Natural product isolation – how to get from biological material to pure compounds

Marine natural products

Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866

Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds

Alpert, A. J. (1990) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)96972-3 · Cited by 1,966

NMR-based metabolomic analysis of plants

Kim, H. K., Choi, Y. H., & Verpoorte, R. (2010) · Nature Protocols · doi:10.1038/nprot.2009.237 · Cited by 934

Stationary and mobile phases in hydrophilic interaction chromatography: a review

Jandera, P. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.02.047 · Cited by 707

Microwave-assisted extractions of active ingredients from plants

Chan, C.-H., Yusoff, R., Ngoh, G.-C., & Kung, F. W.-L. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.07.040 · Cited by 687

Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation

Kingston, D. G. I. (2011) · Journal of Natural Products · doi:10.1021/np100550t · Cited by 516

MALDI-TOF MS in microbiological diagnostics—identification of microorganisms and beyond (mini review)

Wieser, A., Schneider, L., Jung, J., & Schubert, S. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3783-4 · Cited by 453

Comprehensive two‐dimensional gas chromatography‐mass spectrometry: A review

Mondello, L., Tranchida, P. Q., Dugo, P., & Dugo, G. (2008) · Mass Spectrometry Reviews · doi:10.1002/mas.20158 · Cited by 423

Marine natural products

Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2010) · Natural Product Reports · doi:10.1039/b906091j · Cited by 406

Natural product isolation

Sticher, O. (2008) · Natural Product Reports · doi:10.1039/b700306b · Cited by 377

Natural Products Isolation

(2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-624-1 · Cited by 376

Retention and selectivity of stationary phases for hydrophilic interaction chromatography

Guo, Y., & Gaiki, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.052 · Cited by 310

Subcritical water extraction of phenolic compounds from potato peel

Singh, P. P., & Saldaña, M. D. A. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.006 · Cited by 306

Facts about the formation of new antioxidants in natural samples after subcritical water extraction

Plaza, M., Amigo-Benavent, M., del Castillo, M. D., Ibáñez, E., & Herrero, M. (2010) · Food Research International · doi:10.1016/j.foodres.2010.07.036 · Cited by 281

Sponge‐specific clusters revisited: a comprehensive phylogeny of sponge‐associated microorganisms

Simister, R. L., Deines, P., Botté, E. S., Webster, N. S., & Taylor, M. W. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02664.x · Cited by 281

Novel Chemical Space Exploration via Natural Products

Rosén, J., Gottfries, J., Muresan, S., Backlund, A., & Oprea, T. I. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801514w · Cited by 280

Extraction of Plant Secondary Metabolites

Jones, W. P., & Kinghorn, A. D. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-624-1_13 · Cited by 254

Application of ionic liquid for extraction and separation of bioactive compounds from plants

Tang, B., Bi, W., Tian, M., & Row, K. H. (2012) · Journal of Chromatography B · doi:10.1016/j.jchromb.2012.07.020 · Cited by 254

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz, G., & Schmid, M. G. (2001) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.279 · Cited by 242

Application of ionic liquids in the microwave-assisted extraction of polyphenolic compounds from medicinal plants

Du, F., Xiao, X., Xue-jun, L., & Li, G. (2009) · Talanta · doi:10.1016/j.talanta.2009.01.040 · Cited by 237

Microwave-Assisted Extraction in Natural Products Isolation

Delazar, A., Nahar, L., Hamedeyazdan, S., & Sarker, S. D. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-624-1_5 · Cited by 232

Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.

Medina, R. A., Goeger, D. E., Hills, P., Mooberry, S. L., Huang, N., Romero, L. I., Ortega-Barría, E., Gerwick, W. H., & McPhail, K. L. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801383f · Cited by 231

Optimization of supercritical fluid extraction of bioactive compounds from grape (Vitis labrusca B.) peel by using response surface methodology

Ghafoor, K., Park, J., & Choi, Y.-H. (2010) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2010.01.013 · Cited by 221

Thin-layer chromatography with biological detection in phytochemistry

Marston, A. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.12.068 · Cited by 220

Subcritical water extraction of flavonol quercetin from onion skin

Ko, M.-J., Cheigh, C.-I., Cho, S.-W., & Chung, M.-S. (2011) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2010.09.008 · Cited by 216

Subcritical water extraction of phenolic compounds from pomegranate (Punica granatum L.) seed residues and investigation into their antioxidant activities with HPLC–ABTS+ assay

