cited by 443 · see citing works
Cooley, S., Trachtenberg, E., Bergemann, T. L., Saeteurn, K., Klein, J. P., Le, C. T., Marsh, S. G. E., Guethlein, L. A., Parham, P., Miller, J. S., et al. (2008) · Blood · doi:10.1182/blood-2008-07-171926 · Cited by 433 · see citing works
Animal models of Parkinson’s disease
Blandini, F., & Armentero, M. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08491.x · Cited by 428 · see citing works
The immunogenetics of multiple sclerosis: A comprehensive review
Hollenbach, J. A., & Oksenberg, J. R. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.06.010 · Cited by 423 · see citing works
Self-citationClass II HLA interactions modulate genetic risk for multiple sclerosis
the International Multiple Sclerosis Genetics Consortium (2015) · Nature Genetics · doi:10.1038/ng.3395 · Cited by 418 · see citing works
Moesta, A. K., Norman, P. J., Yawata, M., Yawata, N., Gleimer, M., & Parham, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3969 · Cited by 380 · see citing works
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
Chiu, I., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S., Vartanian, T., Brown, R. H., & Carroll, M. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0804610105 · Cited by 374 · see citing works
MHC Class I: An Unexpected Role in Neuronal Plasticity
Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.044 · Cited by 369 · see citing works
Powley, J. M. (1964) · The Lancet · doi:10.1016/s0140-6736(64)91052-9 · Cited by 366 · see citing works
The Yin and Yang of HLA and KIR in human disease
Kulkarni, S., Martin, M. P., & Carrington, M. N. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.06.003 · Cited by 362 · see citing works
Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Oksenberg, J. R., Barcellos, L. F., Cree, B., Baranzini, S. E., Bugawan, T. L., Khan, O. A., Lincoln, R., Swerdlin, A., Mignot, E. J.-M., Lin, L., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/380997 · Cited by 334 · see citing works
Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men
Holling, T. M., Schooten, E., & van Den Elsen, P. J. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.01.005 · Cited by 334 · see citing works
Differential microRNA regulation of HLA-C expression and its association with HIV control
Kulkarni, S., Savan, R., Qi, Y., Gao, X., Yuki, Y., Bass, S. E., Martin, M. P., Hunt, P. W., Deeks, S. G., Telenti, A., et al. (2011) · Nature · doi:10.1038/nature09914 · Cited by 325 · see citing works
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
Barcellos, L. F., Sawcer, S. J., Ramsay, P. P., Baranzini, S. E., Thomson, G. J., Briggs, F. B. S., Cree, B., Begovich, A. B., Villoslada, P., Montalbán, X., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl223 · Cited by 312 · see citing works
Patsopoulos, N. A., Barcellos, L. F., Hintzen, R. Q., Schaefer, C., van Duijn, C. M., Noble, J. A., Raj, T., IMSGC, ANZgene, Gourraud, P.-A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003926 · Cited by 312 · see citing works
Multiple Sclerosis: Association with HL—A3
NAITO, S., NAMEROW, N., MICKEY, M. R., & TERASAKI, P. I. (1972) · Tissue Antigens · doi:10.1111/j.1399-0039.1972.tb00111.x · Cited by 308 · see citing works
Loconto, J., Papes, F., Chang, E. C., Stowers, L., Jones, E. P., Takada, T., Kumánovics, A., Lindahl, K. F., & Dulac, C. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00153-3 · Cited by 295 · see citing works
HLA-DR2 Dose Effect on Susceptibility to Multiple Sclerosis and Influence on Disease Course
Barcellos, L. F., Oksenberg, J. R., Begovich, A. B., Martin, E. R., Schmidt, S., Vittinghoff, E., Goodin, D. S., Pelletier, D., Lincoln, R., Bucher, P., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/367781 · Cited by 293 · see citing works
Yu, L., Chibnik, L. B., Srivastava, G. P., Pochet, N., Yang, J., Xu, J., Kozubek, J., Obholzer, N., Leurgans, S. E., Schneider, J. A., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.3049 · Cited by 290 · see citing works
Yue, W.-H., Wang, H.-F., Sun, L.-D., Tang, F.-L., Liu, Z.-H., Zhang, H.-X., Li, W.-Q., Zhang, Y.-L., Zhang, Y., Ma, C.-C., et al. (2011) · Nature Genetics · doi:10.1038/ng.979 · Cited by 289 · see citing works
Huang, D., Shi, F., Jung, S., Pien, G. C., Wang, J., Salazar‐Mather, T. P., He, T. T., Weaver, J., Ljunggren, H., Biron, C. A., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5465com · Cited by 284 · see citing works
Surface NK receptors and their ligands on tumor cells
Moretta, L., Bottino, C., Pende, D., Castriconi, R., Mingari, M. C., & Moretta, A. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.03.002 · Cited by 282 · see citing works
Haines, J. L. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.8.1229 · Cited by 281 · see citing works
KIR and disease: a model system or system of models?
Khakoo, S. I., & Carrington, M. N. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00459.x · Cited by 281 · see citing works
Uhrberg, M., Parham, P. R., & Wernet, P. (2002) · Immunogenetics · doi:10.1007/s00251-002-0463-7 · Cited by 263 · see citing works
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
International MHC and Autoimmunity Genetics Network (IMAGEN)*, Rioux, J. D., Goyette, P., Vyse, T. J., Hammarström, L. L. G., Fernando, M. M. A., Green, T. J., Jager, P. L. D., Foisy, S., Wang, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909307106 · Cited by 256 · see citing works
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
Dyment, D. A., Herrera, B. M., Cader, M. Z., Willer, C. J., Lincoln, M. R., Sadovnick, A. D., RISCH, N. J., & Ebers, G. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi206 · Cited by 243 · see citing works
Synapse elimination and learning rules co-regulated by MHC class I H2-Db
Lee, H., Brott, B. K., Kirkby, L. A., Adelson, J. D., Cheng, S., Feller, M. B., Datwani, A., & Shatz, C. J. (2014) · Nature · doi:10.1038/nature13154 · Cited by 228 · see citing works
Cutting Edge: Allele-Specific and Peptide-Dependent Interactions between KIR3DL1 and HLA-A and HLA-B
Thananchai, H., Gillespie, G. M. A., Martin, M. P., Bashirova, A. A., Yawata, N., Yawata, M., Easterbrook, P., McVicar, D. W., Maenaka, K., Parham, P., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.33 · Cited by 227 · see citing works
