A hitchhiker's guide to G-quadruplex ligands

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091

Quadruplex DNA: sequence, topology and structure

Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K., & Neidle, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl655 · Cited by 2,408

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription

Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,238

Prevalence of quadruplexes in the human genome

Huppert, J. L., & Balasubramanian, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki609 · Cited by 1,741

G‐Quartets 40 Years Later: From 5′‐GMP to Molecular Biology and Supramolecular Chemistry

Davis, J. T. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200300589 · Cited by 1,626

G-quadruplexes in promoters throughout the human genome

Huppert, J. L., & Balasubramanian, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1057 · Cited by 1,356

DNA and its associated processes as targets for cancer therapy

Hurley, L. H. (2002) · Nature Reviews Cancer · doi:10.1038/nrc749 · Cited by 1,349

Highly prevalent putative quadruplex sequence motifs in human DNA

Todd, A. K. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki553 · Cited by 978

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

Patel, D. J., Phan, A. T., & Kuryavyi, V. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm711 · Cited by 882

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Sun, D., Thompson, B., Cathers, B. E., Salazar, M., Kerwin, S. M., Trent, J. O., Jenkins, T. C., Neidle, S., & Hurley, L. H. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970199z · Cited by 794

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

Cogoi, S., & Xodo, L. E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl286 · Cited by 739

Solution Structure of the Biologically Relevant G-Quadruplex Element in the Human c-MYC Promoter. Implications for G-Quadruplex Stabilization

Ambrus, A., Chen, D., Dai, J., Jones, R. A., & Yang, D. (2005) · Biochemistry · doi:10.1021/bi048242p · Cited by 683

Telomere maintenance as a target for anticancer drug discovery

Neidle, S., & Parkinson, G. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd793 · Cited by 624

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H. J., & Plückthun, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141229498 · Cited by 606

DNA tetraplex formation in the control region of c-myc

Simonsson, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1167 · Cited by 598

The G-Quadruplex-Interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent with Telomere Targeting and Interference with Telomerase Function

Burger, A. M., Dai, F., Schultes, C. M., Reszka, A. P., Moore, M. J., Double, J. A., & Neidle, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2910 · Cited by 587

Targeting telomeres and telomerase

De Cian, A., Lacroix, L., Douarre, C., Temime-Smaali, N., Trentesaux, C., Riou, J.-F., & Mergny, J.-L. (2008) · Biochimie · doi:10.1016/j.biochi.2007.07.011 · Cited by 572

Sequence and Structural Selectivity of Nucleic Acid Binding Ligands

Ren, J., & Chaires, J. B. (1999) · Biochemistry · doi:10.1021/bi992070s · Cited by 564

Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N. (2004) · Genes & Development · doi:10.1101/gad.1200804 · Cited by 553

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

Paeschke, K., Simonsson, T., Postberg, J., Rhodes, D., & Lipps, H. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb982 · Cited by 532

Gene function correlates with potential for G4 DNA formation in the human genome

Eddy, J., & Maizels, N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl529 · Cited by 528

Telomestatin, a Potent Telomerase Inhibitor That Interacts Quite Specifically with the Human Telomeric Intramolecular G-Quadruplex

Kim, M.-Y., Vankayalapati, H., Shin-ya, K., Wierzba, K., & Hurley, L. H. (2002) · Journal of the American Chemical Society · doi:10.1021/ja017308q · Cited by 525

Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter

Phan, A. T., Kuryavyi, V., Gaw, H. Y., & Patel, D. J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio723 · Cited by 519

Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus

Shin-ya, K., Wierzba, K., Matsuo, K.-I., Ohtani, T., Yamada, Y., Furihata, K., Hayakawa, Y., & Seto, H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005780q · Cited by 509

Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

De Cian, A., DeLemos, E., Mergny, J.-L., Teulade-Fichou, M.-P., & Monchaud, D. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067352b · Cited by 451

Dynamic roles for G4 DNA in the biology of eukaryotic cells

Maizels, N. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1171 · Cited by 418

An Intramolecular G-Quadruplex Structure with Mixed Parallel/Antiparallel G-Strands Formed in the Human BCL-2 Promoter Region in Solution

Dai, J., Dexheimer, T. S., Chen, D., Carver, M., Ambrus, A., Jones, R. A., & Yang, D. (2006) · Journal of the American Chemical Society · doi:10.1021/ja055636a · Cited by 413