Li, H., Zhang, X., Xu, H., Xu, C., Yuan, F., Knez, Ž., Novak, Z., & Gao, Y. (2011) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2011.03.003 · Cited by 214

DNA Damage in Plant Herbarium Tissue

Staats, M., Cuenca, A., Richardson, J. E., Ginkel, R. V.-V., Petersen, G., Seberg, O., & Bakker, F. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028448 · Cited by 212

Application of ionic liquids in the microwave-assisted extraction of trans-resveratrol from Rhizma Polygoni Cuspidati

Du, F.-Y., Xiao, X.-H., & Li, G.-K. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.11.049 · Cited by 206

HPLC in Natural Product Analysis: The Detection Issue

Wolfender, J. (2009) · Planta Medica · doi:10.1055/s-0028-1088393 · Cited by 201

Fourier transform infrared spectroscopy as a tool to characterize molecular composition and stress response in foodborne pathogenic bacteria

Alvarez-Ordóñez, A., Mouwen, D. J. M., López, M., & Prieto, M. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.01.009 · Cited by 193

Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica

Chan, K., Shaw, D., Simmonds, M. S. J., Leon, C. J., Xu, Q., Lu, A., Sutherland, I., Ignatova, S., Zhu, Y.-P., Verpoorte, R., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.01.038 · Cited by 191

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Buriani, A., Garcia-Bermejo, M. L., Bosisio, E., Xu, Q., Li, H., Dong, X., Simmonds, M. S. J., Carrara, M., Tejedor, N., Lucio-Cazana, J., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.01.055 · Cited by 184

Comparative Assessment of Technologies for Extraction of Artemisinin

Lapkin, A. A., Plucinski, P. K., & Cutler, M. (2006) · Journal of Natural Products · doi:10.1021/np060375j · Cited by 181

Theoretical models for supercritical fluid extraction

Huang, Z., Shi, X.-H., & Jiang, W. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.04.032 · Cited by 174

Quality Control of Herbal Material and Phytopharmaceuticals with MS and NMR Based Metabolic Fingerprinting

van der Kooy, F., Maltese, F., Hae Choi, Y., Kyong Kim, H., & Verpoorte, R. (2009) · Planta Medica · doi:10.1055/s-0029-1185450 · Cited by 168

Ionic liquid-based microwave-assisted extraction of phenolic alkaloids from the medicinal plant Nelumbo nucifera Gaertn.

Lu, Y., Ma, W., Hu, R., Dai, X., & Pan, Y. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.08.070 · Cited by 164

Metabolic classification of South American Ilex species by NMR-based metabolomics

Kim, H. K., Saifullah, Khan, S., Wilson, E. G., Kricun, S. D. P., Meissner, A., Göraler, S., Deelder, A. M., Choi, Y. H., & Verpoorte, R. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.02.001 · Cited by 162

Influence of Altitudinal Variation on the Content of Phenolic Compounds in Wild Populations of Calluna vulgaris, Sambucus nigra, and Vaccinium myrtillus

Rieger, G., Müller, M., Guttenberger, H., & Bučar, F. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801104e · Cited by 161

Ultrasound-assisted extraction of capsaicinoids from Capsicum frutescens on a lab- and pilot-plant scale

Boonkird, S., Phisalaphong, C., & Phisalaphong, M. K. M. (2008) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2008.04.010 · Cited by 155

Statin-like Principles of Bergamot Fruit (Citrus bergamia): Isolation of 3-Hydroxymethylglutaryl Flavonoid Glycosides

Donna, L. D., Luca, G. D., Mazzotti, F., Napoli, A., Salerno, R., Taverna, D., & Sindona, G. (2009) · Journal of Natural Products · doi:10.1021/np900096w · Cited by 148

Subcritical water extraction of polyphenolic compounds from Terminalia chebula Retz. fruits

Rangsriwong, P., Rangkadilok, N., Satayavivad, J., Goto, M., & Shotipruk, A. (2008) · Separation and Purification Technology · doi:10.1016/j.seppur.2008.11.023 · Cited by 147

Discrimination of Ganoderma lucidum according to geographical origin with near infrared diffuse reflectance spectroscopy and pattern recognition techniques

Chen, Y., Xie, M., Yan, Y., Zhu, S.-B., Nie, S., Li, C., Wang, Y., & Gong, X. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.04.055 · Cited by 132

High Performance Liquid Chromatography in Phytochemical Analysis

(2010) · doi:10.1201/b10320 · Cited by 130

Improved microwave steam distillation apparatus for isolation of essential oils

Sahraoui, N., Vian, M. A., Bornard, I., Boutekedjiret, C., & Chemat, F. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.09.078 · Cited by 130

