Flash chemistry: flow chemistry that cannot be done in batch

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Rapid Microfluidic Mixing

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Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

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Cross-coupling in flow

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Advanced organic synthesis using microreactor technology

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Flash Chemistry: Fast Organic Synthesis in Microsystems

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A Microreactor for Microwave-Assisted Capillary (Continuous Flow) Organic Synthesis

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Generation and Reactions of o-Bromophenyllithium without Benzyne Formation Using a Microreactor

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Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block

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Multiphase Organic Synthesis in Microchannel Reactors

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Miniaturized continuous flow reaction vessels: influence on chemical reactions

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A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds

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“Cation Flow” Method: A New Approach to Conventional and Combinatorial Organic Syntheses Using Electrochemical Microflow Systems

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Systematic synthesis design. IV. Numerical codification of construction reactions

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Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

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Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation Reactions

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Control of Extremely Fast Competitive Consecutive Reactions using Micromixing. Selective Friedel−Crafts Aminoalkylation

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Cation Pool-Initiated Controlled/Living Polymerization Using Microsystems

Nagaki, A., Kawamura, K., Suga, S., Ando, T., Sawamoto, M., & Yoshida, J.-I. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044879k · Cited by 211

Enhancement of Chemical Selectivity by Microreactors

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Efficient Mixing and Reactions within Microfluidic Channels Using Microbead-Supported Catalysts

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Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize

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Photodimerization of Maleic Anhydride in a Microreactor Without Clogging

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Total Synthesis of Resveratrol‐Based Natural Products: A Chemoselective Solution

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Flash chemistry using electrochemical method and microsystems

Yoshida, J.-I. (2005) · Chemical Communications · doi:10.1039/b508341a · Cited by 167

Aryllithium Compounds Bearing Alkoxycarbonyl Groups: Generation and Reactions Using a Microflow System

Nagaki, A., Kim, H., & Yoshida, J. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803205 · Cited by 164

Cross‐Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling

Nagaki, A., Kenmoku, A., Moriwaki, Y., Hayashi, A., & Yoshida, J. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201002763 · Cited by 164

Solving the Clogging Problem: Precipitate‐Forming Reactions in Flow

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Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

Browne, D. L., Deadman, B. J., Ashe, R., Baxendale, I. R., & Ley, S. V. (2011) · Organic Process Research & Development · doi:10.1021/op2000223 · Cited by 160

Controlled Autocatalytic Nitration of Phenol in a Microreactor

Ducry, L., & Roberge, D. M. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502387 · Cited by 157

Integrated microfluidic reactors

Lin, W., Wang, Y., Wang, S., & Tseng, H. (2009) · Nano Today · doi:10.1016/j.nantod.2009.10.007 · Cited by 146

Concise Synthesis of Pauciflorol F Using a Larock Annulation

Jeffrey, J. L., & Sarpong, R. (2009) · Organic Letters · doi:10.1021/ol902141z · Cited by 134

Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market

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Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

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A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

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A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

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Generation and reaction of cyano-substituted aryllithium compounds using microreactors

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Oxiranyl Anion Methodology Using Microflow Systems

Nagaki, A., Takizawa, E., & Yoshida, J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809325a · Cited by 110

Lithiation of 1,2‐Dichloroethene in Flow Microreactors: Versatile Synthesis of Alkenes and Alkynes by Precise Residence‐Time Control

Nagaki, A., Matsuo, C., Kim, S., Saito, K., Miyazaki, A., & Yoshida, J. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201108932 · Cited by 108

Synthetic Retinoids: Recent Developments Concerning Structure and Clinical Utility

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Integrated Micro Flow Synthesis Based on Sequential Br–Li Exchange Reactions of p‐, m‐, and o‐Dibromobenzenes

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Dimensionless number for identification of flow patterns inside a T-micromixer

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Kinetic and Scale-Up Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures

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Micro Reaction Technology in Organic Synthesis

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Heck reactions using segmented flow conditions

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Flash Chemistry Extensively Optimized: High‐Temperature Swern–Moffatt Oxidation in an Automated Microreactor Platform

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Controlling hazardous chemicals in microreactors: Synthesis with iodine azide

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Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki–Miyaura coupling without intentionally added base

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Enantioselective β‐Arylation of Ketones Enabled by Lithiation/Borylation/1,4‐Addition Sequence Under Flow Conditions

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Disguised chemical selectivities

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Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates

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Flow microreactor synthesis of disubstituted pyridines from dibromopyridines via Br/Li exchange without using cryogenic conditions

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The Selectivity of Chemical Reactions Disguised by Diffusion. Part I: Chemical Selectivity Disguised by Mixing

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Generation and Reactions of Oxiranyllithiums by Use of a Flow Microreactor System

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Diastereoselective Chain‐Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

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Cross‐Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors

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Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

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Generation and Reactions of Pyridyllithiums via Br/Li Exchange Reactions Using Continuous Flow Microreactor Systems

Nagaki, A., Yamada, D., Yamada, S., Doi, M., Ichinari, D., Tomida, Y., Takabayashi, N., & Yoshida, J. (2013) · Australian Journal of Chemistry · doi:10.1071/ch12440 · Cited by 33

Initial Clinical Trial of Oral TAC-101, a Novel Retinoic Acid Receptor-Alpha Selective Retinoid, in Patients With Advanced Cancer

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The Future of Organic Synthesis

Kündig, P. E. (2006) · Science · doi:10.1126/science.1134084 · Cited by 31

Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems

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The Hitchhiker’s Guide to Flow Chemistry

Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995

Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications

Chen, M., Zhong, M., & Johnson, J. A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00671 · Cited by 1,202

Automating drug discovery

Schneider, G. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.232 · Cited by 910

Taming hazardous chemistry by continuous flow technology

Movsisyan, M., Delbeke, E. I. P., Berton, J. K. E. T., Battilocchio, C., Ley, S. V., & Stevens, C. V. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00902b · Cited by 692

Expanding the medicinal chemistry synthetic toolbox

Boström, J., Brown, D. G., Young, R. J., & Keserü, G. M. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.116 · Cited by 665