Bridging the gap: microfluidic devices for short and long distance cell–cell communication

The origins and the future of microfluidics

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Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

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Materials for Microfluidic Chip Fabrication

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Quorum sensing controls biofilm formation in Vibrio cholerae

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In vitro and ex vivo strategies for intracellular delivery

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Communication in bacteria: an ecological and evolutionary perspective

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Microfluidics-based diagnostics of infectious diseases in the developing world

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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

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A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

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Intercellular communication: diverse structures for exchange of genetic information

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T-cell-antigen recognition and the immunological synapse

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Co-culture systems and technologies: taking synthetic biology to the next level

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Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

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Three-dimensional manipulation of single cells using surface acoustic waves

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Microfluidic control of cell pairing and fusion

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Probing the role of multicellular organization in three-dimensional microenvironments

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Is quorum sensing a side effect of diffusion sensing?

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Patterning cells and their environments using multiple laminar fluid flows in capillary networks

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Exosomes: New players in cell–cell communication

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Large-Scale Single-Cell Trapping And Imaging Using Microwell Arrays

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Integration of Cell Culture and Microfabrication Technology

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Does efficiency sensing unify diffusion and quorum sensing?

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Defined spatial structure stabilizes a synthetic multispecies bacterial community

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Single-cell analysis tools for drug discovery and development

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Microfluidic culture platform for neuroscience research

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Paper-supported 3D cell culture for tissue-based bioassays

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A novel 3D mammalian cell perfusion-culture system in microfluidic channels

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Controlling cell–cell interactions using surface acoustic waves

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Microenvironment design considerations for cellular scale studies

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Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

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Single-cell technologies for monitoring immune systems

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Microfluidic tools for cell biological research

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Biological implications of cell fusion

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Laser-based direct-write techniques for cell printing

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Microfluidic Local Perfusion Chambers for the Visualization and Manipulation of Synapses

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Microfluidic Multicompartment Device for Neuroscience Research

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Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells

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Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium

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Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

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Laser Printing of Three-Dimensional Multicellular Arrays for Studies of Cell–Cell and Cell–Environment Interactions

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Cell-surface sensors for real-time probing of cellular environments

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Cell Fusion as a Hidden Force in Tumor Progression

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Heterogeneity in immune responses: from populations to single cells

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Leakage-Free Bonding of Porous Membranes into Layered Microfluidic Array Systems

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Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

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Classification of human natural killer cells based on migration behavior and cytotoxic response

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Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments

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High-throughput combinatorial cell co-culture using microfluidics

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Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing

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Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

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A microfluidic array with cellular valving for single cell co-culture

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Chapter 10 The Cancer Cell–Leukocyte Fusion Theory of Metastasis

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Screening individual hybridomas by microengraving to discover monoclonal antibodies

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Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations

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Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

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Cell electrofusion using nanosecond electric pulses

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Inkjet-like printing of single-cells

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Microfluidic techniques for high throughput single cell analysis

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On-chip cell migration assay using microfluidic channels

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A microfluidic wound-healing assay for quantifying endothelial cell migration

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Block-Cell-Printing for live single-cell printing

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A paper-based invasion assay: Assessing chemotaxis of cancer cells in gradients of oxygen

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Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

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Hydrodynamic Cellular Volume Changes Enable Glioma Cell Invasion

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Three‐Dimensional Paper‐Based Model for Cardiac Ischemia

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Micropatterned cell–cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues

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Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel

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Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

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Advantages and Limitations of Commonly used Methods to Assay the Molecular Permeability of Gap Junctional Intercellular Communication

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Co-culture of neurons and glia in a novel microfluidic platform

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Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

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Single Cell Genomics of the Brain: Focus on Neuronal Diversity and Neuropsychiatric Diseases

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NK Cells: Immune Cross-Talk and Therapeutic Implications

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An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells

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Microfluidic gradient platforms for controlling cellular behavior

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Regulation of Motility by the ExpR/Sin Quorum-Sensing System in Sinorhizobium meliloti

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Hardwiring Stem Cell Communication through Tissue Structure

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Apoptosis‐induced cancer cell fusion: a mechanism of breast cancer metastasis

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Deformability-based microfluidic cell pairing and fusion

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Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells