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands

Riou, J. F., Guittat, L., Mailliet, P., Laoui, A., Renou, E., Petitgenet, O., Mégnin-Chanet, F., Hélène, C., & Mergny, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052698099 · Cited by 394

Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter

Dexheimer, T. S., Sun, D., & Hurley, L. H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0563861 · Cited by 383

Fluorescence-based melting assays for studying quadruplex ligands

DECIAN, A., GUITTAT, L., KAISER, M., SACCA, B., AMRANE, S., BOURDONCLE, A., ALBERTI, P., TEULADEFICHOU, M., LACROIX, L., & MERGNY, J. (2007) · Methods · doi:10.1016/j.ymeth.2006.10.004 · Cited by 381

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region

Dai, J., Chen, D., Jones, R. A., Hurley, L. H., & Yang, D. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl610 · Cited by 373

NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA

Fedoroff, O. Y., Salazar, M., Han, H., Chemeris, V. V., Kerwin, S. M., & Hurley, L. H. (1998) · Biochemistry · doi:10.1021/bi981330n · Cited by 369

Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.

Izbicka, E., Wheelhouse, R. T., Raymond, É., Davidson, K. K., Lawrence, R. A., Sun, D., Windle, B. E., Hurley, L. H., & Hoff, D. D. V. (1999) · PubMed · Cited by 366

Natural and pharmacological regulation of telomerase

Mergny, J.-L. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.839 · Cited by 352

Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by Square-Planar Nickel(II) Complexes

Reed, J. E., Arnal, A. A., Neidle, S., & Vilar, R. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058509n · Cited by 338

Telomestatin and Diseleno Sapphyrin Bind Selectively to Two Different Forms of the Human Telomeric G-Quadruplex Structure

Rezler, E. M., Seenisamy, J., Bashyam, S., Kim, M.-Y., White, E., Wilson, W. D., & Hurley, L. H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0505088 · Cited by 338

Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition

Han, F. X., Wheelhouse, R. T., & Hurley, L. H. (1999) · Journal of the American Chemical Society · doi:10.1021/ja984153m · Cited by 336

Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure

Seenisamy, J., Bashyam, S., Gokhale, V., Vankayalapati, H., Sun, D., Siddiqui-Jain, A., Streiner, N., Shin-ya, K., White, E., Wilson, W. D., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0444482 · Cited by 319

Structural Basis for Binding of Porphyrin to Human Telomeres,

Parkinson, G. N., Ghosh, R., & Neidle, S. (2007) · Biochemistry · doi:10.1021/bi062244n · Cited by 318

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure.

Fry, M., & Loeb, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4950 · Cited by 317

Physiological relevance of telomeric G‐quadruplex formation: a potential drug target

Oganesian, L., & Bryan, T. M. (2007) · BioEssays · doi:10.1002/bies.20523 · Cited by 309

A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity

Gowan, S. M., Harrison, J. R., Patterson, L., Valenti, M., Read, M. A., Neidle, S., & Kelland, L. R. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12212-2 · Cited by 303

Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

De Cian, A., Cristofari, G., Reichenbach, P., De Lemos, E., Monchaud, D., Teulade-Fichou, M.-P., Shin-ya, K., Lacroix, L., Lingner, J., & Mergny, J.-L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707365104 · Cited by 292

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

Mergny, J.-L., Lacroix, L., Teulade-Fichou, M.-P., Hounsou, C., Guittat, L., Hoarau, M., Arimondo, P. B., Vigneron, J.-P., Lehn, J.-M., Riou, J.-F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051620698 · Cited by 291

Stabilization of G-Quadruplex DNA and Down-Regulation of Oncogene c-myc by Quindoline Derivatives

Ou, T.-M., Lu, Y.-J., Zhang, C., Huang, Z.-S., Wang, X.-D., Tan, J.-H., Chen, Y., Ma, D.-L., Wong, K.-Y., Tang, J. C.-O., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0610088 · Cited by 288

Evidence for the Presence of a Guanine Quadruplex Forming Region within a Polypurine Tract of the Hypoxia Inducible Factor 1α Promoter

De Armond, R., Wood, S., Sun, D., Hurley, L. H., & Ebbinghaus, S. W. (2005) · Biochemistry · doi:10.1021/bi051618u · Cited by 285

Structure of a G-quadruplex–Ligand Complex

Haider, S. M., Parkinson, G. N., & Neidle, S. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01354-2 · Cited by 275

