Cited by 273Cellular Mechanics and Interactions3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Microfluidic platforms for mechanobiology

Open access
Polacheck, William J., Li, Ran, Uzel, Sebastien G. M., Kamm, Roger D.·2013·Lab on a Chip

Abstract

Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on in vivo experiments with limited control or direct access, or on large-scale in vitro studies lacking many of the potentially important physiological factors. With the advent of microfluidics, many of the previous limitations of in vitro testing were eliminated or reduced through greater control or combined functionalities. At the same time, imaging capabilities were tremendously enhanced. In this review, we discuss how microfluidics has transformed the study of mechanotransduction. This is done in the context of the various cell types that exhibit force-induced responses and the new biological insights that have been elucidated. We also discuss new microfluidic studies that could produce even more realistic models of in vivo conditions by combining multiple stimuli or creating a more realistic microenvironment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1039/c3lc41393d

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • These microfluidic systems enable continuous delivery of oxygen, nutrients, and therapeutic agents while introducing shear stress and directional mass transport, allowing investigation of flow-regulated processes within a tumor-relevant architecture.

    “These systems enable continuous delivery of oxygen, nutrients, and therapeutic agents while introducing shear stress and directional mass transport, thereby allowing the investigation of flow-regulated processes within a tumor-relevant architecture [224,225,226,227,228].”

    From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [224]

    Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 133 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [99]Jain RK Baxter LT Cancer Res 1988 7022 7032 3191477

Cited by

Sorted by citations

Authors
Polacheck, W. J., Li, R., Uzel, S. G. M., & Kamm, R. D.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Kamm, Roger D.
Venue
Lab on a Chip
Published
2013
Volume
13
Issue
12
Pages
2252
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2144850941
Cited by
272
References
133
Citations by year
2026: 15 · 2025: 19 · 2024: 14 · 2023: 22 · 2022: 16 · 2021: 22 · 2020: 20 · 2019: 18 · 2018: 22 · 2017: 29 · 2016: 34 · 2015: 19 · 2014: 16 · 2013: 5
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Lab on a Chip (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
  • National Science Foundation (0939511)
  • Emergent Behaviors of Integrated Cellular Systems (0939511, CBET0939511))
  • National Cancer Institute (R21CA140096)
  • Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET-0939511, 0939511)
  • Janssen Pharmaceuticals
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
mechanotransduction, mechanobiology, microfluidic platform, mechanical forces, cell imaging
MeSH terms
Blood Cells, Epithelial Cells, Humans, Neoplastic Cells, Circulating, Muscle Cells, Shear Strength, Mechanotransduction, Cellular, Microfluidic Analytical Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review