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Individual Motile CD4+ T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells

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Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites

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Mesenchymal‐Mode Migration Assay and Antimetastatic Drug Screening with High‐Throughput Microfluidic Channel Networks

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Microfluidic Migration and Wound Healing Assay Based on Mechanically Induced Injuries of Defined and Highly Reproducible Areas

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Imaging of Cell–Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics

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Efficient cell pairing in droplets using dual-color sorting

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Spatiotemporal Micropatterning of Cells on Arbitrary Substrates

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Distal modulation of bacterial cell–cell signalling in a synthetic ecosystem using partitioned microfluidics

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A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration

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Microfluidic wound-healing assay to assess the regenerative effect of HGF on wounded alveolar epithelium

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Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication

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Microfluidic Assay To Study the Combinatorial Impact of Substrate Properties on Mesenchymal Stem Cell Migration

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It's hard to keep all things angiogenic in one JAR!

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Single-cell analyses of circulating tumor cells.

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Retinal synaptic regeneration via microfluidic guiding channels

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Microfluidic platform for the study of intercellular communication via soluble factor-cell and cell-cell paracrine signaling

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Modulation of collective cell behaviour by geometrical constraints

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Cellular Communication Via Nanoparticle-Transporting Biovesicles

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A novel chip-based parallel transfection assay to evaluate paracrine cell interactions

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A microfabricated, optically accessible device to study the effects of mechanical cues on collagen fiber organization

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Single-Cell Characterization of in vitro Migration and Interaction Dynamics of T Cells Expanded with IL-2 and IL-7

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Determination of Relevant Neuron–Neuron Connections for Neural Prosthetics Using Time-Delayed Mutual Information: Tutorial and Preliminary Results

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Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

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Microfluidics for Protein Biophysics

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Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation

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Tissue engineering of the retina: from organoids to microfluidic chips

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Acoustofluidics for cell patterning and tissue engineering

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Message in a Bottle: Endothelial Cell Regulation by Extracellular Vesicles

Palazzo, C., D’Alessio, A., & Tamagnone, L. (2022) · Cancers · doi:10.3390/cancers14081969 · Cited by 22 · see citing works

Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange

Finetti, F., Cassioli, C., & Baldari, C. T. (2017) · F1000Research · doi:10.12688/f1000research.11944.1 · Cited by 22 · see citing works

Analysis of Leukocyte Behaviors on Microfluidic Chips

Liu, Y., Yang, Q., Cao, L., & Xu, F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801406 · Cited by 22 · see citing works

Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools

Yuan, S., Zhang, P., Zhang, F., Yan, S., Dong, R., Wu, C., & Deng, J. (2024) · iScience · doi:10.1016/j.isci.2024.111663 · Cited by 21 · see citing works

Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance

Li, L., Wu, T., Wang, Y., Ran, M., Kang, Y., Ouyang, Q., & Luo, C. (2019) · Communications Biology · doi:10.1038/s42003-019-0533-0 · Cited by 19 · see citing works

Multiplexed microfluidic chip for cell co-culture

Watson, C., Liu, C., Ansari, A., Miranda, H. C., Somoza, R. A., & Senyo, S. E. (2022) · The Analyst · doi:10.1039/d2an01344d · Cited by 18 · see citing works

Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications

Kosaka, T., Yamaguchi, S., Izuta, S., Yamahira, S., Shibasaki, Y., Tateno, H., & Okamoto, A. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c07321 · Cited by 17 · see citing works

Microfluidic-based platforms for cell-to-cell communication studies

Zhu, L., Tang, Q., Mao, Z., Chen, H., Wu, L. J., & Qin, Y. (2023) · Biofabrication · doi:10.1088/1758-5090/ad1116 · Cited by 17 · see citing works

Microfluidic-based cell handling devices for biochemical applications

Lee, S., Kim, H., Lee, W., & Kim, J. (2018) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/aae4fc · Cited by 16 · see citing works

Signal Transduction in Artificial Cells

Yu, X., Mukwaya, V., Mann, S., & Dou, H. (2023) · Small Methods · doi:10.1002/smtd.202300231 · Cited by 15 · see citing works

Fabrication Strategies for Engineered Thin Membranous Tissues

McLoughlin, S. T., McKenna, A. R., & Fisher, J. P. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00133 · Cited by 14 · see citing works

