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Mesoporous silica nanoparticles in biomedical applications
Abstract
This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol-gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.
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Cites
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
Kresge, C. T., Leonowicz, M. E., Roth, W. J., Vartuli, J. C., & Beck, J. S. (1992) · Nature · doi:10.1038/359710a0 · Cited by 16,275
Controlled growth of monodisperse silica spheres in the micron size range
Stöber, W., Fink, A., & Bohn, E. (1968) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(68)90272-5 · Cited by 14,532
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J., Wang, A., Langer, R., & Farokhzad, O. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,657
A New Property of MCM-41: Drug Delivery System
Vallet-Regi, M., Rámila, A., del Real, R. P., & Pérez-Pariente, J. (2001) · Chemistry of Materials · doi:10.1021/cm0011559 · Cited by 2,182
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,929
Self-citationYanagisawa, T., Shimizu, T., Kuroda, K., & Kato, C. (1990) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.63.988 · Cited by 1,783
Paul Ehrlich's magic bullet concept: 100 years of progress
Strebhardt, K., & Ullrich, A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2394 · Cited by 1,457
Lu, J., Liong, M., Li, Z., Zink, J. I., & Tamanoi, F. (2010) · Small · doi:10.1002/smll.201000538 · Cited by 1,074
Self-citationMesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
Lu, J., Liong, M., Zink, J. I., & Tamanoi, F. (2007) · Small · doi:10.1002/smll.200700005 · Cited by 1,012
Self-citationMesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
Vivero‐Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S. ‐. (2010) · Small · doi:10.1002/smll.200901789 · Cited by 998
Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Self-citationMaeda, H., Sawa, T., & Konno, T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00309-1 · Cited by 925
Meng, H., Liong, M., Xia, T., Li, Z., Ji, Z., Zink, J. I., & Nel, A. E. (2010) · ACS Nano · doi:10.1021/nn100690m · Cited by 902
Self-citationSlowing, I., Trewyn, B. G., & Lin, V. S.-Y. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0645943 · Cited by 846
A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent
Radu, D. R., Lai, C.-Y., Jeftinija, K., Rowe, E. W., Jeftinija, S., & Lin, V. S.-Y. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046275m · Cited by 840
Lim, M. H., & Stein, A. (1999) · Chemistry of Materials · doi:10.1021/cm990369r · Cited by 828
Dilute Solution Routes to Various Controllable Morphologies of MCM-41 Silica with a Basic Medium
Cai, Q., Luo, Z.-S., Pang, W.-Q., Fan, Y.-W., Chen, X.-H., & Cui, F.-Z. (2001) · Chemistry of Materials · doi:10.1021/cm990661z · Cited by 679
He, Q., Zhang, Z., Gao, F., Li, Y., & Shi, J. (2011) · Small · doi:10.1002/smll.201001459 · Cited by 661
The synthesis of micrometer‐ and submicrometer‐size spheres of ordered mesoporous oxide MCM‐41
Grün, M., Lauer, I., & Unger, K. K. (1997) · Advanced Materials · doi:10.1002/adma.19970090317 · Cited by 652
MCM-41 Organic Modification as Drug Delivery Rate Regulator
Muñoz, B., Rámila, A., Pérez-Pariente, J., Díaz, I., & Vallet-Regí, M. (2003) · Chemistry of Materials · doi:10.1021/cm021217q · Cited by 618
Chung, T.-H., Wu, S.-H., Yao, M., Lu, C.-W., Lin, Y.-S., Hung, Y., Mou, C.-Y., Chen, Y.-C., & Huang, D.-M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.006 · Cited by 617
Thomas, C. R., Ferris, D. P., Lee, J.-H., Choi, E., Cho, M. H., Kim, E. S., Stoddart, J. F., Shin, J.-S., Cheon, J., & Zink, J. I. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1022267 · Cited by 615
Self-citationAndersson, J., Rosenholm, J., Areva, S., & Lindén, M. (2004) · Chemistry of Materials · doi:10.1021/cm0401490 · Cited by 605
Meng, H., Xue, M., Xia, T., Zhao, Y.-L., Tamanoi, F., Stoddart, J. F., Zink, J. I., & Nel, A. E. (2010) · Journal of the American Chemical Society · doi:10.1021/ja104501a · Cited by 595
Self-citationEnzyme-Responsive Snap-Top Covered Silica Nanocontainers
