Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005 · see citing works

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993 · see citing works

Reengineering Translational Science: The Time Is Right

Collins, F. S. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002747 · Cited by 481 · see citing works

Phase III and submission failures: 2007–2010

Arrowsmith, J. E. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3375 · Cited by 480 · see citing works

Obstacles facing translational research in academic medical centers

POBER, J. S., NEUHAUSER, C. S., & POBER, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.01-0540lsf · Cited by 132 · see citing works

Uncertainty in the Translation of Preclinical Experiments to Clinical Trials. Why do Most Phase III Clinical Trials Fail?

Lowenstein, P. R., & Castro, M. G. (2009) · Current Gene Therapy · doi:10.2174/156652309789753392 · Cited by 89 · see citing works

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Edington, C. D., Chen, W. L. K., Geishecker, E., Kassis, T., Soenksen, L. R., Bhushan, B. M., Freake, D., Kirschner, J., Maass, C., Tsamandouras, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22749-0 · Cited by 487 · see citing works

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

Schwartz, M. P., Hou, Z., Propson, N. E., Zhang, J., Engstrom, C. J., Costa, V. S., Jiang, P., Nguyen, B. K., Bolin, J. M., Daly, W., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516645112 · Cited by 325 · see citing works

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Phan, D. T. T., Wang, X., Craver, B. M., Sobrino, A., Zhao, D., Chen, J. C., Lee, L. Y. N., George, S. C., Lee, A. P., & Hughes, C. C. W. (2017) · Lab on a Chip · doi:10.1039/c6lc01422d · Cited by 325 · see citing works

The relevance and potential roles of microphysiological systems in biology and medicine

Wikswo, J. P. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214542068 · Cited by 248 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Tsamandouras, N., Chen, W. L. K., Edington, C. D., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0122-4 · Cited by 222 · see citing works

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

Maschmeyer, I., Hasenberg, T., Jaenicke, A., Lindner, M., Lorenz, A., Zech, J., Garbe, L., Sonntag, F., Hayden, P. J., Ayehunie, S., et al. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.002 · Cited by 220 · see citing works

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

Satoh, T., Sugiura, S., Shin, K., Onuki-Nagasaki, R., Ishida, S., Kikuchi, K., Kakiki, M., & Kanamori, T. (2018) · Lab on a Chip · doi:10.1039/c7lc00952f · Cited by 181 · see citing works

Tissue chips – innovative tools for drug development and disease modeling

Low, L. A., & Tagle, D. A. (2017) · Lab on a Chip · doi:10.1039/c7lc00462a · Cited by 141 · see citing works

Next generation organoids for biomedical research and applications

Lou, Y., & Leung, A. W. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.10.005 · Cited by 132 · see citing works

Organs-on-chips: Progress, challenges, and future directions

Low, L. A., & Tagle, D. A. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217700523 · Cited by 126 · see citing works

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

Loskill, P., Marcus, S. G., Mathur, A., Reese, W. M., & Healy, K. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139587 · Cited by 123 · see citing works

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

Tsamandouras, N., Kostrzewski, T. M., Stokes, C. L., Griffith, L. G., Hughes, D. J., & Cirit, M. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237495 · Cited by 119 · see citing works

Health risks of chemicals in consumer products: A review

Li, D., & Suh, S. (2019) · Environment International · doi:10.1016/j.envint.2018.12.033 · Cited by 101 · see citing works

Alternatives of Animal Models for Biomedical Research: a Comprehensive Review of Modern Approaches

Vashishat, A., Patel, P., Gupta, G. D., & Kurmi, B. D. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10701-x · Cited by 108 · see citing works

Laminar ventricular myocardium on a microelectrode array-based chip

Kujala, V. J., Pasqualini, F. S., Goss, J. A., Nawroth, J. C., & Parker, K. K. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00324a · Cited by 90 · see citing works

Integration Concepts for Multi-Organ Chips: How to Maintain Flexibility?!