Profiling of Resveratrol Oligomers, Important Stress Metabolites, Accumulating in the Leaves of Hybrid Vitis vinifera (Merzling × Teroldego) Genotypes Infected with Plasmopara viticola

Mattivi, F., Vrhovšek, U., Malacarne, G., Masuero, D., Zulini, L., Stefanini, M., Moser, C., Velasco, R., & Guella, G. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200771y · Cited by 129

Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana

Nakabayashi, R., Kusano, M., Kobayashi, M., Tohge, T., Yonekura‐Sakakibara, K., Kogure, N., Yamazaki, M., Kitajima, M., Saito, K., & Takayama, H. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.03.021 · Cited by 124

Eco-friendly and cleaner process for isolation of essential oil using microwave energy

Farhat, A., Giniès, C., Romdhane, M., et al. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.04.084 · Cited by 122

Initial and Bulk Extraction of Natural Products Isolation

Seidel, V. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-624-1_2 · Cited by 121

Gas chromatographic–mass spectrometric analysis of volatiles obtained by four different techniques from Salvia rosifolia Sm., and evaluation for biological activity

Özek, G., Demi̇rci̇, F., Özek, T., Tabanca, N., Wedge, D. E., Khan, S. I., Başer, K. H. C., Duran, A., & Hamzaoğlu, E. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.11.086 · Cited by 118

Advances in Techniques for Profiling Crude Extracts and for the Rapid Identificationof Natural Products: Dereplication, Quality Control and Metabolomics

Wolfender, J., Marti, G., & Queiroz, E. F. (2010) · Current Organic Chemistry · doi:10.2174/138527210792927645 · Cited by 111

Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics

Georgiev, M. I., Ali, K., Alipieva, K. I., Verpoorte, R., & Choi, Y. H. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.07.005 · Cited by 109

Ultrasound-assisted dynamic extraction of valuable compounds from aromatic plants and flowers as compared with steam distillation and superheated liquid extraction

Roldán-Gutiérrez, J. M., Ruiz‐Jiménez, J., & LUQUEDECASTRO, M. (2008) · Talanta · doi:10.1016/j.talanta.2008.01.057 · Cited by 109

Microplanktonic Community Structure in a Coastal System Relative to a Phaeocystis Bloom Inferred from Morphological and Tag Pyrosequencing Methods

Monchy, S., Grattepanche, J., Breton, E., Meloni, D., Sanciu, G., Chabé, M., Delhaès, L., Viscogliosi, É., Sime‐Ngando, T., & Christaki, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039924 · Cited by 104

Distillable ionic liquid extraction of tannins from plant materials

Chowdhury, S., Vijayaraghavan, R. K., & MacFarlane, D. R. (2010) · Green Chemistry · doi:10.1039/b923248f · Cited by 102

Strong Attraction of the Parasitoid Cotesia marginiventris Towards Minor Volatile Compounds of Maize

D’Alessandro, M., Brunner, V., von Mérey, G. E., & Turlings, T. C. J. (2009) · Journal of Chemical Ecology · doi:10.1007/s10886-009-9692-7 · Cited by 100

Natural Products Chemistry and Taxonomy of the Marine Cyanobacterium Blennothrix cantharidosmum

Clark, B. R., Engene, N., Teasdale, M. E., et al. (2008) · Journal of Natural Products · doi:10.1021/np800088a · Cited by 96

Detection and Isolation of Bioactive Natural Products

Ghisalberti, E. L. (2007) · CRC Press eBooks · doi:10.1201/9781420006889.ch2 · Cited by 93

Pitipeptolides C–F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam

Montaser, R., Paul, V. J., & Luesch, H. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.07.014 · Cited by 91

Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery

Tu, Y., Jeffries, C. T., Ruan, H., Nelson, C., Smithson, D. C., Shelat, A. A., Brown, K. M., Li, X., Hester, J. P., Smillie, T. J., et al. (2010) · Journal of Natural Products · doi:10.1021/np9007359 · Cited by 88

Separation of phenolic acids from natural plant extracts using molecularly imprinted anion-exchange polymer confined ionic liquids

Bi, W., Tian, M., & Row, K. H. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.08.054 · Cited by 88

Explorative Solid-Phase Extraction (E-SPE) for Accelerated Microbial Natural Product Discovery, Dereplication, and Purification