Overcoming double Poisson limitation for co-encapsulation in droplets through hydrodynamic close packing of cells

Luo, X., & Lee, A. P. (2022) · Microfluidics and Nanofluidics · doi:10.1007/s10404-022-02600-9 · Cited by 13 · see citing works

Biochips—New Platforms for Cell‐Based Immunological Assays

Shao, N., & Qin, L. (2017) · Small Methods · doi:10.1002/smtd.201700254 · Cited by 12 · see citing works

Synthesis of a Cyberphysical Hybrid Microfluidic Platform for Single-Cell Analysis

Ibrahim, M., Chakrabarty, K., & Schlichtmann, U. (2018) · IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems · doi:10.1109/tcad.2018.2846662 · Cited by 11 · see citing works

High-throughput deterministic pairing and coculturing of single cells in a microwell array using combined hydrodynamic and recirculation flow captures

Fan, L., Guan, Z., Luo, T., Ren, J., Lam, R. H. W., & Sun, D. B. (2021) · Biomicrofluidics · doi:10.1063/5.0066668 · Cited by 11 · see citing works

Cell pairing for biological analysis in microfluidic devices

Tang, X., Huang, Q., Arai, T., & Liu, X. (2022) · Biomicrofluidics · doi:10.1063/5.0095828 · Cited by 9 · see citing works

In Situ Investigation of Intercellular Signal Transduction Based on Detection of Extracellular pH and ROS by Scanning Electrochemical Microscopy

Wu, T., Jing, T., Lu, Y., Zhang, F., & He, P. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04655 · Cited by 9 · see citing works

Picosecond Laser Processing of Photosensitive Glass for Generation of Biologically Relevant Microenvironments

Jipa, F., Orobeti, S., Butnaru, C. M., Zamfirescu, M., Axente, E., Sima, F., & Sugioka, K. (2020) · Applied Sciences · doi:10.3390/app10248947 · Cited by 8 · see citing works

Subtractive Manufacturing of Microfluidic 3D Braid Mixers

Salieb–Beugelaar, G. B., Liu, K., & Hunziker, P. (2018) · Advanced Engineering Materials · doi:10.1002/adem.201800243 · Cited by 8 · see citing works

A modular and reconfigurable microfluidic device for culturing spheroids under continuous perfusion

Aljayyousi, H., Sahloul, S., Orozaliev, A., Baban, N. S., Van, D.-A., Nuairi, A. A., John, P., Zam, A., Percipalle, P., & Song, Y. (2025) · APL Bioengineering · doi:10.1063/5.0262536 · Cited by 5 · see citing works

A universal microfluidic approach for integrated analysis of temporal homocellular and heterocellular signaling and migration dynamics

Yang, H., Sinha, N., Rand, U., Häuser, H., Köster, M., de Greef, T. F. A., & Tel, J. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114353 · Cited by 5 · see citing works

Engineering microfluidic devices to mimic signaling cascades in continuous-flow cell culture as multiorgan microphysiological systems

Ortiz-Collazos, S., Sousa-Batista, A. J., & Balbino, T. A. (2024) · Biochemical Engineering Journal · doi:10.1016/j.bej.2024.109475 · Cited by 5 · see citing works

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

Lou, K., Mao, Q.-C., Chi, J.-P., Zhang, J.-K., Guo, H., Wu, J.-T., & Cui, Y.-S. (2025) · Visual Information Expert Workshop · doi:10.1002/viw.20250011 · Cited by 4 · see citing works

Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device

Otte, E. A., Smith, T. N., Glass, N. R., Wolvetang, E. J., & Cooper-White, J. J. (2023) · Lab on a Chip · doi:10.1039/d3lc00670k · Cited by 3 · see citing works

Investigation of tumour environments through advancements in microtechnology and nanotechnology

Liu, Z., Fan, Y. L., Cui, M., Wang, X., & Zhao, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117230 · Cited by 3 · see citing works

In Situ Investigation of Intercellular Communication in Ferroptosis Integrated Scanning Electrochemical Microscopy with Microfluidic Devices

