Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation
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Stiffness tunable 3D HA-based hydrogel models were implemented to control the progenitor properties and neuronal differentiation of hiPSC-NPCs or DS-NPCs.
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Hyaluronic acid and mixtures of hyaluronic acid and chitosan have been extensively used in the growth and construction of neural organoids.
“Similarly, hyaluronic acid and mixtures of hyaluronic acid and chitosan have been extensively used in the growth and construction of neural organoids111–116.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [114]
The differentiation of both normal and Down syndrome iPSCs into neurons was dependent on matrix stiffness; cells could be grown at a softer elastic modulus of ca. 500 Pa but not ca. 1500 Pa.
“The authors found that the differentiation of both normal and Down syndrome iPSCs into neurons was dependent on matrix stiffness; cells could be grown at a softer elastic modulus of ca. 500 Pa but not ca. 1500 Pa, as indicated by higher expression of β-2 tubulin and microtubule-associated protein 2.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [114]
Down syndrome patient-derived iPSCs differentiated in the softer gel showed no discernable neurite outgrowth, suggesting a block in the maturation of the differentiated neurons.
“However, Down syndrome patient-derived iPSCs that were differentiated in the softer gel showed no discernable neurite outgrowth, suggesting a block in the maturation of the differentiated neurons.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [114]
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- Authors
- Wu, S., Xu, R., Duan, B., & Jiang, P.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Duan, Bin
- Jiang, Peng
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 5
- Issue
- 21
- Pages
- 3870-3878
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- PMC
- PMC5536346
- OpenAlex
- W2606080624
- Cited by
- 111
- References
- 81
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 12 · 2022: 14 · 2021: 23 · 2020: 15 · 2019: 15 · 2018: 14
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA036727)
- National Institute of General Medical Sciences (P30GM106397, P30GM110768)
- National Institute of Neurological Disorders and Stroke (R01NS102382)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- hyaluronic acid hydrogel, methacrylated hyaluronic acid, 3D cell culture, neuronal differentiation, Down syndrome, spheroid formation, neurite outgrowth, cell encapsulation
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