Brown adipose tissue uncoupling protein content in human infants, children and adults

A simplified method for the quantitative assay of small amounts of protein in biologic material

Schacterle, G. R., & Pollack, R. L. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90523-x · Cited by 1,798 · see citing works

Thermogenic mechanisms in brown fat.

Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602 · see citing works

A simple procedure for removal of triton X-100 from protein samples

Holloway, P. W. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90436-3 · Cited by 858 · see citing works

Basic Statistical Methods.

Dunn, O. J., Downie, N. M., & Heath, R. W. (1959) · Journal of the American Statistical Association · doi:10.2307/2282519 · Cited by 557 · see citing works

[8] Mitochondria from brown adipose tissue: Isolation and properties

Cannon, B., & Lindberg, O. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)55010-1 · Cited by 224 · see citing works

Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria

Lin, C. S., & Klingenberg, M. (1982) · Biochemistry · doi:10.1021/bi00541a023 · Cited by 216 · see citing works

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-803 · Cited by 164 · see citing works

Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis

Dauncey, M. J. (1981) · British Journal Of Nutrition · doi:10.1079/bjn19810102 · Cited by 126 · see citing works

Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria

Desautels, M., & Himms‐Hagen, J. (1979) · Canadian Journal of Biochemistry · doi:10.1139/o79-118 · Cited by 122 · see citing works

Obesity may be due to a malfunctioning of brown fat.

Himms‐Hagen, J. (1979) · PubMed · Cited by 120 · see citing works

Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue

Mory, G., Bouillaud, F., Combes‐George, M., & Ricquier, D. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80120-9 · Cited by 113 · see citing works

Participation of Brown Fat in Pathogenesis of Experimental Poliomyelitis of Monkeys.

Shwartzman, G., & Aronson, S. M. (1954) · Experimental Biology and Medicine · doi:10.3181/00379727-86-21228 · Cited by 101 · see citing works

The characterization and energetic potential of brown adipose tissue in man

Cunningham, S. A., Leslie, P. J., Hopwood, D., Illingworth, P. J., Jung, R. T., Nicholls, D. G., Peden, N. R., Rafael, J., & Rial, E. (1985) · Clinical Science · doi:10.1042/cs0690343 · Cited by 91 · see citing works

Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: Increased concentration after cold acclimation

Lean, M. E. J., Branch, W. J., James, W. P. T., Jennings, G., & Ashwell, M. (1983) · Bioscience Reports · doi:10.1007/bf01121572 · Cited by 85 · see citing works

Uncoupling protein in human brown adipose tissue mitochondria

Lean, M. E. J., & James, W. P. T. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80826-6 · Cited by 79 · see citing works

Effect of acclimation temperature on the concentration of the mitochondrial ‘uncoupling’ protein measured by radioimmunoassay in mouse brown adipose tissue

Ashwell, M., Jennings, G., Richard, D., Stirling, D. M., & Trayhurn, P. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80740-6 · Cited by 68 · see citing works

Measurement by radioimmunoassay of the mitochondrial uncoupling protein from brown adipose tissue of obese (ob/ob) mice and Zucker (fa/fa) rats at different ages

Ashwell, M., Holt, S., Jennings, G., Stirling, D. M., Trayhurn, P., & York, D. A. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80525-1 · Cited by 46 · see citing works

ENERGY REQUIREMENTS AND OBESITY

James, W. P. T. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90354-9 · Cited by 36 · see citing works

Decrease in mitochondrial GDP binding without parallel changes in uncoupling protein in brown adipose tissue of the guinea pig

Ashwell, M., Jennings, G., Stirling, D. M., & Trayhurn, P. (1986) · Biochemical Society Transactions · doi:10.1042/bst0140283 · Cited by 6 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

Bi-directional interconversion of brite and white adipocytes

Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 792 · see citing works

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 748 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