DNA architecture: from G to Z

Phan, A. T., Kuryavyi, V., & Patel, D. J. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.05.011 · Cited by 270

Preferential binding of a G-quadruplex ligand to human chromosome ends

Granotier, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki722 · Cited by 270

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

Salvati, E., Leonetti, C., Rizzo, A., Scarsella, M., Mottolese, M., Galati, R., Sperduti, I., Stevens, M. F. G., D’Incalci, M., Blasco, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32461 · Cited by 266

Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the RET Oncogene

Guo, K., Pourpak, A., Beetz-Rogers, K., Gokhale, V., Sun, D., & Hurley, L. H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072185g · Cited by 257

Trisubstituted Isoalloxazines as a New Class of G-Quadruplex Binding Ligands: Small Molecule Regulation of c-kit Oncogene Expression

Bejugam, M., Sewitz, S., Shirude, P. S., Rodriguez, R., Shahid, R., & Balasubramanian, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja075881p · Cited by 248

Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands

Pennarun, G., Granotier, C., Gauthier, L. R., Gomez, D., Hoffschir, F., Mandine, E., Riou, J.-F., Mergny, J.-L., Mailliet, P., & Boussin, F. D. (2005) · Oncogene · doi:10.1038/sj.onc.1208468 · Cited by 241

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells

Tahara, H., Shin-ya, K., Seimiya, H., Yamada, H., Tsuruo, T., & Ide, T. (2006) · Oncogene · doi:10.1038/sj.onc.1209217 · Cited by 239

Dinuclear Monointercalating RuII Complexes That Display High Affinity Binding to Duplex and Quadruplex DNA

Rajput, C., Rutkaite, R., Swanson, L., Haq, I., & Thomas, J. A. (2006) · Chemistry – A European Journal · doi:10.1002/chem.200501349 · Cited by 239

Fluorescence Resonance Energy Transfer as a Probe for G-Quartet Formation by a Telomeric Repeat

Mergny, J.-L., & Maurizot, J.-C. (2001) · ChemBioChem · doi:10.1002/1439-7633(20010202)2:2<124::aid-cbic124>3.0.co;2-l · Cited by 237

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Gomez, D. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh181 · Cited by 236

Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry

Moorhouse, A. D., Santos, A. M., Gunaratnam, M., Moore, M., Neidle, S., & Moses, J. E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0661919 · Cited by 228

2,7-Disubstituted Amidofluorenone Derivatives as Inhibitors of Human Telomerase

Perry, P. J., Read, M. A., Davies, R. T., Gowan, S. M., Reszka, A. P., Wood, A. A., Kelland, L. R., & Neidle, S. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990084q · Cited by 226

Chemical approaches to the discovery and development of cancer therapies

Neidle, S., & Thurston, D. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1587 · Cited by 224

Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands

Monchaud, D., Allain, C., & Teulade-Fichou, M.-P. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.06.067 · Cited by 224

Intercalative G-Tetraplex Stabilization of Telomeric DNA by a Cationic Porphyrin1

Haq, I., Trent, J. O., Chowdhry, B. Z., & Jenkins, T. C. (1999) · Journal of the American Chemical Society · doi:10.1021/ja981554t · Cited by 221

Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

Koeppel, F. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.5.1087 · Cited by 221

Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

Tauchi, T., Shin-ya, K., Sashida, G., Sumi, M., Okabe, S., Ohyashiki, J. H., & Ohyashiki, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209577 · Cited by 218

Stabilization of the c-myc gene promoter quadruplex by specific ligands’ inhibitors of telomerase

Lemarteleur, T., Gomez, D., Paterski, R., Mandine, E., Mailliet, P., & Riou, J.-F. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.150 · Cited by 218

Structure of the First Parallel DNA Quadruplex-Drug Complex

Clark, G. R., Pytel, P. D., Squire, C. J., & Neidle, S. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0297988 · Cited by 212

Natural and synthetic G-quadruplex interactive berberine derivatives

Franceschin, M., Rossetti, L., D’Ambrosio, A., Schirripa, S., Bianco, A., Ortaggi, G., Savino, M., Schultes, C., & Neidle, S. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.12.001 · Cited by 212

Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells

Gomez, D., Wenner, T., Brassart, B., Douarre, C., O'Donohue, M.-F., El Khoury, V., Shin-ya, K., Morjani, H., Trentesaux, C., & Riou, J.-F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605828200 · Cited by 206