Genome‐wide association study of schizophrenia in Ashkenazi Jews
Goes, F. S., McGrath, J., Avramopoulos, D., Wolyniec, P., Pirooznia, M., Ruczinski, I., Nestadt, G., Kenny, E. E., Vacic, V., Peters, I., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32349 · Cited by 226 · see citing works
Hao, J., Liu, R., Piao, W., Zhou, Q., Vollmer, T. L., Campagnolo, D. I., Xiang, R., Cava, A. L., Kaer, L. V., & Shi, F. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092749 · Cited by 215 · see citing works
The global burden of neurologic diseases
Chin, J. H., & Vora, N. (2014) · Neurology · doi:10.1212/wnl.0000000000000610 · Cited by 213 · see citing works
HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review
Schmidt, H., Williamson, D., & Ashley-Koch, A. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk118 · Cited by 212 · see citing works
A Genome-Wide Association Study of Myasthenia Gravis
Renton, A. E., Pliner, H. A., Provenzano, C., Evoli, A., Ricciardi, R., Nalls, M. A., Marangi, G., Abramzon, Y. A., Arepalli, S., Chong, S., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4103 · Cited by 206 · see citing works
Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region
Wissemann, W. T., Hill-Burns, E. M., Zabetian, C. P., Factor, S. A., Patsopoulos, N., Hoglund, B., Holcomb, C., Donahue, R. J., Thomson, G., Erlich, H., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.009 · Cited by 189 · see citing works
Hwang, Y., Kim, J., Shin, J.-Y., Kim, J.-I., Seo, J.-S., Webster, M. J., Lee, D., & Kim, S. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.94 · Cited by 189 · see citing works
Natural killer cells determine the outcome of B cell–mediated autoimmunity
Shi, F., Wang, H., Li, H., Hong, S., Taniguchi, M., Link, H., Kaer, L. V., & Ljunggren, H. (2000) · Nature Immunology · doi:10.1038/79792 · Cited by 187 · see citing works
Kikuchi-Maki, A., Yusa, S.-I., Catina, T. L., & Campbell, K. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3415 · Cited by 183 · see citing works
Yamasaki, K. (1999) · Brain · doi:10.1093/brain/122.9.1689 · Cited by 180 · see citing works
Shi, F., Takeda, K., Akira, S., Sarvetnick, N., & Ljunggren, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3099 · Cited by 178 · see citing works
Association between genetic traits for immune-mediated diseases and Alzheimer disease
Yokoyama, J. S., Wang, Y., Schork, A. J., Thompson, W. K., Karch, C. M., Cruchaga, C., McEvoy, L. K., Witoelar, A., Chen, C.-H., Holland, D., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0150 · Cited by 176 · see citing works
Ishii, T., Hirota, J., & Mombaerts, P. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00092-7 · Cited by 175 · see citing works
Okuda, D. T., Srinivasan, R., Oksenberg, J. R., Goodin, D. S., Baranzini, S. E., Beheshtian, A., Waubant, E. L., Zamvil, S. S., Leppert, D., Qualley, P., et al. (2008) · Brain · doi:10.1093/brain/awn301 · Cited by 175 · see citing works
A second major histocompatibility complex susceptibility locus for multiple sclerosis
Yeo, T. W., Jager, P. L. D., Gregory, S. G., Barcellos, L. F., Walton, A., Goris, A., Fenoglio, C., Ban, M., Taylor, C. J., Goodman, R. S., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21063 · Cited by 175 · see citing works
VELTKAMP, J. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91082-9 · Cited by 175 · see citing works
Genome-Wide Association Study of Schizophrenia in a Japanese Population
Ikeda, M., Aleksić, B., Kinoshita, Y., Okochi, T., Kawashima, K., Kushima, I., Ito, Y., Nakamura, Y., Kishi, T., Okumura, T., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.010 · Cited by 172 · see citing works
Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
Lincoln, M. R., Ramagopalan, S. V., Chao, M. J., Herrera, B. M., DeLuca, G. C., Orton, S. M., Dyment, D. A., Sadovnick, A. D., & Ebers, G. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812664106 · Cited by 170 · see citing works
Risk for myasthenia gravis maps to a 151 Pro→Ala change in TNIP1 and to human leukocyte antigen‐B*08
Gregersen, P. K., Kosoy, R., Lee, A. T., Lamb, J. A., Sussman, J. D., McKee, D., Simpfendorfer, K. R., Pirskanen, R., Piehl, F., Pan‐Hammarström, Q., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23691 · Cited by 168 · see citing works
Liu, X., Cheng, R., Verbitsky, M., Kisselev, S., Browne, A., Mejia‐Santana, H., Louis, E. D., COTE, L. J., Andrews, H., Waters, C., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-104 · Cited by 168 · see citing works
The role of inflammation in sporadic and familial Parkinson’s disease
Deleidi, M., & Gasser, T. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1352-y · Cited by 167 · see citing works
HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis
Hensiek, A. E. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.2.184 · Cited by 167 · see citing works
(2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.035 · Cited by 166 · see citing works
Peptide antagonism as a mechanism for NK cell activation
Fadda, L., Borhis, G., Ahmed, P. S., Cheent, K. S., Pageon, S. V., Cazaly, A. M., Stathopoulos, S., Middleton, D., Mulder, A., Claas, F. H. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913745107 · Cited by 158 · see citing works
A Novel Variant Marking HLA-DP Expression Levels Predicts Recovery from Hepatitis B Virus Infection
Thomas, R., Thio, C. L., Apps, R., Qi, Y., Gao, X., Marti, D., Stein, J. L., Soderberg, K. A., Moody, M. A., Goedert, J. J., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00406-12 · Cited by 158 · see citing works
Maternal KIR in Combination with Paternal HLA-C2 Regulate Human Birth Weight
Hiby, S. E., Apps, R., Chazara, O., Farrell, L. E., Magnus, P. M., Trogstad, L., Gjessing, H. K., Carrington, M. N., & Moffett, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400577 · Cited by 157 · see citing works
Genetic basis for clinical expression in multiple sclerosis
The Multiple Sclerosis Genetics Group, Barcellos, L. F., Oksenberg, J. R., Green, A. J., Bucher, P., Rimmler, J. B., Schmidt, S., Garcia, M., Lincoln, R., Pericak‐Vance, M. A., et al. (2002) · Brain · doi:10.1093/brain/awf009 · Cited by 154 · see citing works
How Does the Maternal Immune System Contribute to the Development of Pre-eclampsia?
