The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders
Open accessAbstract
Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to small sample sizes, and measurement and tissue differences. The current two EWA analyses of 473 World Trade Center responders are the largest to date for both PTSD and MDD. These analyses investigated DNA methylation patterns and biological pathways influenced by differentially methylated genes associated with each disorder. Methylation was profiled on blood samples using Illumina 450 K Beadchip. Two EWA analyses compared current versus never PTSD, and current versus never MDD, adjusting for cell types and demographic confounders. Pathway and gene set enrichment analyses were performed to understand the complex biological systems of PTSD and MDD. No significant epigenome-wide associations were found for PTSD or MDD at an FDR P<0.05. The majority of genes with differential methylation at a suggestive threshold did not overlap between the two disorders. Pathways significant in PTSD included a regulator of synaptic plasticity, oxytocin signaling, cholinergic synapse and inflammatory disease pathways, while only phosphatidylinositol signaling and cell cycle pathways emerged in MDD. The failure of the current EWA analyses to detect significant epigenome-wide associations is in contrast with disparate findings from previous, smaller EWA and candidate gene studies of PTSD and MDD. Enriched gene sets involved in several biological pathways, including stress response, inflammation and physical health, were identified in PTSD, supporting the view that multiple genes play a role in this complex disorder.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Two EWAS studies in PTSD found differences in DNAm across genes part of biological pathways involved with inflammation and immune response (Kuan et al., 2017; Uddin et al., 2010).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Kuan et al., 2017
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Epigenetic disruption has been clearly implicated in cancer, aging, and a range of complex diseases, including psychiatric disorders, such as depression [33] and PTSD [34,35].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Gene ontology analysis for RNA-seq: accounting for selection bias
Young, M. D., Wakefield, M. J., Smyth, G. K., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-2-r14 · Cited by 7,107
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
DNA methylation arrays as surrogate measures of cell mixture distribution
Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-86 · Cited by 3,175
Self-citationHammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
Monroe, S. M., & Simons, A. D. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.406 · Cited by 2,143
Du, P., Zhang, X., Huang, C.-C., Jafari, N., Kibbe, W. A., Hou, L., & Lin, S. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-587 · Cited by 2,136
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Teschendorff, A. E., Marabita, F., Lechner, M., Bartlett, T. E., Tegner, J. N., Gómez-Cabrero, D., & Beck, S. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts680 · Cited by 1,686
Chen, Y. A., Lemire, M., Choufani, S., Butcher, D. T., Grafodatskaya, D., Zanke, B. W., Gallinger, S., Hudson, T. J., & Weksberg, R. (2013) · Epigenetics · doi:10.4161/epi.23470 · Cited by 1,547
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447
Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Epigenome-wide association studies for common human diseases
Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3000 · Cited by 1,288
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273
Reinius, L. E., Acevedo, N., Joerink, M., Pershagen, G., Dahlén, S., Greco, D., Söderhäll, C., Scheynius, A., & Kere, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041361 · Cited by 1,037
Liu, Y., Aryee, M. J., Padyukov, L., Fallin, M. D., Hesselberg, E., Rúnarsson, Á. R., Reinius, L. E., Acevedo, N., Taub, M. A., Ronninger, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2487 · Cited by 997
missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform
Phipson, B., Maksimovic, J., & Oshlack, A. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv560 · Cited by 870
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786
Posttraumatic stress disorder and depression following trauma: understanding comorbidity.