Trisubstituted Acridines as G-quadruplex Telomere Targeting Agents. Effects of Extensions of the 3,6- and 9-Side Chains on Quadruplex Binding, Telomerase Activity, and Cell Proliferation

Moore, M. J. B., Schultes, C. M., Cuesta, J., Cuenca, F., Gunaratnam, M., Tanious, F. A., Wilson, W. D., & Neidle, S. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm050555a · Cited by 206

A G-Quadruplex Ligand with 10000-Fold Selectivity over Duplex DNA

Dixon, I. M., Lopez, F., Tejera, A. M., Estève, J.-P., Blasco, M. A., Pratviel, G., & Meunier, B. (2007) · Journal of the American Chemical Society · doi:10.1021/ja065591t · Cited by 204

Ultraviolet B Regulation of Transcription Factor Families: Roles of Nuclear Factor-kappa B (NF-κB) and Activator Protein-1 (AP-1) in UVB-Induced Skin Carcinogenesis

Cooper, S., & Bowden, G. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780809714 · Cited by 204

Biosensor-surface plasmon resonance: Quantitative analysis of small molecule–nucleic acid interactions

Nguyen, B., Tanious, F. A., & Wilson, W. D. (2007) · Methods · doi:10.1016/j.ymeth.2006.09.009 · Cited by 203

Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule

Rangan, A., Fedoroff, O. Y., & Hurley, L. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005962200 · Cited by 203

The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.

Kim, M.-Y., Gleason-Guzman, M. C., Izbicka, E., Nishioka, D., & Hurley, L. H. (2003) · PubMed · Cited by 203

The G-quadruplex Ligand Telomestatin Inhibits POT1 Binding to Telomeric Sequences In vitro and Induces GFP-POT1 Dissociation from Telomeres in Human Cells

Gomez, D., O'Donohue, M.-F., Wenner, T., Douarre, C., Macadré, J., Koebel, P., Giraud-Panis, M.-J., Kaplan, H., Kolkes, A., Shin-ya, K., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1581 · Cited by 200

Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

White, E. W., Tanious, F., Ismail, M. A., Reszka, A. P., Neidle, S., Boykin, D. W., & Wilson, W. D. (2007) · Biophysical Chemistry · doi:10.1016/j.bpc.2006.06.006 · Cited by 199

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

Phatak, P., Cookson, J. C., Dai, F., Smith, V, Gartenhaus, R. B., Stevens, M. F. G., & Burger, A. M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603691 · Cited by 191

Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat

Gavathiotis, E., Heald, R. A., Stevens, M. F. G., & Searle, M. S. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.018 · Cited by 190

Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase

Zhou, J.-L., Lu, Y.-J., Ou, T.-M., Zhou, J.-M., Huang, Z.-S., Zhu, X.-F., Du, C.-J., Bu, X.-Z., Ma, L., Gu, L.-Q., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050041b · Cited by 175

Selective Recognition of G-Quadruplex Telomeric DNA by a Bis(quinacridine) Macrocycle

Teulade-Fichou, M.-P., Carrasco, C., Guittat, L., Bailly, C., Alberti, P., Mergny, J.-L., David, A., Lehn, J.-M., & Wilson, W. D. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021299j · Cited by 174

Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands

Shirude, P. S., Gillies, E. R., Ladame, S., Godde, F., Shin-ya, K., Huc, I., & Balasubramanian, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073775h · Cited by 171

Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

Perry, P. J., Reszka, A. P., Wood, A. A., Read, M. A., Gowan, S. M., Dosanjh, H. S., Trent, J. O., Jenkins, T. C., Kelland, L. R., & Neidle, S. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm981067o · Cited by 165

Detection of Quadruplex DNA Structures in Human Telomeres by a Fluorescent Carbazole Derivative

Chang, C.-C., Kuo, I.-C., Ling, I.-F., Chen, C.-T., Chen, H.-C., Lou, P.-J., Lin, J.-J., & Chang, T.-C. (2004) · Analytical Chemistry · doi:10.1021/ac049510s · Cited by 160

Triplex and quadruplex DNA structures studied by electrospray mass spectrometry

Rosu, F., Gabelica, V., Houssier, C., Colson, P., & Pauw, E. D. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.778 · Cited by 160

1,4- and 2,6-Disubstituted Amidoanthracene-9,10-dione Derivatives as Inhibitors of Human Telomerase