Moffett, A., & Hiby, S. E. (2007) · Placenta · doi:10.1016/j.placenta.2006.11.008 · Cited by 153 · see citing works
Harbo, H. F., Lie, B. A., Sawcer, S. J., Celius, E. G., Dai, K., Oturai, A. B., Hillert, J. A., Lorentzen, Å. R., Laaksonen, M., Myhr, K. M., et al. (2004) · Tissue Antigens · doi:10.1111/j.0001-2815.2004.00173.x · Cited by 149 · see citing works
Cooley, S., Weisdorf, D. J., Guethlein, L. A., Klein, J. P., Wang, T., Marsh, S. G. E., Spellman, S. R., Haagenson, M. D., Saeturn, K., Ladner, M. B., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302517 · Cited by 148 · see citing works
HLA/KIR Restraint of HIV: Surviving the Fittest
Bashirova, A. A., Thomas, R., & Carrington, M. N. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101332 · Cited by 148 · see citing works
Song, S., Miranda, C. J., Braun, L., Meyer, K., Frakes, A. E., Ferraiuolo, L., Likhite, S. B., Bevan, A. K., Foust, K. D., McConnell, M. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4052 · Cited by 148 · see citing works
Kikuchi-Maki, A., Catina, T. L., & Campbell, K. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.3859 · Cited by 147 · see citing works
Copy Number Variation of KIR Genes Influences HIV-1 Control
Pelak, K., Need, A. C., Fellay, J., Shianna, K. V., Feng, S., Urban, T. J., Ge, D., Luca, A. D., Martínez‐Picado, J., Wolinsky, S. M., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001208 · Cited by 143 · see citing works
Harel‐Bellan, A., Quillet‐Mary, A., Marchiol, C., DeMars, R., Tursz, T., & FRADELIZI, D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5688 · Cited by 142 · see citing works
HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis
Brum, D. G., Barreira, A. A., dos Santos, A. C., Kaimen-Maciel, D. R., Matiello, M., Costa, R. M., Deghaide, N. H. S., Costa, L. S., Louzada‐Júnior, P., Diniz, P. R. B., et al. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509350741 · Cited by 139 · see citing works
Strong association of MuSK antibody–positive myasthenia gravis and HLA-DR14-DQ5
Niks, E. H., Kuks, J. B. M., Roep, B. O., Haasnoot, G. W., Verduijn, W., Ballieux, B. E. P. B., Baets, M. H. D., Vincent, A. C., & Verschuuren, J. J. G. M. (2006) · Neurology · doi:10.1212/01.wnl.0000218159.79769.5c · Cited by 138 · see citing works
Boudreau, J. E., Giglio, F., Gooley, T. A., Stevenson, P. A., Luduec, J.-B. L., Shaffer, B. C., Rajalingam, R., Hou, L., Hurley, C. K., Noreen, H. J., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.7059 · Cited by 138 · see citing works
Schizophrenia and HLA: a review
Wright, P., Nimgaonkar, V. L., Donaldson, P. T., & Murray, R. M. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00022-0 · Cited by 137 · see citing works
Genetic basis of myasthenia gravis – A comprehensive review
Avidan, N., Panse, R. L., Berrih‐Aknin, S., & Miller, A. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.12.001 · Cited by 136 · see citing works
Hugh, A. E., & Fox, J. (1963) · The Lancet · doi:10.1016/s0140-6736(63)90353-2 · Cited by 134 · see citing works
Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen
Vollmer, T. L., Liu, R., Price, M. A., Rhodes, S. N., Cava, A. L., & Shi, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2696 · Cited by 134 · see citing works
Yoshimura, S., Isobe, N., Matsushita, T., Yonekawa, T., Masaki, K., Sato, S., Kawano, Y., & Kira, J. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302925 · Cited by 134 · see citing works
The regulatory role of natural killer cells in multiple sclerosis
Takahashi, K. (2004) · Brain · doi:10.1093/brain/awh219 · Cited by 133 · see citing works
Marrosu, M. G., Murru, M. R., Costa, G., Cucca, F., Sotgiu, S., Rosati, G., & Francesco Muntoni, A. (1997) · The American Journal of Human Genetics · doi:10.1016/s0002-9297(07)64074-9 · Cited by 132 · see citing works
The Inheritance of Resistance Alleles in Multiple Sclerosis
Ramagopalan, S. V., Morris, A. P., Dyment, D. A., Herrera, B. M., DeLuca, G. C., Lincoln, M. R., Orton, S. M., Chao, M. J., Sadovnick, A. D., & Ebers, G. C. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030150 · Cited by 132 · see citing works
Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis
Xu, W. B., Fazekas, G., Hara, H., & Tabira, T. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.02.011 · Cited by 128 · see citing works
Late Onset Myasthenia Gravis Is Associated with HLA DRB1*15:01 in the Norwegian Population
Maniaol, A. H., Elsais, A., Lorentzen, Å. R., Owe, J. F., Viken, M. K., Sæther, H. S., Flåm, S. T., Bråthen, G., Kampman, M. T., Midgard, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036603 · Cited by 128 · see citing works
B-LYMPHOCYTE ALLOANTIGENS ASSOCIATED WITH MULTIPLE SCLEROSIS
Compston, D. A. S. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92027-4 · Cited by 128 · see citing works
Interferon γ Gene Expression in Sensory Neurons: Evidence for Autocrine Gene Regulation
Neumann, H., Schmidt, H., Wilharm, E., Behrens, L., & Wekerle, H. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2023 · Cited by 128 · see citing works
HL‐A Antigens and Multiple Sclerosis
Bertrams, J., Kuwert, E. K., & LIEDTKE, U. (1972) · Tissue Antigens · doi:10.1111/j.1399-0039.1972.tb00060.x · Cited by 126 · see citing works
Whole-genome and whole-exome sequencing in neurological diseases
Foo, J. N., Liu, J., & Tan, E. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.148 · Cited by 121 · see citing works
Association between Parkinson's disease and the HLA‐DRB1 locus
Ahmed, I., Tamouza, R., Delord, M., Krishnamoorthy, R., Tzourio, C., Mulot, C., Nacfer, M., Lambert, J., Beaune, P. H., Laurent‐Puig, P., et al. (2012) · Movement Disorders · doi:10.1002/mds.25035 · Cited by 120 · see citing works
Natural killer type 2 bias in remission of multiple sclerosis
Takahashi, K., Miyake, S., Kondo, T., Terao, K., Hatakenaka, M., Hashimoto, S., & Yamamura, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11819 · Cited by 120 · see citing works
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Björkström, N. K., Béziat, V., Cichocki, F. M., Liu, L. L., Levine, J. J., Larsson, S., Koup, R. A., Anderson, S. K., Ljunggren, H., & Malmberg, K. (2012) · Blood · doi:10.1182/blood-2012-03-416867 · Cited by 119 · see citing works
Matsushita, T., Matsuoka, T., Isobe, N., Kawano, Y., Minohara, M., Shi, N., Nishimura, Y., Ochi, H., & Kira, J. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2008.01172.x · Cited by 119 · see citing works
Is neuromyelitis optica associated with human leukocyte antigen?