Rogal, J., Probst, C., & Loskill, P. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0092 · Cited by 80 · see citing works

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology

Watson, D. E., Hunziker, R., & Wikswo, J. P. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217732765 · Cited by 80 · see citing works

Engineered tissues and strategies to overcome challenges in drug development

Khalil, A. S., Jaenisch, R., & Mooney, D. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.09.012 · Cited by 74 · see citing works

Organoid technology for brain and therapeutics research

Wang, Z., Wang, S., Xu, T., Miao, Z., Su, D., & Miao, C. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12754 · Cited by 65 · see citing works

Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images

Urban, G., Bache, K., Phan, D. T. T., Sobrino, A., Shmakov, A., Hachey, S. J., Hughes, C. C. W., & Baldi, P. (2018) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2018.2841396 · Cited by 62 · see citing works

Computational Simulations in Advanced Microfluidic Devices: A Review

Carvalho, V. M., Rodrigues, R. O., Lima, R. A., & Teixeira, S. (2021) · Micromachines · doi:10.3390/mi12101149 · Cited by 58 · see citing works

Organ-on-a-chip technology: turning its potential for clinical benefit into reality

Haddrick, M., & Simpson, P. B. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.03.011 · Cited by 57 · see citing works

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Lee-Montiel, F. T., Laemmle, A., Charwat, V., Lee, C. S., Lee, C. S., Huebsch, N., Okochi, H., HANCOCK, M. J., Siemons, B. A., Boggess, S. C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.667010 · Cited by 63 · see citing works

Pathophysiologically relevant in vitro tumor models for drug screening

Das, V., Bruzzese, F., Konečný, P., Iannelli, F., Budillon, A., & Hajdúch, M. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.04.004 · Cited by 53 · see citing works

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi‐MPS Integration

Yu, J., Cilfone, N., Large, E. M., Sarkar, U., Wishnok, J. S., Tannenbaum, S. R., Hughes, D., Lauffenburger, D. A., Griffith, L. G., Stokes, C., et al. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12010 · Cited by 52 · see citing works

Animal use for science in Europe

Daneshian, M. (2015) · ALTEX · doi:10.14573/altex.1509081 · Cited by 52 · see citing works

Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake

Hausmann, C., Zoschke, C., Wolff, C., Darvin, M. E., Sochorová, M., Kováčik, A., Wanjiku, B., Schumacher, F., Tigges, J., Kleuser, B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39770-6 · Cited by 52 · see citing works

Physiologically relevant human tissue models for infectious diseases

Mills, M., & Estes, M. K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.020 · Cited by 50 · see citing works

Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology Evaluation

Isoherranen, N., Madabushi, R., & Huang, S. M. (2019) · Clinical and Translational Science · doi:10.1111/cts.12627 · Cited by 50 · see citing works

Farm and Companion Animal Organoid Models in Translational Research: A Powerful Tool to Bridge the Gap Between Mice and Humans

Kawasaki, M., Goyama, T., Tachibana, Y., Nagao, I., & Ambrosini, Y. M. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.895379 · Cited by 48 · see citing works

Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions

Bale, S. S., Moore, L., Yarmush, M. L., & Jindal, R. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0031 · Cited by 46 · see citing works

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium

Rusyn, I., Sakolish, C., Kato, Y., Stephan, C., Vergara, L., Hewitt, P., Bhaskaran, V., Davis, M., Hardwick, R. N., Ferguson, S. S., et al. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac061 · Cited by 43 · see citing works

Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues

Huang, M., Liu, Z., Baugh, L. M., DeFuria, J., Maione, A. G., Smith, A., Kashpur, O., Black, L. D., Georgakoudi, I., Whitfield, M. L., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0159-8 · Cited by 39 · see citing works

Tissue chips to aid drug development and modeling for rare diseases

Low, L. A., & Tagle, D. A. (2016) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2016.1244479 · Cited by 39 · see citing works

Neural organoids for disease phenotyping, drug screening and developmental biology studies

Hartley, B. J., & Brennand, K. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.004 · Cited by 38 · see citing works