Perry, P. J., Gowan, S. M., Reszka, A. P., Polucci, P., Jenkins, T. C., Kèlland, L. R., & Neidle, S. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9801105 · Cited by 159

Tetraplex DNA and its interacting proteins

Fry, M. (2007) · Frontiers in Bioscience · doi:10.2741/2391 · Cited by 159

A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells

Incles, C. M., Schultes, C. M., Kempski, H., Koehler, H., Kelland, L. R., & Neidle, S. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1201.3.10 · Cited by 158

Stabilization and Structure of Telomeric and c-myc Region Intramolecular G-Quadruplexes: The Role of Central Cations and Small Planar Ligands

Gabelica, V., Baker, E. S., Teulade‐Fichou, M., Pauw, E. D., & Bowers, M. T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja065989p · Cited by 157

Molecular Modeling Studies on G-Quadruplex Complexes of Telomerase Inhibitors: Structure−Activity Relationships

Read, M. A., Wood, A. A., Harrison, J. R., Gowan, S. M., Kèlland, L. R., Dosanjh, H. S., & Neidle, S. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990287e · Cited by 155

Interactions of cryptolepine and neocryptolepine with unusual DNA structures

Guittat, L., Alberti, P., Rosu, F., Miert, S. V., Thetiot, E., Pieters, L. A. C., Gabelica, V., Pauw, E. D., Ottaviani, A., Riou, J., et al. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00035-x · Cited by 147

Biophysical Studies of the c-MYC NHE III1 Promoter: Model Quadruplex Interactions with a Cationic Porphyrin

Freyer, M. W., Buscaglia, R., Kaplan, K. A., Cashman, D. J., Hurley, L. H., & Lewis, E. A. S. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.097246 · Cited by 146

Mechanism of acridine-based telomerase inhibition and telomere shortening

Gunaratnam, M., Greciano, O., Martins, C., Reszka, A. P., Schultes, C. M., Morjani, H., Riou, J., & Neidle, S. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.011 · Cited by 145

Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere Pathway

Kèlland, L. R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0422 · Cited by 145

Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition

Dixon, I. M., Lopez, F., Estève, J., Tejera, Á. M., Blasco, M. A., Pratviel, G., & Meunier, B. (2004) · ChemBioChem · doi:10.1002/cbic.200400113 · Cited by 144

9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA

Zhang, W., Ou, T., Lu, Y., Huang, Y.-Y., Wu, W., Huang, Z., Zhou, J.-L., Wong, K., & Gu, L. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.05.050 · Cited by 135

Tetramethylpyridiniumporphyrazines—a new class of G-quadruplex inducing and stabilising ligands

Gonçalves, D. P. N., Rodriguez, R., Balasubramanian, S., & Sanders, J. K. M. (2006) · Chemical Communications · doi:10.1039/b611731g · Cited by 133

Ligand‐Driven G‐Quadruplex Conformational Switching By Using an Unusual Mode of Interaction

Rodriguez, R., Pantoş, G. D., Gonçalves, D. P. N., Sanders, J. K. M., & Balasubramanian, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200605075 · Cited by 130

Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit

Shirude, P. S., Okumuş, B., Ying, L., Ha, T., & Balasubramanian, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja070497d · Cited by 128

The Design of G-quadruplex Ligands as Telomerase Inhibitors

Cuesta, J., Read, M., & Neidle, S. (2003) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557033405502 · Cited by 127

Telomere Inhibition and Telomere Disruption as Processes for Drug Targeting

Rezler, E. M., Bearss, D. J., & Hurley, L. H. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135733 · Cited by 126

Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands

Jantos, K., Rodriguez, R., Ladame, S., Shirude, P. S., & Balasubramanian, S. (2006) · Journal of the American Chemical Society · doi:10.1021/ja064713e · Cited by 126

Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions

Redon, S. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg259 · Cited by 125

Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.