Zéphir, H., Fajardy, I., Outteryck, O., Blanc, F., Roger, N., Fleury, M., Rudolf, G., Marignier, R., Vukusic, S., Confavreux, C., et al. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458508102085 · Cited by 118 · see citing works
Sardinian multiple sclerosis is associated with HLA‐DR4
Marrosu, M. G., Francesco Muntoni, A., Murru, M. R., Spinicci, G., Pischedda, M. P., Goddi, F., Cossu, P., & Pirastu, M. (1988) · Neurology · doi:10.1212/wnl.38.11.1749 · Cited by 117 · see citing works
Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis
Celius, E. G., Harbo, H. F., EGELAND, T., Vartdal, F., Vandvik, B., & Spurkland, A. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00389-0 · Cited by 116 · see citing works
Alzheimer’s disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci
Karch, C. M., Ezerskiy, L. A., Bertelsen, S., Alzheimer’s Disease Genetics Consortium (ADGC), & Goate, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148717 · Cited by 111 · see citing works
Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss
Ratelade, J., Zhang, H., Saadoun, S., Bennett, J. L., Papadopoulos, M. C., & Verkman, A. S. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0986-4 · Cited by 106 · see citing works
A bird's eye view of NK cell receptor interactions with their MHC class I ligands
Saunders, P. M., Vivian, J. P., O’Connor, G. M., Sullivan, L. C., Pymm, P., Rossjohn, J., & Brööks, A. G. (2015) · Immunological Reviews · doi:10.1111/imr.12319 · Cited by 105 · see citing works
KIR haplotype content at the allele level in 77 Northern Irish families
Middleton, D., Meenagh, A., & Gourraud, P. (2007) · Immunogenetics · doi:10.1007/s00251-006-0181-7 · Cited by 103 · see citing works
Wang, H., Dai, Y., Qiu, W., Zhong, X., Wu, A., Wang, Y., Lu, Z., Bao, J., & Hu, X. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.11.004 · Cited by 103 · see citing works
HANGING IN THE BALANCE: KIR and Their Role in Disease
Williams, A. P. (2005) · Molecular Interventions · doi:10.1124/mi.5.4.6 · Cited by 102 · see citing works
Solerte, S. B., Cravello, L., Ferrari, E., & Fioravanti, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05399.x · Cited by 99 · see citing works
Vandiedonck, C., Beaurain, G., Giraud, M., Hue-Beauvais, C., Eymard, B., Tranchant, C., Gajdos, P., Dausset, J. B., & Garchon, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406756101 · Cited by 98 · see citing works
Extended major histocompatibility complex haplotypes in patients with multiple sclerosis
Hauser, S. L., Fleischnick, E., Weiner, H. L., Marcus, D., Awdeh, Z., Yunis, E. J., & Alper, C. A. (1989) · Neurology · doi:10.1212/wnl.39.2.275 · Cited by 91 · see citing works
Deschamps, R., Paturel, L., Jeannin, S., Chausson, N., Olindo, S., Béra, O., Bellance, R., Smadja, D., Césaire, D., & Cabre, P. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510382810 · Cited by 91 · see citing works
Steele, N. Z. R., Carr, J. S., Bonham, L. W., Geier, E. G., Damotte, V., Miller, Z. A., Desikan, R. S., Boehme, K. L., Mukherjee, S., Crane, P. K., et al. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002272 · Cited by 91 · see citing works
Self-citationLindå, H., Hammarberg, H., Cullheim, S., Levinovitz, A., Khademi, M., & Olsson, T. P. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6768 · Cited by 90 · see citing works
HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5
Bartoccioni, E., Scuderi, F., Augugliaro, A., Ranieri, S. C., Sauchelli, D., Alboino, P., Marino, M., & Evoli, A. (2009) · Neurology · doi:10.1212/01.wnl.0000339103.08830.86 · Cited by 89 · see citing works
Natural killer cells and their receptors in multiple sclerosis
Kaur, G., Trowsdale, J., & Fugger, L. H. (2012) · Brain · doi:10.1093/brain/aws159 · Cited by 84 · see citing works
Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study
Swaminathan, S., Shen, L., Kim, S., Inlow, M. H., West, J. D., Faber, K. M., Foroud, T., Mayeux, R. P., & Saykin, A. J. (2012) · Current Alzheimer Research · doi:10.2174/156720512802455331 · Cited by 84 · see citing works
HLA Class II Susceptibility to Multiple Sclerosis Among Ashkenazi and Non-Ashkenazi Jews
Kwon, O. J., Karni, A., Israel, S., Brautbar, C., Amar, A., Meiner, Z., Abramsky, O., & Karussis, D. M. (1999) · Archives of Neurology · doi:10.1001/archneur.56.5.555 · Cited by 82 · see citing works
Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China
Jiao, B., Liu, X., Zhou, L., Wang, M. H., Zhou, Y., Xiao, T., Zhang, W., Sun, R., Waye, M. M. Y., Tang, B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144898 · Cited by 82 · see citing works
Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients
Yoshimura, S., Isobe, N., Yonekawa, T., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Yamamoto, K., & Kira, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048592 · Cited by 80 · see citing works
Lindå, H., Hammarberg, H., Piehl, F., Khademi, M., & Olsson, T. P. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00135-6 · Cited by 79 · see citing works
Natural killer cells inhibit hepatitis C virus expression
Li, Y., Zhang, T., Ho, C., Orange, J. S., Douglas, S. D., & Ho, W. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0604372 · Cited by 78 · see citing works
Genetic associations between myasthenia gravis and the HL-A system.
Pirskanen, R. (1976) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.39.1.23 · Cited by 76 · see citing works
Selector function of MHC I molecules is determined by protein plasticity
Bailey, A. G., Dalchau, N., Carter, R., Emmott, S., Phillips, A., Werner, J. M., & Elliott, T. J. (2015) · Scientific Reports · doi:10.1038/srep14928 · Cited by 76 · see citing works
The Leucocyte Antigenic System HL-A as a Possible Genetic Marker of Schizophrenia
Cazzullo, C. L., Smeraldi, E., & Penati, G. (1974) · The British Journal of Psychiatry · doi:10.1192/bjp.125.1.25 · Cited by 75 · see citing works
HLA class II associated risk and protection against multiple sclerosis—a Finnish family study
Laaksonen, M., Pastinen, T., Sjöroos, M., Kuokkanen, S., Ruutiainen, J., Sumelahti, M., Reijonen, H., Salonen, R., Wikstrom, J., Panelius, M., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00456-8 · Cited by 75 · see citing works
Seldin, M. F., Alkhairy, O. K., Lee, A. T., Lamb, J. A., Sussman, J. D., Pirskanen, R., Piehl, F., Verschuuren, J. J. G. M., Kostera‐Pruszczyk, A., Szczudlik, P., et al. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00232 · Cited by 75 · see citing works
Late-onset Alzheimer disease risk variants mark brain regulatory loci
Allen, M., Kachadoorian, M., Carrasquillo, M. M., Karhade, A., Manly, L., Burgess, J. D., Wang, C., Serie, D., Wang, X., Siuda, J., et al. (2015) · Neurology Genetics · doi:10.1212/nxg.0000000000000012 · Cited by 73 · see citing works
Yovel, G., Sirota, P., Mazeh, D., Shakhar, G., Rosenne, E., & Ben‐Eliyahu, S. (2000) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0574 · Cited by 72 · see citing works
Janer, M., Cowland, A., PICARD, J. K., Campbell, D., Pontarotti, P., Newsom–Davis, J., Bunce, M., Welsh, K. I., Demaine, A. G., Wilson, A. G., et al. (1999) · Human Immunology · doi:10.1016/s0198-8859(99)00062-2 · Cited by 72 · see citing works
Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations
Hollenbach, J. A., Nocedal, I., Ladner, M. B., Single, R. M., & Trachtenberg, E. (2012) · Immunogenetics · doi:10.1007/s00251-012-0629-x · Cited by 69 · see citing works
Self-citationParham, P. R. (2004) · Immunology Letters · doi:10.1016/j.imlet.2003.11.016 · Cited by 69 · see citing works
Association of the human leucocyte antigen region with susceptibility to Parkinson's disease
Saiki, M., Baker, A., Williams‐Gray, C. H., Foltynie, T., Goodman, R. S., Taylor, C. J., Compston, D. A. S., Barker, R., Sawcer, S. J., & Goris, A. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.162883 · Cited by 68 · see citing works
Effects of Peptide on NK Cell-Mediated MHC I Recognition
Cassidy, S. A., Cheent, K. S., & Khakoo, S. I. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00133 · Cited by 68 · see citing works
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis
Goris, A., Pauwels, I., Gustavsen, M. W., van Son, B., Hilven, K., Bos, S. D., Celius, E. G., Berg‐Hansen, P., Aarseth, J. H., Myhr, K., et al. (2015) · Brain · doi:10.1093/brain/awu405 · Cited by 68 · see citing works
Gene-based aggregate SNP associations between candidate AD genes and cognitive decline
Nettiksimmons, J., Tranah, G. J., Evans, D. S., Yokoyama, J. S., & Yaffe, K. S. (2016) · AGE · doi:10.1007/s11357-016-9885-2 · Cited by 68 · see citing works
Mihara, T., Nakashima, M., Kuroiwa, A., Akitake, Y., Ono, K., Hosokawa, M., Yamada, T., & Takahashi, M. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.05.013 · Cited by 66 · see citing works
Identification of rare genetic variation of NLRP1 gene in familial multiple sclerosis
Maver, A., Lavtar, P., Ristič, S., Stopinšek, S., Simčič, S., Hočevar, K., Sepčić, J., Drulovic, J. S., Pekmezovic, T. D., Novaković, I. V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03536-9 · Cited by 66 · see citing works
Natural killer cells fertile with receptors for HLA-G?