Månsson, M., Phipps, R. K., Gram, L., Munro, M. H. G., Larsen, T. O., & Nielsen, K. F. (2010) · Journal of Natural Products · doi:10.1021/np100151y · Cited by 82

Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides

Matthew, S., Ross, C., Paul, V. J., & Luesch, H. (2008) · Tetrahedron · doi:10.1016/j.tet.2008.02.035 · Cited by 80

Cyclic Heptapeptides, Cordyheptapeptides C–E, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities

Chen, Z., Song, Y., Chen, Y., Huang, H., Zhang, W., & Ju, J. (2012) · Journal of Natural Products · doi:10.1021/np300152d · Cited by 78

Advances in mass spectrometry for the identification of pathogens

Ho, Y., & Reddy, P. M. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20320 · Cited by 77

Structure and Relative Potency of Several Karlotoxins from Karlodinium veneficum

Wagoner, R. M. V., Deeds, J. R., Tatters, A. O., Place, A. R., Tomas, C. R., & Wright, J. L. C. (2010) · Journal of Natural Products · doi:10.1021/np100158r · Cited by 77

Combination of dynamic time warping and multivariate analysis for the comparison of comprehensive two-dimensional gas chromatograms

Vial, J., Noçairi, H., Sassiat, P., et al. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.09.027 · Cited by 76

Hantupeptin A, a Cytotoxic Cyclic Depsipeptide from a Singapore Collection of Lyngbya majuscula

Tripathi, A., Puddick, J., Prinsep, M. R., Lee, P. P. F., & Tan, L. T. (2008) · Journal of Natural Products · doi:10.1021/np800448t · Cited by 76

Molassamide, a Depsipeptide Serine Protease Inhibitor from the Marine Cyanobacterium Dichothrix utahensis

Gunasekera, S. P., Miller, M. W., Kwan, J. C., Luesch, H., & Paul, V. J. (2010) · Journal of Natural Products · doi:10.1021/np900603f · Cited by 75

Ultra High Pressure Liquid Chromatography for Crude Plant Extract Profiling

Eugster, P. J., Guillarme, D., Rudaz, S. L., Veuthey, J., Carrupt, P., & Wolfender, J. (2011) · Journal of AOAC International · doi:10.1093/jaoac/94.1.51 · Cited by 75

Kempopeptins A and B, Serine Protease Inhibitors with Different Selectivity Profiles from a Marine Cyanobacterium, Lyngbya sp.

Taori, K., Paul, V. J., & Luesch, H. (2008) · Journal of Natural Products · doi:10.1021/np8002172 · Cited by 74

Optimization of anthocyanin, flavonol and phenolic acid extractions from Delonix regia tree flowers using ultrasound-assisted water extraction

Adjé, F., Lozano, Y. F., Lozano, P. R., Adima, A. A., Chemat, F., & Gaydou, E. M. (2010) · Industrial Crops and Products · doi:10.1016/j.indcrop.2010.06.011 · Cited by 74

High resolution ultra high pressure liquid chromatography–time-of-flight mass spectrometry dereplication strategy for the metabolite profiling of Brazilian Lippia species

Funari, C. S., Eugster, P. J., Martel, S., Carrupt, P., Wolfender, J., & Silva, D. H. S. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.03.069 · Cited by 72

Enzymatic Degradation of Cichoric Acid in Echinacea purpurea Preparations

Nüsslein, B., Kurzmann, M., Bauer, R., & Kreis, W. (2000) · Journal of Natural Products · doi:10.1021/np0002839 · Cited by 70

Peptidolipins B–F, Antibacterial Lipopeptides from an Ascidian-Derived Nocardia sp.

Wyche, T. P., Hou, Y., Vazquez-Rivera, E., Braun, D., & Bugni, T. S. (2012) · Journal of Natural Products · doi:10.1021/np300016r · Cited by 67

Triterpene Glycosides from Antarctic Sea Cucumbers. 1. Structure of Liouvillosides A1, A2, A3, B1, and B2 from the Sea Cucumber Staurocucumis liouvillei: New Procedure for Separation of Highly Polar Glycoside Fractions and Taxonomic Revision

Antonov, A. S., Avilov, S. A., Kalinovsky, A. I., et al. (2008) · Journal of Natural Products · doi:10.1021/np800173c · Cited by 65

Antimicrobial Metabolites from the Paracel Islands Sponge Agelas mauritiana

Yang, F., Hamann, M. T., Zou, Y., Zhang, M., Gong, X., Xiao, J., Chen, W., & Lin, H. (2012) · Journal of Natural Products · doi:10.1021/np2009016 · Cited by 64

Liquid chromatography–nuclear magnetic resonance coupling as alternative to liquid chromatography–mass spectrometry hyphenations: Curious option or powerful and complementary routine tool?