Sandwiched White Adipose Tissue: A Microphysiological System of Primary Human Adipose Tissue

Lau, F. H., Vogel, K., Luckett, J. P., Hunt, M. G., Meyer, A., Rogers, C. L., Tessler, O., Dupin, C. L., Hilaire, H. S., Islam, K. N., et al. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0339 · Cited by 37 · see citing works

Recent Advances in Retinal Stem Cell Therapy

Bhattacharya, S., Gangaraju, R., & Chaum, E. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0069-3 · Cited by 34 · see citing works

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

Fabre, K. M., Delsing, L., Hicks, R., Colclough, N., Crowther, D. C., & Ewart, L. C. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.009 · Cited by 32 · see citing works

Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

Urbaczek, A. C., Leão, P. A. G. C., de Souza, F. Z. R., Afonso, A., Alberice, J. V., Cappelini, L. T. D., Carlos, I. Z., & Carrilho, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-11043-0 · Cited by 30 · see citing works

Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?

Cyr, K. J., Avaldi, O. M., & Wikswo, J. P. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217732766 · Cited by 29 · see citing works

Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity

Kaushik, G., Gupta, K., Harms, V. M., Torr, E., Evans, J., Johnson, H. J., Soref, C. M., Acevedo‐Acevedo, S., Antosiewicz‐Bourget, J., Mamott, D., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000825 · Cited by 28 · see citing works

Facilitating implementation of organs-on-chips by open platform technology

Vollertsen, A. R., Vivas, A., van Meer, B. J., van den Berg, A., Odijk, M., & van der Meer, A. D. (2021) · Biomicrofluidics · doi:10.1063/5.0063428 · Cited by 25 · see citing works

Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment

Middelkamp, H. H. T., van der Meer, A. D., Hummel, J. M., Stamatialis, D. F., Mummery, C. L., Passier, R. C., & IJzerman, M. J. (2016) · Applied In Vitro Toxicology · doi:10.1089/aivt.2015.0029 · Cited by 26 · see citing works

Clinically Relevant Tissue Scale Responses as New Readouts from Organs-on-a-Chip for Precision Medicine

Guenat, O. T., Geiser, T., & Francois Berthiaume, B. (2020) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061318-114919 · Cited by 22 · see citing works

PiFlow: A biocompatible low-cost programmable dynamic flow pumping system utilizing a Raspberry Pi Zero and commercial piezoelectric pumps

Kassis, T., Perez, P. M., Yang, C. J. W., Soenksen, L. R., Trumper, D. L., & Griffith, L. G. (2018) · HardwareX · doi:10.1016/j.ohx.2018.e00034 · Cited by 20 · see citing works

An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications

Shah, D., Dave, B. P., Chorawala, M. R., Prajapati, B. G., Singh, S. K., Elossaily, G. M., Ansari, M. N., & Ali, N. (2024) · ACS Omega · doi:10.1021/acsomega.3c10271 · Cited by 19 · see citing works

Biology coming full circle: Joining the whole and the parts

Wikswo, J. P., & Porter, A. P. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370214564534 · Cited by 19 · see citing works

You-on-a-chip’ for precision medicine

Low, L. A., & Tagle, D. A. (2018) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2018.1456333 · Cited by 18 · see citing works

Development of quantitative systems pharmacology and toxicology models within consortia: experiences and lessons learned through DILIsym development

Howell, B. A., Siler, S. Q., Barton, H. A., Joshi, E., Cabal, A., Eichenbaum, G. M., & Watkins, P. B. (2016) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2017.04.001 · Cited by 17 · see citing works

Microphysiological Systems (Tissue Chips) and their Utility for Rare Disease Research

Low, L. A., & Tagle, D. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-67144-4_23 · Cited by 17 · see citing works

Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction

Martins, A. M. G., Wilkins, M. D., Ligler, F. S., Daniele, M. A.-A., & Freytes, D. O. (2021) · ACS Sensors · doi:10.1021/acssensors.0c02172 · Cited by 16 · see citing works

