Cited by 80Luminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionPhotochemistry and Electron Transfer Studies

Facial Control Intramolecular Charge Transfer of Quinoid Conjugated Polymers for Efficient in Vivo NIR-II Imaging

Zhang, Wansu, Huang, Ting, Li, Jiewei, Sun, Pengfei, Wang, Yufeng, Shi, Wei, Han, Wei, Wang, Wenjun +2 more·2019·ACS Applied Materials & Interfaces

Abstract

Low-band gap conjugated polymers with donor-acceptor (D-A) structures have emerged as second near-infrared (NIR-II) fluorescence probes for biological imaging. However, how to control the intramolecular charge transfer (ICT) to maintain the low band gap and improve the NIR-II fluorescence intensity is an urgent issue. Here, the quinoid polymers have been developed to effectively regulate the ICT for brighter NIR-II fluorescence signals. Thiophene repeat chain units of different lengths (T, 2T, and 3T) were utilized to link with electron-withdrawing ester-substituted thieno[3,4- b]thiophene (TT) to alter the density of the electron-withdrawing side groups for controlling the ICT. By increasing the thiophene chain length from TT-T to TT-3T, the density of the electron-withdrawing groups decreased and the ICT was weakened. In the case of NIR absorption and NIR-II emission, weakened ICT leads to brighter NIR-II fluorescence. After the preparation of the water-soluble quinoid polymer probes (CPs), TT-3T CPs with weak ICT exhibited the brightest NIR-II fluorescent signals among the three quinoid polymer probes. Several NIR-II biomedical imaging applications, including in vivo cell tracking, blood vascular system images, and lymphatic drainage mapping, show that the TT-3T CP-based nanoprobe had excellent characteristics of long-term stability and high NIR-II spatial resolutions in vivo.

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Crossref · 10.1021/acsami.9b02597

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Authors
Zhang, W., Huang, T., Li, J., Sun, P., Wang, Y., Shi, W., Han, W., Wang, W., Fan, Q., & Huang, W.
Affiliations
  • Nanjing University of Posts and Telecommunications (CN)
  • Nanjing Tech University (CN)
  • Nanjing University (CN)
  • Liaocheng University (CN)
  • Northwestern Polytechnical University (CN)
Corresponding author
  • Sun, Pengfei
  • Fan, Quli
Venue
ACS Applied Materials & Interfaces
Published
2019-04-17
Volume
11
Issue
18
Pages
16311-16319
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2940442761
Cited by
80
References
53
Citations by year
2026: 6 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 16 · 2021: 14 · 2020: 18 · 2019: 4
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (21604042, 21674048, 21574064)
  • Nanjing University of Posts and Telecommunications (NY211003)
  • Ministry of Science and Technology of the People's Republic of China (2015CB932200)
  • Government of Jiangsu Province (BE2016770, BRA2016379)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords
intramolecular charge transfer, NIR-II fluorescence, donor-acceptor polymers, electron-withdrawing substituents, water-soluble polymers, in vivo imaging, cell tracking, vascular imaging, lymphatic mapping, fluorescent nanoprobes
MeSH terms
Electrons, Fluorescent Dyes, Humans, Polymers, Spectrometry, Fluorescence, Thiophenes, Molecular Structure, Spectroscopy, Near-Infrared, Nanoparticles, Cell Tracking

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