Chen, Q., Kuntz, I. D., & Shafer, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2635 · Cited by 123

Total Synthesis of (R)-Telomestatin

Doi, T., Yoshida, M., Shin‐ya, K., & Takahashi, T. (2006) · Organic Letters · doi:10.1021/ol061793i · Cited by 122

Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines

Zhou, J.-M., Zhu, X.-F., Lu, Y.-J., Deng, R., Huang, Z.-S., Mei, Y.-P., Wang, Y., Huang, W.-L., Liu, Z.-C., Gu, L.-Q., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209067 · Cited by 121

G‐Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study

Hounsou, C., Guittat, L., Monchaud, D., Jourdan, M., Saettel, N., Mergny, J., & Teulade‐Fichou, M. (2007) · ChemMedChem · doi:10.1002/cmdc.200600286 · Cited by 118

Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ

Lew, A., Rutter, W. J., & Kennedy, G. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12508 · Cited by 117

Interaction of the dye ethidium bromide with DNA containing guanine repeats

Guo, Q., Lu, M., Marky, L. A., & Kallenbach, N. R. (1992) · Biochemistry · doi:10.1021/bi00124a002 · Cited by 115

Retinoblastoma susceptibility genes contain 5' sequences with a high propensity to form guanine-tetrad structures

Murchie, A. I. H., & Lilley, D. M. J. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.49 · Cited by 114

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

Reed, J. E., Neidle, S., & Vilar, R. (2007) · Chemical Communications · doi:10.1039/b709898g · Cited by 114

Parallel-Stranded Guanine Quadruplex Interactions with a Copper Cationic Porphyrin

Keating, L. R., & Szalai, V. A. (2004) · Biochemistry · doi:10.1021/bi0483209 · Cited by 113

Molecular recognition of nucleic acids: Coralyne binds strongly to poly(A)

Xing, F., Song, G., Ren, J., Chaires, J. B., & Qu, X. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.091 · Cited by 113

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

Caprio, V. E., Guyen, B., Opoku‐Boahen, Y., Mann, J., Gowan, S. M., Kèlland, L. R., Read, M. A., & Neidle, S. (2000) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00378-4 · Cited by 112

Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase

Guyen, B., Schultes, C. M., Hazel, P., Mann, J., & Neidle, S. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b316055f · Cited by 107

Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects.

Duan, W., Rangan, A., Vankayalapati, H., Kim, M. Y., Zeng, Q., Sun, D., Han, H., Fedoroff, O. Y., Nishioka, D., Rha, S. Y., et al. (2001) · PubMed · Cited by 107

Quadruplex-Based Molecular Beacons as Tunable DNA Probes

Bourdoncle, A., Estevez‐Torres, A., Gosse, C., Lacroix, L., Vekhoff, P., Saux, T. L., Jullien, L., & Mergny, J. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0608040 · Cited by 106

Pharmacodynamics of the G-Quadruplex-Stabilizing Telomerase Inhibitor 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in Vitro: Activity in Human Tumor Cells Correlates with Telomere Length and Can Be Enhanced, or Antagonized, with Cytotoxic Agents

Cookson, J. C., Dai, F., Smith, V., Heald, R. A., Laughton, C. A., Stevens, M. F. G., & Burger, A. M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.013300 · Cited by 98

End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes

Evans, S. E., Méndez, M., Turner, K. B., Keating, L. R., Grimes, R. T., Melchoir, S., & Szalai, V. A. (2007) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-007-0292-0 · Cited by 98

Specific interactions of distamycin with G-quadruplex DNA

Cocco, M. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg392 · Cited by 96

Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)4

Gavathiotis, E., Heald, R. A., Stevens, M. F. G., & Searle, M. S. (2001) · Angewandte Chemie International Edition · Cited by 92

A platinum–quinacridine hybrid as a G-quadruplex ligand

Bertrand, H. C., Bombard, S., Monchaud, D., & Teulade‐Fichou, M. (2007) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-007-0273-3 · Cited by 88

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation

Cian, A. D., & Mergny, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm098 · Cited by 88

A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells

Brassart, B., Gómez, D., Cian, A. D., Boujemaa‐Paterski, R., Montagnac, A., Khuong‐Huu, Q., Temime‐Smaali, N., Trentesaux, C., Mergny, J., Guéritte, F., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.036574 · Cited by 87

The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA

Khateb, S., Weisman-Shomer, P., Hershco-Shani, I., Ludwig, A. L., & Fry, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm636 · Cited by 87

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding

Harrison, R. J., Reszka, A. P., Haider, S. M., Romagnoli, B., Morrell, J. M., Read, M. A., Gowan, S. M., Incles, C. M., Kèlland, L. R., & Neidle, S. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.09.037 · Cited by 86

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

Minhas, G. S., Pilch, D. S., Kerrigan, J. E., LaVoie, E. J., & Rice, J. E. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.05.038 · Cited by 84

Cyclo[n]pyrroles: Size and Site-Specific Binding to G-Quadruplexes

Baker, E. S., Lee, J. T., Sessler, J. L., & Bowers, M. T. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0564968 · Cited by 83

Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells

Binz, N., Shalaby, T., Rivera, P., Shin‐ya, K., & Grotzer, M. A. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.025 · Cited by 83

Interaction of an Acridine Dimer with DNA Quadruplex Structures

Alberti, P., Ren, J., Teulade‐Fichou, M., Guittat, L., Riou, J., Chaires, J. B., Hélène, C., Vigneron, J., Lehn, J., & Mergny, J. (2001) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2001.10506758 · Cited by 83

A Phenol Quaternary Ammonium Porphyrin as a Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA

Wang, P., Ren, L., He, H., Liang, F., Zhou, X., & Tan, Z. (2006) · ChemBioChem · doi:10.1002/cbic.200600036 · Cited by 83

Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc

Maiti, S., Chaudhury, N. K., & Chowdhury, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.052 · Cited by 78

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

Sissi, C., Lucatello, L., Krapcho, A. P., Maloney, D. J., Boxer, M. B., Camarasa, M. V., Pezzoni, G., Menta, E., & Palumbo, M. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.09.029 · Cited by 74

Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA

Sun, H., Tang, Y., Xiang, J., Xu, G., Zhang, Y., Zhang, H., & Xu, L. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.03.087 · Cited by 73

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

Barbieri, C. M., Srinivasan, A. R., Rzuczek, S. G., Rice, J. E., LaVoie, E. J., & Pilch, D. S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm188 · Cited by 73

Selective interactions of perylene derivatives having different side chains with inter- and intramolecular G-quadruplex DNA structures. A correlation with telomerase inhibition

Rossetti, L., Franceschin, M., Schirripa, S., Bianco, A., Ortaggi, G., & Savino, M. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.10.061 · Cited by 72

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents

Martins, C., Gunaratnam, M., Stuart, J. W., Makwana, V., Greciano, O., Reszka, A. P., Kèlland, L. R., & Neidle, S. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.01.056 · Cited by 71

Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro

Guittat, L., Cian, A. D., Rosu, F., Gabelica, V., Pauw, E. D., Delfourne, E., & Mergny, J. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.04.023 · Cited by 71

Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition

Kaiser, M., Cian, A. D., Sainlos, M., Renner, C., Mergny, J., & Teulade‐Fichou, M. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b516378a · Cited by 63

Resistance to the Short Term Antiproliferative Activity of the G-quadruplex Ligand 12459 Is Associated with Telomerase Overexpression and Telomere Capping Alteration

Gómez, D., Aouali, N., Londoño‐Vallejo, A., Lacroix, L., Mégnin-Chanet, F., Lemarteleur, T., Douarre, C., Shin‐ya, K., Mailliet, P., Trentesaux, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308440200 · Cited by 59

Porphyrin–aminoquinoline conjugates as telomerase inhibitors

Maraval, A., Franco, S., Vialas, C., Pratviel, G., Blasco, M. A., & Meunier, B. (2003) · Organic & Biomolecular Chemistry · doi:10.1039/b211634k · Cited by 58

Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins

Gonçalves, D. P. N., Ladame, S., Balasubramanian, S., & Sanders, J. K. M. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b608494j · Cited by 56

Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: A new class of telomerase inhibitors

Franceschin, M., Alvino, A., Casagrande, V., Mauriello, C., Pascucci, E., Savino, M., Ortaggi, G., & Bianco, A. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.11.032 · Cited by 53

Oxidative Damage Generated by an Oxo-Metalloporphyrin onto the Human Telomeric Sequence

Vialas, C., Pratviel, G., & Meunier, B. (2000) · Biochemistry · doi:10.1021/bi000743x · Cited by 52

Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

Douarre, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki514 · Cited by 52

Interactions of daidzin with intramolecular G‐quadruplex

Li, W., Zhang, M., Zhang, J., Li, H., Zhang, X.-C., Sun, Q., & Qiu, C.-M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.08.007 · Cited by 50

Affinity and selectivity of G4 ligands measured by FRET

Cian, A. D., Guittat, L., Shin‐ya, K., Riou, J., & Mergny, J. (2005) · Nucleic Acids Symposium Series · doi:10.1093/nass/49.1.235 · Cited by 50

BNIP-Sα induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain

Zhou, Y., Guy, G. R., & Low, B. C. (2005) · Oncogene · doi:10.1038/sj.onc.1209274 · Cited by 49