O’Donnell, M. L., Creamer, M., & Pattison, P. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1390 · Cited by 770
Passos, I. C., Vasconcelos-Moreno, M. P., Costa, L. G., Kunz, M., Brietzke, E., Quevedo, J., Salum, G., Magalhães, P. V., Kapczinski, F., & Kauer-Sant'Anna, M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00309-0 · Cited by 743
Smith, T. C., Ryan, M. A. K., Wingard, D. L., Slymen, D. J., Sallis, J. F., & Kritz‐Silverstein, D. C. (2008) · BMJ · doi:10.1136/bmj.39430.638241.ae · Cited by 631
Association of Mental Disorders With Subsequent Chronic Physical Conditions
Scott, K., Lim, C., Al-Hamzawi, A., Alonso, J., Bruffaerts, R., Caldas-de-Almeida, J., Florescu, S., de Girolamo, G., Hu, C.-Y., de Jonge, P., et al. (2015) · JAMA psychiatry · doi:10.1001/jamapsychiatry.2015.2688 · Cited by 553
Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548
Epigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518
Self-citationPerroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Mouthon, D., Stouder, C., Dieben, K., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.60 · Cited by 516
Price, E. M., Cotton, A. M., Lam, L. L. C., Farré, P., Emberly, E. G., Brown, C. J., Robinson, W. P., & Kobor, M. S. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-4 · Cited by 494
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder
Smith, A. K., Conneely, K. N., Kilaru, V., Mercer, K. B., Weiss, T. E., Bradley, B., Tang, Y., Gillespie, C. F., Cubells, J. F., & Ressler, K. J. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31212 · Cited by 355
Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.002 · Cited by 353
Meta-review of depressive subtyping models
Harald, B., & Gordon, P. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.015 · Cited by 328
Weder, N., Zhang, H., Jensen, K., Yang, B. Z., Simen, A., Jackowski, A., Lipschitz, D., Douglas-Palumberi, H., Ge, M., Perepletchikova, F., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.12.025 · Cited by 324
Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.21 · Cited by 301
Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study
Wisnivesky, J. P., Teitelbaum, S. L., Todd, A. C., Boffetta, P., Crane, M., Crowley, L. E., de la Hoz, R. E., Dellenbaugh, C., Harrison, D. J., Herbert, R., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61180-x · Cited by 300
Self-citationPhilibert, R. A., Sandhu, H., Hollenbeck, N., Gunter, T., Adams, W., & Madan, A. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30657 · Cited by 300
Yehuda, R., Cai, G., Golier, J. A., Sarapas, C., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Holsboer, F., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.034 · Cited by 294
Yehuda, R., Flory, J. D., Bierer, L. M., Henn-Haase, C., Lehrner, A., Desarnaud, F., Makotkine, I., Daskalakis, N. P., Marmar, C. R., & Meaney, M. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.006 · Cited by 293
Herbert, R., Moline, J. M., Skloot, G. S., Metzger, K. B., Baron, S., Luft, B. J., Markowitz, S. B., Udasin, I. G., Harrison, D. J., Stein, D., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9592 · Cited by 270
Self-citationAssociation of SLC6A4 methylation with early adversity, characteristics and outcomes in depression
Kang, H.-J., Kim, J.-M., Stewart, R., Kim, S.-Y., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Shin, M.-G., & Yoon, J.-S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.01.006 · Cited by 254
Accounting for Population Stratification in DNA Methylation Studies
Barfield, R., Almli, L. M., Kilaru, V., Smith, A. K., Mercer, K. B., Duncan, R., Klengel, T., Mehta, D., Binder, E. B., Epstein, M. P., et al. (2014) · Genetic Epidemiology · doi:10.1002/gepi.21789 · Cited by 248
Wells, T. S., LeardMann, C. A., Fortuna, S. O., Smith, B., Smith, T. C., Ryan, M. A. K., Boyko, E. J., Blazer, D. G., & for the Millennium Cohort Study Team (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.155432 · Cited by 248
Aberg, K. A., McClay, J. L., Nerella, S., Clark, S., Kumar, G., Chen, W., Khachane, A. N., Xie, L., Hudson, A., Gao, G., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3730 · Cited by 248
Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions
Zannas, A. S., Provençal, N., & Binder, E. B. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.003 · Cited by 218
Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited
Harwood, A. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001618 · Cited by 209
Posttraumatic stress disorder after cancer diagnosis in adults: A meta-analysis
Swartzman, S., Booth, J. N., Munro, A., & Sani, F. (2016) · Depression and Anxiety · doi:10.1002/da.22542 · Cited by 205
Cellular and molecular mechanisms in the long-term action of antidepressants.