A clinical perspective of obesity, metabolic syndrome and cardiovascular disease

Han, T. S., & Lean, M. E. (2016) · JRSM Cardiovascular Disease · doi:10.1177/2048004016633371 · Cited by 500 · see citing works

Thyroid Hormone Control of Thermogenesis and Energy Balance

Silva, J. E. (1995) · Thyroid · doi:10.1089/thy.1995.5.481 · Cited by 379 · see citing works

Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

Betz, M. J., & Enerbäck, S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.132 · Cited by 355 · see citing works

Brown adipose tissue thermogenesis and obesity

Himms‐Hagen, J. (1989) · Progress in Lipid Research · doi:10.1016/0163-7827(89)90009-x · Cited by 324 · see citing works

Implications of nonshivering thermogenesis for energy balance regulation in humans

Lichtenbelt, W. D. V. M., & Schrauwen, P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00652.2010 · Cited by 306 · see citing works

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 279 · see citing works

The role of high-fat diets and physical activity in the regulation of body weight

Schrauwen, P., & Westerterp, K. R. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001720 · Cited by 273 · see citing works

The uncoupling proteins, a review

Boss, O., Muzzin, P., & Giacobino, J.-P. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390001 · Cited by 264 · see citing works

Human Brown Adipose Tissue: What We Have Learned So Far

Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223 · see citing works

The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy

Rowland, L. A., Bal, N. C., & Periasamy, M. (2014) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12157 · Cited by 221 · see citing works

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

Poher, A.-L., Altirriba, J., Veyrat‐Durebex, C., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00004 · Cited by 213 · see citing works

Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance

Lee, P. C., Swarbrick, M. M., & Ho, K. K. Y. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1081 · Cited by 207 · see citing works

UCP2 and UCP3 in muscle controlling body metabolism

Schrauwen, P., & Hesselink, M. K. C. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.15.2275 · Cited by 205 · see citing works

Brown adipose tissue in humans

Lean, M. E. J. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890036 · Cited by 199 · see citing works

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194 · see citing works

Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans

Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 191 · see citing works

Convertible adipose tissue in mice.

Lončar, D. (1991) · Cell and Tissue Research · doi:10.1007/bf00678721 · Cited by 187 · see citing works

Transcriptional Synergy and the Regulation of Ucp1 during Brown Adipocyte Induction in White Fat Depots

Xue, B., Coulter, A. A., Rim, J. S., Koza, R. A., & Kozak, L. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8311-8322.2005 · Cited by 179 · see citing works

Regulatory circuits controlling white versus brown adipocyte differentiation

Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works

Brown adipose tissue

Townsend, K. L., & Tseng, Y. (2012) · Adipocyte · doi:10.4161/adip.18951 · Cited by 172 · see citing works

Three years with adult human brown adipose tissue

Nedergaard, J., Bengtsson, T., & Cannon, B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05905.x · Cited by 158 · see citing works

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

Schulz, T. J., & Tseng, Y.-H. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.019 · Cited by 154 · see citing works

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Xu, P., Xu, F., Sáez, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.016 · Cited by 147 · see citing works

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y.-X., Liu, N., Rudnicki, M. A., & Kuang, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003626 · Cited by 144 · see citing works

Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice

Bal, N. C., Singh, S. K., Reis, F. C. G., Maurya, S. K., Pani, S., Rowland, L. A., & Periasamy, M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.790451 · Cited by 140 · see citing works

Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs.

Champigny, O., Ricquier, D., Blondel, O., Mayers, R. M., BRISCOE, M. G., & Holloway, B. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10774 · Cited by 137 · see citing works

On the Evolutionary Origins of Obesity: A New Hypothesis

Sellayah, D., Cagampang, F. R. A., & Cox, R. (2014) · Endocrinology · doi:10.1210/en.2013-2103 · Cited by 141 · see citing works

There and Back Again: Leptin Actions in White Adipose Tissue

Martínez‐Sánchez, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176039 · Cited by 135 · see citing works

The role of uncoupling proteins in the regulation of metabolism

Erlanson‐Albertsson, C. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01159.x · Cited by 121 · see citing works