Deep-space applications for point-of-care technologies

Strangman, G. E., Sawyer, A., Fabre, K. M., Urquieta, E., Hury, J., Wu, J. H., Peterman, A., Hoffman, J., & Donoviel, D. B. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.08.014 · Cited by 16 · see citing works

Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems

Przekwas, A. J., & Somayaji, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817202-5.00011-5 · Cited by 15 · see citing works

Stem Cells in Skeletal Tissue Engineering: Technologies and Models

Langhans, M. T., Yu, S., & Tuan, R. S. (2015) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x10666151001115248 · Cited by 15 · see citing works

Microfluidic Invasion Chemotaxis Platform for 3D Neurovascular Co-Culture

Sokullu, E., Cücük, Z. L., Sarabi, M. R., Birtek, M. T., Bagheri, H. S., & Taşoğlu, S. (2022) · Fluids · doi:10.3390/fluids7070238 · Cited by 14 · see citing works

Load-induced osteoarthritis on a chip

Gottardi, R. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0427-y · Cited by 13 · see citing works

A Review of the Application of Body-on-a-Chip for Drug Test and Its Latest Trend of Incorporating Barrier Tissue

Jin, H., & Yu, Y. (2015) · SLAS TECHNOLOGY · doi:10.1177/2211068215619126 · Cited by 13 · see citing works

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interactionPreprint

Lee-Montiel, F. T., Laemmle, A., Dumont, L., Lee, C. S., Huebsch, N., Charwat, V., Okochi, H., HANCOCK, M. J., Siemons, B. A., Boggess, S. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.24.112771 · Cited by 11 · see citing works

Neural Microphysiological Systems for In Vitro Modeling of Peripheral Nervous System Disorders

Pollard, K. J., Sharma, A. D., & Moore, M. J. (2019) · Bioelectronics in Medicine · doi:10.2217/bem-2019-0018 · Cited by 10 · see citing works

A proof-of-concept study poised to remodel the drug development process

Nahle, Z. A. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.1053588 · Cited by 11 · see citing works

Global expansion of microphysiological systems (MPS) and Japan's initiatives: Innovation in pharmaceutical development and path to regulatory acceptance

Yamazaki, D., & Ishida, S. (2024) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2024.101047 · Cited by 9 · see citing works

Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

Berridge, B. R., Schultze, A. E., Heyen, J., Searfoss, G. H., & Sarazan, R. D. (2016) · ILAR Journal · doi:10.1093/ilar/ilw028 · Cited by 9 · see citing works

Recent Advances in Molecular Diagnosis of Pulmonary Fibrosis for Precision Medicine

Jeong, M. H., Han, H., Lagares, D., & Im, H. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00028 · Cited by 9 · see citing works

Evaluation of a microphysiological human placental barrier model for studying placental drug transfer

Rahman, S. M., Kwee, B. J., Li, M., Chidambaram, M., He, X., Bryant, M., Mehta, D., Nakamura, N., Phanavanh, B., Fisher, J. W., et al. (2023) · Reproductive Toxicology · doi:10.1016/j.reprotox.2023.108523 · Cited by 7 · see citing works

Advances in Ophthalmic Organ-on-a-Chip Models: Bridging Translational Gaps in Disease Modeling and Drug Screening

Lu, R. (2024) · International Journal of Translational Medicine · doi:10.3390/ijtm4040049 · Cited by 7 · see citing works

Discover Toxicology: An Early Safety Assessment Approach

Baker, T. K., Engle, S. K., Halstead, B. W., Paisley, B. M., Searfoss, G. H., & Willy, J. A. (2017) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-50042-3_5 · Cited by 5 · see citing works

Personalizing Cancer Treatments Empirically in the Laboratory: Patient-Specific Tumor Organoids for Optimizing Precision Medicine

Mazzocchi, A. R., Votanopoulos, K. I., & Skardal, A. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0122-z · Cited by 5 · see citing works

PiFlow: A Biocompatible Low-Cost Programmable Dynamic Flow Pumping System Utilizing a Raspberry Pi Zero and Commercial Piezoelectric PumpsPreprint