Patel, K., Angelos, S., Dichtel, W. R., Coskun, A., Yang, Y.-W., Zink, J. I., & Stoddart, J. F. (2008) · Journal of the American Chemical Society · doi:10.1021/ja0772086 · Cited by 576
Self-citationThe biocompatibility of mesoporous silicates
Hudson, S. P., Padera, R. F., Langer, R., & Kohane, D. S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.007 · Cited by 538
Targeting of Porous Hybrid Silica Nanoparticles to Cancer Cells
Rosenholm, J. M., Meinander, A., Peuhu, E., Niemi, R., Eriksson, J. E., Sahlgren, C., & Lindén, M. (2009) · ACS Nano · doi:10.1021/nn800781r · Cited by 520
Mechanised nanoparticles for drug delivery
Cotí, K. K., Belowich, M. E., Liong, M., Ambrogio, M. W., Lau, Y. A., Khatib, H. A., Zink, J. I., Khashab, N. M., & Stoddart, J. F. (2009) · Nanoscale · doi:10.1039/b9nr00162j · Cited by 512
Self-citationMeng, H., Xue, M., Xia, T., Ji, Z., Tarn, D. Y., Zink, J. I., & Nel, A. E. (2011) · ACS Nano · doi:10.1021/nn200809t · Cited by 509
Self-citationNguyen, T. D., Tseng, H.-R., Celestre, P. C., Flood, A. H., Liu, Y., Stoddart, J. F., & Zink, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504109102 · Cited by 463
Self-citationLight‐Activated Nanoimpeller‐Controlled Drug Release in Cancer Cells
Lu, J., Choi, E., Tamanoi, F., & Zink, J. I. (2008) · Small · doi:10.1002/smll.200700903 · Cited by 462
Self-citationCancer theranostics: the rise of targeted magnetic nanoparticles
Cole, A. J., Yang, V. C., & David, A. E. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2011.03.001 · Cited by 425
Manzano, M., Aina, V., Areán, C. O., Balas, F., Cauda, V., Colilla, M., Delgado, M. R., & Vallet-Regí, M. (2008) · Chemical Engineering Journal · doi:10.1016/j.cej.2007.07.078 · Cited by 422
Xiong, X.-B., & Lavasanifar, A. (2011) · ACS Nano · doi:10.1021/nn2013707 · Cited by 411
Plummer, R., Wilson, R. H., Calvert, H., Boddy, A. V., Griffin, M., Sludden, J., Tilby, M. J., Eatock, M., Pearson, D. G., Ottley, C. J., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.6 · Cited by 390
Suzuki, K., Ikari, K., & Imai, H. (2004) · Journal of the American Chemical Society · doi:10.1021/ja038250d · Cited by 375
Mesoporous silica nanoparticles as nanocarriers
Wu, S.-H., Hung, Y., & Mou, C.-Y. (2011) · Chemical Communications · doi:10.1039/c1cc11760b · Cited by 372
New developments in ordered mesoporous materials for drug delivery
Manzano, M., & Vallet-Regí, M. (2010) · Journal of Materials Chemistry · doi:10.1039/b922651f · Cited by 359
Photoregulation of Mass Transport through a Photoresponsive Azobenzene-Modified Nanoporous Membrane
Liu, Dunphy, D. R., Atanassov, P., Bunge, S. D., Chen, Z., López, G. P., Boyle, T. J., & Brinker, C. J. (2004) · Nano Letters · doi:10.1021/nl0350783 · Cited by 348
Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.048 · Cited by 337
de Smet, M., Heijman, E., Langereis, S., Hijnen, N. M., & Grüll, H. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.036 · Cited by 330
Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles
Souris, J. S., Lee, C.-H., Cheng, S.-H., Chen, C.-T., Yang, C.-S., Ho, J.-A. A., Mou, C.-Y., & Lo, L.-W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.048 · Cited by 320
pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles
Zhao, Y.-L., Li, Z., Kabehie, S., Botros, Y. Y., Stoddart, J. F., & Zink, J. I. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105371u · Cited by 304
Self-citationControl of Molecular Transport Through Stimuli‐Responsive Ordered Mesoporous Materials
Fu, Q., Rao, G. V. R., Ista, L. K., Wu, Y., Andrzejewski, B. P., Sklar, L. A., Ward, T. L., & López, G. P. (2003) · Advanced Materials · doi:10.1002/adma.200305165 · Cited by 282
Photo-Switched Storage and Release of Guest Molecules in the Pore Void of Coumarin-Modified MCM-41
Mal, N. K., Fujiwara, M., Tanaka, Y., Taguchi, T., & Matsukata, M. (2003) · Chemistry of Materials · doi:10.1021/cm0343296 · Cited by 274
van Schooneveld, M. M., Vucic, E., Koole, R., Zhou, Y., Stocks, J., Cormode, D. P., Tang, C. Y., Gordon, R. E., Nicolay, K., Meijerink, A., et al. (2008) · Nano Letters · doi:10.1021/nl801596a · Cited by 256