Lanier, L. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5343 · Cited by 64 · see citing works
Debnath, M., Cannon, D. M., & Venkatasubramanian, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.009 · Cited by 64 · see citing works
de Jong, S., van Eijk, K. R., Zeegers, D. W. L. H., Strengman, E., Janson, E., Veldink, J. H., van den Berg, L. H., Cahn, W., Kahn, R. S., Boks, M. P., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.38 · Cited by 64 · see citing works
Genetic risk variants in African Americans with multiple sclerosis
Isobe, N., Gourraud, P., Harbo, H. F., Caillier, S. J., Santaniello, A., Khankhanian, P., Maiers, M. J., Spellman, S. R., Cereb, N., Yang, S., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829bfe2f · Cited by 64 · see citing works
Gorer, P. A. (1936) · Journal of Genetics · doi:10.1007/bf02982499 · Cited by 64 · see citing works
Lidman, O., Olsson, T. P., & Piehl, F. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00904.x · Cited by 63 · see citing works
MHC-Resident Variation Affects Risks After Unrelated Donor Hematopoietic Cell Transplantation
Petersdorf, E. W., Malkki, M., Gooley, T. A., Spellman, S. R., Haagenson, M. D., Horowitz, M. M., & Wang, T. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003974 · Cited by 62 · see citing works
Solerte, S. B., Fioravanti, M., Pascale, A., Ferrari, E., Govoni, S. M., & Battaini, F. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00050-5 · Cited by 61 · see citing works
Killer immunoglobulin‐like receptor ligand HLA‐Bw4 protects against multiple sclerosis
Lorentzen, Å. R., Karlsen, T. H., Olsson, M., Smestad, C., Mero, I., Woldseth, B., Sun, J., Senitzer, D., Celius, E. G., Thorsby, E., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21695 · Cited by 61 · see citing works
Susceptibility to Crohn’s disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand
Hollenbach, J. A., Ladner, M. B., Saeteurn, K., Taylor, K. D., Mei, L., Haritunians, T., McGovern, D. P. B., Erlich, H. A., Rotter, J. I., & Trachtenberg, E. (2009) · Immunogenetics · doi:10.1007/s00251-009-0396-5 · Cited by 59 · see citing works
Self-citationKIR/HLA Ligand Incompatibility in Kidney Transplantation
Kunert, K., Seiler, M., Mashreghi, M., Klippert, K., Schönemann, C., Neumann, K., Pratschke, J., Reinke, P., Volk, H., & Kotsch, K. (2007) · Transplantation · doi:10.1097/01.tp.0000290681.41859.41 · Cited by 59 · see citing works
Building global capacity for brain and nervous system disorders research
Cottler, L. B., Zunt, J. R., Weiss, B., Kamal, A. K., & Vaddiparti, K. (2015) · Nature · doi:10.1038/nature16037 · Cited by 57 · see citing works
Direct NK Cell-Mediated Lysis of Syngenic Dorsal Root Ganglia Neurons In Vitro
Backström, E., Chambers, B. J., Kristensson, K., & Ljunggren, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4895 · Cited by 56 · see citing works
Henschke, P. J., Bell, D., & Cape, R. D. T. (1978) · Tissue Antigens · doi:10.1111/j.1399-0039.1978.tb01308.x · Cited by 56 · see citing works
Mero, I., Gustavsen, M. W., Sæther, H. S., Flåm, S. T., Berg‐Hansen, P., Søndergaard, H. B., Jensen, P. E., Berge, T., Bjølgerud, A., Muggerud, A. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058352 · Cited by 56 · see citing works
The HLA locus and multiple sclerosis in Sicily
Brassat, D., Salemi, G., Barcellos, L. F., McNeill, G., Proia, P., Hauser, S. L., Oksenberg, J. R., & Savettieri, G. (2005) · Neurology · doi:10.1212/01.wnl.0000149765.71212.0a · Cited by 55 · see citing works
Behzad, M., Yılmaz, V., Gülşen-Parman, Y., Aysal, F., Oflazer, P., Deymeer, F., & Saruhan‐Direskeneli, G. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.08.271 · Cited by 55 · see citing works
Natural killer cell‐mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions
Backström, E., Chambers, B. J., Ho, E. L., Naidenko, O. V., Mariotti, R., Fremont, D. H., Yokoyama, W. M., Kristensson, K., & Ljunggren, H. (2002) · European Journal of Immunology · doi:10.1002/immu.200390012 · Cited by 55 · see citing works
Panse, R. L., & Berrih‐Aknin, S. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328364d6cd · Cited by 53 · see citing works
HL‐A Haplotypes of 32 Diseases
Terasaki, P. I., & Mickey, M. R. (1975) · Immunological Reviews · doi:10.1111/j.1600-065x.1975.tb01553.x · Cited by 53 · see citing works
Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis
Harbo, H. F., Isobe, N., Berg‐Hansen, P., Bos, S. D., Caillier, S. J., Gustavsen, M. W., Mero, I., Celius, E. G., Hauser, S. L., Oksenberg, J. R., et al. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513506503 · Cited by 49 · see citing works
Testi, M., Terracciano, C., Guagnano, A., Testa, G., Marfia, G. A., Pompeo, E., Andreani, M., & Massa, R. (2012) · Autoimmune Diseases · doi:10.1155/2012/541760 · Cited by 48 · see citing works
Influence of KIR Diversity on Human Immunity
Parham, P. R. (2007) · Springer eBooks · doi:10.1007/0-387-24180-9_6 · Cited by 47 · see citing works
HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease
Guo, Y., Deng, X., Zheng, W., Xu, H., Song, Z. J., Liang, H. W., Jin, L., Jiang, X., Luo, Z., & Deng, H. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.245 · Cited by 47 · see citing works
KIRs and their HLA ligands in Remitting–Relapsing Multiple Sclerosis
Fusco, C., Guerini, F. R., Nocera, G., Ventrella, G., Caputo, D., Valentino, M. A., Agliardi, C., Gallotti, J., Morra, V. B., Florio, C., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.004 · Cited by 45 · see citing works
HLA-DR antigens associated with major genetic risk for late-onset Alzheimerʼs disease
Curran, M. D., Middleton, D., Edwardson, J. A., Perry, R. H., McKeith, I. G., Morris, C. M., & Neill, D. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00028 · Cited by 43 · see citing works
Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis
Matsuoka, T., Matsushita, T., Osoegawa, M., Kawano, Y., Minohara, M., Mihara, F., Nishimura, Y., Ohyagi, Y., & Kira, J. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508097818 · Cited by 43 · see citing works
Neuromyelitis Optica (NMO IgG+) and Genetic Susceptibility, Potential Ethnic Influences
Rivas‐Alonso, V., Flores-Rivera, J. D. J., Garci, Y. R., Granados, J., Sánchez-Correa, T. E., Mena‐Hernández, L., & Corona, T. (2018) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524916666160229115047 · Cited by 43 · see citing works
Histocompatibility Typing in Amyotrophic Lateral Sclerosis
Antel, J. P., Arnason, B. G. W., Fuller, T. C., & Lehrich, J. R. (1976) · Archives of Neurology · doi:10.1001/archneur.1976.00500060029007 · Cited by 42 · see citing works
