Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles
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Biomimetic multi-scale wrinkles alters macrophage cell shape and promotes antiinflammatory activation in vitro , and modulates the host response in vivo , suggesting a potential benefit for wrinkled material surfaces to promote tissue healing and remodeling.
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Irregular topographies with dimensions similar to aligned patterns produce circularly spreading macrophages with M1 characteristics.
“irregular topographies with similar dimensions produce circularly spreading macrophages with M1 characteristics”
From Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy (2024) · cites this paper as [37]
Aligned patterns with micron-level feature sizes promote M2 macrophage differentiation through forced alignment.
“Aligned patterns with feature sizes in the micron level were shown to promote M2 macrophage differentiation through forced alignment”
From Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy (2024) · cites this paper as [37]
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Nanomaterial-mediated metabolic reprogramming for functional wound regeneration
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- Authors
- Wang, T., Luu, T. U., Chen, A., Khine, M., & Liu, W. F.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Liu, Wendy F.
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 4
- Issue
- 6
- Pages
- 948-952
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- PMC
- PMC9061279
- OpenAlex
- W2345190553
- Cited by
- 77
- References
- 24
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 18 · 2020: 3 · 2019: 9 · 2018: 3 · 2017: 8
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH Office of the Director (1DP2OD007283)
- National Institute of Dental and Craniofacial Research (DP2DE023319)
- California Institute for Regenerative Medicine (TG2-01152)
- Topics
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- macrophage phenotype, surface topography, shape memory polymers, foreign body reaction, biomedical implants, alternative macrophage activation, arginase-1, IL-10, TNF-α, macrophage adhesion, collagen deposition, biomimetic surfaces
- MeSH terms
- ADAM17 Protein, Animals, Arginase, Cell Line, Collagen, Inflammation, Macrophages, Surface Properties, Wound Healing, Biomarkers, Interleukin-10, Topography, Medical, Mice
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