The role and importance of brown adipose tissue in energy homeostasis

Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32833a8d6e · Cited by 118 · see citing works

Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth

Casteilla, L., Champigny, O., Bouillaud, F., Robelin, J., & Ricquier, D. (1989) · Biochemical Journal · doi:10.1042/bj2570665 · Cited by 119 · see citing works

Role of Exercise in the Activation of Brown Adipose Tissue

Sánchez‐Delgado, G., Martínez‐Téllez, B., Olza, J., Aguilera, C. M., Gil, Á., & Ruiz, J. R. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437173 · Cited by 114 · see citing works

Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress

Rowland, L. A., Bal, N. C., Kozak, L. P., & Periasamy, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.637603 · Cited by 116 · see citing works

Mitochondrial Uncoupling Proteins in Energy Expenditure

Kozak, L. P., & Harper, M. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.339 · Cited by 114 · see citing works

Epididymal white adipose tissue after cold stress in rats II. Mitochondrial changes

Lonćar, D., Afzelius, B. A., & Cannon, B. (1988) · Journal of Ultrastructure and Molecular Structure Research · doi:10.1016/0889-1605(88)90010-9 · Cited by 111 · see citing works

Obesity and thermoregulation

Speakman, J. R. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00026-6 · Cited by 110 · see citing works

Brown vs white adipocytes: The PPARγ coregulator story

Koppen, A., & Kalkhoven, E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.035 · Cited by 108 · see citing works

The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research

González‐Barroso, M. M., Ricquier, D., & Cassard, A. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00009.x · Cited by 109 · see citing works

Transcriptional regulation of the uncoupling protein-1 gene

Villarroya, F., Peyrou, M., & Giralt, M. (2017) · Biochimie · doi:10.1016/j.biochi.2016.09.017 · Cited by 108 · see citing works

Evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig

Trayhurn, P., Temple, N. J., & Aerde, J. V. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-239 · Cited by 107 · see citing works

The Role of Thermogenesis in Antipsychotic Drug‐induced Weight Gain

Stefanidis, A., Verty, A. N. A., Allen, A. M., Owens, N. C., Cowley, M. A., & Oldfield, B. J. (2008) · Obesity · doi:10.1038/oby.2008.468 · Cited by 104 · see citing works

Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity

Trayhurn, P. (2016) · Biochimie · doi:10.1016/j.biochi.2016.09.007 · Cited by 102 · see citing works

The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

Jia, J., Tian, Y., Cao, Z.-H., Tao, L., Zhang, X., Gao, S., Ge, C., Lin, Q., & Jois, M. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9550-2 · Cited by 96 · see citing works

Relevance of brown adipose tissue in infancy and adolescence

Gilsanz, V., Hu, P., & Kajimura, S. (2012) · Pediatric Research · doi:10.1038/pr.2012.141 · Cited by 95 · see citing works

Interactions between central nervous system and peripheral metabolic organs

Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 96 · see citing works

Human Uncoupling Proteins and Obesity

Schrauwen, P., Walder, K. R., & Ravussin, É. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00396.x · Cited by 89 · see citing works

Brown Adipose Tissue in Human Infants

Lidell, M. E. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_118 · Cited by 85 · see citing works

Role of SERCA Pump in Muscle Thermogenesis and Metabolism

Periasamy, M., Maurya, S. K., Sahoo, S. K., Singh, S. K., Reis, F. C. G., & Bal, N. C. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160030 · Cited by 85 · see citing works

The role of adipose tissue in cancer-associated cachexia

Vaitkus, J. A., & Celi, F. S. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216683282 · Cited by 78 · see citing works

Brown fat thermogenesis and body weight regulation in mice: relevance to humans

Kozak, L. P., Koza, R. A., & Anunciado‐Koza, R. P. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.179 · Cited by 78 · see citing works