Lu, Y., Ge, Y., Tu, F., Li, X., Geng, P., Zhang, F., & Wang, Q. (2025) · ACS Sensors · doi:10.1021/acssensors.5c00176 · Cited by 3 · see citing works

A core-shell structured collagen hydrogel microsphere with removable superparamagnetic alginate coating for cell coculture and rapid separation

Liu, J., Wang, Q., Sun, Y., Lin, H., Liang, J., Fan, Y., & Zhang, X. (2019) · Materials Letters · doi:10.1016/j.matlet.2019.04.059 · Cited by 3 · see citing works

Fully-Automated On-Chip Multi-Cell Arraying With Deterministic Quantities

Liu, X., Tang, X., Chen, Z., Kojima, M., Huang, Q., & Arai, T. (2022) · IEEE Transactions on Automation Science and Engineering · doi:10.1109/tase.2022.3151152 · Cited by 2 · see citing works

Harnessing the Manipulation of Single Cells to Construct Biological Structures: Tools and Applications

Liu, C., Chen, Y., Tong, R., Wang, Z., Zhang, D., Chen, H., & Zhang, P. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202316357 · Cited by 2 · see citing works

Two-step fabrication of clear view SLA millifluidic device for long-term in-vitro cultures

Saha, D., Pandillapally, R., Dhyani, V., Harsha, K. S., Swain, S., Duraiswamy, S., & Giri, L. (2024) · Rapid Prototyping Journal · doi:10.1108/rpj-02-2024-0071 · Cited by 2 · see citing works

Graph-Based 3-Dimensional Spatial Gene Neighborhood Networks of Single Cells in Gels and Tissues

Fang, Z., Krusen, K., Priest, H., Wang, M., Kim, S., Sriram, A., Yellanki, A., Singh, A. K., Horwitz, E. M., & Coskun, A. F. (2025) · BME Frontiers · doi:10.34133/bmef.0110 · Cited by 2 · see citing works

A taxonomy of agents

Martinelli, E. (2025) · Philosophical Explorations · doi:10.1080/13869795.2025.2521296 · Cited by 1 · see citing works

Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain

Sandvig, A., & Sandvig, I. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00630 · Cited by 1 · see citing works

Novel, Emerging Chip Models of the Blood-Brain Barrier and Future Directions

Holloway, P. M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2289-6_11 · Cited by 1 · see citing works

A Microscale Approach to Investigate Breast Cancer Cellular Communication and Migration

Rahman, S. M. M. (2021) · doi:10.31390/gradschool_dissertations.5444

Probing T-cell activation in nanoliter tumor co-cultures using membrane displacement trap arrays

Yeh, M., Salazar-Cavazos, E., Krishnan, A. Y., Altan-Bonnet, G. Y., & DeVoe, D. L. (2024) · Integrative Biology · doi:10.1093/intbio/zyae014

Organ-on-a-chip in the diagnosis and treatment of chronic respiratory disorders and its application to advanced drug delivery systems

Verma, N., Kanojia, N., Thapa, K., Chandel, P., & Dua, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-27345-2.00008-4

New Insights into Neurodegenerative Diseases: Intercellular Transmission

Xiu-lan, J., Zhao, T.-H., Guo, W., Xue, J., & Yin, D. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00991

Probing cell–cell communication with microfluidic devices

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Microfluidic-based platforms for cell-to-cell communication studies

Zhu, L., Tang, Q., Mao, Z., Chen, H., Wu, L. J., & Qin, Y. (2023) · Biofabrication · doi:10.1088/1758-5090/ad1116 · Cited by 17 · see citing works

Highly efficient microfluidic device for cell trapping and pairing towards cell-cell communication analysis

Zhu, J., Wang, Y., Chen, P., Su, H., Du, W., & Liu, B. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.12.078 · Cited by 30 · see citing works

Microfluidics-Based Single-Cell Research for Intercellular Interaction

Pang, L., Ding, J., Liu, X.-X., Kou, Z., Guo, L., Xi Tao, X. U., & Fan, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.680307 · Cited by 28 · see citing works

Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools

Yuan, S., Zhang, P., Zhang, F., Yan, S., Dong, R., Wu, C., & Deng, J. (2024) · iScience · doi:10.1016/j.isci.2024.111663 · Cited by 21 · see citing works