Sturm, S., & Seger, C. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.05.032 · Cited by 60

Extraction of Volatile Oil from Aromatic Plants with Supercritical Carbon Dioxide: Experiments and Modeling

Coelho, J. P., Cristino, A. F., Matos, P., Rauter, A. P., Nobre, B. P., Mendes, R. L., Barroso, J. G., Mainar, A. M., Urieta, J. S., Fareleira, J. M. N. A., et al. (2012) · Molecules · doi:10.3390/molecules170910550 · Cited by 59

Nrf2‐mediated induction of detoxifying enzymes by alantolactone present in Inula helenium

Seo, J. Y., Lim, S. S., Kim, J. R., Lim, J., Ha, Y. R., Lee, I. A., Kim, E. J., Park, J. H. Y., & Kim, J. (2008) · Phytotherapy Research · doi:10.1002/ptr.2521 · Cited by 59

Recent developments in the rapid analysis of plants and tracking their bioactive constituents

van Beek, T. A., Tetala, K. K. R., Koleva, I. I., Dapkevicius, A., Exarchou, V., Jeurissen, S. M. F., Claassen, F. W., & van der Klift, E. J. C. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-009-9125-9 · Cited by 58

Malyngolide Dimer, a Bioactive Symmetric Cyclodepside from the Panamanian Marine Cyanobacterium Lyngbya majuscula

Gutiérrez, M., Tidgewell, K. J., Capson, T. L., Engene, N., Almanza, A., Schemies, J., Jung, M., & Gerwick, W. H. (2010) · Journal of Natural Products · doi:10.1021/np9005184 · Cited by 58

Cyclopeptides with Anti-inflammatory Activity from Seeds of Annona montana

Chuang, P., Hsieh, P., Yang, Y., et al. (2008) · Journal of Natural Products · doi:10.1021/np8001282 · Cited by 54

Structural and Synthetic Investigations of Tanikolide Dimer, a SIRT2 Selective Inhibitor, and Tanikolide seco-Acid from the Madagascar Marine Cyanobacterium Lyngbya majuscula

Gutiérrez, M., Andrianasolo, E. H., Shin, W., Goeger, D. E., Yokochi, A., Schemies, J., Jung, M., France, D. S., Cornell-Kennon, S., Lee, E., et al. (2009) · The Journal of Organic Chemistry · doi:10.1021/jo900578j · Cited by 54

Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids

Bi, W., Tian, M., & Row, K. H. (2011) · Talanta · doi:10.1016/j.talanta.2011.04.054 · Cited by 53

Chromatographic Fingerprint Analysis of Herbal Medicines Volume IV

Staudinger, A., Melchart, D., Bauer, R., & Wagner, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-32328-2 · Cited by 53

Ionic Liquid-Based Ultrasonic/Microwave-Assisted Extraction Combined with UPLC for the Determination of Anthraquinones in Rhubarb

Lu, C., Wang, H., Lv, W., et al. (2011) · Chromatographia · doi:10.1007/s10337-011-2023-5 · Cited by 50

Advanced development in analysis of phytochemicals from medicine and food dual purposes plants used in China

Zhao, J., Lv, G., Chen, Y., & Li, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.06.041 · Cited by 50

Accelerated Solvent Extraction for Natural Products Isolation

Mottaleb, M. A., & Sarker, S. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-624-1_4 · Cited by 49

Ionic liquid-supported solid–liquid extraction of bioactive alkaloids. I. New HPLC method for quantitative determination of glaucine in Glaucium flavum Cr. (Papaveraceae)

Bogdanov, M. G., Svinyarov, I., Keremedchieva, R., & Sidjimov, A. K. (2012) · Separation and Purification Technology · doi:10.1016/j.seppur.2012.02.001 · Cited by 48

From Retrospective Assessment to Prospective Decisions in Natural Product Isolation: HPLC-SPE-NMR Analysis of Carthamus oxyacantha

Kongstad, K. T., Wubshet, S. G., Nyberg, N. T., & Jaroszewski, J. W. (2011) · Journal of Natural Products · doi:10.1021/np200780m · Cited by 47

Selective extraction and separation of oxymatrine from Sophora flavescens Ait. extract by silica-confined ionic liquid

Bi, W., Tian, M., & Row, K. H. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.11.025 · Cited by 46

Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus

Yang, P., Li, M., Zhao, J. Y., Zhu, M., Shang, H., Li, J. R., Cui, X., Huang, R., & Wen, M. (2010) · Folia Microbiologica · doi:10.1007/s12223-010-0002-0 · Cited by 45

Characterization of the volatile fraction emitted by Pinus spp. by one- and two-dimensional chromatographic techniques with mass spectrometric detection

Mateus, E. P., Barata, R. C., Zrostlíková, J., da Silva, M. G., & Paiva, M. R. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.01.045 · Cited by 45

Carriebowmide, a New Cyclodepsipeptide from the Marine Cyanobacterium Lyngbya polychroa

Gunasekera, S. P., Ritson‐Williams, R., & Paul, V. J. (2008) · Journal of Natural Products · doi:10.1021/np800453t · Cited by 44

Recognition of molecularly imprinted polymers for a quaternary alkaloid of berberine

Chen, C., Wang, C., & Chen, A.-H. (2011) · Talanta · doi:10.1016/j.talanta.2011.03.009 · Cited by 43

Towards large-scale FAME-based bacterial species identification using machine learning techniques

Slabbinck, B., Bernard De Baets, C., Dawyndt, P., & Vos, P. D. (2009) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2009.01.003 · Cited by 43

Ganoderma species discrimination by dual-mode chromatographic fingerprinting: A study on stationary phase effects in hydrophilic interaction chromatography and reduction of sample misclassification rate by additional use of reversed-phase chromatography

Chen, Y., Bicker, W., Wu, J., Xie, M. Y., & Lindner, W. F. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.12.024 · Cited by 43

Isolation of Thuridillins D–F, Diterpene Metabolites from the Australian Sacoglossan Mollusk Thuridilla splendens ; Relative Configuration of the Epoxylactone Ring

Somerville, M. J., Katavic, P. L., Lambert, L. K., Pierens, G. K., Blanchfield, J. T., Cimino, G., Mollo, E., Gavagnin, M., Banwell, M. G., & Garson, M. J. (2012) · Journal of Natural Products · doi:10.1021/np300442s · Cited by 42

neo-Clerodane Diterpenoids from Ajuga bracteosa

Castro, A., Coll, J., & Arfan, M. (2011) · Journal of Natural Products · doi:10.1021/np100929u · Cited by 40

Supercritical fluid extraction of bioactive compounds from Macela (Achyrocline satureioides) flowers: Kinetic, experiments and modeling

Hatami, T., Cavalcanti, R. N., Takeuchi, T. M., & Meireles, M. A. A. (2012) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2012.03.001 · Cited by 40

Largamides A–C, Tiglic Acid-Containing Cyclodepsipeptides with Elastase-Inhibitory Activity from the Marine CyanobacteriumLyngbya confervoides

Matthew, S., Paul, V. J., & Luesch, H. (2009) · Planta Medica · doi:10.1055/s-0029-1185332 · Cited by 38

Automated high-throughput Vibrio fischeri assay for (eco)toxicity screening: Application to ionic liquids

Pinto, P. C. A. G., Costa, S. P. F., Lima, J. L. F. C., & Saraiva, M. L. M. F. S. (2012) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2012.02.013 · Cited by 36

Production of Salvianolic Acid B in Roots of Salvia miltiorrhiza (Danshen) During the Post-Harvest Drying Process

Li, X., Wang, W., Zhou, G.-J., Li, Y., Xie, X., & Tong-shui, Z. (2012) · Molecules · doi:10.3390/molecules17032388 · Cited by 35

Purification of active bufadienolides from toad skin by preparative reversed‐phase liquid chromatography coupled with hydrophilic interaction chromatography

Liu, Y., Feng, J., Xiao, Y., Guo, Z., Zhang, J., Xue, X., Ding, J., Zhang, X., & Liang, X. (2010) · Journal of Separation Science · doi:10.1002/jssc.200900848 · Cited by 34

Positive GABAAReceptor Modulators fromAcorus calamusand Structural Analysis of (+)-Dioxosarcoguaiacol by 1D and 2D NMR and Molecular Modeling

Zaugg, J., Eickmeier, Η., Ebrahimi, S. N., Baburin, I., Hering, S., & Hamburger, M. O. (2011) · Journal of Natural Products · doi:10.1021/np200181d · Cited by 34

1-Methyl-3-octylimidazolium Chloride—Sorption and Primary Biodegradation Analysis in Activated Sewage Sludge