Kassis, T., Perez, P. M., Yang, C. J. W., Soenksen, L. R., Trumper, D. L., & Griffith, L. G. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/192047 · Cited by 3 · see citing works

Induced pluripotent stem cells to generate skin tissue models

Kashpur, O., Smith, A., Mukhamedshina, N., Baskin, J., Shamis, Y., Hewitt, K. J., Gerami‐Naini, B., & Garlick, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810545-0.00017-6 · Cited by 2 · see citing works

Machine Learning to Predict Developmental Neurotoxicity with High-Throughput Data from 2D Bio-Engineered Tissues

Kuusisto, F., Costa, V. S., Hou, Z., Thomson, J., Page, D., & Stewart, R. M. (2019) · International Conference on Machine Learning and Applications · doi:10.1109/icmla.2019.00055 · Cited by 2 · see citing works

The National Cancer Institute’s Efforts in Promoting Research in the Tumor Microenvironment

Zahir, N., Woodhouse, E. C., & Mohla, S. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000130 · Cited by 1 · see citing works

Human Pluripotent Stem Cells for Toxicological Screening

Du, L., & Chen, D. (2016) · doi:10.1002/9781119135449.ch4

Maintaining an Emphasis on Rare Diseases With Research Initiatives and Resources at the National Center for Advancing Translational Sciences

Groft, S. C., & Gopal-Srivastava, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802101-9.00033-8

Desenvolvimento de vaso sanguíneo biomimético em plataforma microfluídica de poliéster-toner (PT)

Leão, P. A. G. G. C. (2017) · doi:10.11606/t.75.2017.tde-01022017-153404

Microphysiological Systems: gold standard approach towards in vitro biomimetics and its potential to drive forward the fisheries sector to the next level

Sharma, A., & Shah, T. K. (2020) · International Journal of Chemical Studies · doi:10.22271/chemi.2020.v8.i2q.8913

Microfluidic and Microengineered Systems for Automated Cardiac Organ-on-a-Chip Tissue Culture

Vivas, A. (2022) · doi:10.3990/1.9789036554930

"Microfluidic vessels-on-chips for vascular disease modelling"

Middelkamp, H. H. T. (2023) · doi:10.3990/1.9789036557245

Three-Dimensional Models: Biomimetic Tools That Recapitulate Breast Tissue Architecture and Microenvironment to Study Ductal Carcinoma In Situ Transition to Invasive Ductal Breast Cancer

Shah, S., Osuala, K. O., Brock, E. J., Ji, K., Sloane, B. F., & Mattingly, R. R. (2025) · Cells · doi:10.3390/cells14030220

Modeling Genetic Susceptibility in Toxicology

Narke, D., & Moorthy, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00266-7

Research Design and Causal Inferences in Human Resource Management Research

Stone‐Romero, E. F. (2020) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-64802-090-220251004

Modeling glioblastoma niche-by-niche: recent advancements in bioengineering of organotypic models of glioblastoma for precision medicine

Abedi, K., Sissoko, C. A., Pun, S., Kappagantula, S., Zucca, B., & Barrile, R. (2026) · Biofabrication · doi:10.1088/1758-5090/ae7832

Organs-on-chips for safety testing and disease modeling

Ewart, L. C. (2021) · Toxicology Letters · doi:10.1016/s0378-4274(21)00325-8

Organs-On-a-Chip: A New Tool for the Study of Human Physiology

Maoz, B. M. (2022) · Advanced Materials and Devices for Nanomedicine (AMDN) · doi:10.29363/nanoge.amamed.2022.001 · Cited by 1 · see citing works

Organs-on-a-chip

(n.d.)

Of human-on-a-chip and humans: Considerations for creating and using microphysiological systems

Slikker, W. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214537754 · Cited by 13 · see citing works

Human microphysiological systems for drug development

Roth, A., & 2019, M.-W. B. (2021) · Science · doi:10.1126/science.abc3734 · Cited by 94 · see citing works