Exercise-Induced Adaptations to Adipose Tissue Thermogenesis

Vidal, P., & Stanford, K. I. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00270 · Cited by 78 · see citing works

Synergistic Gene Interactions Control the Induction of the Mitochondrial Uncoupling Protein (Ucp1) Gene in White Fat Tissue

Koza, R. A., Hohmann, S. M., Guerra, C. E., Rossmeisl, M., & Kozak, L. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002136200 · Cited by 76 · see citing works

Supraclavicular skin temperature and BAT activity in lean healthy adults

van der Lans, A. A. J. J., Vosselman, M. J., Hanssen, M. J. W., Brans, B. T., & Lichtenbelt, W. D. V. M. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0398-z · Cited by 73 · see citing works

Direct Evidence of Brown Adipocytes in Different Fat Depots in Children

Rockstroh, D., Landgraf, K., Wagner, I. V., Gesing, J. K., Tauscher, R., Lakowa, N., Kieß, W., Bühligen, U., Wojan, M., Till, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117841 · Cited by 71 · see citing works

Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone

Rabelo, R., Reyes, C., Schifman, A. L., & Silva, J. E. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754777 · Cited by 68 · see citing works

Brown adipose tissue during puberty and with aging

Rogers, N. H. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914807 · Cited by 64 · see citing works

Role of Human Brown Fat in Obesity, Metabolism and Cardiovascular Disease: Strategies to Turn Up the Heat

Ruiz, J. R., Martínez‐Téllez, B., Sánchez‐Delgado, G., Osuna‐Prieto, F. J., Rensen, P. C. N., & Boon, M. R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.002 · Cited by 64 · see citing works

Women have more potential to induce browning of perirenal adipose tissue than men

van den Beukel, J. C., Grefhorst, A., Hoogduijn, M. J., Steenbergen, J., Mastroberardino, P. G., Dor, F. J. M. F., & Themmen, A. P. N. (2015) · Obesity · doi:10.1002/oby.21166 · Cited by 59 · see citing works

Human brown adipose tissue: Classical brown rather than brite/beige?

Cannon, B., de Jong, J. M. A., Fischer, A. W., Nedergaard, J., & Petrovič, N. (2020) · Experimental Physiology · doi:10.1113/ep087875 · Cited by 62 · see citing works

Transcriptional Activation of the Human ucp1 Gene in a Rodent Cell Line

González‐Barroso, M. M., Pecqueur, C., Gelly, C., Sanchı́s, D., Alves‐Guerra, M., Bouillaud, F., Ricquier, D., & Cassard, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001678200 · Cited by 59 · see citing works

Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice

Shankar, K., Kumar, D., Gupta, S., Varshney, S., Rajan, S., Srivastava, A., Gupta, A., Gupta, A. P., Vishwakarma, A. L., Gayen, J. R., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.044 · Cited by 56 · see citing works

Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles

Richardson, R. B., & Mailloux, R. J. (2023) · Antioxidants · doi:10.3390/antiox12030674 · Cited by 55 · see citing works

Lipid Transport in Brown Adipocyte Thermogenesis

Wade, G., McGahee, A., Ntambi, J. M., & Simcox, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.787535 · Cited by 53 · see citing works

Combinatorial Transcription Factor Regulation of the Cyclic AMP-response Element on the Pgc-1α Promoter in White 3T3-L1 and Brown HIB-1B Preadipocytes

Karamitri, A., Shore, A., Docherty, K., Speakman, J. R., & Lomax, M. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021766 · Cited by 51 · see citing works

Regulation of immunometabolism in adipose tissue

Kumari, M., Heeren, J., & Scheja, L. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0668-3 · Cited by 52 · see citing works

Renaissance of Brown Adipose Tissue

Tews, D., & Wabitsch, M. (2011) · Hormone Research in Paediatrics · doi:10.1159/000324806 · Cited by 51 · see citing works

Perinatal thermogenesis

Gunn, T. R., & Gluckman, P. D. (1995) · Early Human Development · doi:10.1016/0378-3782(95)01647-l · Cited by 51 · see citing works