Racagni, G., & Popoli, M. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/gracagni · Cited by 192
Uddin, M., Koenen, K. C., Aiello, A. E., Wildman, D. E., de los Santos, R., & Galea, S. (2011) · Psychological Medicine · doi:10.1017/s0033291710001674 · Cited by 174
Self-citationKoenen, K. C., Uddin, M., Chang, S.-C., Aiello, A. E., Wildman, D. E., Goldmann, E., & Galea, S. (2011) · Depression and Anxiety · doi:10.1002/da.20825 · Cited by 174
Self-citationEpigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques
Kinnally, E. L., Capitanio, J. P., Leibel, R., Deng, L., LeDuc, C., Haghighi, F., & Mann, J. J. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00588.x · Cited by 155
DNA Methylation in Whole Blood: Uses and Challenges
Houseman, E. A., Kim, S., Kelsey, K. T., & Wiencke, J. K. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-015-0050-3 · Cited by 151
Na, K., Chang, H. S., Won, E., Han, K., Choi, S., Tae, W., Yoon, H., Kim, Y., Joe, S., Jung, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085425 · Cited by 144
Mahon, P. B., Zandi, P. P., Potash, J. B., Nestadt, G., & Wand, G. S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2956-x · Cited by 140
Genome-Wide DNA Methylation Scan in Major Depressive Disorder
Sabunciyan, S., Aryee, M. J., Irizarry, R. A., Rongione, M. A., Webster, M. J., Kaufmann, W. E., Murakami, P. N., Lessard, A., Yolken, R. H., Feinberg, A. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034451 · Cited by 139
Olsson, C. A., Foley, D. L., Parkinson-Bates, M., Byrnes, G., McKenzie, M., Patton, G. C., Morley, R., Anney, R. J. L., Craig, J. M., & Saffery, R. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2009.12.003 · Cited by 137
Ota, K. T., Pierre, V. J., Ploski, J. E., Queen, K., & Schafe, G. E. (2008) · Learning & Memory · doi:10.1101/lm.1114808 · Cited by 134
Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression
Dempster, E. L., Wong, C. C. Y., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. S., & Eley, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.013 · Cited by 132
Gene-set analysis is severely biased when applied to genome-wide methylation data
Geeleher, P., Hartnett, L., Egan, L. J., Golden, A., Ali, R. A. R., & Seoighe, C. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt311 · Cited by 128
Kinnally, E. L., Tarara, E. R., Mason, W. A., Mendoza, S. P., Abel, K., Lyons, L. A., & Capitanio, J. P. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00533.x · Cited by 125
Traumatic stress and human DNA methylation: A critical review
Vinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z., Turner, J. D., & Boks, M. P. (2015) · Epigenomics · doi:10.2217/epi.15.11 · Cited by 112
Biomarkers in Posttraumatic Stress Disorder: Overview and Implications for Future Research
Schmidt, U., Kaltwasser, S. F., & Wotjak, C. T. (2013) · Disease Markers · doi:10.1155/2013/835876 · Cited by 103
Byrne, E. M., Carrillo‐Roa, T., Henders, A. K., Bowdler, L. M., McRae, A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Krause, L., & Wray, N. R. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.45 · Cited by 100
Epigenetics and depressive disorders: a review of current progress and future directions
Januar, V., Saffery, R., & Ryan, J. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu273 · Cited by 99
Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
Davies, M. N., Krause, L., Bell, J. T., Gao, F., Ward, K. J., Wu, H., Lu, H., Liu, Y., Tsai, P.-C., Collier, D. A., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-4-r56 · Cited by 98
A statistical framework for Illumina DNA methylation arrays
Kuan, P. F., Wang, S., Zhou, X., & Chu, H. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq553 · Cited by 98
Self-citationG protein signaling and the molecular basis of antidepressant action
Donati, R. J., & Rasenick, M. M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00249-2 · Cited by 97
Chang, S.-C., Koenen, K. C., Galea, S., Aiello, A. E., Soliven, R., Wildman, D. E., & Uddin, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039184 · Cited by 81
Self-citationAttenuation of Phospholipid Signaling Provides a Novel Mechanism for the Action of Valproic Acid
Xu, X., Müller‐Taubenberger, A., Adley, K. E., Pawolleck, N., Lee, V. W. Y., Wiedemann, C. G., Sihra, T. S., Maniak, M., Jin, T., & Williams, R. S. B. (2007) · Eukaryotic Cell · doi:10.1128/ec.00104-06 · Cited by 77
Uddin, M., Sipahi, L., Li, J., & Koenen, K. C. (2013) · Depression and Anxiety · doi:10.1002/da.22167 · Cited by 66