Furan Based Cyclic Oligopeptides Selectively Target G-Quadruplex

Chakraborty, T. K., Arora, A., Roy, S., Kumar, N., & Maiti, S. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070619c · Cited by 48

G-Quadruplex DNA binding by a series of carbocyanine dyes

Kerwin, S. M., Sun, D., Kern, J. T., Rangan, A., & Thomas, P. W. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00490-5 · Cited by 47

Selectivity of an indolyl berberine derivative for tetrameric G‐quadruplex DNA

Gornall, K. C., Samosorn, S., Talib, J., Bremner, J. B., & Beck, J. L. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3019 · Cited by 46

Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Alberti, P., Schmitt, P., Nguyen, C.-H., Rivalle, C., Hoarau, M., Grierson, D. S., & Mergny, J. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00080-x · Cited by 43

New highly hydrosoluble and not self-aggregated perylene derivatives with three and four polar side-chains as G-quadruplex telomere targeting agents and telomerase inhibitors

Franceschin, M., Pascucci, E., Alvino, A., D’Ambrosio, D., Bianco, A., Ortaggi, G., & Savino, M. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.02.021 · Cited by 42

Energetics of Quadruplex-Drug Recognition in Anticancer Therapy

Pagano, B., & Giancola, C. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907781662257 · Cited by 42

Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up-Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant Cells to Combination Treatment with a Telomerase Inhibitor

Incles, C. M., Schultes, C. M., Kèlland, L. R., & Neidle, S. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1101 · Cited by 35

Binding of G-Quadruplex-interactive Agents to Distinct G-Quadruplexes Induces Different Biological Effects in MiaPaCa Cells

Liu, W., Sun, D., & Hurley, L. H. (2005) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770500267238 · Cited by 34

Interaction between Human Telomere and a Carbazole Derivative: A Molecular Dynamics Simulation of a Quadruplex Stabilizer and Telomerase Inhibitor

Yang, D., & Sheu, S. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp071963o · Cited by 32

Novel Antitumor and Neuroprotective Substances Discovered by Characteristic Screenings Based on Specific Molecular Targets

Shin‐ya, K. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.867 · Cited by 32

Design, Synthesis, and Evaluation of Novel Biarylpyrimidines: A New Class of Ligand for Unusual Nucleic Acid Structures

Wheelhouse, R. T., Jennings, S. A., Phillips, V. A., Pletsas, D., Murphy, P. M., Garbett, N. C., Chaires, J. B., & Jenkins, T. C. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060315a · Cited by 31

Spectral properties and G-quadruplex DNA binding selectivities of a series of unsymmetrical perylene diimides

Dinçalp, H., Avcıbaşı, N., & İçli, S. (2006) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2006.04.035 · Cited by 24

A G-Quadruplex Ligand 3,3′-Diethyloxadicarbocyanine Iodide Induces Mitochondrion-Mediated Apoptosis But Not Decrease of Telomerase Activity in Nasopharyngeal Carcinoma NPC-TW01 Cells

Li, C., Huang, J.-H., Chang, A.-C., Hung, Y., Lin, C., Chao, Y., Lee, S., Whang‐Peng, J., & Huang, T. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000012166.44521.1f · Cited by 21

Spectroscopic study and G-quadruplex DNA binding affinity of two bioactive papaverine-derived ligands

Gałęzowska, E., Masternak, A., Rubiś, B., Czyrski, A., Rybczyńska, M., Hermann, T., & Juskowiak, B. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.07.008 · Cited by 20

Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative

Juskowiak, B., Gałęzowska, E., Koczorowska, N., & Hermann, T. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.05.029 · Cited by 19

Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent

Hooda, J., Bednarski, D. W., Irish, L., & Firestine, S. M. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.10.047 · Cited by 16

The Structure and Function of DNA G-Quadruplexes

Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920

Metal Cations in G-Quadruplex Folding and Stability

Bhattacharyya, D., Mirihana Arachchilage, G., & Basu, S. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00038 · Cited by 621

1,10-Phenanthroline: A versatile building block for the construction of ligands for various purposes

Bencini, A., & Lippolis, V. (2010) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2010.04.008 · Cited by 615

G-quadruplex nucleic acids as therapeutic targets

Balasubramanian, S., & Neidle, S. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.04.637 · Cited by 586

Nucleic Acid Based Molecular Devices

Krishnan, Y., & Simmel, F. C. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.200907223 · Cited by 572