TSH receptor activation and body composition

Lloyd, A. D., Bursell, J., Gregory, J. W., Rees, A., & Ludgate, M. E. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0262 · Cited by 51 · see citing works

The influence of sex steroids on adipose tissue growth and function

Law, J., Bloor, I. D., Budge, H., & Symonds, M. E. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0015 · Cited by 48 · see citing works

Brown adipose tissue: The heat is on the heart

Thoonen, R., Hindle, A. G., & Scherrer‐Crosbie, M. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00698.2015 · Cited by 44 · see citing works

The role of leptin in the transition from fetus to neonate

Mostyn, A., Keisler, D. H., WEBB, R., Stephenson, T. J., & Symonds, M. E. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200086 · Cited by 44 · see citing works

Frequency and significance of the A→G (−3826) polymorphism in the promoter of the gene for uncoupling protein‐1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population‐based Caucasian cohort

Schäffler, Palitzsch, Watzlawek, Drobnik, Schwer, Schölmerich, & Schmitz (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00529.x · Cited by 44 · see citing works

Uncoupling Proteins—a New Family of Proteins With Unknown Function

Erlanson‐Albertsson, C. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290007038 · Cited by 41 · see citing works

The rs1421085 variant within FTO promotes brown fat thermogenesis

Zhang, Z., Chen, N., Yin, N., Liu, R., He, Y., Li, D., Tong, M., Gao, A., Lu, P., Zhao, Y., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00847-2 · Cited by 40 · see citing works

Environmental Pollutants Effect on Brown Adipose Tissue

Gregorio, I. D., Busiello, R. A., Burgos-Aceves, M. A., Lepretti, M., Paolella, G., & Lionetti, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01891 · Cited by 40 · see citing works

The UCP1 Gene Polymorphism A-3826G in Relation to DM2 and Body Composition in Czech Population

Šrámková, D., Krejbichova, S., Včelák, J., Vaňková, M., Šamalíková, P., Hill, M., Kvasničková, H., Dvořáková, K., Vondra, K., Hainer, V., et al. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-977732 · Cited by 40 · see citing works

Uncoupling Protein-1 mRNA Expression in Lipomas from Patients Bearing Pathogenic Mitochondrial DNA Mutations

Vilà, M. R., Gámez, J., Solano, A., Playán, A., Schwartz, S., Santorelli, F. M., Cervera, C., Casali, C., Montoya, J., & Villarroya, F. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3828 · Cited by 39 · see citing works

Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status

Gavrila, A., Hasselgren, P.-O. J., Glasgow, A. L., Doyle, A. N., Lee, A. J., Fox, P. T., Gautam, S., Hennessey, J. V., Kolodny, G. M., & Cypess, A. M. (2016) · Thyroid · doi:10.1089/thy.2015.0646 · Cited by 38 · see citing works

Brown adipose tissue, energy expenditure, and biomarkers of cardio‐metabolic health among the Yakut (Sakha) of northeastern Siberia

Lévy, S., Klimova, T. M., Николаевна, З. Р., Federov, A. I., Fedorov, A. I., Baltakhinova, M. E., & Leonard, W. R. (2018) · American Journal of Human Biology · doi:10.1002/ajhb.23175 · Cited by 38 · see citing works

Metabolic Adaptations to Exercise in the Cold

Shephard, R. J. (1993) · Sports Medicine · doi:10.2165/00007256-199316040-00005 · Cited by 37 · see citing works

Brown Adipose Tissue—A Therapeutic Target in Obesity?