Markiewicz, M., Jungnickel, C., Markowska, A., Szczepaniak, U., Paszkiewicz, M., & Hupka, J. (2009) · Molecules · doi:10.3390/molecules14114396 · Cited by 34

Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5 Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana

Ankli, A., Reich, E., & Steiner, M. (2008) · Journal of AOAC International · doi:10.1093/jaoac/91.6.1257 · Cited by 34

Aqueous ionic liquid based ultrasonic assisted extraction of four acetophenones from the Chinese medicinal plant Cynanchum bungei Decne

Sun, Y., Liu, Z., Wang, J., Yang, S., Li, B., & Xu, N. (2012) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2012.07.002 · Cited by 33

Rapid isolation procedure for Δ9-tetrahydrocannabinolic acid A (THCA) from Cannabis sativa using two flash chromatography systems

Wohlfarth, A., Mahler, H., & Auwärter, V. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.09.012 · Cited by 32

Isolation and Structure Determination of Malevamide E, a Dolastatin 14 Analogue, from the Marine Cyanobacterium Symploca laete-viridis

Adams, B., Pörzgen, P., Pittman, E. I., Yoshida, W. Y., Westenburg, H. E., & Horgen, F. D. (2008) · Journal of Natural Products · doi:10.1021/np070346o · Cited by 31

Selin-11-en-4α-ol from the essential oil of

Corbett, R. E., & Smith, R. A. J. (1967) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)90626-9 · Cited by 31

Isolation of Natural Products by Low-Pressure Column Chromatography

Reid, R. G., & Sarker, S. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-624-1_7 · Cited by 30

Birch inner bark procyanidins can be resolved with enhanced sensitivity by hydrophilic interaction HPLC‐MS

Karonen, M., Liimatainen, J., & Sinkkonen, J. (2011) · Journal of Separation Science · doi:10.1002/jssc.201100569 · Cited by 30

Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products

Challal, S., Bohni, N., Buenafe, O. E. M., Esguerra, C. V., de Witte, P. A. M., Wolfender, J., & Crawford, A. D. (2012) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2012.229 · Cited by 30

Application of accelerated solvent extraction coupled with high-performance counter-current chromatography to extraction and online isolation of chemical constituents from Hypericum perforatum L.

Zhang, Y., Liu, C., Yu, M., Zhang, Z., Qi, Y., Wang, J., Wu, G., Li, S., Yu, J., & Hu, Y. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.03.007 · Cited by 30

GC/MS of terpenes in walnut‐tree leaves after accelerated solvent extraction

Fojtová, J., Lojková, L., & Kubáň, V. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700371 · Cited by 30

Identification of acetylcholinesterase inhibitors from seeds of plants of genusPeganumby thin-layer chromatography-bioautography

Zheng, X.-Y., Zhang, L., Cheng, X. M., Zhang, Z., Wang, C., & Wang, Z. (2011) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.24.2011.6.3 · Cited by 27

Forced-flow planar liquid chromatographic techniques (after twenty-two years)

Tyihák, E., & Mincsovics, E. (2010) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.23.2010.6.1 · Cited by 26

Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle

Teruya, T., Sasaki, H., & Suenaga, K. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.06.086 · Cited by 26

Fractionation of Volatile Constituents fromCurcumaRhizome by Preparative Gas Chromatography

Yang, F. Q., Wang, H. K., Chen, H., et al. (2011) · Journal of Automated Methods and Management in Chemistry · doi:10.1155/2011/942467 · Cited by 25

Separation ofcis- andtrans-Asarone fromAcorus tatarinowiiby Preparative Gas Chromatography

Zuo, H., Yang, F. Q., Zhang, X. M., et al. (2012) · Journal of Analytical Methods in Chemistry · doi:10.1155/2012/402081 · Cited by 24

Characterization of [8-ethyl]-chlorophyll c3 from Emiliania huxleyi

Álvarez, S., Zapata, M., Garrido, J. L., & Vaz, B. (2012) · Chemical Communications · doi:10.1039/c2cc31329d · Cited by 23

Isolation, Structure Elucidation, and Synthesis of Eudistomides A and B, Lipopeptides from a Fijian Ascidian Eudistoma sp.

