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Thiol redox control via thioredoxin and glutaredoxin systems

Holmgren, A., Johansson, C., Berndt, C., Lönn, M.E., Hudemann, C., Lillig, C.H.·2005·Biochemical Society Transactions
DOI 10.1042/bst0331375
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Abstract

The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.

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Metadata

Authors
Holmgren, A., Johansson, C., Berndt, C., Lönn, M. E., Hudemann, C., & Lillig, C. H.
Venue
Biochemical Society Transactions
Publisher
Portland Press Ltd.
Published
2005-10-26
Volume
33
Issue
6
Pages
1375-1377
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
DOI
10.1042/bst0331375
OpenAlex
W2000998571
Cited by
463
References
4
FWCI
9.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Thiol redox control via thioredoxin and glutaredoxin systems. https://app.cochat.ai/papers/10.1042/bst0331375
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Holmgren, A., Johansson, C., Berndt, C., Lönn, M. E., Hudemann, C., & Lillig, C. H. (2005). Thiol redox control via thioredoxin and glutaredoxin systems. Biochemical Society Transactions. https://doi.org/10.1042/bst0331375

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