Dalakas, M. C., & Illa, I. (1995) · Annals of Neurology · doi:10.1002/ana.410370615 · Cited by 41 · see citing works
Human leukocyte antigen variation and Parkinson’s disease
Puschmann, A., Verbeeck, C., Heckman, M. G., Soto‐Ortolaza, A. I., Lynch, T., Jasińska‐Myga, B., Opala, G., Krygowska‐Wajs, A., Barcikowska, M., Uitti, R. J., et al. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.03.008 · Cited by 41 · see citing works
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
Noristani, H. N., Sabourin, J. C., Gerber, Y. N., Teigell, M., Sommacal, A., Vivanco, M. D., Weber, M., & Perrin, F. E. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0023-x · Cited by 40 · see citing works
Immune modulation in corneal transplantation
Fu, H., Larkin, F., & George, A. J. T. (2008) · Transplantation Reviews · doi:10.1016/j.trre.2007.12.005 · Cited by 40 · see citing works
Quelvennec, E., Béra, O., Cabre, P., Alizadeh, M., Smadja, D., Jugdé, F., Edan, G., & Sémana, G. (2003) · Tissue Antigens · doi:10.1046/j.0001-2815.2002.00008.x · Cited by 38 · see citing works
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients
García‐León, J. A., Pinto-Medel, M. J., Trujillo, L. G., Gomez, C. L., Oliver‐Martos, B., Prat-Arrojo, I., Marín-Bañasco, C., Suardíaz, M., Maldonado-Sánchez, R., Fernández-Fernández, Ó., et al. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.05.018 · Cited by 38 · see citing works
Sun, C., Wei, L., Luo, F., Li, Y., Li, J., Zhu, F., Kang, P., Xu, R., Xiao, L., Liu, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048594 · Cited by 37 · see citing works
A high-resolution view of NK-cell receptors: structure and function
Colonna, M., Moretta, A., Vely, F., & Vivier, É. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01697-2 · Cited by 36 · see citing works
Fukazawa, T., Kikuchi, S., Miyagishi, R., Miyazaki, Y., Yabe, I., Hamada, T., & Sasaki, H. (2005) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1252oa · Cited by 35 · see citing works
HLA and age of onset in myasthenia gravis
Santos, E., Bettencourt, A., SILVA, A. C. F. D., Boleixa, D., Lopes, D., Brás, S., Costa, P., Lopes, C., Gonçalves, G., Leite, M. I., et al. (2017) · Neuromuscular Disorders · doi:10.1016/j.nmd.2017.04.002 · Cited by 35 · see citing works
16th IHIW: Population Global Distribution of Killer Immunoglobulin‐like Receptor (KIR) and Ligands
Hollenbach, J. A., Augusto, D. G., Alaez, C., Bubnova, L. N., Faé, I., Fischer, G., González-Galarza, F. F., Gorodezky, C., Karabon, L., Kuśnierczyk, P., et al. (2012) · International Journal of Immunogenetics · doi:10.1111/iji.12028 · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
2 of the 240 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Jamshidi J, Movafagh A, Emamalizadeh B, Zare Bidoki A, Manafi A, Ghasemi Firouz- abadi S et al. HLA-DRA is associated with Parkinson's disease in Iranian population. Int J Immunogenet 2014; 41:508-11.
- Akaho R, Matsushita I, Narita K, Okazaki Y, Okabe Y, Matsushita M et al. Support for an association between HLA-DR1 and schizophrenia in the Japanese population. Am J Med Genet 2000; 96:725-7. 118
- Nikolic AV, Andric ZP, Simonovic RB, Rakocevic Stojanovic VM, Basta IZ, Bojic SD et al. High frequency of DQB1*05 and absolute absence of DRB1*13 in muscle-speci- fic tyrosine kinase positive myasthenia gravis. Eur J Neurol 2015; 22:59-63. 138
Cited by
Sorted by citations
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946 · see citing works
Self-citationNeurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease
Marogianni, C., Sokratous, M., Dardiotis, E., Hadjigeorgiou, G. M., Bogdanos, D. P., & Xiromerisiou, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228421 · Cited by 369 · see citing works
RNA editing underlies genetic risk of common inflammatory diseases
Li, Q., Gloudemans, M. J., Geisinger, J. M., Fan, B., Aguet, F., Sun, T., Ramaswami, G., Li, Y., Ma, J., Pritchard, J. K., et al. (2022) · Nature · doi:10.1038/s41586-022-05052-x · Cited by 186 · see citing works
Clinical Research on Alzheimer’s Disease: Progress and Perspectives
Sun, B., Li, W., Zhu, C., Jin, W., Zeng, F., Liu, Y.-H., Bu, X., Zhu, J., Yao, X., & Wang, Y. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0249-z · Cited by 164 · see citing works
Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish
Yamaguchi, T., & Dijkstra, J. M. (2019) · Cells · doi:10.3390/cells8040378 · Cited by 129 · see citing works
Wang, Q., Shen, Z., Zhang, S., Sun, Y., Zheng, F., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1022053 · Cited by 61 · see citing works
CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders
Guan, L., Han, Y., Yang, C., Lu, S., Du, J., Li, H., & Lin, J. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02638-w · Cited by 58 · see citing works
Sun, J., Ludvigsson, J. F., Ingre, C., Piehl, F., Wirdefeldt, K., Zagai, U., Ye, W., & Fang, F. (2022) · PLoS Medicine · doi:10.1371/journal.pmed.1004092 · Cited by 51 · see citing works
The plasma peptides of Alzheimer’s disease
Florentinus-Mefailoski, A., Bowden, P., Scheltens, P., Killestein, J., Teunissen, C. E., & Marshall, J. G. (2021) · Clinical Proteomics · doi:10.1186/s12014-021-09320-2 · Cited by 46 · see citing works
Eva, L., Pleș, H., Covache-Busuioc, R.-A., Glavan, L.-A., Bratu, B.-G., Bordeianu, A., Dumitrascu, D.-I., Corlatescu, A.-D., & Ciurea, A. V. (2023) · Biomedicines · doi:10.3390/biomedicines11092489 · Cited by 44 · see citing works
The Potential Role of SARS-COV-2 in the Pathogenesis of Parkinson's Disease
Chaná‐Cuevas, P., Salles, P. A., Rojas‐Fernández, A., Salinas-Rebolledo, C., & Milán, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.01044 · Cited by 40 · see citing works
Circulating nucleic acids in the plasma and serum as potential biomarkers in neurological disorders
Bruno, D. D. C. F., Donatti, A., Martin, M., de Almeida, V. S., Geraldis, J. C., de Oliveira, F. S., Dogini, D. B., & Lopes‐Cendes, Í. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20209881 · Cited by 35 · see citing works
Alzheimer Disease Pathogenesis: The Role of Autoimmunity
Lim, B., Prassas, I., & Diamandis, E. P. (2020) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfaa171 · Cited by 35 · see citing works
Lokki, M., & Paakkanen, R. (2018) · HLA · doi:10.1111/tan.13429 · Cited by 31 · see citing works
Mariella, E., Marotta, F., Grassi, E., Gilotto, S., & Provero, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00714 · Cited by 25 · see citing works
The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia
Misiak, B., Samochowiec, J., Kowalski, K., Gäebel, W., Bassetti, C. L., Chan, A., Gorwood, P. A. P. M., Papiol, S., Dom, G., Volpe, U., et al. (2023) · European Psychiatry · doi:10.1192/j.eurpsy.2023.2432 · Cited by 28 · see citing works
Rahman, M. R., Islam, T., Huq, F., Quinn, J. M. W., & Moni, M. A. (2019) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2019.100193 · Cited by 26 · see citing works
van Drongelen, V., Scavuzzi, B. M., Nogueira, S. V., Miller, F. W., Sawalha, A. H., & Holoshitz, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-82195-3 · Cited by 26 · see citing works
Modelling the Human Blood–Brain Barrier in Huntington Disease
Vignone, D., Paz, O. G., Fini, I., Cellucci, A., Auciello, G., Battista, M. R., Gloaguen, I., Fortuni, S., Cariulo, C., Khetarpal, V. K., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147813 · Cited by 24 · see citing works
Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease
Singh, H., Singh, A., Khan, A. A., & Gupta, V. K. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105023 · Cited by 23 · see citing works
The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia
Tao, S., Kichula, K. M., Harrison, G. F., Farias, T. D. J., Palmer, W. H., Leaton, L. A., Hajar, C. G. N., Zulkafli, Z. B., Edinur, H. A., Zhu, F., et al. (2020) · Immunology · doi:10.1111/imm.13289 · Cited by 22 · see citing works
CD4+ Cytotoxic T Cells Involved in the Development of EBV-Associated Diseases
Ruiz-Pablos, M. (2022) · Pathogens · doi:10.3390/pathogens11080831 · Cited by 20 · see citing works
Misra, M. K., Augusto, D. G., Montero-Martín, G., Nemat‐Gorgani, N., Sauter, J., Hofmann, J. A., Traherne, J. A., González-Quezada, B. A., Gorodezky, C., Bultitude, W. P., et al. (2018) · Human Immunology · doi:10.1016/j.humimm.2018.10.003 · Cited by 20 · see citing works
Self-citationNeuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease
Altmann, D. M. (2018) · Immunology · doi:10.1111/imm.12943 · Cited by 20 · see citing works
Zhang, L., Liao, J.-X., Liu, Y.-Y., Luo, H.-L., & Zhang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1280186 · Cited by 19 · see citing works
Kulski, J. K., Suzuki, S., Shiina, T., Pfaff, A. L., & Kõks, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1349030 · Cited by 18 · see citing works
Elyaman, W., Stern, L. J., Jiang, N. J., Dressman, D., Bradley, P. H., Klatzmann, D., Bradshaw, E. M., Färber, D. L., Kent, S. C., Chizari, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14548 · Cited by 16 · see citing works
Bader, J. M., Makarov, C., Richter, S., Strauss, M. T., Held, F., Wahle, M., Lorenz, M., Pöschl, L., Skowronek, P., Thielert, M., et al. (2026) · Cell · doi:10.1016/j.cell.2026.01.017 · Cited by 15 · see citing works
The role of critical immune genes in brain disorders: insights from neuroimaging immunogenetics
Bian, B., Couvy‐Duchesne, B., Wray, N. R., & McRae, A. F. (2022) · Brain Communications · doi:10.1093/braincomms/fcac078 · Cited by 13 · see citing works
What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?
McCombe, P., Garton, F. C., Katz, M., Wray, N. R., & Henderson, R. D. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1785873 · Cited by 12 · see citing works
Misra, M. K., Damotte, V., & Hollenbach, J. A. (2018) · Genes and Immunity · doi:10.1038/s41435-017-0009-5 · Cited by 12 · see citing works
Self-citationFrolov, A., Guzmán, M. A., Hayat, G. R., & Martin, J. R. (2024) · Cureus · doi:10.7759/cureus.56023 · Cited by 10 · see citing works
The Role of Clinical Assessment in the Era of Biomarkers
Carlos, A. F., & Josephs, K. A. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01410-3 · Cited by 10 · see citing works
Description of a CSF-Enriched miRNA Panel for the Study of Neurological Diseases
Martín, M. M., Gómez, I., Miguela, A., Belchí, O., Robles‐Cedeño, R., Quintana, E., & Ramió‐Torrentà, L. (2021) · Life · doi:10.3390/life11070594 · Cited by 10 · see citing works
Rani, A., Patra, P., Verma, T., Singh, A., Jain, A. K., Jaiswal, N., Narang, S., Mittal, N., Parmar, H. S., & Jha, H. C. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00012 · Cited by 9 · see citing works
Banerjee, P. P., Pang, L., Soldan, S. S., Miah, S. M. S., Eisenberg, A., Maru, S. Y., Waldman, A., Smith, E. A., Rosenberg‐Hasson, Y., Hirschberg, D. L., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.027 · Cited by 9 · see citing works
Ruiz-Pablos, M., Paiva, B., & Zabaleta, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1710571 · Cited by 11 · see citing works
Hughes, L. S., Fröhlich, A., Pfaff, A. L., Bubb, V. J., Quinn, J. P., & Kõks, S. (2024) · Biomolecules · doi:10.3390/biom14030358 · Cited by 8 · see citing works
Hart, D. A. (2021) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2021.145018 · Cited by 7 · see citing works
Nanoneuroscience: Cutting-edge Approach for Disease Management
Malhotra, S., Jain, N., Rathee, J., Kaul, S., Nagaich, U., Pandey, M., Gorain, B., & Gupta, G. (2023) · Recent Patents on Nanotechnology · doi:10.2174/1872210517666230403105152 · Cited by 6 · see citing works
Kloske, C. M., Mahinrad, S., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Butts, B., Carrillo, M. C., Chakrabarty, P., Chen, X., Craft, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14291 · Cited by 6 · see citing works
Sinaei, F., Fatehi, F., Gharan, S. O., Ehsan, S., Kamali, K., Amirzargar, A., Mahmoudi, M., Vaghefifar, A., & Nafissi, S. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210700 · Cited by 5 · see citing works
Implications of systems biology in understanding the pathophysiology of neurological diseases
Mishra, S., Singh, A., Naqvi, W., Garg, P., Srivastava, N., & Srivastava, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22326-6.00020-1 · Cited by 5 · see citing works
HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis
Nona, R. J., Greer, J. M., Henderson, R. D., & McCombe, P. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2078665 · Cited by 5 · see citing works
Didonna, A., Damotte, V., Shams, H., Matsunaga, A., Caillier, S. J., Dandekar, R., Misra, M. K., Mofrad, M. R. K., Oksenberg, J. R., & Hollenbach, J. A. (2020) · Immunology · doi:10.1111/imm.13273 · Cited by 4 · see citing works
Self-citationNakane, S., Matsuo, H., & Nakatsuji, Y. (2024) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2024.103967 · Cited by 3 · see citing works
The novel HLA‐C*03 allele, HLA‐C*03:597 , identified in a Chinese patient
Zhou, X. ‐., Wu, Q., Yang, X., Cai, J., & Yin, J. (2022) · HLA · doi:10.1111/tan.14726 · Cited by 3 · see citing works
