Bioprinted thrombosis-on-a-chip
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A novel bioprinted model of thrombosis was developed to study thrombosis and thrombolysis in vitro .
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These microfluidic devices have an endothelialized lumen that can reliably capture features of blood vessels such as atherosclerotic plaque deposition and bifurcations by altering channel geometry and flow patterns.
“These devices possess endothelialized lumen that can reliably capture several features of blood vessels such as atherosclerosis (i.e. fatty plaque deposition and formation) and bifurcations (i.e. branches and bends) by changing the channel geometries and flow patterns, ranging from laminar steady flow to pulsatile flow [287–290,295–304].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [296]
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- [26]Oklu R Wicky S Catheter-directed thrombolysis of deep venous thrombosis 2013 23483455
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Self-citation
- Authors
- Zhang, Y. S., Davoudi, F., Walch, P., Manbachi, A., Luo, X., Dell'Erba, V., Miri, A. K., Albadawi, H., Arneri, A., Li, X., Wang, X., Dokmeci, M. R., Khademhosseini, A., & Oklu, R.
- Affiliations
- Brigham and Women's Hospital (US)
- Biomaterials Innovation Research Center
- Massachusetts General Hospital (US)
- Corresponding author
- Khademhosseini, Ali
- ORCID
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 16
- Issue
- 21
- Pages
- 4097-4105
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC5072176
- OpenAlex
- W2511720699
- Cited by
- 227
- References
- 49
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 18 · 2023: 27 · 2022: 23 · 2021: 38 · 2020: 33 · 2019: 28 · 2018: 21 · 2017: 14
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR057837, DE021468, EB012597, HL099073, R56AI105024)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- thrombosis, 3D bioprinting, GelMA hydrogel, whole blood coagulation, tissue plasminogen activator, blood clot dissolution, fibroblast migration, post-thrombotic syndrome
- MeSH terms
- Humans, Thrombosis, Collagen Type I, Lab-On-A-Chip Devices, Human Umbilical Vein Endothelial Cells, Bioprinting
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