Trayhurn, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01672 · Cited by 36 · see citing works

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Pravednikova, A. E., Shevchenko, S. Y., Kerchev, V. V., Схиртладзе, М. Р., Николаевна, Л. С., Kachaev, Z. M., Egorov, A. D., & Shidlovskii, Y. V. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00180-4 · Cited by 36 · see citing works

Acute effects of a β-adrenoceptor agonist (BRL 26830A) on rat brown-adipose-tissue mitochondria. Increased GDP binding and GDP-sensitive proton conductance without changes in the concentration of uncoupling protein

Milner, R. E., Wilson, S., Arch, J. R. S., & Trayhurn, P. (1988) · Biochemical Journal · doi:10.1042/bj2490759 · Cited by 36 · see citing works

The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects

Shin, H. D., Kim, K. S., Ho, M., & Yoon, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.096 · Cited by 35 · see citing works

The contribution of FTO and UCP-1SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals

Ramos, A. V., Bastos‐Rodrigues, L., Resende, B., Friedman, E., Campanha-Versiani, L., de Miranda, D. M., Sarquis, M., & Marco, L. A. D. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-101 · Cited by 35 · see citing works

Uncoupling Protein 3: Its Possible Biological Role and Mode of Regulation in Rodents and Humans

Muzzin, P., Boss, O., & Giacobino, J. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005448423731 · Cited by 35 · see citing works

Functional atrophy of brown adipose tissue during lactation in mice. Effects of lactation and weaning on mitochondrial GDP binding and uncoupling protein

Trayhurn, P., & Jennings, G. (1987) · Biochemical Journal · doi:10.1042/bj2480273 · Cited by 34 · see citing works

Developmental influences on circuits programming susceptibility to obesity

Zeltser, L. M. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.07.002 · Cited by 33 · see citing works

Thermogenic adipose tissue aging: Mechanisms and implications

Silva, G. D. N., & Amato, A. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.955612 · Cited by 33 · see citing works

A novel PPARα agonist ameliorates insulin resistance in dogs fed a high-fat diet

Tsunoda, M., Kobayashi, N., Ide, T., Utsumi, M., Nagasawa, M., & Murakami, K. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00627.2007 · Cited by 32 · see citing works

Brown adipose tissue and nutritional energetics—where are we now?

Trayhurn, P. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890026 · Cited by 32 · see citing works

Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases

Poursharifi, P., Madiraju, S. R. M., Oppong, A. K., Kajimura, S., Nolan, C. J., Blondin, D. P., & Prentki, M. (2025) · Physiological Reviews · doi:10.1152/physrev.00024.2024 · Cited by 29 · see citing works

Thermoregulation: Advances in Preterm Infants

Roychoudhury, S., & Yusuf, K. (2017) · NeoReviews · doi:10.1542/neo.18-12-e692 · Cited by 29 · see citing works

The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation

Kim, K. S., Cho, D.-Y., Kim, Y., Choi, S. M., Kim, J. Y., Shin, S. U., & Yoon, Y. S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.026 · Cited by 29 · see citing works

Brown adipose tissue uncoupling protein in infants and children

Lean, M. E. J., James, W. P. T., Jennings, G., & Trayhurn, P. (1986) · Biochemical Society Transactions · doi:10.1042/bst0140288

The characterization and energetic potential of brown adipose tissue in man

Cunningham, S. A., Leslie, P. J., Hopwood, D., Illingworth, P. J., Jung, R. T., Nicholls, D. G., Peden, N. R., Rafael, J., & Rial, E. (1985) · Clinical Science · doi:10.1042/cs0690343 · Cited by 91 · see citing works

Brown adipose tissue activity in pyrexial cases of cot death.

Lean, M. E. J., & Jennings, G. (1989) · Journal of Clinical Pathology · doi:10.1136/jcp.42.11.1153 · Cited by 23 · see citing works

Brown adipose tissue uncoupling protein in adult humans

Lean, M. E. J., James, W. P. T., Jennings, G., & Trayhurn, P. (1986) · Biochemical Society Transactions · doi:10.1042/bst0140289 · Cited by 2 · see citing works

Uncoupling protein and its mRNA in brown adipose tissue of newborn rabbits

Rozon, D. K., Harris, W. H., & Gibbins, A. M. V. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-009 · Cited by 4 · see citing works