Immunogenetic Epidemiology of Motor Neuron Diseases in 14 Continental Western European Countries
James, L. M., & Georgopoulos, A. P. (2021) · Journal of Immunological Sciences · doi:10.29245/2578-3009/2021/3.1221 · Cited by 3 · see citing works
Polymer-Mediated Delivery of CRISPR-Cas9 Genome-Editing Therapeutics for CNS Disease
Iqbal, S., Alexander-Bryant, A. A., & Larsen, J. (2022) · Springer eBooks · doi:10.1007/978-3-031-11409-0_6 · Cited by 3 · see citing works
AI applications in diagnostic technologies and services
Catania, L. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-824477-7.00005-5 · Cited by 3 · see citing works
Genetics in multiple sclerosis: Updates in the era of big data
Isobe, N. (2018) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12443 · Cited by 3 · see citing works
Kalomoiri, M., Prakash, C. R., Lagström, S., Hauschulz, K., Ewing, E., Shchetynsky, K., Kular, L., Needhamsen, M., & Jagodic, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1251772 · Cited by 3 · see citing works
Gargus, M., Poyhia, L., Errico, J. P., Rogers, M. K. N., & Tremblay, M. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1827714 · Cited by 2 · see citing works
Experiences in implementing immunopsychiatry in real life
Cunningham, J. L., Nordmark, G., Fällmar, D., Červenka, S., Gallwitz, M., Säll, R., Schmidt, P. T., Rönnelid, J., Persson, B., Kindmark, A., et al. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100597 · Cited by 2 · see citing works
Introduction: Nanomedicine in the Brain
Li, T., Huang, L., & Xue, X. (2019) · Springer eBooks · doi:10.1007/978-981-13-8731-9_1 · Cited by 2 · see citing works
High‐resolution KIR and HLA genotyping in three Chinese ethnic minorities reveals distinct origins
Tao, S., Norman, P. J., You, X., Kichula, K. M., Dong, L., Chen, N., He, Y., Chen, C., Zhang, W., & Zhu, F. (2024) · HLA · doi:10.1111/tan.15482 · Cited by 2 · see citing works
Plasmapheresis in Treatment of Myasthenia Gravis
Voinov, V. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81354 · Cited by 2 · see citing works
Vakrakou, A. G., Brinia, M.-E., Cheiraki, A., Alexaki, A., Papadopoulou, A., Vatsellas, G., Kokala-Dimitropoulou, V., Derventzi, A., Constantinides, V. C., Stathopoulos, P., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1640532 · Cited by 1 · see citing works
Gene Editing in Neurological Disorders: Role of CRISPR-Cas9 in Targeted Therapies
Aminabee, S., Chaitanya, M. M. S. N., Begum, M. A., Jonnalagadda, S. K., Devi, M. S., Thanmai, P., Deepika, M. B. N., & Lakshmi, S. V. M. (2026) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3396 · Cited by 1 · see citing works
Basics of immunogenetics: application and future perspectives
Hajam, Y. A., Kumar, R., Bhat, R. A., Rani, R., Sharma, B., & Sharma, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90053-9.00001-4 · Cited by 1 · see citing works
Neurological diseases: A perspective genetic approach & dietary intervention
Chikkara, G., Mittal, P., & Chikara, S. K. (2022) · International journal of applied research · doi:10.22271/allresearch.2022.v8.i8b.10055 · Cited by 1 · see citing works
Minibajeva, O., Karelis, G., Zolovs, M., & Ķēniņa, V. (2024) · Biomedicines · doi:10.3390/biomedicines12122709 · Cited by 1 · see citing works
Bouchtout, M. N., Meçabih, F., Mihoubi, E., Boukadir, C., Attal, E., Smail, D., Touil–Boukoffa, C., Raache, R., & Attal, N. (2021) · Meta Gene · doi:10.1016/j.mgene.2021.100937
Immunogenetics in the diagnosis of clinical disorders
Ash, D., & Roy, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90250-2.00012-1
Immunognetics: a tool for the identification of novel therapeutic targets in immune disorders
Maqbool, I., Ali, S. I., Paul, V. I., & Muzaffer, U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90250-2.00015-7
Immunogenetic Factors in the Pathogenesis of Schizophrenia
Plotnikova, M. Y., Станиславовна, К. С., Rozhdestvenskikh, E. V., & Андреева, Т. В. (2023) · Russian Journal of Genetics · doi:10.1134/s1022795423100101
Immunogenetics of Alzheimer’s disease: the human leukocyte antigen
Costescu, C., Vică, L. M., Bâlici, Ș., Nicula, G. Z., Nemeş, B., Coman, H. G., & Matei, H. V. (2023) · Psihiatru ro · doi:10.26416/psih.75.4.2023.8928
Immunogenetic Factors in the Pathogenesis of Schizophrenia
Plotnikova, M. Y., Станиславовна, К. С., Rozhdestvenskikh, E. V., & Андреева, Т. В. (2023) · Генетика · doi:10.31857/s0016675823100107
Autoreactomes in Healthy Individuals Vary According to HLA Class II GenotypePreprint
Suseno, R., Boquett, J. A., Dandekar, R., Ituarte, T., Sharathchandra, A., Alvarenga, B. D., Vierra‐Green, C., Spellman, S. R., Maiers, M. J., DeRisi, J. L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706904 · Cited by 1 · see citing works
Self-citationMolecular mechanism of Alzheimer’s disease using integrated multi-omics
Alhusaini, M., Mussa, B. M., İlçe, B. Y., Alhaj, H. A., & Hamoudi, R. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1735696
Unresolved questions and challenges in immunogenetics
Kumar, R., Mishra, P. S., Sheikh, A., RAHMAN, S., Mishra, R., & Patel, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33590-7.00013-7
Ye, H., Huang, S., Shi, L., & Chai, L. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107340
曹勇, Ma, Q., Chen, L. O., Liu, J., Liu, L., & Zhang, Q. (2026) · BMC Public Health · doi:10.1186/s12889-026-28245-9
Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia
CASALE, A. D., Girardi, P., Arena, J. F., Cantelmi, C., Modesti, M. N., Bronzatti, L., Zanini, L., Veneziani, G., Giraldi, E., Mazzani, S., et al. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03263-4
- Authors
- Misra, M. K., Damotte, V., & Hollenbach, J. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Hollenbach, Jill A.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2017-12-11
- Volume
- 153
- Issue
- 4
- Pages
- 399-414
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC5838423
- OpenAlex
- W2769066475
- Cited by
- 74
- References
- 240
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 7
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (U19NS095774, R01AI128775)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- immunogenetics, major histocompatibility complex, killer cell immunoglobulin-like receptors, neurological disorders, multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis, amyotrophic lateral sclerosis, genetic susceptibility, polygenic inheritance, non-coding variants, antigen presentation
- MeSH terms
- Animals, Humans, Immunogenetics, Nervous System Diseases, Genetic Variation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