Tsai, C.-P., Chen, C.-Y., Hung, Y., Chang, F.-H., & Mou, C.-Y. (2009) · Journal of Materials Chemistry · doi:10.1039/b905158a · Cited by 252
Hom, C., Lu, J., Liong, M., Luo, H., Li, Z., Zink, J. I., & Tamanoi, F. (2010) · Small · doi:10.1002/smll.200901966 · Cited by 239
Self-citationPhoto-Driven Expulsion of Molecules from Mesostructured Silica Nanoparticles
Angelos, S., Choi, E., Vögtle, F., De Cola, L., & Zink, J. I. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp070721l · Cited by 227
Self-citationFolate-decorated nanogels for targeted therapy of ovarian cancer
Nukolova, N. V., Oberoi, H. S., Cohen, S. M., Kabanov, A. V., & Bronich, T. K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.006 · Cited by 223
Ferris, D. P., Lu, J., Gothard, C., Yanes, R., Thomas, C. R., Olsen, J., Stoddart, J. F., Tamanoi, F., & Zink, J. I. (2011) · Small · doi:10.1002/smll.201002300 · Cited by 217
Self-citationSelective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
Symon, Z., Peyser, A., Tzemach, D., Lyass, O., Sucher, E., Shezen, E., & Gabizon, A. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990701)86:1<72::aid-cncr12>3.0.co;2-1 · Cited by 213
Lu, J., Liong, M., Sherman, S., Xia, T., Kovochich, M., Nel, A. E., Zink, J. I., & Tamanoi, F. (2007) · NanoBiotechnology · doi:10.1007/s12030-008-9003-3 · Cited by 192
Self-citationDrug delivery from ordered mesoporous matrices
Manzano, M., Colilla, M., & Vallet-Regí, M. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903304024 · Cited by 186
Veiseh, O., Kievit, F. M., Fang, C., Mu, N., Jana, S., Leung, M. C., Mok, H., Ellenbogen, R. G., Park, J. O., & Zhang, M. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.016 · Cited by 185
Photoresponsive Nanocomposite Formed by Self‐Assembly of an Azobenzene‐Modified Silane
Liu, N., Chen, Z., Dunphy, D. R., Jiang, Y., Assink, R. A., & Brinker, C. J. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250189 · Cited by 174
Qu, F., Zhu, G., Lin, H., Zhang, W., Sun, J., Li, S., & Qiu, S. (2006) · Journal of Solid State Chemistry · doi:10.1016/j.jssc.2006.04.002 · Cited by 171
Moghimi, S. M., & Hunter, A. C. (2001) · Pharmaceutical Research · doi:10.1023/a:1011054123304 · Cited by 161
Influence of superficial organic modification of MCM-41 matrices on drug delivery rate
Horcajada, P., Ramila, A., Férey, G., & Vallet‐Regí, M. (2006) · Solid State Sciences · doi:10.1016/j.solidstatesciences.2006.04.016 · Cited by 146
Mortera, R., Vivero-Escoto, J. L., Slowing, I. I., Garrone, E., Onida, B., & Lin, V. S. ‐. (2009) · Chemical Communications · doi:10.1039/b900559e · Cited by 141
Kono, K., Nakashima, S., Kokuryo, D., Aoki, I., Shimomoto, H., Aoshima, S., Maruyama, K., Yuba, E., Kojima, C., Harada, A., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.050 · Cited by 123
Ambrogio, M. W., Pecorelli, T. A., Patel, K., Khashab, N. M., Trabolsi, A., Khatib, H. A., Botros, Y. Y., Zink, J. I., & Stoddart, J. F. (2010) · Organic Letters · doi:10.1021/ol101286a · Cited by 117
Self-citationPhillips, W. T., Goins, B., & Bao, A. (2008) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.3 · Cited by 110
Photoisomerization of Azobenzene Derivatives in Nanostructured Silica
Sierocki, P., Maas, H., Dragut, P., Richardt, G., Vögtle, F., De Cola, L., Brouwer, F. (. M. )., & Zink, J. I. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp0641334 · Cited by 92
Self-citationAbdalla, M. O. A., Karna, P., Sajja, H. K., Mao, H. Z., Yates, C. C., Turner, T., & Aneja, R. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.030 · Cited by 88
Lombardi, G., Zustovich, F., Farinati, F., Cillo, U., Vitale, A., Zanus, G., Donach, M. E., Farina, M., Zovato, S., & Pastorelli, D. (2010) · Cancer · doi:10.1002/cncr.25578 · Cited by 63
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Metadata
- Authors
- Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 7
- Pages
- 2590
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2111423624
- Cited by
- 1,907
- References
- 67
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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