Self-citationRosen, R. L., Levy‐Carrick, N. C., Reibman, J., Xu, N., Shao, Y., Liu, M., Ferri, L., Kazeros, A., Caplan‐Shaw, C., Pradhan, D. R., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.01.007 · Cited by 66
Early life trauma, depression and the glucocorticoid receptor gene—An epigenetic perspective
Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H. (2015) · Psychological Medicine · doi:10.1017/s0033291715001555 · Cited by 61
The Genboree Microbiome Toolset and the analysis of 16S rRNA microbial sequences
Riehle, K. P., Coarfa, C., Jackson, A., Ma, J., Tandon, A., Paithankar, S., Raghuraman, S., Mistretta, T., Saulnier, D. M. A., Raza, S., et al. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s13-s11 · Cited by 55
Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review
Heinzelmann, M., & Gill, J. (2013) · Nursing Research and Practice · doi:10.1155/2013/417010 · Cited by 50
Koenen, K. C., Duncan, L. E., Liberzon, I., & Ressler, K. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.022 · Cited by 47
Self-citationSeng, J. S. (2010) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2010.496075 · Cited by 31
Oxytocin affects spontaneous neural oscillations in trauma-exposed war veterans
Eidelman-Rothman, M., Goldstein, A., Lévy, J., Weisman, O., Schneiderman, I., Mankuta, D., Zagoory‐Sharon, O., & Feldman, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00165 · Cited by 29
Hydroxymethylated cytosine in development and disease
Pfeifer, G. P. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-s1-o8 · Cited by 13
Ahmadi, N., Arora, R. R., Vaidya, N. A., Yehuda, R., & Ebrahimi, R. (2013) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(13)61347-9 · Cited by 12
Flagged first, then by citations
Research works printed but not linked: 1
- First MB, Spitzer RL, Gibbon M, Williams JB . Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition (February 1996 Final), SCID-I/P: Biometrics Research Department. New York State Psychiatric Institute: New York, NY, 1998.
Cited by
Sorted by citations
Recent Genetics and Epigenetics Approaches to PTSD
Daskalakis, N. P., Rijal, C. M., King, C. D., Huckins, L. M., & Ressler, K. J. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0898-7 · Cited by 152
Smith, A. K., Ratanatharathorn, A. D., Maihofer, A. X., Naviaux, R. K., Aiello, A. E., Amstadter, A. B., Ashley‐Koch, A. E., Baker, D. G., Beckham, J. C., Boks, M. P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19615-x · Cited by 141
Self-citationThe role of epigenetics in psychological resilience
Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30515-0 · Cited by 108
the Traumatic Stress Brain Study Group, Logue, M. W., Miller, M. W., Wolf, E. J., Huber, B. R., Morrison, F. G., Zhou, Z., Zheng, Y., Smith, A. K., Daskalakis, N. P., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-0820-0 · Cited by 105
A review of epigenetic contributions to post-traumatic stress disorder
Howie, J. H., Rijal, C. M., & Ressler, K. J. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/kressler · Cited by 103
Metadata
- Authors
- Kuan, P.-F., Waszczuk, M. A., Kotov, R., Marsit, C. J., Guffanti, G., Gonzalez, A., Yang, X., Koenen, K., Bromet, E., & Luft, B. J.
- Affiliations
- Stony Brook University (US)
- Emory University (US)
- Harvard University (US)
- Corresponding author
- Luft, B J
- Venue
- Translational Psychiatry
- Published
- 2017-06-27
- Volume
- 7
- Issue
- 6
- Pages
- e1158-e1158
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC5537648
- OpenAlex
- W2634894186
- Cited by
- 103
- References
- 80
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 17 · 2021: 16 · 2020: 15 · 2019: 12 · 2018: 13 · 2017: 1
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Stony Brook University
- Centers for Disease Control and Prevention
- National Institute for Occupational Safety and Health (U01OH010416, U01 OH010416-01)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, major depressive disorder, DNA methylation, epigenome-wide association study, World Trade Center responders, differentially methylated genes, gene set enrichment analysis, synaptic plasticity, oxytocin signaling, cholinergic synapses, phosphoinositide signaling, cell cycle, stress response, inflammation
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Humans, Male, Middle Aged, Stress Disorders, Post-Traumatic, Signal Transduction, CpG Islands, DNA Methylation, Epigenesis, Genetic, September 11 Terrorist Attacks, Genome-Wide Association Study, Epigenomics, Emergency Responders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