Whitson, E. L., Ratnayake, A. S., Bugni, T. S., Harper, M. K., & Ireland, C. M. (2008) · The Journal of Organic Chemistry · doi:10.1021/jo8022582 · Cited by 23

Cytotoxic and Antibacterial Beilschmiedic Acids from a Gabonese Species of Beilschmiedia

Williams, R. B., Martin, S. M., Hu, J., Norman, V. L., Goering, M. G., Loss, S., O’Neil-Johnson, M., Eldridge, G. R., & Starks, C. M. (2012) · Journal of Natural Products · doi:10.1021/np300241d · Cited by 22

Optimization of the culture medium used for direct TLC-bioautography. Application to the detection of antimicrobial compounds fromCordia gilletiiDe Wild (Boraginaceae)

Okusa, P. N., Stévigny, C., Devleeschouwer, M. J., & Duez, P. (2010) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/jpc.23.2010.4.1 · Cited by 22

Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum: Quantification and mathematical modeling

Barros, F., Silva, F. C., Nunes, J. D. M., Vargas, R. M. F., Cassel, E., & von Poser, G. L. (2011) · Journal of Separation Science · doi:10.1002/jssc.201100455 · Cited by 22

DNA profiling of complex bacterial populations: toxic cyanobacterial blooms

Saker, M. L., Moreira, C., Martins, J., Neilan, B. A., & Vasconcelos, V. M. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2180-8 · Cited by 21

Cross‐linked agarose for separation of low molecular weight natural products in hydrophilic interaction liquid chromatography

Tan, T., Su, Z. G., Gu, M., et al. (2010) · Biotechnology Journal · doi:10.1002/biot.201000017 · Cited by 21

Fingerprint analysis and the application of HPTLC to the determination of identity and quality of botanicals, from an industry perspective

Sudberg, S., Sudberg, E. M., Terrazas, J., Sudberg, S., Patel, K., Pineda, J., & Fine, B. (2010) · Journal of AOAC International · doi:10.1093/jaoac/93.5.1367 · Cited by 17

Isolation of Natural Products by Preparative Gas Chromatography

Özek, T., & Demi̇rci̇, F. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-624-1_11 · Cited by 17

Influence of saponin plants on the volatile fraction of thyme in herbal teas

Tschiggerl, C., & Bučar, F. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.05.006 · Cited by 17

Application of Phase-Trafficking Methods to Natural Products Research

Araya, J. J., Montenegro, G., Mitscher, L. A., & Timmermann, B. N. (2010) · Journal of Natural Products · doi:10.1021/np100465h · Cited by 16

An Introduction to Planar Chromatography and Its Application to Natural Products Isolation

Gibbons, S. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-624-1_6 · Cited by 15

Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD

Moradi-Afrapoli, F., Ebrahimi, S. N., Smieško, M., Raith, M., Zimmermann, S. Y., Nadjafi, F., Brun, R., & Hamburger, M. O. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2012.08.017 · Cited by 15

Optimization of ultrasound-assisted extraction of cyanidin 3-rutinoside from litchi (Lichi chinensis Sonn.) fruit pericarp

Rao, G. H. (2010) · Analytical Methods · doi:10.1039/c0ay00203h · Cited by 14

Overpressured Layer Chromatography (OPLC) – A Flexible Tool of Analysis and Isolation

Mincsovics, E., & Tyihák, E. (2011) · Natural Product Communications · doi:10.1177/1934578x1100600528 · Cited by 14

Characterisation of Chamomile Volatiles by Simultaneous Distillation Solid-Phase Extraction in Comparison to Hydrodistillation and Simultaneous Distillation Extraction

Krüger, H. (2009) · Planta Medica · doi:10.1055/s-0029-1240704 · Cited by 13

Enzyme bei der Gewinnung von Drogen und der Herstellung von Phytopharmaka

Kreis, W. (2006) · Springer eBooks · doi:10.1007/978-3-540-34281-6_11 · Cited by 1

Current approaches and challenges for the metabolite profiling of complex natural extracts

Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

Nothias, L.-F., Nothias-Esposito, M., da Silva, R., Wang, M., Protsyuk, I., Zhang, Z., Sarvepalli, A., Leyssen, P., Touboul, D., Costa, J., et al. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00737 · Cited by 433

Alternative and efficient extraction methods for marine-derived compounds

Grosso, C., Valentão, P., Ferreres, F., & Andrade, P. (2015) · Marine Drugs · doi:10.3390/md13053182 · Cited by 248

Chitosan-Coating Effect on the Characteristics of Liposomes: A Focus on Bioactive Compounds and Essential Oils: A Review

Sebaaly, C., Trifan, A., Sieniawska, E., & Greige-Gerges, H. (2021) · Processes · doi:10.3390/pr9030445 · Cited by 133

Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products

Wang, M., Wang, J., Zhang, Y., Xia, Q., Bi, W., Yang, X., & Chen, D. D. Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.03.061 · Cited by 108